clonidine has been researched along with Depression in 88 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study examines the efficacy of clonidine in smoking cessation and the influence of gender, history of major depression, and measures of nicotine dependence." | 9.07 | Smoking cessation, clonidine, and vulnerability to nicotine among dependent smokers. ( Cooper, TB; Covey, LS; Dalack, GW; Fleiss, J; Glassman, AH; Rivelli, SK; Stetner, F, 1993) |
| "The efficacy of tizanidine in chronic tension-type headache was compared with placebo in a randomized, double-blind and cross-over study in 37 women aged 20 to 59 years with a history of headache for 7 months to 30 years (median 5 years)." | 9.07 | Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study. ( Fogelholm, R; Murros, K, 1992) |
| " The typical neuroleptics, chlorpromazine and haloperidol, led to prolonged depression of responding lasting at least 4 h, whereas response rates after similarly effective doses of the atypical agents, clozapine and risperidone, recovered to control levels in the same period." | 7.70 | Rapid recovery of self-stimulation responding from depression by clozapine is prevented by the alpha 2-adrenoceptor agonist, clonidine. ( Grottick, AJ; Herberg, LJ; Montgomery, AM, 1999) |
| "IP administration of various doses of clonidine produces significant increases in growth hormone levels in the Wistar rats but not in the Fawn-Hooded (FH) rats, a rat strain suggested to be a genetic model of depression." | 7.69 | Lithium treatment restores clonidine's effect in an animal model of depression. ( Aulakh, CS; Hill, JL; Murphy, DL, 1994) |
| "In the present study we report two typical cases of trigeminal neuralgia in whom all conventional drug treatments were attempted without success, and in whom low doses of pimozide, a dopaminergic blocking agent, provoked a definite and sustained improvement." | 7.67 | Definite and sustained improvement with pimozide of two patients with severe trigeminal neuralgia. Some neurochemical, neurophysiological and neuroendocrinological findings. ( Amat, J; Arocha, L; Cabrera, A; Gómez, F; Jiménez, V; Lechin, AE; Lechin, F; Lechin, ME; van der Dijs, B, 1988) |
| "Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment." | 6.67 | Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992) |
| "Lycopene and chrysin were used to correct the concentrations of noradrenaline and serotonin hippocampal tissue concentrations." | 5.91 | Lycopene and Chrysin through Mitigation of Neuroinflammation and Oxidative Stress Exerted Antidepressant Effects in Clonidine-Induced Depression-like Behavior in Rats. ( Abd Al Haleem, EN; Ahmed, HI; El-Naga, RN, 2023) |
| "This study examines the efficacy of clonidine in smoking cessation and the influence of gender, history of major depression, and measures of nicotine dependence." | 5.07 | Smoking cessation, clonidine, and vulnerability to nicotine among dependent smokers. ( Cooper, TB; Covey, LS; Dalack, GW; Fleiss, J; Glassman, AH; Rivelli, SK; Stetner, F, 1993) |
| "The efficacy of tizanidine in chronic tension-type headache was compared with placebo in a randomized, double-blind and cross-over study in 37 women aged 20 to 59 years with a history of headache for 7 months to 30 years (median 5 years)." | 5.07 | Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study. ( Fogelholm, R; Murros, K, 1992) |
| " In this report, we describe a 15-year-old adolescent girl who experienced continued delirium 5 days after an overdose of quetiapine, trazodone, and clonidine." | 3.76 | Prolonged delirium after quetiapine overdose. ( Pedapati, EV; Rhyee, SH; Thompson, J, 2010) |
