clonidine and Diarrhea studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Research Excerpts

Excerpt	Relevance	Reference
" Clonidine, an alpha 2-adrenergic agonist, was used to treat three patients with "idiopathic" diabetic diarrhea after other treatments had failed: The volume of diarrhea declined significantly (p less than 0."	7.67	Treatment of diabetic diarrhea with clonidine. ( Chang, EB; Fedorak, RN; Field, M, 1985)
"A patient with watery diarrhea syndrome secondary to bronchogenic carcinoma responded to treatment with clonidine and lidamidine."	7.66	Clonidine and lidamidine to inhibit watery diarrhea in a patient with lung cancer. ( Anderson, DS; Dharmsathaphorn, K; Durbin, TE; McArthur, KE; Orloff, MJ, 1982)
"This study was designed to examine the effects of centrally or peripherally administered clonidine on small intestinal transit (SIT) in rats with diarrhea."	3.68	A comparison of peripheral and central effects of clonidine on rat intestinal transit. ( Kisara, K; Stewart, JJ; Tadano, T, 1992)
" Reduced alpha-adrenergic tone has been demonstrated in the enterocytes of diabetic rats, and its correction by clonidine might explain the beneficial effect that the drug has on diabetic diarrhea."	3.68	Effect of clonidine on gallbladder contraction and small bowel transit time in insulin-treated diabetics. ( Braverman, DZ; Goldstein, R; Jacobsohn, WZ; Lissi, J; Morali, GA, 1991)
" Clonidine, an alpha 2-adrenergic agonist, was used to treat three patients with "idiopathic" diabetic diarrhea after other treatments had failed: The volume of diarrhea declined significantly (p less than 0."	3.67	Treatment of diabetic diarrhea with clonidine. ( Chang, EB; Fedorak, RN; Field, M, 1985)
"A patient with watery diarrhea syndrome secondary to bronchogenic carcinoma responded to treatment with clonidine and lidamidine."	3.66	Clonidine and lidamidine to inhibit watery diarrhea in a patient with lung cancer. ( Anderson, DS; Dharmsathaphorn, K; Durbin, TE; McArthur, KE; Orloff, MJ, 1982)
"Chronic diarrhea is a frequent and challenging problem in clinical medicine."	2.48	Functional diarrhea. ( Tack, J, 2012)
"4."	1.29	The inhibitory effects of alpha(2)-adrenoceptor agonists on gastrointestinal transit during croton oil-induced intestinal inflammation. ( Ferrer, I; Pol, O; Puig, MM; Valle, L, 1996)
"Pre-treatment with clonidine (5-10 micrograms/kg i."	1.28	Suppression of castor oil-induced diarrhoea by alpha 2-adrenoceptor agonists. ( Hellström, PM; Svensson, TH; Thollander, M, 1991)
"Thus, diarrhea is not observed consistently and reliably in this species to allow valid evaluation of potential antidiarrheal agents."	1.28	Cecectomized rat. A model of experimental secretory diarrhea in conscious animals. ( Burnham, DB; Fondacaro, JD; Kolpak, DC; McCafferty, GP, 1990)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (60.00)	18.7374
1990's	10 (28.57)	18.2507
2000's	2 (5.71)	29.6817
2010's	2 (5.71)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Rtibi, K	1
Hammami, I	1
Selmi, S	1
Grami, D	1
Sebai, H	1
Amri, M	1
Marzouki, L	1
Gould, M	1
Sellin, JH	1
Tack, J	1
Ma, H	1
Tang, J	1
White, PF	1
Wender, RH	1
Leverone, T	1
Quon, R	1
Pearce, S	1
Chiao, F	1
Erice, S	1
Beubler, E	1
Bukhave, K	1
Rask-Madsen, J	1
Nakaki, T	1
Chang, PC	1
Tokunaga, Y	1
Kato, R	1
Spraggs, CF	1
Bunce, KT	1
