clonidine has been researched along with Drug Overdose in 46 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To describe a patient who experienced a hypertensive crisis and myocardial infarction following a massive dose of parenteral clonidine." | 7.70 | Hypertensive crisis and myocardial infarction following massive clonidine overdose. ( Frye, CB; Vance, MA, 2000) |
| "Glucagon has been used to treat the hypotension associated with calcium channel antagonist poisoning in adult patients." | 7.69 | The use of glucagon in nifedipine poisoning complicated by clonidine ingestion. ( Fant, JS; Fiser, RT; James, LP; Kearns, GL, 1997) |
| "Naloxone was not associated with improved outcomes." | 5.46 | Adult clonidine overdose: prolonged bradycardia and central nervous system depression, but not severe toxicity. ( Heppell, SP; Isbister, GK; Page, CB; Ryan, NM, 2017) |
| " Fifteen minutes later, each group was randomly subdivided into two equal groups and an infusion of bupivacaine or ropivacaine, 3 mg kg(-1) min(-1), was given until cardiac arrest (asystole) occurred." | 3.72 | Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats. ( Aydin, Y; Gulec, S; Senturk, Y; Uzuner, K; Yelken, B, 2004) |
| "To describe a patient who experienced a hypertensive crisis and myocardial infarction following a massive dose of parenteral clonidine." | 3.70 | Hypertensive crisis and myocardial infarction following massive clonidine overdose. ( Frye, CB; Vance, MA, 2000) |
| "Glucagon has been used to treat the hypotension associated with calcium channel antagonist poisoning in adult patients." | 3.69 | The use of glucagon in nifedipine poisoning complicated by clonidine ingestion. ( Fant, JS; Fiser, RT; James, LP; Kearns, GL, 1997) |
| "A patient at a psychiatric hospital with a diagnosis of major depression and polysubstance abuse was administered a clonidine patch for opiate detoxification." | 3.68 | Clonidine patch ingestion in an adult. ( Finkelstein, S; Raber, JH; Shinar, C, 1993) |
| "Clonidine has a narrow therapeutic index, and toxicity can occur with inadvertent double dosing." | 1.51 | Clonidine exposures in children under 6 (2004-2017): a retrospective study. ( Brown, JA; Buckley, NA; Cairns, R, 2019) |
| "We aimed to determine if naloxone administration reversed the effects of clonidine or caused any adverse effects." | 1.48 | Naloxone reversal of clonidine toxicity: dose, dose, dose. ( Loden, JK; Seger, DL, 2018) |
| "Naloxone was not associated with improved outcomes." | 1.46 | Adult clonidine overdose: prolonged bradycardia and central nervous system depression, but not severe toxicity. ( Heppell, SP; Isbister, GK; Page, CB; Ryan, NM, 2017) |
| "Clonidine is an imidazoline derivative antihypertensive medication that is also used as adjunctive therapy for neuropathic pain disorders via topical administration." | 1.40 | Dermal exposure to a compounded pain cream resulting in severely elevated clonidine concentration. ( Fantz, CR; Gooden, CE; Morgan, BW; Pomerleau, AC, 2014) |
| " The amount dispensed was a 30-day supply but the bottle was empty on day 19, leading us to suspect a possible accelerated dosing error." | 1.35 | Toxicity from a clonidine suspension. ( Benson, B; Farooqi, M; Johnson, M; Kunkel, S; Seifert, S, 2009) |
| " This study was designed to determine whether data from the American Association of Poison Control Centers Toxic Exposure Surveillance System (TESS) could be utilized to determine a dose-response relationship for pediatric clonidine exposure." | 1.33 | TESS-based dose-response using pediatric clonidine exposures. ( Benson, BE; Spyker, DA; Troutman, WG; Watson, WA, 2006) |
