clonidine has been researched along with Down Syndrome in 2 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Levodopa and clonidine were given, and blood was drawn for determining serum GH levels." | 1.29 | Hypothalamic versus pituitary dysfunction in Down's syndrome as cause of growth retardation. ( Beaulieu, I; Castells, S; Gelato, MC; Torrado, C; Wisniewski, KE; Zarny, S, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Castells, S | 2 |
| Beaulieu, I | 1 |
| Torrado, C | 2 |
| Wisniewski, KE | 2 |
| Zarny, S | 1 |
| Gelato, MC | 1 |
| Bastian, W | 1 |
2 other studies available for clonidine and Down Syndrome
| Article | Year |
|---|---|
Hypothalamic versus pituitary dysfunction in Down's syndrome as cause of growth retardation.
Topics: Anthropometry; Child, Preschool; Clonidine; Down Syndrome; Dwarfism, Pituitary; Female; Growth Hormo | 1996 |
Growth hormone deficiency in Down's syndrome children.
Topics: Adolescent; Anthropometry; Child; Child, Preschool; Clonidine; Down Syndrome; Dwarfism, Pituitary; F | 1992 |