McArthur, KE	1
Anderson, DS	1
Durbin, TE	1
Orloff, MJ	1
Dharmsathaphorn, K	2
Shearman, GT	2
Lal, H	2
Ursillo, RC	2
Schreier, WA	1
Burks, TF	1
Schwörer, H	1
Münke, H	1
Stöckmann, F	1
Ramadori, G	1
Pol, O	1
Valle, L	1
Ferrer, I	1
Puig, MM	1
Rovera, G	1
Furukawa, H	1
Reyes, J	1
Todo, S	1
Hutson, W	1
Saperia, J	1
Tadano, T	1
Kisara, K	1
Stewart, JJ	1
Mourad, FH	1
Gorard, D	1
Thillainayagam, AV	1
Colin-Jones, D	1
Farthing, MJ	1
Dionyssopoulos, T	1
Hope, W	1
Coupar, IM	1
Thollander, M	2
Hellström, PM	2
Svensson, TH	2
Scholz, J	1
Bause, H	1
Reymann, A	1
Dürig, M	1
Morali, GA	1
Braverman, DZ	1
Lissi, J	1
Goldstein, R	1
Jacobsohn, WZ	1
Fondacaro, JD	1
Kolpak, DC	1
Burnham, DB	1
McCafferty, GP	1
Cox, E	2
Cools, V	2
Houvenaghel, A	2
Chang, EB	2
Fedorak, RN	2
Field, M	2
Menezes, AM	1
Rao, VS	1
Migliore, A	1
Barone, C	1
Manna, R	1
Greco, AV	1
Bretzke, G	1
Björkqvist, SE	1
Baeyens, JM	1
Esposito, E	1
Ossowska, G	1
Samanin, R	1
Roof, LW	1
Sacerdote, A	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Double Blind, Placebo Controlled, Cross Over Study to Investigate the Effectiveness and Safety of Eluxadoline in the Treatment of Diabetic Diarrhea[NCT04313088]			Phase 2/Phase 3	0 participants (Actual)	Interventional	2022-07-01	Withdrawn (stopped due to This study did not enroll any subjects)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Phytochemical properties and pharmacological effects of Quercus ilex L. aqueous extract on gastrointestinal physiological parameters in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 94 Topics: Animals; Antidiarrheals; Biological Transport; Castor Oil; Clonidine; Diarrhea; Dose-Response Relati	2017
Diabetic diarrhea. Current gastroenterology reports, 2009, Volume: 11, Issue:5 Topics: Algorithms; Antidiarrheals; Celiac Disease; Clonidine; Colitis; Diabetes Complications; Diabetes Mel	2009
The effect of clonidine on gastrointestinal side effects associated with ultra-rapid opioid detoxification. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Diarrhea; Female; Gastrointestinal Diseases; Humans; Hy	2003
Colonic secretion mediated by prostaglandin E2 and 5-hydroxytryptamine may contribute to diarrhea due to morphine withdrawal in the rat. Gastroenterology, 1984, Volume: 87, Issue:5 Topics: Animals; Atropine; Clonidine; Colon; Cyclic AMP; Diarrhea; Dinoprostone; Female; Humans; Indomethaci	1984
alpha 2-adrenoceptors modulating diarrhoea in morphine-dependent rats. The Journal of pharmacy and pharmacology, 1981, Volume: 33, Issue:6 Topics: Animals; Clonidine; Diarrhea; Humans; Male; Morphine Dependence; Naloxone; Rats; Receptors, Adrenerg	1981
Alpha 2-adrenoceptors and the delay of castor oil-induced diarrhoea by clonidine in rats. The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:5 Topics: Animals; Castor Oil; Clonidine; Diarrhea; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic; R	1983
Clonidine and lidamidine to inhibit watery diarrhea in a patient with lung cancer. Annals of internal medicine, 1982, Volume: 96, Issue:3 Topics: Aged; Antidiarrheals; Biological Transport, Active; Carcinoma, Bronchogenic; Clonidine; Diarrhea; Dr	1982
Effectiveness of lofexidine in blocking morphine-withdrawal signs in the rat. Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:4 Topics: Animals; Behavior, Animal; Clonidine; Diarrhea; Dose-Response Relationship, Drug; Humans; Male; Morp	1980
