clonidine has been researched along with Disease Models, Animal in 214 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The α2 agonists, dexmedetomidine and clonidine, are used as sedative drugs during critical illness." | 9.01 | The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies. ( Baillie, JK; Edwardson, SA; Flanders, CA; Rocke, AS; Walsh, TS, 2019) |
| " Results obtained in the present study showed that EZJF and JB significantly inhibited clonidine-induced catalepsy, milk-induced leucocytosis and eosinophilia, clonidine-induced mast cell degranulation, and passive paw anaphylaxis." | 7.91 | Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B. - Possible role in the treatment of asthma. ( Ninave, PB; Patil, SD, 2019) |
| " We hypothesized that early and unselective beta-blockade with propranolol alone or in combination with the alfa2-agonist clonidine would decrease brain edema, blood-brain barrier permeability, and glycocalyx disruption at 24 hours after trauma." | 7.88 | Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat. ( Bentzer, P; Genét, GF; Hansen, MB; Johansson, PI; Ostrowski, SR, 2018) |
| "Male Sprague-Dawley rats underwent 6 days of restraint stress after lung contusion/hemorrhagic shock during which the animals received clonidine (75 μg/kg) after the restraint stress." | 7.85 | Clonidine reduces norepinephrine and improves bone marrow function in a rodent model of lung contusion, hemorrhagic shock, and chronic stress. ( Alamo, IG; Efron, PA; Kannan, KB; Loftus, TJ; Mohr, AM; Ramos, H, 2017) |
| " To test this hypothesis, the effects of 2 clinically available α-2 AR agonists (dexmedetomidine and clonidine) on the occurrence of VTs were assessed in a methoxamine-sensitized rabbit model of acquired long QT syndrome (Study 1: n=45)." | 7.78 | Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome. ( Ajiki, K; Hayami, N; Kanamori, K; Kunishima, T; Mikamo, T; Murakawa, Y; Sugiura, A; Tsutsui, K; Watanabe, H; Yamagishi, N; Yamagishi, S, 2012) |
| " Although rigidity was reduced by efaroxan (an imidazoline I(1) receptor and alpha(2)-adrenoceptor antagonist) and idazoxan (an imidazoline I(1) and I(2) receptor and alpha(2)-adrenoceptor antagonist), SKF86466 and yohimbine, both of which are alpha(2)-adrenoceptor antagonists with no affinity for imidazoline receptors, also suppressed rigidity, suggesting that activation rather than blockade of imidazoline I(1) receptors contributes to reduction of reserpine-induced muscle rigidity." | 7.74 | Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. ( Hashimoto, M; Ono, H; Tanabe, M, 2008) |
| "Clonidine can effectively reduce pain and/or hypersensitivity." | 7.74 | Effects of topical application of clonidine cream on pain behaviors and spinal Fos protein expression in rat models of neuropathic pain, postoperative pain, and inflammatory pain. ( Arita, H; Hanaoka, K; Hayashida, M; Li, C; Sawamura, S; Sekiyama, H; Sumida, T; Takeda, K; Yamada, Y, 2007) |
| "We studied whether peripheral alpha2-adrenergic receptors are involved in the antihyperalgesic effects of oxcarbazepine by examining the effects of yohimbine (selective alpha2-adrenoceptor antagonist), BRL 44408 (selective alpha(2A)-adrenoceptor antagonist), MK-912 (selective alpha2C-adrenoceptor antagonist), and clonidine (alpha2-adrenoceptor agonist) on the antihyperalgesic effect of oxcarbazepine in the rat model of inflammatory pain." | 7.74 | The involvement of peripheral alpha 2-adrenoceptors in the antihyperalgesic effect of oxcarbazepine in a rat model of inflammatory pain. ( Bosković, B; Paranos, SLj; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2007) |
| "Clonidine prevented the L-NNA induced hypertension dose-dependently, but did not effect the heart rates decreased by L-NNA." | 7.74 | [Clonidine prevents development of hypertension in N (omega)-nitro-L-arginine-treated rats]. ( Aksulu, HE; Ilhan, S; Oktar, S, 2008) |
| "The clonidine mydriasis model in rats has been widely applied in preclinical research to characterize alpha(2)-adrenoceptor antagonistic properties of drugs." | 7.73 | Rat clonidine mydriasis model: imidazoline receptors are not involved. ( Koss, MC; Yu, Y, 2005) |
| "Intrathecally administered alpha2-adrenergic receptor subtype-specific antagonists were used to determine which alpha2-adrenergic receptor subtype mediates the analgesic effect of intrathecally administered tizanidine in a chronic constriction injury (CCI) rat model of neuropathic pain." | 7.72 | Alpha2-adrenergic receptor subtype specificity of intrathecally administered tizanidine used for analgesia for neuropathic pain. ( Dills, CV; Leiphart, JW; Levy, RM, 2004) |
| "The relationship between concentration and inhibitory effect of the alpha 2-adrenoceptor antagonist idazoxan on clonidine-induced mydriasis has been studied in the rat using pharmacokinetic-pharmacodynamic simultaneous modelling." | 7.69 | A pharmacokinetic-pharmacodynamic linking model for the alpha 2-adrenergic antagonism of idazoxan on clonidine-induced mydriasis in the rat. ( Jane, F; Menargues, A; Obach, R; Pruñonosa, J; Valles, J, 1995) |
| "IP administration of various doses of clonidine produces significant increases in growth hormone levels in the Wistar rats but not in the Fawn-Hooded (FH) rats, a rat strain suggested to be a genetic model of depression." | 7.69 | Lithium treatment restores clonidine's effect in an animal model of depression. ( Aulakh, CS; Hill, JL; Murphy, DL, 1994) |
| "The effects of muscimol, amino-oxyacetic acid (AOAA), diamino-N-butyric acid (DABA), bicuculline, picrotoxin, diazepam and phenobarbitone on the protective effect of clonidine against pentylenetetrazol-induced seizures were studied in mice." | 7.69 | gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice. ( Amabeoku, G; Bwakura, E; Chikuni, O, 1994) |
| "Pretreatment, but not posttreatment, with intrathecal clonidine significantly delayed the development of thermal hyperesthesia in a dose-dependent manner, and this delay in onset produced by clonidine was 3 days after the nerve injury." | 7.69 | Clonidine, but not morphine, delays the development of thermal hyperesthesia induced by sciatic nerve constriction injury in the rat. ( Nozaki-Taguchi, N; Yamamoto, T, 1996) |
| "The purported alpha 2-adrenergic agonist clonidine was found to inhibit rest tremor at doses of 0." | 7.68 | Effect of clonidine and atropine on rest tremor in the MPTP monkey model of parkinsonism. ( Bédard, PJ; Boucher, R; Gomez-Mancilla, B, 1991) |
| "Chronic administration of clonidine in the drinking water of spontaneously hypertensive (SH) rats from 11 through 17 weeks of age prevented the further development of hypertension in this model." | 7.67 | Long term treatment with clonidine during the development of hypertension in spontaneously hypertensive rats. ( Buccafusco, JJ; Serra, M; Smith, LJ; Sussman, AM, 1985) |
| "Adrenoceptor-mediated responses of the cardiovascular system during propylthiouracil-induced hypothyroidism were investigated." | 7.66 | Changes of adrenoceptor-mediated responses in the pithed rat during propylthiouracil-induced hypothyroidism. ( Borowski, E; Gross, G; Schümann, HJ, 1979) |
| " The concurrent administration of SB203580 reduces the dosage requirements for clonidine, thereby alleviating allodynia without producing undesirable motor or cardiovascular effects." | 5.43 | Clonidine, an alpha-2 adrenoceptor agonist relieves mechanical allodynia in oxaliplatin-induced neuropathic mice; potentiation by spinal p38 MAPK inhibition without motor dysfunction and hypotension. ( Beitz, AJ; Kim, SJ; Lee, JH; Oh, SB; Roh, DH; Yeo, JH; Yoon, SY, 2016) |
| "Current pharmacotherapies for PTSD manage only a subset of these symptoms and typically have adverse side effects which limit their overall effectiveness." | 5.39 | Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. ( Diamond, DM; Fleshner, M; Zoladz, PR, 2013) |
| " These results provide further evidence that alpha(2)-adrenergic receptor activation shortly after perinatal hypoxia-ischemia can promote neural recovery, but highlight the complex dose-response of exogenous therapy." | 5.35 | Partial neuroprotection with low-dose infusion of the alpha2-adrenergic receptor agonist clonidine after severe hypoxia in preterm fetal sheep. ( Bennet, L; Dean, JM; George, S; Gunn, AJ; Mallard, C; Naylor, AS, 2008) |
| " In the mouse formalin test, DBV injection produced a dramatic leftward shift in the dose-response curve for clonidine-induced analgesia." | 5.35 | Acupoint stimulation with diluted bee venom (apipuncture) potentiates the analgesic effect of intrathecal clonidine in the rodent formalin test and in a neuropathic pain model. ( Beitz, AJ; Han, HJ; Kim, HW; Kwon, YB; Lee, HJ; Lee, JH; Roh, DH; Seo, HS; Yoon, SY, 2009) |
| " ITC was delivered locally via catheter to the T2-T4 spinal segments and was dosed to reduce heart rate (HR) by >20% to 25%." | 5.33 | Intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine postinfarction heart failure model. ( Groh, WJ; Hildebrand, KR; Issa, ZF; Miller, JM; Rosenberger, J; Ujhelyi, MR; Zhou, X; Zipes, DP, 2005) |
| "A second spell of arrhythmia of similar intensity and pattern, which had the same latency to onset, was reproduced 60 min after the first spell of arrhythmia." | 5.28 | Isolated paced guinea pig left atrium: a new ouabain-induced arrhythmia model. ( Thomas, GP; Varma, RK, 1991) |
| "Clonidine treatment resulted in less outer medullary microvascular damage (demonstrated by colloidal carbon staining), higher outer medullary blood flow 1 to 2 hours after unclamping, fewer casts, and higher creatinine clearance and free water clearance/creatinine clearance 4 to 6 hours after unclamping compared with controls." | 5.26 | Clonidine after renal ischemia to lessen acute renal failure and microvascular damage. ( Hamilton, B; Ideura, T; Saito, H; Silvia, CB; Solez, K, 1980) |
| "The α2 agonists, dexmedetomidine and clonidine, are used as sedative drugs during critical illness." | 5.01 | The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies. ( Baillie, JK; Edwardson, SA; Flanders, CA; Rocke, AS; Walsh, TS, 2019) |
| " Results obtained in the present study showed that EZJF and JB significantly inhibited clonidine-induced catalepsy, milk-induced leucocytosis and eosinophilia, clonidine-induced mast cell degranulation, and passive paw anaphylaxis." | 3.91 | Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B. - Possible role in the treatment of asthma. ( Ninave, PB; Patil, SD, 2019) |