| "Tizanidine is a centrally acting muscle relaxant with a novel mechanism of action and structurally related to clonidine." | 1.32 | Retrospective review of Tizanidine (Zanaflex) overdose. ( Adamson, LA; Bosse, GM; Spiller, HA, 2004) |
| "Clonidine is a central acting a2-agonist used primarily as an antihypertensive agent." | 1.31 | Clonidine toxicity in an adolescent patient. ( Cox, R; Gitter, MF, 2000) |
| " In dealing with drug toxic states in which the differential diagnosis includes drugs available as transdermal delivery systems, the evaluation should include questions regarding possible dermal exposure and a thorough skin examination." | 1.30 | "Cloniderm" toxicity: another manifestation of clonidine overdose. ( Killian, CA; Krenzelok, EP; Roberge, RJ; Stonage, CL, 1997) |
| "Clonidine overdose is a potentially serious condition, often requiring intensive care management." | 1.30 | Clonidine overdose in childhood: implications of increased prescribing. ( Hanson, RM; Hutchins, P; Kappagoda, C; Schell, DN, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (39.13) | 18.2507 |
| 2000's | 16 (34.78) | 29.6817 |
| 2010's | 11 (23.91) | 24.3611 |
| 2020's | 1 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Adams, A | 1 |
| Copley, C | 1 |
| Seger, DL | 2 |
| Loden, JK | 1 |
| Cairns, R | 1 |
| Brown, JA | 1 |
| Buckley, NA | 1 |
| Toce, MS | 1 |
| Lyons, TW | 1 |
| Pomerleau, AC | 1 |
| Gooden, CE | 1 |
| Fantz, CR | 1 |
| Morgan, BW | 1 |
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Schmitt, C | 1 |
| Kervégant, M | 1 |
| Ajaltouni, Z | 1 |
| Tauber, M | 1 |
| Tichadou, L | 1 |
| de Haro, L | 1 |
| Macala, K | 1 |
| Tabrizchi, R | 1 |
| Guimera, AL | 1 |
| Kulkarni, D | 1 |
| Cates, AL | 1 |
| Wheatley, SM | 1 |
| Katz, KD | 1 |
| Isbister, GK | 1 |
| Heppell, SP | 1 |
| Page, CB | 1 |
| Ryan, NM | 1 |
| Farooqi, M | 1 |
| Seifert, S | 1 |
| Kunkel, S | 1 |
| Johnson, M | 1 |
| Benson, B | 1 |
| Johnson, ML | 1 |
| Visser, EJ | 1 |
| Goucke, CR | 1 |
| Suchard, JR | 1 |
| Graeme, KA | 1 |
| Gulec, S | 1 |
| Aydin, Y | 1 |
| Uzuner, K | 1 |
| Yelken, B | 1 |
| Senturk, Y | 1 |
| Coyne, PJ | 1 |
| Hansen, LA | 1 |
| Laird, J | 1 |
| Buster, P | 1 |
| Smith, TJ | 1 |
| Vusirikala, B | 1 |
| Williams, TA | 1 |
| Ram, AR | 1 |
| Spiller, HA | 2 |
| Bosse, GM | 1 |
| Adamson, LA | 1 |
| Benson, BE | 1 |
| Spyker, DA | 1 |
| Troutman, WG | 1 |
| Watson, WA | 1 |
| Bartlett, D | 1 |
| Sklerov, JH | 1 |
| Cox, DE | 1 |
| Moore, KA | 1 |
| Levine, B | 1 |
| Fowler, D | 1 |
| Klein-Schwartz, W | 1 |
| Behrman, A | 1 |
| Goertemoeller, S | 1 |
| Meyer, C | 1 |
| Cambray, R | 1 |
| Whelan, R | 1 |
| Dearlove, OR | 1 |
| Henretig, FM | 1 |
| Raber, JH | 1 |
| Shinar, C | 1 |
| Finkelstein, S | 1 |
| Zarifis, J | 1 |
| Lip, GY | 1 |
| Ferner, RE | 1 |
| Luciani, A | 1 |
| Brugioni, L | 1 |
| Serra, L | 1 |
| Graziina, A | 1 |
| Ryan, MG | 1 |
| Pearson, CC | 1 |
| Bertoli, M | 1 |
| Roberge, RJ | 2 |
| McGuire, SP | 1 |
| Krenzelok, EP | 2 |
| Hudson, PA | 1 |
| Rose, JS | 1 |
| Perera, I | 1 |
| Killian, CA | 1 |
| Stonage, CL | 1 |
| Fant, JS | 1 |
| James, LP | 1 |
| Fiser, RT | 1 |
| Kearns, GL | 1 |
| Kraft, ME | 1 |
| Broderick-Cantwell, JJ | 1 |
| Kappagoda, C | 1 |
| Schell, DN | 1 |
| Hanson, RM | 1 |
| Hutchins, P | 1 |
| Karnawat, BS | 1 |
| Chowdhry, BR | 1 |
| Frye, CB | 1 |
| Vance, MA | 1 |
| Gitter, MF | 1 |
| Cox, R | 1 |
| Romano, MJ | 1 |
| Dinh, A | 1 |
| Wedin, GP | 1 |
| Richardson, SL | 1 |
| Wallace, GH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
5 reviews available for clonidine and Drug Overdose
| Article | Year |
|---|---|
Massive clonidine overdose during refill of an implanted drug delivery device for intrathecal analgesia: a review of inadvertent soft-tissue injection during implantable drug delivery device refills and its management.