Suppression of morphine withdrawal diarrhea by clonidine. Proceedings of the Western Pharmacology Society, 1981, Volume: 24 Topics: Animals; Clonidine; Diarrhea; Digestive System; Female; Humans; Morphine Dependence; Naloxone; Neost	1981
Nonnarcotic antidiarrheal action of clonidine and lofexidine in the rat. Journal of clinical pharmacology, 1981, Volume: 21, Issue:1 Topics: Animals; Antidiarrheals; Clonidine; Diarrhea; Male; Narcotics; Rats	1981
Treatment of diarrhea in carcinoid syndrome with ondansetron, tropisetron, and clonidine. The American journal of gastroenterology, 1995, Volume: 90, Issue:4 Topics: Antiemetics; Clonidine; Diarrhea; Humans; Indoles; Male; Malignant Carcinoid Syndrome; Middle Aged;	1995
The inhibitory effects of alpha(2)-adrenoceptor agonists on gastrointestinal transit during croton oil-induced intestinal inflammation. British journal of pharmacology, 1996, Volume: 119, Issue:8 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Castor Oil; Clonidine; Cro	1996
The use of clonidine for the treatment of high intestinal output following small bowel transplantation. Transplantation proceedings, 1997, Volume: 29, Issue:3 Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Child, Preschool; Clonidine; Colon; Diarrhea;	1997
Letter: Clonidine overdose. British medical journal, 1975, Dec-06, Volume: 4, Issue:5996 Topics: Adult; Clonidine; Diarrhea; Humans; Male	1975
A comparison of peripheral and central effects of clonidine on rat intestinal transit. Research communications in chemical pathology and pharmacology, 1992, Volume: 78, Issue:2 Topics: Adrenergic alpha-Antagonists; Animals; Brain; Clonidine; Diarrhea; Duodenum; Gastrointestinal Transi	1992
Effective treatment of diabetic diarrhoea with somatostatin analogue, octreotide. Gut, 1992, Volume: 33, Issue:11 Topics: Adult; Clonidine; Diabetes Mellitus, Type 1; Diarrhea; Female; Gastrointestinal Transit; Humans; Oct	1992
Effect of adenosine analogues on the expression of opiate withdrawal in rats. Pharmacology, biochemistry, and behavior, 1992, Volume: 42, Issue:2 Topics: Adenosine; Animals; Behavior, Animal; Clonidine; Diarrhea; Female; Male; Morphine Dependence; Motor	1992
Suppression of castor oil-induced diarrhoea by alpha 2-adrenoceptor agonists. Alimentary pharmacology & therapeutics, 1991, Volume: 5, Issue:3 Topics: Adrenergic alpha-Agonists; Animals; Castor Oil; Clonidine; Diarrhea; Electromyography; Gastrointesti	1991
[Treatment with clonidine in a case of the short bowel syndrome with therapy-refractory diarrhea]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1991, Volume: 26, Issue:5 Topics: Adenylyl Cyclase Inhibitors; Animals; Clonidine; Diarrhea; Drug Therapy, Combination; Humans; In Vit	1991
Effect of clonidine on gallbladder contraction and small bowel transit time in insulin-treated diabetics. The American journal of gastroenterology, 1991, Volume: 86, Issue:8 Topics: Adult; Breath Tests; Clonidine; Diabetes Mellitus, Type 1; Diarrhea; Female; Gallbladder; Gastrointe	1991
Cecectomized rat. A model of experimental secretory diarrhea in conscious animals. Journal of pharmacological methods, 1990, Volume: 24, Issue:1 Topics: Animals; Antidiarrheals; Carbachol; Cecum; Chlorpromazine; Cholera Toxin; Clonidine; Colon; Diarrhea	1990