| " Yohimbine had no effect on form-deprivation myopia, but 200 nmol reduced the myopia-inhibiting effect of goggle removal." | 3.91 | Alpha ( Carr, BJ; Nguyen, CT; Stell, WK, 2019) |
| " We hypothesized that early and unselective beta-blockade with propranolol alone or in combination with the alfa2-agonist clonidine would decrease brain edema, blood-brain barrier permeability, and glycocalyx disruption at 24 hours after trauma." | 3.88 | Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat. ( Bentzer, P; Genét, GF; Hansen, MB; Johansson, PI; Ostrowski, SR, 2018) |
| " effect of test drug on clonidine and haloperidol induced catalepsy, milk-induced leukocytosis and eosinophilia, mast cell stabilizing activity in mice and studies on smooth muscle preparation of guinea pig ileum (in-vitro)." | 3.88 | Antiallergic and antihistaminic actions of Ceasalpinia bonducella seeds: Possible role in treatment of asthma. ( Nirmal, S; Vikhe, S, 2018) |
| " On the other hand, acetic acid-induced writhes indicate visceral pain features of IBS model animals." | 3.88 | Involvement of peripheral alpha2A adrenoceptor in the acceleration of gastrointestinal transit and abdominal visceral pain induced by intermittent deprivation of REM sleep. ( Endo, S; Kozawa, M; Murakami, H; Muto, M; Tadano, T; Tan-No, K; Tsuchiya, M; Yaoita, F, 2018) |
| "Male Sprague-Dawley rats underwent 6 days of restraint stress after lung contusion/hemorrhagic shock during which the animals received clonidine (75 μg/kg) after the restraint stress." | 3.85 | Clonidine reduces norepinephrine and improves bone marrow function in a rodent model of lung contusion, hemorrhagic shock, and chronic stress. ( Alamo, IG; Efron, PA; Kannan, KB; Loftus, TJ; Mohr, AM; Ramos, H, 2017) |
| " The aims of this study were therefore (1) to investigate the anti-dyskinetic effects of piribedil on L-DOPA-induced contralateral turning behaviour, locomotive dyskinesias (LD), axial dystonia (AD), orolingual dyskinesia (OD) and forelimb dyskinesia (FD) and (2) to compare these effects to the α(2) adrenoceptor antagonist, idazoxan, or the α(2) adrenoceptor agonist, clonidine." | 3.79 | The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α(2) adrenergic mechanisms. ( Gerlach, M; Halley, P; Riederer, P; van den Buuse, M, 2013) |
| " To test this hypothesis, the effects of 2 clinically available α-2 AR agonists (dexmedetomidine and clonidine) on the occurrence of VTs were assessed in a methoxamine-sensitized rabbit model of acquired long QT syndrome (Study 1: n=45)." | 3.78 | Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome. ( Ajiki, K; Hayami, N; Kanamori, K; Kunishima, T; Mikamo, T; Murakawa, Y; Sugiura, A; Tsutsui, K; Watanabe, H; Yamagishi, N; Yamagishi, S, 2012) |
| "Therefore there could been an alternative in the treatment of the polycystic ovary syndrome in the rat by using adrenergic agonist and antagonists in combination with naltrexone." | 3.77 | The role of opioid system and its interaction with sympathetic nervous system in the processing of polycystic ovary syndrome modeling in rat. ( Ejtemaeimehr, Sh; Fatemeh, A; Mohammadi, A; Naghizadeh, MM; Zangeneh, FZ, 2011) |
| "Although it is known that both clonidine and loperamide cause delayed colonic transit in mice, these models of drug-induced experimental constipation have not yet been fully characterized." | 3.75 | Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models. ( Doihara, H; Ito, H; Kawabata-Shoda, E; Kojima, R; Nozawa, K; Yokoyama, T, 2009) |
| " Although rigidity was reduced by efaroxan (an imidazoline I(1) receptor and alpha(2)-adrenoceptor antagonist) and idazoxan (an imidazoline I(1) and I(2) receptor and alpha(2)-adrenoceptor antagonist), SKF86466 and yohimbine, both of which are alpha(2)-adrenoceptor antagonists with no affinity for imidazoline receptors, also suppressed rigidity, suggesting that activation rather than blockade of imidazoline I(1) receptors contributes to reduction of reserpine-induced muscle rigidity." | 3.74 | Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. ( Hashimoto, M; Ono, H; Tanabe, M, 2008) |
| " The three models were benchmarked using compounds known to be active in neuropathic pain patients and nerve injury animal models, including gabapentin, amitriptyline and clonidine." | 3.74 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| "Clonidine can effectively reduce pain and/or hypersensitivity." | 3.74 | Effects of topical application of clonidine cream on pain behaviors and spinal Fos protein expression in rat models of neuropathic pain, postoperative pain, and inflammatory pain. ( Arita, H; Hanaoka, K; Hayashida, M; Li, C; Sawamura, S; Sekiyama, H; Sumida, T; Takeda, K; Yamada, Y, 2007) |
| "We studied whether peripheral alpha2-adrenergic receptors are involved in the antihyperalgesic effects of oxcarbazepine by examining the effects of yohimbine (selective alpha2-adrenoceptor antagonist), BRL 44408 (selective alpha(2A)-adrenoceptor antagonist), MK-912 (selective alpha2C-adrenoceptor antagonist), and clonidine (alpha2-adrenoceptor agonist) on the antihyperalgesic effect of oxcarbazepine in the rat model of inflammatory pain." | 3.74 | The involvement of peripheral alpha 2-adrenoceptors in the antihyperalgesic effect of oxcarbazepine in a rat model of inflammatory pain. ( Bosković, B; Paranos, SLj; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2007) |
| "Clonidine prevented the L-NNA induced hypertension dose-dependently, but did not effect the heart rates decreased by L-NNA." | 3.74 | [Clonidine prevents development of hypertension in N (omega)-nitro-L-arginine-treated rats]. ( Aksulu, HE; Ilhan, S; Oktar, S, 2008) |
| "The clonidine mydriasis model in rats has been widely applied in preclinical research to characterize alpha(2)-adrenoceptor antagonistic properties of drugs." | 3.73 | Rat clonidine mydriasis model: imidazoline receptors are not involved. ( Koss, MC; Yu, Y, 2005) |
| "Intrathecally administered alpha2-adrenergic receptor subtype-specific antagonists were used to determine which alpha2-adrenergic receptor subtype mediates the analgesic effect of intrathecally administered tizanidine in a chronic constriction injury (CCI) rat model of neuropathic pain." | 3.72 | Alpha2-adrenergic receptor subtype specificity of intrathecally administered tizanidine used for analgesia for neuropathic pain. ( Dills, CV; Leiphart, JW; Levy, RM, 2004) |
| " The first group was used as control group (Control) (n = 20), in the second group subarachnoid hemorrhage was performed (SAH) (n = 20), in the third group Tizanidine was administered in addition to SAH (SAH + Tizanidine administration) (n = 20)." | 3.70 | The effect of tizanidine on chronic vasospasm in rats. ( Berkman, MK; Berkman, MZ; Erbengi, T; Iplikçioğlu, AC; San, T; Sav, A, 2000) |
| " Using radiotelemetry for monitoring cardiovascular parameters of spontaneously hypertensive rats treated with clonidine or moxonidine, we showed that clonidine, unlike moxonidine, resulted in rebound hypertension after drug withdrawal." | 3.69 | Mechanisms of cardiac cell damage due to catecholamines: significance of drugs regulating central sympathetic outflow. ( Dhalla, KS; Dhalla, NS; Rupp, H, 1994) |
| "The relationship between concentration and inhibitory effect of the alpha 2-adrenoceptor antagonist idazoxan on clonidine-induced mydriasis has been studied in the rat using pharmacokinetic-pharmacodynamic simultaneous modelling." | 3.69 | A pharmacokinetic-pharmacodynamic linking model for the alpha 2-adrenergic antagonism of idazoxan on clonidine-induced mydriasis in the rat. ( Jane, F; Menargues, A; Obach, R; Pruñonosa, J; Valles, J, 1995) |
| "IP administration of various doses of clonidine produces significant increases in growth hormone levels in the Wistar rats but not in the Fawn-Hooded (FH) rats, a rat strain suggested to be a genetic model of depression." | 3.69 | Lithium treatment restores clonidine's effect in an animal model of depression. ( Aulakh, CS; Hill, JL; Murphy, DL, 1994) |
| "The effects of muscimol, amino-oxyacetic acid (AOAA), diamino-N-butyric acid (DABA), bicuculline, picrotoxin, diazepam and phenobarbitone on the protective effect of clonidine against pentylenetetrazol-induced seizures were studied in mice." | 3.69 | gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice. ( Amabeoku, G; Bwakura, E; Chikuni, O, 1994) |
| "Pretreatment, but not posttreatment, with intrathecal clonidine significantly delayed the development of thermal hyperesthesia in a dose-dependent manner, and this delay in onset produced by clonidine was 3 days after the nerve injury." | 3.69 | Clonidine, but not morphine, delays the development of thermal hyperesthesia induced by sciatic nerve constriction injury in the rat. ( Nozaki-Taguchi, N; Yamamoto, T, 1996) |
| "After chronic administration of propranolol (1 and 5 mg/kg, 14 days) to rats time-course of forced swimming changed with the decrease of rhythmical index of depression." | 3.68 | [The antidepressive properties of anaprilin]. ( Arushanian, EB; Beĭer, EV, 1992) |
| "The purported alpha 2-adrenergic agonist clonidine was found to inhibit rest tremor at doses of 0." | 3.68 | Effect of clonidine and atropine on rest tremor in the MPTP monkey model of parkinsonism. ( Bédard, PJ; Boucher, R; Gomez-Mancilla, B, 1991) |
| "During clinical trials, a clonidine transdermal device has been found to induce clonidine-specific allergic contact dermatitis in up to 25% of patients during a treatment period of 1 year." | 3.68 | Low allergenicity of clonidine impedes studies of sensitization mechanisms in guinea pig models. ( Bruynzeel, DP; de Groot, J; Goeptar, AR; Lang, M; Oostendorp, RA; Scheper, RJ; van Tol, RG; von Blomberg, BM, 1990) |
| "Moxonidine (4-chloro-N-(4, 5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine, BDF 5895) reduces blood pressure and heart rate in rats with genetic hypertension (SHR/Okamoto) and in rats with renovascular hypertension (Goldblatt 1 k/1 c)." | 3.67 | General pharmacology of the novel centrally acting antihypertensive agent moxonidine. ( Armah, BI; Hofferber, E; Stenzel, W, 1988) |
| "Chronic administration of clonidine in the drinking water of spontaneously hypertensive (SH) rats from 11 through 17 weeks of age prevented the further development of hypertension in this model." | 3.67 | Long term treatment with clonidine during the development of hypertension in spontaneously hypertensive rats. ( Buccafusco, JJ; Serra, M; Smith, LJ; Sussman, AM, 1985) |