Topics: Analgesics; Clonidine; Drug Delivery Systems; Drug Overdose; Female; Guidelines as Topic; Humans; In | 2011 |
Clonidine toxicity revisited.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Clonidine; Drug Overdose; Female; Humans; Hypertension | 2002 |
Special considerations in the poisoned pediatric patient.
Topics: Acetaminophen; Alcoholic Intoxication; Astemizole; Child; Child, Preschool; Clonidine; Cocaine; Crit | 1994 |
Poisoning with anti-hypertensive drugs: methyldopa and clonidine.
Topics: Antihypertensive Agents; Cardiovascular Diseases; Central Nervous System Diseases; Clonidine; Drug O | 1995 |
Self-induced overdose of ADHD medication.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Clonidine; | 1996 |
41 other studies available for clonidine and Drug Overdose
| Article | Year |
|---|---|
High dose naloxone for acute tizanidine overdose in the emergency department: a case report.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Bradycardia; Clonidine; Drug Overdose; Emergency Servic | 2021 |
Naloxone reversal of clonidine toxicity: dose, dose, dose.
Topics: Adolescent; Antidotes; Antihypertensive Agents; Child; Child, Preschool; Clonidine; Cohort Studies; | 2018 |
Clonidine exposures in children under 6 (2004-2017): a retrospective study.
Topics: Adrenergic alpha-2 Receptor Agonists; Child Behavior Disorders; Child, Preschool; Clonidine; Drug Ov | 2019 |
Case 1: A Medically Complex 10-month-old Boy with Lethargy.
Topics: Antihypertensive Agents; Clonidine; Diagnosis, Differential; Drug Overdose; Humans; Infant; Lethargy | 2019 |
Dermal exposure to a compounded pain cream resulting in severely elevated clonidine concentration.
Topics: Administration, Cutaneous; Adrenergic alpha-2 Receptor Agonists; Adult; Analgesics; Bradycardia; Clo | 2014 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
[Clonidine poisoning in a child: a case report].
Topics: Adrenergic alpha-2 Receptor Agonists; Albuterol; Antihypertensive Agents; Betaxolol; Blood Pressure; | 2014 |
The effect of fat emulsion on hemodynamics following treatment with propranolol and clonidine in anesthetized rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Anesthesia; Animals; Clonidine; D | 2014 |
Altered Mental Status in a 14-Year-Old Girl.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Clonidine; Diagnosis, Differential; Drug Overdose; | 2016 |
Clonidine Overdose in a Toddler Due to Accidental Ingestion of a Compounding Cream.
Topics: Adrenergic alpha-2 Receptor Agonists; Clonidine; Drug Compounding; Drug Overdose; Female; Fluid Ther | 2018 |
Adult clonidine overdose: prolonged bradycardia and central nervous system depression, but not severe toxicity.
Topics: Adolescent; Adult; Aged; Antidotes; Antihypertensive Agents; Atropine; Bradycardia; Central Nervous | 2017 |
Toxicity from a clonidine suspension.
Topics: Adrenergic alpha-Agonists; Child, Preschool; Clonidine; Drug Compounding; Drug Overdose; Humans; Mal | 2009 |
Pediatric clonidine poisoning as a result of pharmacy compounding error.
Topics: Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Drug Com | 2002 |
Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats.
Topics: Adrenergic alpha-Agonists; Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure | 2004 |
Massive hydromorphone dose delivered subcutaneously instead of intrathecally: guidelines for prevention and management of opioid, local anesthetic, and clonidine overdose.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Clonidine; Drug Overdose; Female; Humans; Hydromorpho | 2004 |
A late presentation of ocular quinine toxicity managed with a combination of vasodilatory treatments.
Topics: Adrenergic alpha-Agonists; Adult; Blindness; Clonidine; Drug Overdose; Female; Humans; Muscle Relaxa | 2005 |
Retrospective review of Tizanidine (Zanaflex) overdose.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Charcoal; Child; Child, Preschool; Clonidine; | 2004 |
TESS-based dose-response using pediatric clonidine exposures.
Topics: Accidents; Adrenergic alpha-Agonists; Child, Preschool; Clonidine; Data Interpretation, Statistical; | 2006 |
The vague OD. The symptomatic patient with an unknown exposure.