| " The typical neuroleptics, chlorpromazine and haloperidol, led to prolonged depression of responding lasting at least 4 h, whereas response rates after similarly effective doses of the atypical agents, clozapine and risperidone, recovered to control levels in the same period." | 3.70 | Rapid recovery of self-stimulation responding from depression by clozapine is prevented by the alpha 2-adrenoceptor agonist, clonidine. ( Grottick, AJ; Herberg, LJ; Montgomery, AM, 1999) |
| "IP administration of various doses of clonidine produces significant increases in growth hormone levels in the Wistar rats but not in the Fawn-Hooded (FH) rats, a rat strain suggested to be a genetic model of depression." | 3.69 | Lithium treatment restores clonidine's effect in an animal model of depression. ( Aulakh, CS; Hill, JL; Murphy, DL, 1994) |
| "A patient at a psychiatric hospital with a diagnosis of major depression and polysubstance abuse was administered a clonidine patch for opiate detoxification." | 3.68 | Clonidine patch ingestion in an adult. ( Finkelstein, S; Raber, JH; Shinar, C, 1993) |
| "After chronic administration of propranolol (1 and 5 mg/kg, 14 days) to rats time-course of forced swimming changed with the decrease of rhythmical index of depression." | 3.68 | [The antidepressive properties of anaprilin]. ( Arushanian, EB; Beĭer, EV, 1992) |
| "This experiment demonstrated that behavioral depression produced by exposure of rats to strong uncontrollable shocks could be reversed by infusion of the alpha-2 adrenergic agonist clonidine into the region of the locus coeruleus (LC)." | 3.67 | Reversal of behavioral depression by infusion of an alpha-2 adrenergic agonist into the locus coeruleus. ( Ambrose, MJ; Hoffman, LJ; Simson, PG; Weiss, JM, 1986) |
| "In the present study we report two typical cases of trigeminal neuralgia in whom all conventional drug treatments were attempted without success, and in whom low doses of pimozide, a dopaminergic blocking agent, provoked a definite and sustained improvement." | 3.67 | Definite and sustained improvement with pimozide of two patients with severe trigeminal neuralgia. Some neurochemical, neurophysiological and neuroendocrinological findings. ( Amat, J; Arocha, L; Cabrera, A; Gómez, F; Jiménez, V; Lechin, AE; Lechin, F; Lechin, ME; van der Dijs, B, 1988) |
| " The results indicate that chronic administration of imipramine or of electroshock led to the abolition of the behavioural depression and of the EEG synchronisation induced by clonidine." | 3.66 | Effects of chronic treatment with imipramine, trazodone and electroshock on the behavioural and electroencephalographic modifications induced by clonidine in the rat. ( Passarelli, F; Scotti de Carolis, A, 1983) |
| "Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment." | 2.67 | Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992) |
| " Other reported effects are toxic confusional states and psychotic reactions." | 2.36 | Psychiatric side effects of antihypertensive drugs other than reserpine. ( Fleminger, R; Paykel, ES; Watson, JP, 1982) |
| "For those with PTSD, a suggested treatment approach is long-term supportive psychotherapy with drug treatment directed at reducing the most disruptive symptoms, such as insomnia, nightmares, and irritability or psychosis." | 1.43 | Medical Approach to the Management of Traumatized Refugees. ( Kinzie, JD, 2016) |