| " The results indicate that chronic administration of imipramine or of electroshock led to the abolition of the behavioural depression and of the EEG synchronisation induced by clonidine." | 3.66 | Effects of chronic treatment with imipramine, trazodone and electroshock on the behavioural and electroencephalographic modifications induced by clonidine in the rat. ( Passarelli, F; Scotti de Carolis, A, 1983) |
| "Adrenoceptor-mediated responses of the cardiovascular system during propylthiouracil-induced hypothyroidism were investigated." | 3.66 | Changes of adrenoceptor-mediated responses in the pithed rat during propylthiouracil-induced hypothyroidism. ( Borowski, E; Gross, G; Schümann, HJ, 1979) |
| "Chronic hypertension has been produced in mongrel dogs by the long-term oral administration of metyrapone (100 mg/kg per day)." | 3.65 | Multifactorial analysis of chronic hypertension induced by electrolyte-active steroids in trained, unanesthetized dogs. ( Bravo, EL; Dustan, HP; Tarazi, RC, 1977) |
| " In contradistinction, clonidine caused a dose-related hypotension in conscious unrestrained rats subjected to sodium depletion via furosemide." | 3.65 | Hypotensive effect of clonidine during sodium depletion in the rat. ( Pals, DT, 1975) |
| "Opioid use disorder is a growing concern in the United States." | 1.62 | Validation and characterization of oxycodone physical dependence in C57BL/6J mice. ( Beardsley, PM; Carper, M; Contreras, KM; Damaj, MI; Walentiny, DM, 2021) |
| "Post-traumatic stress disorder (PTSD) is a growing issue worldwide characterized by stress and anxiety in response to re-experiencing traumatic events which strongly impair patient's quality of life and social functions." | 1.46 | Antidepressant-like activity of venlafaxine and clonidine in mice exposed to single prolonged stress - A model of post-traumatic stress disorder. Pharmacodynamic and molecular docking studies. ( Fijałkowski, Ł; Malikowska, N; Nowaczyk, A; Popik, P; Sałat, K, 2017) |
| " The concurrent administration of SB203580 reduces the dosage requirements for clonidine, thereby alleviating allodynia without producing undesirable motor or cardiovascular effects." | 1.43 | Clonidine, an alpha-2 adrenoceptor agonist relieves mechanical allodynia in oxaliplatin-induced neuropathic mice; potentiation by spinal p38 MAPK inhibition without motor dysfunction and hypotension. ( Beitz, AJ; Kim, SJ; Lee, JH; Oh, SB; Roh, DH; Yeo, JH; Yoon, SY, 2016) |
| "Clonidine was intrathecally given after intraplantar injection of complete Freund's adjuvant (CFA) in mice." | 1.42 | Noradrenergic α2 receptor attenuated inflammatory pain through STEP61/ERK signalling. ( Hu, XD; Suo, ZW; Wang, XT; Xu, YM; Yang, X; Zhang, ZY, 2015) |
| " It is concluded that co-administration of Vit B12 and morphine could reduce tolerance to analgesic effect of morphine chronic administration and also reduce its withdrawal symptoms." | 1.40 | Effect of cyanocobalamin (vitamin B12) in the induction and expression of morphine tolerance and dependence in mice. ( Etemad, L; Ghazanfari, S; Hosseinzadeh, H; Imenshahidi, M; Moshiri, M, 2014) |
| "Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life." | 1.39 | Laxative effects of Salecan on normal and two models of experimental constipated mice. ( Chen, J; Chen, P; Jia, P; Xiu, A; Zhan, Y; Zhang, J; Zhao, Y; Zhou, M, 2013) |
| "The adenosinergic system was assessed by systemic (intraperitoneal), central (intrathecal), and peripheral (intraplantar) administration of caffeine." | 1.39 | Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors. ( Cidral-Filho, FJ; Martins, DF; Mazzardo-Martins, L; Santos, AR; Stramosk, J, 2013) |
| "Current pharmacotherapies for PTSD manage only a subset of these symptoms and typically have adverse side effects which limit their overall effectiveness." | 1.39 | Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. ( Diamond, DM; Fleshner, M; Zoladz, PR, 2013) |
| "Peripheral neuropathic pain is a chronic condition that may produce plastic changes in several brain regions." | 1.38 | The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain. ( Alba-Delgado, C; Berrocoso, E; Borges, G; Horrillo, I; Meana, JJ; Mico, JA; Neto, F; Ortega, JE; Sánchez-Blázquez, P, 2012) |
| "Pretreatment with clonidine or yohimbine failed to affect basal plasma corticosterone and ACTH concentrations, but abolished diazepam-induced inhibition of the HPA axis activity." | 1.38 | The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats. ( Muck-Šeler, D; Pivac, N; Švob Štrac, D, 2012) |
| "Many drugs approved for neuropathic pain engage spinal noradrenergic and cholinergic systems for analgesia." | 1.37 | A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury. ( Eisenach, JC; Hayashida, K, 2011) |
| "Posttraumatic stress disorder (PTSD) is a prevalent psychiatric disorder precipitated by exposure to extreme traumatic stress." | 1.37 | The role of norepinephrine in differential response to stress in an animal model of posttraumatic stress disorder. ( Defino, MC; Hague, C; Olson, VG; Peskind, ER; Raskind, MA; Redila, VA; Reh, RK; Rockett, HR; Szot, P; Tran, PM; Venkov, HA, 2011) |
| "Pretreatment with yohimbine (2mg/kg, i." | 1.37 | Icilin-evoked behavioral stimulation is attenuated by alpha₂-adrenoceptor activation. ( Cowan, A; Hirsch, DD; Kim, J; Lisek, R; Rawls, SM; Raymondi, N; Rosenthal, A, 2011) |
| "Neuropathic pain is often "spontaneous" or "stimulus-independent." | 1.37 | Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy. ( Fields, HL; King, T; Lai, J; Okun, A; Porreca, F; Qu, C, 2011) |
| "Cervical incomplete spinal cord injuries often lead to severe and persistent impairments of sensorimotor functions and are clinically the most frequent type of spinal cord injury." | 1.37 | Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome. ( Filli, L; Schwab, ME; Weinmann, O; Zörner, B, 2011) |
| "PSNL induced bilateral behavioral hyperalgesia, with the ipsilateral level displaying a higher extent of behavior changes than the contralateral side." | 1.37 | Effects of clonidine on bilateral pain behaviors and inflammatory response in rats under the state of neuropathic pain. ( Dong, R; Feng, X; Li, W; Liu, J; Wang, H; Xu, J; Yu, B; Zhang, F, 2011) |
| "Clonidine treatment also reduced arterial pressure and increased functional capillary density in the skin and skeletal muscle of WKY." | 1.36 | Microvascular effects of centrally acting antihypertensive drugs in spontaneously hypertensive rats. ( Bousquet, P; Lessa, MA; Nascimento, AR; Sabino, B; Tibiriçá, E, 2010) |
| " Chronic administration of low doses of the neurotoxin 1-methy,4-phenyl,1,2,3,6-tetrahydropyridine (MPTP) can induce cognitive dysfunction in non-human primates, including impaired performance on a variable delayed response (VDR) task with attentional and memory components." | 1.36 | Clonidine improves attentional and memory components of delayed response performance in a model of early Parkinsonism. ( Decamp, E; Schneider, JS; Tinker, JP, 2010) |
| "Clonidine and ET have been reported to have cardiovascular interactions involving the sympathetic nervous system, but it is not known whether ETA receptor antagonist affects clonidine analgesia." | 1.36 | Involvement of imidazoline and opioid receptors in the enhancement of clonidine-induced analgesia by sulfisoxazole. ( Andurkar, SV; Boxwalla, M; Gulati, A; Matwyshyn, G; Puppala, BL, 2010) |
| "Gabapentin and clonidine were concomitantly administered in a fixed-dose ratio proportional to the predetermined ED(50) of these drugs, thereby obtaining a dose-response curve for the drug combination and its ED(50)." | 1.36 | Intrathecal gabapentin and clonidine synergistically inhibit allodynia in spinal nerve-ligated rats. ( Asada, A; Funao, T; Mori, T; Nishikawa, K; Yamama, Y, 2010) |
| " Dose-response studies using two classes of anxiolytics (chlordiazepoxide: 2." | 1.35 | Modelling the anxiety-depression continuum in chicks. ( Acevedo, EO; Huang, CJ; Sufka, KJ; Warnick, JE, 2009) |
| " These results provide further evidence that alpha(2)-adrenergic receptor activation shortly after perinatal hypoxia-ischemia can promote neural recovery, but highlight the complex dose-response of exogenous therapy." | 1.35 | Partial neuroprotection with low-dose infusion of the alpha2-adrenergic receptor agonist clonidine after severe hypoxia in preterm fetal sheep. ( Bennet, L; Dean, JM; George, S; Gunn, AJ; Mallard, C; Naylor, AS, 2008) |
| "Guanfacine, which is an alpha-2 agonist with a higher affinity for the 2A, compared with 2B or 2C, subtypes, also blocked the ability of PCP to increase dopamine efflux in the prefrontal cortex." | 1.35 | Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. ( Elsworth, JD; Jentsch, JD; Roth, RH; Sanchez, D, 2008) |
| " In the mouse formalin test, DBV injection produced a dramatic leftward shift in the dose-response curve for clonidine-induced analgesia." | 1.35 | Acupoint stimulation with diluted bee venom (apipuncture) potentiates the analgesic effect of intrathecal clonidine in the rodent formalin test and in a neuropathic pain model. ( Beitz, AJ; Han, HJ; Kim, HW; Kwon, YB; Lee, HJ; Lee, JH; Roh, DH; Seo, HS; Yoon, SY, 2009) |
| " Cisapride (1, 3 and 10 mg/kg) caused non-significant increases in the indices of gastric emptying, with roughly bell-shaped dose-response curves." | 1.35 | Oral mitemcinal (GM-611), an erythromycin-derived prokinetic, accelerates normal and experimentally delayed gastric emptying in conscious dogs. ( Akima, M; Itoh, Z; Kamei, K; Koga, H; Omura, S; Onoma, M; Ozaki, K; Takanashi, H; Yogo, K, 2008) |
| "Clonidine's effects were prevented by co-administration of an alpha2-adrenoceptor antagonist." | 1.34 | Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis. ( Eisenach, JC; Romero-Sandoval, A, 2007) |
| " ITC was delivered locally via catheter to the T2-T4 spinal segments and was dosed to reduce heart rate (HR) by >20% to 25%." | 1.33 | Intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine postinfarction heart failure model. ( Groh, WJ; Hildebrand, KR; Issa, ZF; Miller, JM; Rosenberger, J; Ujhelyi, MR; Zhou, X; Zipes, DP, 2005) |
| "This study aimed to develop a novel type 2 diabetes model designated the HND (Horio-Niki diabetic) mouse, by transferring diabetogenic genes from wild castaneus mice (Mus musculus castaneus) captured in the Philippines into laboratory mice (C57BL/6J:B6)." | 1.33 | The HND mouse, a nonobese model of type 2 diabetes mellitus with impaired insulin secretion. ( Anunciado, RV; Horio, F; Imamura, T; Kobayashi, M; Namikawa, T; Niki, I; Teradaira, S, 2005) |