Topics: Adult; Cholinergic Agents; Clonidine; Diagnosis, Differential; Drug Overdose; Education, Continuing; | 2006 |
Tizanidine distribution in a postmortem case.
Topics: Adrenergic alpha-Agonists; Bile; Clonidine; Drug Interactions; Drug Overdose; Ethanol; Female; Gastr | 2006 |
Reply to clonidine exposures, not toxicity.
Topics: Adrenergic alpha-Agonists; Child; Clonidine; Drug Overdose; Humans; Poison Control Centers; Sleep St | 2006 |
A sticky situation: toxicity of clonidine and fentanyl transdermal patches in pediatrics.
Topics: Accidents; Administration, Cutaneous; Analgesics, Opioid; Antihypertensive Agents; Clonidine; Coma; | 2007 |
One hundred times the intended dose of caudal clonidine in three pediatric patients.
Topics: Adrenergic alpha-Agonists; Anesthesia, Caudal; Child, Preschool; Clonidine; Drug Overdose; Female; H | 2008 |
Management of clonidine overdose in a child with Tourette syndrome.
Topics: Child; Chlorpromazine; Clonidine; Drug Overdose; Humans; Male; Suicide, Attempted; Tourette Syndrome | 1995 |
Clonidine patch ingestion in an adult.
Topics: Administration, Cutaneous; Adult; Clonidine; Depression; Drug Overdose; Humans; Male; Substance-Rela | 1993 |
Sino-atrial and atrio-ventricular node dysfunction in a case of tizanidine overdose.
Topics: Adult; Atrioventricular Node; Clonidine; Drug Overdose; Female; Humans; Hypnotics and Sedatives; Lor | 1995 |
Attention-deficit disorder with hyperactivity.
Topics: Attention Deficit Disorder with Hyperactivity; Child, Preschool; Clonidine; Drug Overdose; Female; H | 1996 |
Clonidine removal by hemoperfusion in a uremic patient.
Topics: Antihypertensive Agents; Clonidine; Drug Overdose; Hemoperfusion; Humans; Male; Middle Aged; Renal D | 1996 |
Yohimbine as an antidote for clonidine overdose.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Antidotes; Clonidine; Drug Overdose; | 1996 |
Real-time ultrasound guided internal jugular vein catheterization in the emergency department.
Topics: Catheterization, Central Venous; Clonidine; Drug Overdose; Emergency Service, Hospital; Female; Huma | 1997 |
What you need to know: addiction--cough mixture.
Topics: Acute Disease; Adrenergic alpha-Agonists; Antitussive Agents; Chronic Disease; Clonidine; Codeine; D | 1997 |
"Cloniderm" toxicity: another manifestation of clonidine overdose.
Topics: Administration, Cutaneous; Antihypertensive Agents; Child; Clonidine; Drug Overdose; Female; Humans | 1997 |
The use of glucagon in nifedipine poisoning complicated by clonidine ingestion.
Topics: Adolescent; Antidotes; Antihypertensive Agents; Calcium Channel Blockers; Clonidine; Drug Interactio | 1997 |
A 9-month-old with bradycardia and periodic apnea.
Topics: Antihypertensive Agents; Apnea; Bradycardia; Clonidine; Drug Overdose; Emergency Nursing; Female; Hu | 1998 |
Case study: accidental clonidine patch overdose in attention-deficit/hyperactivity disorder patients.
Topics: Administration, Cutaneous; Adolescent; Adrenergic alpha-Agonists; Attention Deficit Disorder with Hy | 1999 |
Clonidine overdose in childhood: implications of increased prescribing.
Topics: Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Bradycardia; Child; Child, | 1998 |
Clonidine overdose.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Child, Preschool; Clonidine; Drug Overdose; Emer | 1998 |
Hypertensive crisis and myocardial infarction following massive clonidine overdose.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Breast Neoplasms; Clonidine; Drug Overdose; Drug Ther | 2000 |
Clonidine toxicity in an adolescent patient.
Topics: Accidents, Home; Antihypertensive Agents; Child; Clonidine; Drug Overdose; Emergency Service, Hospit | 2000 |
A 1000-fold overdose of clonidine caused by a compounding error in a 5-year-old child with attention-deficit/hyperactivity disorder.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Attention Deficit Disorder with Hyperactivity; C | 2001 |
Clonidine poisoning in children.
Topics: Child, Preschool; Clonidine; Drug Overdose; Emergencies; Humans; Male | 1990 |