clonidine has been researched along with Depressive Disorder, Major in 16 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with major depressive disorder (MDD) often suffer from impaired declarative, episodic and working memory." | 2.79 | Noradrenergic blockade and memory in patients with major depression and healthy participants. ( Eikelmann, S; Kuehl, LK; Kuffel, A; Löwe, B; Mau, G; Otte, C; Spitzer, C; Terfehr, K; Wingenfeld, K, 2014) |
| " The utility of the neuroendocrine response to serotonergic (ipsapirone) and noradrenergic (clonidine) probes as predictors of venlafaxine dosage required for effective treatment was also explored." | 2.71 | Efficacy of open-label venlafaxine in subjects with major depressive disorder: associations with neuroendocrine response to serotonergic and noradrenergic probes. ( Goodman, M; Grossman, R; Mitropoulou, V; New, A; Reynolds, D; Schmeidler, J; Siever, LJ; Silverman, J, 2004) |
| "Clonidine was used and was an effective treatment option to successfully withdraw the patient from dexmedetomidine." | 1.48 | Effectivness of Clonidine in Treating Dexmedetomidine Withdrawal in a Patient with Co-Existing Psychiatric Illness: A Case Report. ( Al Anany, R; Elshafei, M; Gazwi, K; Mahmoud, S; Mohamed, A; Saad, MO, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (81.25) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mathews, M | 1 |
| Mathews, N | 1 |
| Jamal, F | 1 |
| Papa-Molter, A | 1 |
| Mohamed, A | 1 |
| Mahmoud, S | 1 |
| Saad, MO | 1 |
| Gazwi, K | 1 |
| Elshafei, M | 1 |
| Al Anany, R | 1 |
| Kuffel, A | 1 |
| Eikelmann, S | 1 |
| Terfehr, K | 1 |
| Mau, G | 1 |
| Kuehl, LK | 1 |
| Otte, C | 1 |
| Löwe, B | 1 |
| Spitzer, C | 1 |
| Wingenfeld, K | 1 |
| Meyer, JH | 1 |
| McMain, S | 1 |
| Kennedy, SH | 1 |
| Korman, L | 1 |
| Brown, GM | 1 |
| DaSilva, JN | 1 |
| Wilson, AA | 1 |
| Blak, T | 1 |
| Eynan-Harvey, R | 1 |
| Goulding, VS | 1 |
| Houle, S | 1 |
| Links, P | 1 |
| Ordway, GA | 1 |
| Schenk, J | 1 |
| Stockmeier, CA | 1 |
| May, W | 1 |
| Klimek, V | 1 |
| Pitchot, W | 2 |
| Reggers, J | 2 |
| Pinto, E | 2 |
| Hansenne, M | 2 |
| Ansseau, M | 2 |
| Holt, A | 1 |
| Grossman, R | 1 |
| Reynolds, D | 1 |
| Goodman, M | 1 |
| New, A | 1 |
| Silverman, J | 1 |
| Schmeidler, J | 1 |
| Mitropoulou, V | 1 |
| Siever, LJ | 1 |
| Scantamburlo, G | 1 |
| Fuchs, S | 1 |
| Legros, JJ | 1 |
| Duval, F | 2 |
| Mokrani, MC | 1 |
| Monreal-Ortiz, JA | 1 |
| Fattah, S | 1 |
| Champeval, C | 1 |
| Schulz, P | 1 |
| Macher, JP | 2 |
| Sahoo, M | 1 |
| Subho, C | 1 |
| Coffey, B | 1 |
| Wieland, N | 1 |
| Mokrani, M | 1 |
| Diep, TS | 1 |
| Bailey, PE | 1 |
| Gerra, G | 1 |
| Zaimovic, A | 1 |
| Zambelli, U | 1 |
| Delsignore, R | 1 |
| Baroni, MC | 1 |
| Laviola, G | 1 |
| Macchia, T | 1 |
| Brambilla, F | 1 |
| Paparrigopoulos, T | 1 |
| Psarros, C | 1 |
| Bergiannaki, JD | 1 |
| Varsou, E | 1 |
| Dafni, U | 1 |
| Stefanis, C | 1 |
| Schittecatte, M | 1 |
| Dumont, F | 1 |
| Machowski, R | 1 |
| Fontaine, E | 1 |
| Cornil, C | 1 |
| Mendlewicz, J | 1 |
| Wilmotte, J | 1 |
1 review available for clonidine and Depressive Disorder, Major
| Article | Year |
|---|---|
Imidazoline binding sites on receptors and enzymes: emerging targets for novel antidepressant drugs?