| " Similar responses were observed after oral dosing and in lean littermates." | 1.32 | The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X. ( Ernsberger, P; Velliquette, RA, 2003) |
| "The present study compares postoperative pain scores in male and female rats and how they respond to analgesic interventions." | 1.32 | Postoperative pain and analgesic responses are similar in male and female Sprague-Dawley rats. ( Buvanendran, A; Kroin, JS; Nagalla, SK; Tuman, KJ, 2003) |
| "Cholestasis is associated with elevated plasma level of endogenous opioid peptides." | 1.31 | Clonidine attenuates naloxone-induced opioid-withdrawal syndrome in cholestatic mice. ( Arad, MA; Dehpour, AR; Namiranian, K; Samini, M, 2001) |
| "When clonidine was administered, locomotion reduction was not observed on any post-stress day." | 1.31 | Clonidine immediately after immobilization stress prevents long-lasting locomotion reduction in the rat. ( Mugishima, G; Shinba, T; Shinozaki, T, 2001) |
| "Tizanidine was given systemically to rats with experimental postoperative pain." | 1.31 | Systemic tizanidine hydrochloride (Zanaflex) partially decreases experimental postoperative pain in rats. ( Azevedo, MI; Denson, DD; Hord, AH, 2001) |
| "Tizanidine was effective in reducing sensitivity to heat, as measured by paw withdrawal latency, and did not cause sedation at smaller doses." | 1.31 | Systemic tizanidine hydrochloride (Zanaflex) relieves thermal hyperalgesia in rats with an experimental mononeuropathy. ( Azevedo, MI; Chalfoun, AG; Denson, DD; Hord, AH, 2001) |
| "Tizanidine was administered orally at 0." | 1.30 | Effects of tizanidine administration on precipitated opioid withdrawal signs in rats. ( Pinelli, A; Spezia, R; Trivulzio, S, 1998) |
| "Moxonidine is a centrally acting antihypertensive with a selective action on I1-imidazoline receptors in RVLM." | 1.29 | Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla. ( Dreshaj, I; Ernsberger, P; Haxhiu, MA; Schäfer, SG, 1994) |
| "Morphine pre-treatment was less effective in preventing development of hyperalgesia; however, whilst the ipsilateral (146 +/- 18 g) paw withdrawal threshold tended to be lower than the contralateral (183 +/- 8 g), this was not significant." | 1.29 | Pre-emptive administration of clonidine prevents development of hyperalgesia to mechanical stimuli in a model of mononeuropathy in the rat. ( Birch, PJ; Elliott, PJ; Harrison, SM; Smith, GD; Wiseman, J, 1993) |
| "Alinidine is a recently developed antiarrhythmic medication that acts directly on the cardiac pacemaker cells to reduce heart rate (HR)." | 1.28 | Addition of alinidine, a specific bradycardic agent, to dobutamine in a canine model of endotoxic shock. ( Moulart, D; Preiser, JC; Vincent, JL, 1992) |
| "A second spell of arrhythmia of similar intensity and pattern, which had the same latency to onset, was reproduced 60 min after the first spell of arrhythmia." | 1.28 | Isolated paced guinea pig left atrium: a new ouabain-induced arrhythmia model. ( Thomas, GP; Varma, RK, 1991) |
| "Treatment with clonidine significantly slowed the rate of recovery (Kruskal-Wallis H = 8." | 1.28 | Clonidine impairs recovery of beam-walking after a sensorimotor cortex lesion in the rat. ( Davis, JN; Goldstein, LB, 1990) |
| "DOCA-salt hypertension was associated with hyporeninemia and mild hypokalemia, without consistent changes in heart rate or plasma catecholamines." | 1.27 | Production and reversal of DOCA-salt hypertension in baboons. ( Goldstein, DS; Turkkan, JS, 1987) |
| "Naloxone was found to reverse this hypoalgesic state." | 1.27 | Association between hypoalgesia and hypertension in rats after short-term isolation. ( Fuentes, JA; Naranjo, JR, 1985) |
| "Physostigmine (P) was used as a model in anesthetized rats for the development of hypertension by a central cholinergic mechanism." | 1.26 | Mechanism of the antihypertensive action of clonidine on the pressor response to physostigmine. ( Buccafusco, JJ; Finberg, JP; Spector, S, 1980) |
| "Clonidine treatment resulted in less outer medullary microvascular damage (demonstrated by colloidal carbon staining), higher outer medullary blood flow 1 to 2 hours after unclamping, fewer casts, and higher creatinine clearance and free water clearance/creatinine clearance 4 to 6 hours after unclamping compared with controls." | 1.26 | Clonidine after renal ischemia to lessen acute renal failure and microvascular damage. ( Hamilton, B; Ideura, T; Saito, H; Silvia, CB; Solez, K, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (17.76) | 18.7374 |
| 1990's | 41 (19.16) | 18.2507 |
| 2000's | 57 (26.64) | 29.6817 |
| 2010's | 70 (32.71) | 24.3611 |
| 2020's | 8 (3.74) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, YJ | 1 |
| Guernon, J | 1 |
| McClure, A | 1 |
| Luo, G | 1 |
| Rajamani, R | 1 |
| Ng, A | 1 |
| Easton, A | 1 |
| Newton, A | 1 |
| Bourin, C | 1 |
| Parker, D | 1 |
| Mosure, K | 1 |
| Barnaby, O | 1 |
| Soars, MG | 1 |
| Knox, RJ | 1 |
| Matchett, M | 1 |
| Pieschl, R | 1 |
| Herrington, J | 1 |
| Chen, P | 2 |
| Sivarao, DV | 1 |
| Bristow, LJ | 1 |
| Meanwell, NA | 1 |
| Bronson, J | 1 |
| Olson, R | 1 |
| Thompson, LA | 1 |
| Dzierba, C | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 3 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Turcu, AL | 1 |
| Companys-Alemany, J | 1 |
| Phillips, MB | 1 |
| Patel, DS | 1 |
| Griñán-Ferré, C | 1 |
| Loza, MI | 1 |
| Brea, JM | 1 |
| Pérez, B | 1 |
| Soto, D | 1 |
| Sureda, FX | 1 |
| Kurnikova, MG | 1 |
| Johnson, JW | 1 |
| Pallàs, M | 1 |
| Vázquez, S | 1 |
| Flanders, CA | 1 |
| Rocke, AS | 1 |
| Edwardson, SA | 1 |
| Baillie, JK | 1 |
| Walsh, TS | 1 |
| Sanna, MD | 1 |
| Borgonetti, V | 1 |
| Masini, E | 1 |
| Galeotti, N | 1 |
| Andoh, T | 1 |
| Suzuki, K | 1 |
| Konno, M | 1 |
| Tsuneyama, K | 1 |
| Kuraishi, Y | 1 |
| Sun, M | 1 |
| Dong, Y | 1 |
| Li, M | 1 |
| Zhang, Y | 3 |
| Liang, F | 1 |
| Zhang, J | 2 |
| Soriano, SG | 1 |
| Xie, Z | 1 |
| Zou, X | 1 |
| Wang, Y | 2 |
| Yang, J | 1 |
| Guo, H | 1 |
| Cai, Z | 1 |
| Carper, M | 1 |
| Contreras, KM | 1 |
| Walentiny, DM | 1 |
| Beardsley, PM | 1 |
| Damaj, MI | 1 |
| Tanaka, M | 1 |
| Inoue, Y | 1 |
| Imai, T | 1 |
| Tanida, N | 1 |
| Takahashi, K | 1 |
| Hara, H | 1 |
| Antkiewicz-Michaluk, L | 1 |
| Romańska, I | 1 |
| Wąsik, A | 1 |
| Michaluk, J | 1 |
| Malikowska, N | 1 |
| Fijałkowski, Ł | 1 |
| Nowaczyk, A | 1 |
| Popik, P | 1 |
| Sałat, K | 1 |
| Genét, GF | 1 |
| Bentzer, P | 1 |
| Hansen, MB | 1 |
| Ostrowski, SR | 1 |
| Johansson, PI | 1 |
| Vikhe, S | 1 |
| Nirmal, S | 1 |
| Yaoita, F | 1 |
| Muto, M | 1 |
| Murakami, H | 1 |
| Endo, S | 1 |
| Kozawa, M | 1 |
| Tsuchiya, M | 1 |
| Tadano, T | 1 |
| Tan-No, K | 1 |
| Calzavacca, P | 1 |
| Booth, LC | 1 |
| Lankadeva, YR | 1 |
| Bailey, SR | 1 |
| Burrell, LM | 1 |
| Bailey, M | 1 |
| Bellomo, R | 1 |
| May, CN | 1 |
| Horman, T | 1 |
| Fernandes, MF | 1 |
| Zhou, Y | 1 |
| Fuller, B | 1 |
| Tigert, M | 1 |
| Leri, F | 2 |
| Rorabaugh, BR | 1 |
| Bui, AD | 1 |
| Seeley, SL | 1 |
| Eisenmann, ED | 1 |
| Rose, RM | 1 |
| Johnson, BL | 1 |
| Huntley, MR | 1 |
| Heikkila, ME | 1 |
| Zoladz, PR | 2 |
| Ninave, PB | 1 |
| Patil, SD | 1 |
| Carr, BJ | 1 |
| Nguyen, CT | 1 |
| Stell, WK | 1 |
| Zhou, M | 1 |
| Jia, P | 1 |
| Chen, J | 1 |
| Xiu, A | 1 |
| Zhao, Y | 1 |
| Zhan, Y | 2 |
| Park, PE | 1 |
| Vendruscolo, LF | 1 |
| Schlosburg, JE | 1 |
| Edwards, S | 1 |
| Schulteis, G | 1 |
| Koob, GF | 1 |
| Raczak-Gutknecht, J | 1 |
| Frąckowiak, T | 1 |
| Nasal, A | 1 |
| Kaliszan, R | 1 |
| Delaunois, A | 1 |
| De Ron, P | 1 |
| Dedoncker, P | 1 |
| Rosseels, ML | 1 |
| Cornet, M | 1 |
| Jnoff, E | 1 |
| Hanon, E | 1 |
| Guyaux, M | 1 |
| Depelchin, BO | 1 |
| Ghazanfari, S | 1 |
| Imenshahidi, M | 1 |
| Etemad, L | 1 |
| Moshiri, M | 1 |
| Hosseinzadeh, H | 1 |
| Ohnesorge, H | 1 |
| Feng, Z | 1 |
| Zitta, K | 1 |
| Steinfath, M | 1 |
| Albrecht, M | 1 |
| Bein, B | 1 |
| Kawaura, K | 1 |
| Karasawa, J | 1 |
| Chaki, S | 1 |
| Hikichi, H | 1 |
| Beltrán-Villalobos, KL | 1 |
| Ramírez-Marín, PM | 1 |
| Cruz, CA | 1 |
| Déciga-Campos, M | 1 |
| Macala, K | 1 |
| Tabrizchi, R | 1 |
| Xu, YM | 1 |
| Wang, XT | 1 |
| Zhang, ZY | 1 |
| Suo, ZW | 1 |
| Yang, X | 1 |
| Hu, XD | 1 |
| Jabaris, SS | 1 |
| Sumathy, H | 1 |
| Girish, R | 1 |
| Narayanan, S | 1 |
| Sugumar, M | 1 |
| Saravana Babu, C | 1 |
| Thanikachalam, S | 1 |
| Thanikachalam, M | 1 |
| Cummins Jacklin, E | 1 |
| Boughner, E | 1 |
| Kent, K | 1 |
| Kwiatkowski, D | 1 |
| MacDonald, T | 1 |
| Chabot-Doré, AJ | 1 |
| Millecamps, M | 1 |
| Naso, L | 1 |
| Devost, D | 1 |
| Trieu, P | 1 |
| Piltonen, M | 1 |
| Diatchenko, L | 1 |
| Fairbanks, CA | 1 |
| Wilcox, GL | 1 |
| Hébert, TE | 1 |
| Stone, LS | 1 |
| Yoon, SY | 4 |
| Kang, SY | 1 |
| Kim, HW | 3 |
| Kim, HC | 1 |
| Roh, DH | 4 |
| Yeo, JH | 1 |
| Kim, SJ | 1 |
| Oh, SB | 1 |
| Lee, JH | 3 |
| Beitz, AJ | 3 |
| Lim, SM | 1 |
| Park, SH | 1 |
| Sharma, N | 1 |
| Kim, SS | 1 |
| Lee, JR | 1 |
| Jung, JS | 1 |
| Suh, HW | 1 |
| Norozpour, Y | 1 |
| Nasehi, M | 1 |
| Sabouri-Khanghah, V | 1 |
| Torabi-Nami, M | 1 |
| Zarrindast, MR | 1 |
| Kimura, M | 2 |
| Eisenach, JC | 6 |
| Hayashida, KI | 1 |
| Zhang, L | 1 |
| Wang, G | 1 |
| Ma, J | 1 |
| Liu, C | 1 |
| Liu, X | 1 |
| Zhang, M | 1 |
| Horrillo, I | 2 |
| Ortega, JE | 2 |
| Diez-Alarcia, R | 1 |
| Urigüen, L | 1 |
| Meana, JJ | 2 |
| Alamo, IG | 1 |
| Kannan, KB | 1 |
| Ramos, H | 1 |
| Loftus, TJ | 1 |
| Efron, PA | 1 |
| Mohr, AM | 1 |
| Warnick, JE | 1 |
| Huang, CJ | 1 |
| Acevedo, EO | 1 |
| Sufka, KJ | 2 |
| Dean, JM | 1 |
| George, S | 1 |
| Naylor, AS | 1 |
| Mallard, C | 1 |
| Gunn, AJ | 1 |
| Bennet, L | 1 |
| Brusberg, M | 1 |
| Ravnefjord, A | 1 |
| Lindgreen, M | 1 |
| Larsson, H | 1 |
| Lindström, E | 1 |
| Martinez, V | 1 |
| Lazahari, MI | 1 |
| Sattar, MA | 1 |
| Abdullah, NA | 2 |
| Khan, MA | 1 |
| Johns, EJ | 3 |
| Tanabe, M | 1 |
| Hashimoto, M | 1 |
| Ono, H | 1 |
| Katayama, K | 1 |
| Yamada, K | 1 |
| Ornthanalai, VG | 1 |
| Inoue, T | 1 |
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| Murphy, NP | 1 |
| Aruga, J | 1 |
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| Socratous, F | 1 |
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| Nazarian, A | 1 |
| Christianson, CA | 1 |
| Hua, XY | 1 |
| Yaksh, TL | 3 |
| Jentsch, JD | 1 |
| Sanchez, D | 1 |
| Elsworth, JD | 1 |
| Roth, RH | 1 |
| Kwon, YB | 2 |
| Seo, HS | 1 |
| Han, HJ | 2 |
| Lee, HJ | 1 |
| Gulati, A | 2 |
| Bhalla, S | 1 |
| Matwyshyn, G | 2 |
| Zhang, Z | 1 |
| Andurkar, SV | 2 |
| Cosmi, S | 1 |
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| Feng, X | 2 |