Suppression of small intestinal motility and morphine withdrawal diarrhoea by clonidine: peripheral site of action. Acta physiologica Scandinavica, 1989, Volume: 137, Issue:3 Topics: Animals; Clonidine; Diarrhea; Gastrointestinal Motility; Intestine, Small; Male; Morphine; Morphine	1989
Effect of antisecretory drugs on experimentally induced weanling diarrhoea in piglets. Veterinary research communications, 1989, Volume: 13, Issue:2 Topics: Animals; Animals, Newborn; Chlorpromazine; Clonidine; Diarrhea; Disease Models, Animal; Escherichia	1989
Experimental diabetic diarrhea in rats. Intestinal mucosal denervation hypersensitivity and treatment with clonidine. Gastroenterology, 1986, Volume: 91, Issue:3 Topics: Adrenergic alpha-Agonists; Animals; Antidiarrheals; Clonidine; Denervation; Diabetes Mellitus, Exper	1986
Alpha 2-adrenergic agonists: a newer class of antidiarrheal drug. Gastroenterology, 1986, Volume: 91, Issue:3 Topics: Adrenergic alpha-Agonists; Antidiarrheals; Clonidine; Diabetes Complications; Diarrhea; Humans	1986
Effect of an alpha 2-adrenoceptor agonist on experimentally induced diarrhoea in newly-weaned piglets. Zentralblatt fur Veterinarmedizin. Reihe A, 1988, Volume: 35, Issue:10 Topics: Animals; Clonidine; Diarrhea; Escherichia coli Infections; Female; Gastroenteritis, Transmissible, o	1988
Effect of Astronium urundeuva (aroeira) on gastrointestinal transit in mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1988, Volume: 21, Issue:3 Topics: Animals; Clonidine; Diarrhea; Gastrointestinal Motility; Gastrointestinal Transit; Mice; Physostigmi	1988
Diabetic diarrhea and clonidine. Annals of internal medicine, 1988, Jul-15, Volume: 109, Issue:2 Topics: Adult; Clonidine; Diabetes Mellitus, Type 1; Diarrhea; Humans; Male	1988
[Therapy of diarrhea in diabetic enteropathy with clonidine]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1987, Dec-01, Volume: 42, Issue:23 Topics: Aged; Clonidine; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Diarrhea; Female; Gastrointestina	1987
Clonidine therapy for alcohol withdrawal. Acta psychiatrica Scandinavica. Supplementum, 1986, Volume: 327 Topics: Carbamazepine; Clonidine; Diarrhea; Drug Therapy, Combination; Ethanol; Humans; Hyperhidrosis; Hyper	1986
Effects of peripheral and central administration of calcium channel blockers in the naloxone-precipitated abstinence syndrome in morphine-dependent rats. European journal of pharmacology, 1987, May-07, Volume: 137, Issue:1 Topics: Animals; Body Weight; Brain; Calcium Channel Blockers; Clonidine; Diarrhea; Flunarizine; Injections,	1987
Treatment of diabetic diarrhea with clonidine. The American journal of medicine, 1987, Volume: 83, Issue:3 Topics: Administration, Cutaneous; Clonidine; Diabetes Mellitus, Type 1; Diarrhea; Female; Humans; Middle Ag	1987
Topical clonidine for diabetic diarrhea. Annals of internal medicine, 1986, Volume: 105, Issue:1 Topics: Administration, Topical; Clonidine; Diabetes Complications; Diarrhea; Female; Humans; Middle Aged	1986
Treatment of diabetic diarrhea with clonidine. Annals of internal medicine, 1985, Volume: 102, Issue:2 Topics: Chronic Disease; Clonidine; Diabetes Mellitus, Type 1; Diarrhea; Feces; Humans; Substance Withdrawal	1985

clonidine and Diarrhea

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