Topics: Adrenergic alpha-Agonists; Antidepressive Agents; Binding Sites; Brain; Clonidine; Depressive Disord | 2003 |
5 trials available for clonidine and Depressive Disorder, Major
| Article | Year |
|---|---|
Noradrenergic blockade and memory in patients with major depression and healthy participants.
Topics: Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Adrenergic Neurons; Adult; Blood Pressur | 2014 |
Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm.
Topics: Adolescent; Adult; Attitude; Brain Mapping; Cerebral Cortex; Clonidine; Depressive Disorder, Major; | 2003 |
Efficacy of open-label venlafaxine in subjects with major depressive disorder: associations with neuroendocrine response to serotonergic and noradrenergic probes.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Antidepressive Agents, Second-Generation; | 2004 |
AVP- and OT-neurophysins response to apomorphine and clonidine in major depression.
Topics: Adrenergic alpha-Agonists; Adult; Apomorphine; Arginine Vasopressin; Clonidine; Depressive Disorder, | 2005 |
Melatonin response to clonidine administration in depression: indication of presynaptic alpha2-adrenoceptor dysfunction.
Topics: Adult; Clonidine; Depressive Disorder, Major; Female; Humans; Male; Melatonin; Middle Aged; Receptor | 2001 |
10 other studies available for clonidine and Depressive Disorder, Major
| Article | Year |
|---|---|
Bupropion-Induced Nightmares Treated With Clonidine.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Bupropion; Clonidine; Depressive Disorder, Major; | 2019 |
Effectivness of Clonidine in Treating Dexmedetomidine Withdrawal in a Patient with Co-Existing Psychiatric Illness: A Case Report.
Topics: Adult; Central Nervous System Agents; Clonidine; Depressive Disorder, Major; Dexmedetomidine; Female | 2018 |
Elevated agonist binding to alpha2-adrenoceptors in the locus coeruleus in major depression.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Affinity Labels; Aged; Autop | 2003 |
Catecholamine and HPA axis dysfunction in depression: relationship with suicidal behavior.
Topics: Adrenergic alpha-Agonists; Adult; Apomorphine; Catecholamines; Clonidine; Depressive Disorder, Major | 2003 |
Cortisol hypersecretion in unipolar major depression with melancholic and psychotic features: dopaminergic, noradrenergic and thyroid correlates.
Topics: Adrenocorticotropic Hormone; Adult; Affective Disorders, Psychotic; Apomorphine; Clonidine; Cushing | 2006 |
Cortisol hypersecretion in unipolar major depression with melancholic and psychotic features: dopaminergic, noradrenergic and thyroid correlates.
Topics: Clonidine; Depressive Disorder; Depressive Disorder, Major; Dopamine; Growth Hormone; Humans; Hydroc | 2007 |
Tics, anxiety, and possible PANDAS in an adolescent.
Topics: Adolescent; Adrenergic alpha-Agonists; Antidepressive Agents, Second-Generation; Anxiety; Autoimmune | 2007 |
Multihormonal responses to clonidine in patients with affective and psychotic symptoms.
Topics: Adrenocorticotropic Hormone; Adult; Clonidine; Depressive Disorder, Major; Female; Hormones; Human G | 2000 |
Neuroendocrine correlates of depression in abstinent heroin-dependent subjects.
Topics: Adrenergic alpha-Agonists; Adult; Analysis of Variance; Biomarkers; Brain; Bromocriptine; Case-Contr | 2000 |
Mirtazapine, but not fluvoxamine, normalizes the blunted REM sleep response to clonidine in depressed patients: implications for subsensitivity of alpha(2)-adrenergic receptors in depression.
Topics: Adrenergic alpha-Agonists; Antidepressive Agents, Tricyclic; Clonidine; Depressive Disorder, Major; | 2002 |