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| Lai, J | 2 |
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| Chen, JJ | 1 |
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| Boxwalla, M | 1 |
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| Neto, F | 1 |
| Berrocoso, E | 1 |
| Peters, CM | 1 |
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| Polat, B | 1 |
| Alp, HH | 1 |
| Keles, ON | 1 |
| Salman, AB | 1 |
| Suleyman, H | 1 |
| Backman, LJ | 1 |
| Andersson, G | 1 |
| Fong, G | 1 |
| Alfredson, H | 1 |
| Scott, A | 1 |
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| Walker, SM | 1 |
| Grafe, M | 1 |
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| Halley, P | 1 |
| Riederer, P | 1 |
| van den Buuse, M | 1 |
| Švob Štrac, D | 1 |
| Muck-Šeler, D | 1 |
| Pivac, N | 1 |
| Yoshizumi, M | 1 |
| Hobo, S | 1 |
| Obata, H | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Renal SympAthetic DenerVation on Chronic HypErtension[NCT01628198] | 38 participants (Actual) | Interventional | 2011-10-31 | Terminated (stopped due to recommendation by the study's DSMB due to insufficient data to determine efficacy.) | |||
| Renal Sympathetic Denervation for the Management of Chronic Hypertension[NCT01628172] | 96 participants (Actual) | Interventional | 2011-01-31 | Completed | |||
| Phase I-II Clinical Trial to Determine the Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia[NCT01862250] | Phase 1/Phase 2 | 13 participants (Actual) | Interventional | 2013-10-03 | Completed | ||
| The Effects of Topical Treatment With Clonidine + Pentoxifylline in Patients With Neuropathic Pain[NCT03342950] | Phase 2 | 4 participants (Actual) | Interventional | 2019-02-19 | Terminated (stopped due to Low recruitment due to the COVID-19 pandemic) | ||
| Clinical Trial of Etanercept (TNF-α Blocker) for Treatment of Blast-Induced Tinnitus[NCT04066348] | Phase 2 | 310 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment: Double Blinded Comparison Between Botulinum Toxin and Baclofen.[NCT02462317] | Phase 4 | 184 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The change in diastolic blood pressure as measured by 24 hour ambulatory monitoring at 6 months as compared to from baseline. (NCT01628198)
Timeframe: baseline and 6 months
| Intervention | mmHg mean change (Mean) |
|---|---|
| Renal Denervation Group | -5.5 |
The change in systolic blood pressure as measured by 24 hour ambulatory monitoring at 6 months as compared to from baseline. (NCT01628198)
Timeframe: baseline and 6 months
| Intervention | mmHg (Mean) |
|---|---|
| Renal Denervation Group | -10.2 |
The total number of anti-hypertensive medications at baseline, 6 months, and 12 months (NCT01628198)
Timeframe: Baseline, 6 months, 12 months
| Intervention | medications (Mean) | ||
|---|---|---|---|
| Baseline | 6 months | 12 months | |
| Renal Denervation Group | 5.37 | 4.79 | 4.64 |
A blood urea nitrogen (BUN) test measures the amount of nitrogen in blood that comes from the waste product urea. Urea is made when protein is broken down in the body. Urea is made in the liver and passed out in the urine. (NCT01628198)
Timeframe: baseline, 6 months, 12 months
| Intervention | mg/dL (Mean) | ||
|---|---|---|---|
| Baseline | 6 months | 12 months | |
| Renal Denervation Group | 20.82 | 22.15 | 23.11 |
Creatinine measures the level of the waste product in the body. The amount of creatinine in the blood depends partly on the amount of muscle tissue you have. Men generally have higher creatinine levels than women.Normal levels of creatinine in the blood are approximately 0.6 to 1.2 milligrams (mg) per deciliter (dL) in adult males and 0.5 to 1.1 milligrams per deciliter in adult females. High levels of creatinine indicates kidney impairment. (NCT01628198)
Timeframe: baseline, 6 months, 12 months
| Intervention | mg/dl (Mean) | ||
|---|---|---|---|
| Baseline | 6 months | 12 months | |
| Renal Denervation Group | 1.6 | 1.68 | 2.03 |
Different time points office diastolic blood pressure measurements (NCT01628198)
Timeframe: baseline, 6 month, 12 months
| Intervention | mm Hg (Mean) | ||
|---|---|---|---|
| Baseline | 6 months | 12 months | |
| Renal Denervation Group | 87.06 | 86.93 | 87.75 |
Different time points office systolic blood pressure measurements (NCT01628198)
Timeframe: baseline, 6 month, 12 months
| Intervention | mm Hg (Mean) | ||
|---|---|---|---|
| Baseline | 6 months | 12 months | |
| Renal Denervation Group | 156.86 | 151.19 | 158.45 |
Renal artery blood flow as measured by Renal Aortic Ratio (RAR) = Peak systolic Velocity renal artery / Peak Systolic Velocity Aorta. A >60% stenosis is reported when there is a >3.5:1 Renal to Aortic Ratio. (NCT01628198)
Timeframe: Baseline and 12 months
| Intervention | ratio (Mean) | |||
|---|---|---|---|---|
| Baseline Right RAR | Baseline Left RAR | 12 months Right RAR | 12 months Left RAR | |
| Renal Denervation Group | 1.38 | 1.52 | 1.41 | 1.52 |
Dimensions of renal artery, right and left (NCT01628198)
Timeframe: baseline and 12 months
| Intervention | mm (Mean) | |||
|---|---|---|---|---|
| Baseline R Kidney | Baseline L Kidney | 12 months R Kidney | 12 months L Kidney | |
| Renal Denervation Group | 11.43 | 11.68 | 11.26 | 11.39 |
Renal artery blood flow as measured by Resistive Index. RI = (peak systolic velocity - end diastolic velocity ) / peak systolic velocity. the normal value is ~ 0.60, with 0.70 being around the upper limits of normal (NCT01628198)
Timeframe: Baseline and 12 months
| Intervention | index (Mean) | |||
|---|---|---|---|---|
| Baseline Right RI | Baseline Left RI | 12 months Right RI | 12 months Left RI | |
| Renal Denervation Group | 0.67 | 0.72 | 0.72 | 0.72 |
Intravenous morphine (mg/kg) was given. The standard dose is 0.05 mg/kg per dose (NCT01862250)
Timeframe: Up to 2 days
| Intervention | mg/kg (Median) |
|---|---|
| Clonidine Infants With HIE | 0.02 |
Babies were assessed after administration of clonidine for the presence or absence of shivering. (NCT01862250)
Timeframe: 48hrs
| Intervention | Participants (Count of Participants) |
|---|---|
| Clonidine Infants With HIE | 0 |
"Trough clonidine blood levels were measured after 4-7 doses of clonidine were given intravenously with a dosing interval of every 8 hrs. Mean and standard deviation (SD) of the number of doses given prior to levels being drawn was 5.3 (mean) and 0.37 (SD).~Time after last dose before measurement was 9hrs (mean) and 2.7hrs (SD)." (NCT01862250)
Timeframe: 3 days
| Intervention | ng/ml (Median) |
|---|---|
| Clonidine Infants With HIE | 0.6 |
Following 2 hours of therapeutic hypothermia, the temperature of the thermo-blanket is adjusted up half degree per hour allowing passive rewarming until 36.5 degrees is reached (NCT01862250)
Timeframe: Beginning at 72 hours up to 12 hours
| Intervention | Hours (Median) |
|---|---|
| Clonidine Infants With HIE | 8.7 |
12 reviews available for clonidine and Disease Models, Animal
| Article | Year |
|---|---|
The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Critical Illness; Dexmedetomidine; Disease | 2019 |
Mydriasis model in rats as a simple system to evaluate α2-adrenergic activity of the imidazol(in)e compounds.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Disease Models, Animal; Humans; Imidazolin | 2013 |
Sympathetic activation in chronic renal failure.
Topics: Animals; Cardiovascular Diseases; Catecholamines; Clonidine; Debrisoquin; Disease Models, Animal; Ef | 2009 |
Sympathetic activation in chronic renal failure.
Topics: Animals; Cardiovascular Diseases; Catecholamines; Clonidine; Debrisoquin; Disease Models, Animal; Ef | 2009 |
Sympathetic activation in chronic renal failure.
Topics: Animals; Cardiovascular Diseases; Catecholamines; Clonidine; Debrisoquin; Disease Models, Animal; Ef | 2009 |
Sympathetic activation in chronic renal failure.
Topics: Animals; Cardiovascular Diseases; Catecholamines; Clonidine; Debrisoquin; Disease Models, Animal; Ef | 2009 |
Dominant-submissive behavior as models of mania and depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bipolar Disorder; Clonidine; Depression; Disease M | 2005 |
A novel chemically induced animal model of human anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Behavior, Animal; Blood Pressure; Carbolines; Cloni | 1984 |
Withdrawal syndromes following cessation of treatment with antihypertensive drugs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain; Catecholamines; Clonidine; Disease Models, | 1982 |
The clonidine withdrawal syndrome. Its reproduction and evaluation in laboratory animal models.
Topics: Animals; Blood Pressure; Clonidine; Disease Models, Animal; Heart Rate; Humans; Substance Withdrawal | 1981 |
Cardiovascular regulation by central adrenergic mechanisms and its alteration by hypotensive drugs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain Mapping; Brain Stem; Cardiovascular System; | 1975 |
Neural and molecular mechanisms in anxiety.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Binding, Competitive; C | 1985 |
Central nervous system mechanisms in blood pressure control.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Catecholamines; Cloni | 1985 |
The biochemical basis of the behavioral disorder in the Lesch-Nyhan syndrome.
Topics: Adenine Nucleotides; Animals; Central Nervous System; Child; Child, Preschool; Clonidine; Corpus Str | 1985 |
Role of some biogenic substances in migraine and relevant mechanism in antimigraine action of ergotamine--studies in an experimental model for migraine.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Blood Pressure; Bradykinin; Carotid Arteries | 1974 |
202 other studies available for clonidine and Disease Models, Animal
| Article | Year |
|---|---|
Discovery of non-zwitterionic aryl sulfonamides as Na
Topics: Administration, Oral; Animals; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Dru | 2017 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Disease Models, Animal; Memantine; Mice; Recepto | 2022 |
Histamine H
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Neurons; Animals; Benzimidazoles; Clonidine; Diseas | 2020 |
Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic | 2020 |
Dexmedetomidine and Clonidine Attenuate Sevoflurane-Induced Tau Phosphorylation and Cognitive Impairment in Young Mice via α-2 Adrenergic Receptor.
Topics: Adrenergic alpha-2 Receptor Agonists; Age Factors; Animals; Behavior, Animal; Clonidine; Cognition; | 2021 |
Paeoniflorin Alleviates Abnormalities in Rats with Functional Dyspepsia by Stimulating the Release of Acetylcholine.
Topics: Acetylcholine; Animals; Clonidine; Disease Models, Animal; Dyspepsia; Glucosides; Iodoacetamide; Mal | 2020 |
Validation and characterization of oxycodone physical dependence in C57BL/6J mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Clonidine; Disease Models, Animal; Dose-R | 2021 |
Guanabenz and Clonidine, α2-Adrenergic Receptor Agonists, Inhibit Choroidal Neovascularization.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cell Movement; Cell Proliferation; Choroidal Neovascu | 2021 |
Antidepressant-Like Effect of the Endogenous Neuroprotective Amine, 1MeTIQ in Clonidine-Induced Depression: Behavioral and Neurochemical Studies in Rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Biogenic Monoamines; Brain; Brain Che | 2017 |
Antidepressant-like activity of venlafaxine and clonidine in mice exposed to single prolonged stress - A model of post-traumatic stress disorder. Pharmacodynamic and molecular docking studies.
Topics: Animals; Antidepressive Agents; Clonidine; Disease Models, Animal; Dopamine Plasma Membrane Transpor | 2017 |
Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Blood-Brain Barrier; Bra | 2018 |
Antiallergic and antihistaminic actions of Ceasalpinia bonducella seeds: Possible role in treatment of asthma.
Topics: Acetates; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Caesalpinia; Catalepsy; Cell Degranu | 2018 |
Involvement of peripheral alpha2A adrenoceptor in the acceleration of gastrointestinal transit and abdominal visceral pain induced by intermittent deprivation of REM sleep.
Topics: Acetic Acid; Acridines; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; | 2018 |
Effects of Clonidine on the Cardiovascular, Renal, and Inflammatory Responses to Experimental Bacteremia.
Topics: Acute Kidney Injury; Animals; Arginine Vasopressin; Bacteremia; Cardiac Output; Clonidine; Disease M | 2019 |
An exploration of the aversive properties of 2-deoxy-D-glucose in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analysis of Variance; Animals; Beha | 2018 |
Myocardial hypersensitivity to ischemic injury is not reversed by clonidine or propranolol in a predator-based rat model of posttraumatic stress disorder.
Topics: Adrenergic Agents; Animals; Anxiety; Cardiovascular Agents; Clonidine; Disease Models, Animal; Disea | 2019 |
Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B. - Possible role in the treatment of asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Catalepsy; Clonidine; Cytokines; Disease Models, Animal; Eos | 2019 |
Alpha
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Axial Length | 2019 |
Laxative effects of Salecan on normal and two models of experimental constipated mice.
Topics: Animals; beta-Glucans; Clonidine; Constipation; Defecation; Disease Models, Animal; Dose-Response Re | 2013 |
Corticotropin-releasing factor (CRF) and α 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats.
Topics: Acoustic Stimulation; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; | 2013 |
Advantageous safety profile of a dual selective alpha(2C) agonist/alpha(2A) antagonist antinociceptive agent.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; | 2014 |
Effect of cyanocobalamin (vitamin B12) in the induction and expression of morphine tolerance and dependence in mice.
Topics: Analgesics, Opioid; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 2014 |
Influence of clonidine and ketamine on m-RNA expression in a model of opioid-induced hyperalgesia in mice.
Topics: Analgesics, Opioid; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Brain; Clonidine; Disease M | 2013 |
Stimulation of postsynapse adrenergic α2A receptor improves attention/cognition performance in an animal model of attention deficit hyperactivity disorder.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Attention; Attention Defic | 2014 |
Coadministration of tramadol and tizanidine in an experimental acute pain model in rat.
Topics: Acute Pain; Analgesics; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug | 2014 |
The effect of fat emulsion on hemodynamics following treatment with propranolol and clonidine in anesthetized rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Anesthesia; Animals; Clonidine; D | 2014 |
Noradrenergic α2 receptor attenuated inflammatory pain through STEP61/ERK signalling.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Disease Models, Animal; Male; MAP Kinase S | 2015 |
Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system.
Topics: Adrenergic alpha-2 Receptor Agonists; Aminopyridines; Animals; Antihypertensive Agents; Benzamides; | 2015 |
Memory of a drug lapse: Role of noradrenaline.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Animals; Basolateral | 2015 |
Dual allosteric modulation of opioid antinociceptive potency by α2A-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Allosteric Regulation; Analgesics, Opioid; Animals; Clonidine; | 2015 |
Clonidine Reduces Nociceptive Responses in Mouse Orofacial Formalin Model: Potentiation by Sigma-1 Receptor Antagonist BD1047 without Impaired Motor Coordination.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Animals; Blood Pressure; Clonidine; Disease Models | 2015 |
Clonidine, an alpha-2 adrenoceptor agonist relieves mechanical allodynia in oxaliplatin-induced neuropathic mice; potentiation by spinal p38 MAPK inhibition without motor dysfunction and hypotension.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antineoplastic Agents; Blood Pressure; Clonidine; Cyt | 2016 |
Blood glucose regulation mechanism in depressive disorder animal model during hyperglycemic states.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Blood Glucose; Clonidine; Corticosterone; Depressive | 2016 |
The effect of CA1 α2 adrenergic receptors on memory retention deficit induced by total sleep deprivation and the reversal of circadian rhythm in a rat model.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Behavior, An | 2016 |
Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus.
Topics: Amines; Analgesics; Animals; Antihypertensive Agents; Atropine; Bronchodilator Agents; Clonidine; CR | 2016 |
Brain-derived neurotrophic factor (BDNF) in the rostral anterior cingulate cortex (rACC) contributes to neuropathic spontaneous pain-related aversion via NR2B receptors.
Topics: Analgesics; Animals; Avoidance Learning; Brain-Derived Neurotrophic Factor; Clonidine; Conditioning, | 2016 |
Effect of subchronic corticosterone administration on α
Topics: Animals; Anti-Inflammatory Agents; Clonidine; Corticosterone; Disease Models, Animal; Hypothalamo-Hy | 2016 |
Clonidine reduces norepinephrine and improves bone marrow function in a rodent model of lung contusion, hemorrhagic shock, and chronic stress.
Topics: Animals; Bone Marrow; Chronic Disease; Clonidine; Contusions; Disease Models, Animal; Granulocyte Co | 2017 |
Modelling the anxiety-depression continuum in chicks.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Chickens; Chlordiaze | 2009 |
Partial neuroprotection with low-dose infusion of the alpha2-adrenergic receptor agonist clonidine after severe hypoxia in preterm fetal sheep.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Disease Models, Animal; Dose-Response Relation | 2008 |
Oral clonidine inhibits visceral pain-related viscerosomatic and cardiovascular responses to colorectal distension in rats.
Topics: Abdominal Pain; Analgesics; Animals; Blood Pressure; Clonidine; Colonic Diseases; Dilatation, Pathol | 2008 |
Clonidine and a novel clonidine analog AL-12 cause sympathoinhibition in spontaneously hypertensive and diabetic spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Diabetes Mel | 2008 |
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzazepines | 2008 |
Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities.
Topics: Adrenergic alpha-Agonists; Animals; Anxiety; Behavior, Animal; Brain; Chromatography, High Pressure | 2010 |
Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dex | 2008 |
Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2008 |
Acupoint stimulation with diluted bee venom (apipuncture) potentiates the analgesic effect of intrathecal clonidine in the rodent formalin test and in a neuropathic pain model.
Topics: Acupuncture Points; Analgesics; Animals; Bee Venoms; Clonidine; Disease Models, Animal; Dose-Respons | 2009 |
Determination of adrenergic and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by clonidine and BMS182874.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Area Under Curve; Clonidine; Dansyl Compound | 2009 |
Simultaneous telemetric monitoring of tail-skin and core body temperature in a rat model of thermoregulatory dysfunction.
Topics: Adrenergic alpha-Agonists; Animals; Body Temperature; Body Temperature Regulation; Clonidine; Diseas | 2009 |
Intrathecal administration of clonidine attenuates spinal neuroimmune activation in a rat model of neuropathic pain with existing hyperalgesia.
Topics: Animals; Behavior, Animal; Biomarkers; Clonidine; Cytokines; Disease Models, Animal; Enzyme Activati | 2009 |
Pharmacological analysis of alpha(2)-adrenoceptor subtypes mediating analgesic, anti-inflammatory and gastroprotective actions.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2009 |
The antinociceptive properties of reboxetine in acute pain.
Topics: Adrenergic Antagonists; Analgesics; Animals; Antidepressive Agents; Clonidine; Disease Models, Anima | 2009 |
Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models.
Topics: Animals; Atropine; Clonidine; Constipation; Disease Models, Animal; Dose-Response Relationship, Drug | 2009 |
Unmasking the tonic-aversive state in neuropathic pain.
Topics: Adenosine; Analgesics; Analysis of Variance; Animals; Calcium Channel Blockers; Clonidine; Condition | 2009 |
Effects of pre-emptive drug treatment on astrocyte activation in the cuneate nucleus following rat median nerve injury.
Topics: Adrenergic alpha-Agonists; Animals; Astrocytes; Citrates; Clonidine; Disease Models, Animal; Dizocil | 2010 |
The alarm pheromone in male rats as a unique anxiety model: psychopharmacological evidence using anxiolytics.
Topics: Administration, Inhalation; Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Clonidine; Disease Mod | 2010 |
Microvascular effects of centrally acting antihypertensive drugs in spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Capillaries; Clonidine; Dise | 2010 |
Clonidine improves attentional and memory components of delayed response performance in a model of early Parkinsonism.
Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Attention; Clonidine; Cognition Disorders; | 2010 |
Changes in food intake and anxiety-like behaviors after clonidine injected into the median raphe nucleus.
Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Anxiety Disorders; Behavior, Animal; Cloni | 2010 |
Involvement of imidazoline and opioid receptors in the enhancement of clonidine-induced analgesia by sulfisoxazole.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Body Temperature; Clonid | 2010 |
Alpha2-adrenergic receptors and their core involvement in the process of axonal growth in retinal explants.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Autoradiography; Axons; Brimonidine Tartrate; Clonidi | 2010 |
A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury.
Topics: Acetylcholine; Amines; Analgesics; Animals; Carbazoles; Choline O-Acetyltransferase; Clonidine; Cycl | 2011 |
Intrathecal gabapentin and clonidine synergistically inhibit allodynia in spinal nerve-ligated rats.
Topics: Amines; Animals; Clonidine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relat | 2010 |
The role of opioid system and its interaction with sympathetic nervous system in the processing of polycystic ovary syndrome modeling in rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; D | 2011 |
The role of norepinephrine in differential response to stress in an animal model of posttraumatic stress disorder.
Topics: Acoustic Stimulation; Aggression; Animals; Brain Mapping; Clonidine; Disease Models, Animal; Electri | 2011 |
Cortical and hippocampal EEG effects of neurotransmitter agonists in spontaneously hypertensive vs. kainate-treated rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Baclofen; Clonidine; Disease Models, Animal; | 2011 |
Icilin-evoked behavioral stimulation is attenuated by alpha₂-adrenoceptor activation.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Agmatine; Analysis of | 2011 |
Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy.
Topics: Analgesics; Animals; Avoidance Learning; Axotomy; Clonidine; Cocaine; Conditioning, Operant; Disease | 2011 |
Conditioned place preference reveals tonic pain in an animal model of central pain.
Topics: Analgesics; Animals; Buprenorphine; Clonidine; Conditioning, Operant; Disease Models, Animal; Electr | 2011 |
Pharmacological reversal of cognitive bias in the chick anxiety-depression model.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antidepressive Agents; Anxiety; Bias; Chickens; Clo | 2012 |
Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Brown-Sequard Syndrome; Clonidine; Dis | 2011 |
[Effects of estrogen and keishibukuryogan on hot flash-like symptoms induced by yohimbine in ovariectomized rats].
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Body Tempera | 2011 |
Sensitization in relation to posttraumatic stress disorder.
Topics: Acoustic Stimulation; Animals; Brain; Clonidine; Disease Models, Animal; Mice; Norepinephrine; Prazo | 2011 |
Modulation of fear/anxiety responses, but not food intake, following α-adrenoceptor agonist microinjections in the nucleus accumbens shell of free-feeding rats.
Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Anxiety; Clonidine; Disease Models, Animal | 2012 |
Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia.
Topics: Animals; Chronic Disease; Clonidine; Disease Models, Animal; Male; Muscle Relaxants, Central; Neural | 2011 |
Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids.
Topics: Adenosine; Amines; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Cyclohexanecarboxylic | 2011 |
Effects of clonidine on bilateral pain behaviors and inflammatory response in rats under the state of neuropathic pain.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Analysis of Variance; Animals; Clonidine; Cytok | 2011 |
The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Adrenergic Up | 2012 |
Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury.
Topics: Acetylcholine; Adjuvants, Anesthesia; Analgesics; Animals; Anterior Horn Cells; Atropine; Brain-Deri | 2012 |
The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats.
Topics: Acute Kidney Injury; alpha-Methyltyrosine; Animals; Biopsy, Needle; Clonidine; Dihydropyridines; Dis | 2012 |
Alpha-2 adrenergic stimulation triggers Achilles tenocyte hypercellularity: Comparison between two model systems.
Topics: Achilles Tendon; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Anim | 2013 |
Intrathecal clonidine in the neonatal rat: dose-dependent analgesia and evaluation of spinal apoptosis and toxicity.
Topics: Age Factors; Analgesics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Carrageenan; Clonid | 2012 |
The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α(2) adrenergic mechanisms.
Topics: Adrenergic Agents; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; An | 2013 |
The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Neurons; Adrenocorticotropic Hormone; alpha-Meth | 2012 |
Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of γ-aminobutyric acid in α2-adrenoceptor and 5-HT3 serotonin receptor analgesia.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesia; Animals; Clonidine; Disease Models, Animal; gamma-A | 2012 |
Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Arrhythmia | 2012 |
Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors.
Topics: Adenosine; Analysis of Variance; Animals; Ankle Joint; Caffeine; Clonidine; Disease Models, Animal; | 2013 |
Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy.
Topics: Acetanilides; Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Conditioning, Psychological; | 2013 |
Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD.
Topics: Adrenocorticotropic Hormone; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antihypertens | 2013 |
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An | 2002 |
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An | 2002 |
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An | 2002 |
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An | 2002 |
The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; Disease Models, Animal; Female; Glucose | 2003 |
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti- | 2003 |
Effects of clonidine on the experimental hypertension by abdominal aortic coarctation in rats.
Topics: Adrenergic alpha-Agonists; Animals; Aortic Coarctation; Blood Pressure; Clonidine; Disease Models, A | 2003 |
Elevated startle during withdrawal from acute morphine: a model of opiate withdrawal and anxiety.
Topics: Acoustic Stimulation; Acute Disease; Animals; Chlordiazepoxide; Clonidine; Disease Models, Animal; I | 2004 |
Postoperative pain and analgesic responses are similar in male and female Sprague-Dawley rats.
Topics: Acetates; Amines; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Cholinesterase Inhibito | 2003 |
Clonidine preconditioning decreases infarct size and improves neurological outcome from transient forebrain ischemia in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2004 |
Evidence for alterations in alpha2-adrenergic receptor sensitivity in rats exposed to repeated cocaine administration.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Cocaine; Cocaine-Related Disorders; Corticoste | 2004 |
The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats.
Topics: Animals; Blood Glucose; Clonidine; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Res | 2004 |
Norepinephrine increases alveolar fluid reabsorption and Na,K-ATPase activity.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amiloride; Ani | 2004 |
Pharmacological characterisation of the rat brachial plexus avulsion model of neuropathic pain.
Topics: Acetates; Amines; Analgesics; Analysis of Variance; Animals; Brachial Plexus; Brachial Plexus Neurop | 2004 |
Alpha2-adrenergic receptor subtype specificity of intrathecally administered tizanidine used for analgesia for neuropathic pain.
Topics: Adrenergic alpha-Agonists; Analgesia; Animals; Clonidine; Disease Models, Animal; Injections, Spinal | 2004 |
Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model.
Topics: Acetylcholine; Animals; Aorta; Clonidine; Cyclic GMP-Dependent Protein Kinases; Diabetes Mellitus, E | 2004 |
Rat clonidine mydriasis model: imidazoline receptors are not involved.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; | 2005 |
Reduction of adrenergic neurotransmission with clonidine aggravates spike-wave seizures and alters activity in the cortex and the thalamus in WAG/Rij rats.
Topics: Adrenergic alpha-Agonists; Animals; Brain Mapping; Cerebral Cortex; Clonidine; Disease Models, Anima | 2005 |
A pharmacological modulation of opiate withdrawal using an up-/down-regulation of the noradrenergic system in opiate-dependent rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Behavior, An | 2006 |
Intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine postinfarction heart failure model.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Disease Models, Animal; Dogs; Electro | 2005 |
Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; | 2005 |
The HND mouse, a nonobese model of type 2 diabetes mellitus with impaired insulin secretion.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Animals, Wild; Blood Glucose; Clonidine; Crosses, | 2005 |
Lipid-lowering actions of imidazoline antihypertensive agents in metabolic syndrome X.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2006 |
[Role of alpha-adrenergic receptors in vascular hyperreactivity in rats with high level spinal injury].
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Abdominal; Clonidine; Disease Models, Animal; Female; Mal | 2006 |
Intrathecal clonidine suppresses zymosan-induced peripheral leukocyte migration in a mouse air pouch model via activation of spinal muscarinic type 2 receptors and sympathoadrenal medullary activity.
Topics: Adrenalectomy; Analysis of Variance; Animals; Cell Count; Cell Movement; Choline O-Acetyltransferase | 2006 |
Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis.
Topics: Adrenergic alpha-Agonists; Analgesics; Analysis of Variance; Anesthesia, Local; Animals; Apoptosis; | 2007 |
Transient allodynia pain models in mice for early assessment of analgesic activity.
Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarb | 2008 |
Effects of topical application of clonidine cream on pain behaviors and spinal Fos protein expression in rat models of neuropathic pain, postoperative pain, and inflammatory pain.
Topics: Administration, Topical; Analgesics; Animals; Behavior, Animal; Clonidine; Disease Models, Animal; D | 2007 |
Role of selective alpha and beta adrenergic receptor mechanisms in rat jejunal longitudinal muscle contractility.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Clonidine; Disease Models, Animal; Dos | 2008 |
Antinociceptive synergistic interaction between clonidine and ouabain on thermal nociceptive tests in the rat.
Topics: Analgesics; Animals; Behavior, Animal; Clonidine; Disease Models, Animal; Dose-Response Relationship | 2007 |
The involvement of peripheral alpha 2-adrenoceptors in the antihyperalgesic effect of oxcarbazepine in a rat model of inflammatory pain.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Carbamazepine; Clonidine; Disease Models, Animal; Dos | 2007 |
Oral mitemcinal (GM-611), an erythromycin-derived prokinetic, accelerates normal and experimentally delayed gastric emptying in conscious dogs.
Topics: Acetaminophen; Administration, Oral; Animals; Cisapride; Clonidine; Disease Models, Animal; Dogs; Do | 2008 |
[Clonidine prevents development of hypertension in N (omega)-nitro-L-arginine-treated rats].
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Clonidine; Disease Models, Animal | 2008 |
beta-Endorphin: possible involvement in the antihypertensive effect of central alpha-receptor activation.
Topics: Adrenergic alpha-Agonists; Animals; Brain Stem; Clonidine; Disease Models, Animal; Endorphins; Hyper | 1981 |
Alpha 1- and alpha 2-adrenoceptor binding in the Dahl rat model of hypertension.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Brain; Cerebral Cortex; Clonidine; Dioxanes; | 1984 |
Development of an animal model for the study of antihypertensive agents.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Disease Models, Animal; Heart Rate; Hum | 1984 |
[Antihypertensive effect of isoteolin in model hypertension].
Topics: Animals; Antihypertensive Agents; Aporphines; Blood Pressure; Cats; Clonidine; Disease Models, Anima | 1984 |
Effects of chronic treatment with imipramine, trazodone and electroshock on the behavioural and electroencephalographic modifications induced by clonidine in the rat.
Topics: Animals; Behavior, Animal; Brain; Clonidine; Depression; Disease Models, Animal; Electroencephalogra | 1983 |
Animal models of neuropsychiatric disorders and their relevance for Tourette syndrome.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Clonidine; Disease Models, Animal; Dopamine; | 1982 |
Mechanism of the antihypertensive action of clonidine on the pressor response to physostigmine.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Blood Pressure; Brain Chemistry; Clonidine; Dimethy | 1980 |
Clonidine after renal ischemia to lessen acute renal failure and microvascular damage.
Topics: Acute Kidney Injury; Animals; Clonidine; Creatinine; Disease Models, Animal; Diuresis; Female; Ische | 1980 |
Alpha 1-adrenoceptor subtypes mediating adrenergic vasoconstriction in kidney, one-clip Goldblatt and deoxycorticosterone acetate-salt hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Amlodipine; Animals; Clonidine; Desoxycorticosterone; Disease Models, | 1994 |
Mechanisms of cardiac cell damage due to catecholamines: significance of drugs regulating central sympathetic outflow.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Calcium; Catecholamines; Clo | 1994 |
Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla.
Topics: Adrenergic alpha-Antagonists; Affinity Labels; Animals; Antihypertensive Agents; Benzazepines; Benzo | 1994 |
Increased sensitivity to inhibition by nifedipine of responses of the mesenteric artery bed of the SHRSP to noradrenaline is not dependent on alpha 1-adrenoceptor subtypes.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; An | 1995 |
Systemic clonidine differentially modulates the abnormal reactions to mechanical and thermal stimuli in rats with peripheral mononeuropathy.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Clonidine; Cold Temperature; Dioxanes; | 1995 |
A pharmacokinetic-pharmacodynamic linking model for the alpha 2-adrenergic antagonism of idazoxan on clonidine-induced mydriasis in the rat.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Chromatography, High Pressure Liquid; C | 1995 |
Peri-administration of clonidine or MK801 delays but does not prevent the development of mechanical hyperalgesia in a model of mononeuropathy in the rat.
Topics: Animals; Clonidine; Disease Models, Animal; Dizocilpine Maleate; Hyperalgesia; Injections, Subcutane | 1995 |
Effects of the selective I1 imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Clonidine; Disease Models, Animal; Ethanol; | 1995 |
Suppressed renal response to 2,6-dimethyl clonidine but not clonidine in one kidney-one clip hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Binding Sites; Clonidine; Dioxanes; Disease Models, Animal; Hype | 1993 |
Lithium treatment restores clonidine's effect in an animal model of depression.
Topics: Animals; Clonidine; Depression; Disease Models, Animal; Drug Synergism; Growth Hormone; Lithium Carb | 1994 |
gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice.
Topics: Animals; Clonidine; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Seizu | 1994 |
Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics.
Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Aspirin; Clonidine; Diabetes Mellitus, Experi | 1994 |
Pre-emptive administration of clonidine prevents development of hyperalgesia to mechanical stimuli in a model of mononeuropathy in the rat.
Topics: Analysis of Variance; Animals; Baclofen; Carbamazepine; Clonidine; Disease Models, Animal; Hyperalge | 1993 |
Central and peripheral vasopressin interact differently with sympathetic nervous system and renin-angiotensin system in renal hypertensive rabbits.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Blood Pressure; Captopril; Clonidine; Disease Models, | 1993 |
Clonidine, but not morphine, delays the development of thermal hyperesthesia induced by sciatic nerve constriction injury in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; | 1996 |
Sensitization of mice to topically applied drugs: albuterol, chlorpheniramine, clonidine and nadolol.
Topics: Administration, Cutaneous; Albuterol; Animals; Anti-Asthmatic Agents; Antihypertensive Agents; Biolo | 1996 |
Effect of insulin and clonidine on the evoked release of norepinephrine and serotonin from the nucleus tractus solitarius of the diabetic rat.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Diabetes Mellitus, Experimental; Disease Models, Anim | 1995 |
Growth hormone response to clonidine in the nervous pointer dog model of anxiety.
Topics: Adrenergic alpha-Agonists; Animals; Anxiety Disorders; Clonidine; Disease Models, Animal; Dog Diseas | 1994 |
Role of beta-adrenoceptors in gastric mucosal integrity and gastroprotection induced by epidermal growth factor.
Topics: Adrenalectomy; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Clonidine; Culture Tech | 1997 |
Glaucoma drops control intraocular pressure and protect optic nerves in a rat model of glaucoma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Clonidine; Disease Model | 1998 |
Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Animals; Behavior, Animal; Body Temperature; Clonid | 1997 |
Effects of tizanidine administration on precipitated opioid withdrawal signs in rats.
Topics: Adrenergic alpha-Agonists; Analgesics; Analysis of Variance; Animals; Behavioral Symptoms; Body Temp | 1998 |
Characterization of enhanced behavioral responses to L-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Behavior, An | 1998 |
Regulation of cell cyclic AMP in medullary thick ascending limb of Henle in a rat model of chronic renal failure.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Animals; Calcitonin; Cell Separation; Clonid | 1998 |
Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Axons; Brimonid | 1999 |
Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Analgesics; Animals; Antidepressive Agents; Body T | 1999 |
Intrathecal adenosine: interactions with spinal clonidine and neostigmine in rat models of acute nociception and postoperative hypersensitivity.
Topics: Adenosine; Analgesics, Non-Narcotic; Animals; Clonidine; Disease Models, Animal; Dose-Response Relat | 1999 |
The adrenergic receptor agonist, clonidine, potentiates the anti-parkinsonian action of the selective kappa-opioid receptor agonist, enadoline, in the monoamine-depleted rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzofurans; | 1999 |
Thermal and mechanical antinociceptive action of spinal vs peripherally administered clonidine in the rat inflamed knee joint model.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Arthritis; Clonidine; Disease Models, Animal; Dose-R | 1999 |
Brain-derived TNFalpha: involvement in neuroplastic changes implicated in the conscious perception of persistent pain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Chronic Disease; Clonidine; | 2000 |
Beta-blockers - again, a lesson to us all, especially the research funding community.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Clinical Trials as T | 2000 |
Sympathetic inhibition with clonidine prolongs survival in experimental chronic heart failure.
Topics: Animals; Blood Pressure; Chronic Disease; Clonidine; Disease Models, Animal; Heart Failure; Heart Ra | 2000 |
Effect of SR121463, a selective non-peptide vasopressin V2 receptor antagonist, in a rabbit model of ocular hypertension.
Topics: Administration, Oral; Administration, Topical; Animals; Antidiuretic Hormone Receptor Antagonists; C | 2000 |
The effect of tizanidine on chronic vasospasm in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Chronic Disease; Clonidine; Disease Models, Animal; F | 2000 |
Clonidine attenuates naloxone-induced opioid-withdrawal syndrome in cholestatic mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cholestasis; Clonidine; Disease Mo | 2001 |
Clonidine immediately after immobilization stress prevents long-lasting locomotion reduction in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Anxiety; Clonidine; Disease Models, Animal; Locomotion; Male; Ra | 2001 |
Systemic tizanidine hydrochloride (Zanaflex) partially decreases experimental postoperative pain in rats.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Disease Models, Animal; Male; Pain, Posto | 2001 |
Systemic tizanidine hydrochloride (Zanaflex) relieves thermal hyperalgesia in rats with an experimental mononeuropathy.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Disease Models, Animal; Hot Temperature; Hyperalgesia | 2001 |
Activation of medullary post-inspiratory related neurons during clonidine-induced central apnea in anesthetized goats.
Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Clonidine; Disease Models, Animal; Dopamine; Female; | 2001 |
Differential antihypertensive effects of clonidine in different models of experimental hypertension in rats.
Topics: Animals; Antihypertensive Agents; Clonidine; Desoxycorticosterone; Disease Models, Animal; Hypertens | 1979 |
Changes of adrenoceptor-mediated responses in the pithed rat during propylthiouracil-induced hypothyroidism.
Topics: Animals; Atropine; Blood Pressure; Bupranolol; Clonidine; Disease Models, Animal; Electric Stimulati | 1979 |
A dopaminergic basis for the effects of amphetamine on a mouse "preadolescent hyperkinetic" model.
Topics: Adolescent; Aging; Amphetamine; Animals; Apomorphine; Clonidine; Disease Models, Animal; Humans; Hyp | 1977 |
Multifactorial analysis of chronic hypertension induced by electrolyte-active steroids in trained, unanesthetized dogs.
Topics: Acebutolol; Aldosterone; Animals; Chronic Disease; Clonidine; Corticosterone; Diet, Sodium-Restricte | 1977 |
Proceedings: Effect of prolonged administration of clonidine to spontaneously hypertensive rats on blood pressure, cerebral norepinephrine content and angiographic finding in the kidney.
Topics: Animals; Blood Pressure; Brain; Clonidine; Disease Models, Animal; Female; Hypertension; Kidney; Nor | 1975 |
Hypotensive effect of clonidine during sodium depletion in the rat.
Topics: Animals; Blood Pressure; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 1975 |
Changes in the arterial blood pressure responses of hypertensive rats to some drugs acting on the central sympathetic mechanisms.
Topics: Adrenal Glands; Animals; Blood Pressure; Clonidine; Disease Models, Animal; Hypertension; Male; Phys | 1975 |
[The antidepressive properties of anaprilin].
Topics: Animals; Antidepressive Agents; Clonidine; Depression; Disease Models, Animal; Dose-Response Relatio | 1992 |
Injection of the competitive NMDA receptor antagonist AP-5 into the nucleus accumbens of monoamine-depleted mice induces pronounced locomotor stimulation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Biogenic Monoamines; Clonidine; Disease Models, Animal; Drug S | 1992 |
Development of a new rabbit ear model for the longitudinal study of digital pathophysiology.
Topics: Albuterol; Animals; Aorta, Abdominal; Blood Pressure; Catheterization, Peripheral; Clonidine; Diseas | 1992 |
alpha N-acetyl human beta-endorphin-(1-31) alleviates the morphine withdrawal syndrome in rodents: a comparative study with clonidine.
Topics: Animals; beta-Endorphin; Clonidine; Disease Models, Animal; Male; Mice; Morphine; Naloxone; Rats; Ra | 1992 |
Addition of alinidine, a specific bradycardic agent, to dobutamine in a canine model of endotoxic shock.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Clonidine; Disease Models, Animal; Dobutamine | 1992 |
Synergistic interactions between muscarinic antagonists, adrenergic agonists and NMDA antagonists with respect to locomotor stimulatory effects in monoamine-depleted mice.
Topics: Adrenergic alpha-Agonists; Animals; Atropine; Biperiden; Clonidine; Disease Models, Animal; Dizocilp | 1991 |
Isolated paced guinea pig left atrium: a new ouabain-induced arrhythmia model.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Function, Left; Clonidine; Disease Mod | 1991 |
Intrathecal administration of clonidine suppresses autotomy, a behavioral sign of chronic pain in rats after sciatic nerve section.
Topics: Animals; Chronic Disease; Clonidine; Disease Models, Animal; Humans; Injections, Spinal; Male; Nails | 1991 |
Effect of clonidine and atropine on rest tremor in the MPTP monkey model of parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Atropine; Clonidine; Disease Models, Animal; | 1991 |
Pharmacological alleviation of combined cholinergic/noradrenergic lesion-induced memory deficits in rats.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Benzylamines; Cholinergic Agents; Cholinergic Fibers | 1991 |
Low allergenicity of clonidine impedes studies of sensitization mechanisms in guinea pig models.
Topics: Administration, Cutaneous; Animals; Clonidine; Cyclophosphamide; Dermatitis, Contact; Disease Models | 1990 |
Clonidine impairs recovery of beam-walking after a sensorimotor cortex lesion in the rat.
Topics: Animals; Brain Injuries; Cerebral Cortex; Cerebrovascular Disorders; Clonidine; Disease Models, Anim | 1990 |
The role of prostaglandins in the para-aminoclonidine-induced reduction of intraocular pressure.
Topics: Administration, Topical; Animals; Aqueous Humor; Clonidine; Dinoprost; Dinoprostone; Disease Models, | 1989 |
Effect of antisecretory drugs on experimentally induced weanling diarrhoea in piglets.
Topics: Animals; Animals, Newborn; Chlorpromazine; Clonidine; Diarrhea; Disease Models, Animal; Escherichia | 1989 |
The neural basis of salt sensitivity in the rat: altered hypothalamic function.
Topics: Animals; Blood Pressure; Clonidine; Disease Models, Animal; Heart Rate; Hypertension; Hypothalamus, | 1988 |
Comparison of drugs with different selectivity for central alpha 1-and alpha 2-adrenoceptors in animal models of epilepsy.
Topics: Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; | 1987 |
General pharmacology of the novel centrally acting antihypertensive agent moxonidine.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Cats; Chemical Phenomena; Ch | 1988 |
Clonidine-induced automutilation in mice as a laboratory model for clinical self-injurious behaviour.
Topics: Acetylcholine; Animals; Brain; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; | 1988 |
Production and reversal of DOCA-salt hypertension in baboons.
Topics: Animals; Atenolol; Biofeedback, Psychology; Clonidine; Desoxycorticosterone; Disease Models, Animal; | 1987 |
Is reduced cardiac performance the only mechanism for myocardial infarct size reduction during beta adrenergic blockade?
Topics: Animals; Autoradiography; Cardiac Output; Cats; Clonidine; Disease Models, Animal; Heart Rate; Myoca | 1986 |
Behavioral depression following clonidine withdrawal: a new animal model of long-lasting depression?
Topics: Animals; Clonidine; Depressive Disorder; Desipramine; Disease Models, Animal; Rats; Substance Withdr | 1986 |
Role of brain cholinergic system in the antihypertensive effect of clonidine in different models of rat hypertension.
Topics: Acetylcholine; Animals; Blood Pressure; Brain; Clonidine; Desoxycorticosterone; Disease Models, Anim | 1985 |
Association between hypoalgesia and hypertension in rats after short-term isolation.
Topics: Animals; Clonidine; Disease Models, Animal; Heart Rate; Hypertension; Male; Naloxone; Pain; Rats; Ra | 1985 |
Long term treatment with clonidine during the development of hypertension in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Clonidine; Disease Models, Animal; Hypertension; Male; Rats; Rats, Inbred S | 1985 |
Influence of changes in brain monoamine metabolism on behaviour of herpes simplex-infected mice.
Topics: Aggression; Animals; Apomorphine; Behavior, Animal; Brain; Clonidine; Dihydroxyphenylalanine; Diseas | 1974 |
Antihypertensive activity of four blocking agents in spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Antihypertensive Agents; Blood Pressure; Clonidine | 1972 |
Proceedings: The production of hypertension and the effects of some antihypertensive agents in the conscious unrestrained cat.
Topics: Animals; Antihypertensive Agents; Cats; Cellophane; Clonidine; Corticosterone; Delayed-Action Prepar | 1974 |