| " Dose-response studies using two classes of anxiolytics (chlordiazepoxide: 2." | 1.35 | Modelling the anxiety-depression continuum in chicks. ( Acevedo, EO; Huang, CJ; Sufka, KJ; Warnick, JE, 2009) |
| "Mirtazapine is a new antidepressant with a tetracyclic chemical structure that is not related to selective serotonin reuptake inhibitors, tricyclic antidepressants, or monoamine oxidase inhibitors." | 1.31 | Hypertensive urgency induced by an interaction of mirtazapine and clonidine. ( Abo-Zena, RA; Bobek, MB; Dweik, RA, 2000) |
| "Reboxetine is a non-tricyclic antidepressant with selective noradrenergic (NA) reuptake-blocking effects." | 1.31 | Effect of the selective noradrenergic reuptake inhibitor reboxetine on the firing activity of noradrenaline and serotonin neurons. ( Blier, P; Szabo, ST, 2001) |
| " The dose-response relationship shifted to the left following REMs deprivation (ED50 values in the group-housed, isolated, and REMs-deprived mice were 250, 200, and 27 micrograms/kg, respectively)." | 1.29 | Monoamine depletion attenuates the REM sleep deprivation-induced increase in clonidine response in the forced swimming test. ( Asakura, W; Matsumoto, K; Ohta, H; Watanabe, H, 1994) |
| " The findings suggest that clonidine at a dosage of 1." | 1.28 | Growth hormone and other hormonal responses to clonidine in melancholic and nonmelancholic depressed subjects and controls. ( Boyce, P; Brodaty, H; Hickie, I; Mitchell, P; Parker, G; Smythe, G; Wilhelm, K, 1991) |
| " The dose-response curve to inhibitory effect of clonidine (CLON) on firing rate of locus coeruleus (LC) neurons showed a clear shift to the right." | 1.28 | Time course effects of uncontrollable stress in locus coeruleus neuronal activity. ( Pavcovich, LA; Ramirez, OA, 1991) |
| " Clonidine in the stated dosage had no significant effect on blood pressure and heart rate." | 1.26 | [Treatment of menopausal symptoms with low doses of clonidine (author's transl)]. ( Lauritzen, C, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (45.45) | 18.7374 |
| 1990's | 21 (23.86) | 18.2507 |
| 2000's | 14 (15.91) | 29.6817 |
| 2010's | 10 (11.36) | 24.3611 |
| 2020's | 3 (3.41) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, W | 1 |
| Wang, H | 1 |
| Li, X | 1 |
| Xu, Y | 1 |
| Zhang, J | 1 |
| Wang, W | 1 |
| Gong, Q | 1 |
| Qiu, X | 1 |
| Zhu, J | 1 |
| Mao, F | 1 |
| Zhang, H | 1 |
| Li, J | 1 |
| Malhotra, V | 1 |
| Vats, M | 1 |
| Nath, R | 1 |
| Mehta, S | 1 |
| Kumar, R | 1 |
| Bhalla, M | 1 |
| Sinha, JN | 1 |
| Shanker, K | 1 |
| Pathak, SR | 1 |
| Abd Al Haleem, EN | 2 |
| Ahmed, HI | 2 |
| El-Naga, RN | 2 |
| White, SW | 1 |
| Squires, GD | 1 |
| Smith, SJ | 1 |
| Wright, GM | 1 |
| Sufka, KJ | 3 |
| Rimoldi, JM | 1 |
| Gadepalli, RS | 1 |
| Antkiewicz-Michaluk, L | 1 |
| Romańska, I | 1 |
| Wąsik, A | 1 |
| Michaluk, J | 1 |
| Arora, S | 1 |
| Vohora, D | 1 |
| Kinzie, JD | 1 |
| Warnick, JE | 1 |
| Huang, CJ | 1 |
| Acevedo, EO | 1 |
| Ziedonis, DM | 1 |
| Amass, L | 1 |
| Steinberg, M | 1 |
| Woody, G | 1 |
| Krejci, J | 1 |
| Annon, JJ | 1 |
| Cohen, AJ | 1 |
| Waite-O'Brien, N | 1 |
| Stine, SM | 1 |
| McCarty, D | 1 |
| Reid, MS | 1 |
| Brown, LS | 1 |
| Maslansky, R | 1 |
| Winhusen, T | 1 |
| Babcock, D | 1 |
| Brigham, G | 1 |
| Muir, J | 1 |
| Orr, D | 1 |
| Buchan, BJ | 1 |
| Horton, T | 1 |
| Ling, W | 1 |
| Ghanizadeh, A | 1 |
| Rhyee, SH | 1 |
| Pedapati, EV | 1 |
| Thompson, J | 1 |
| Yeshayahu, Y | 1 |
| Tallett, S | 1 |
| Pacak, K | 1 |
| De Souza, C | 1 |
| Palmert, MR | 1 |
| Iezhitsa, IN | 1 |
| Spasov, AA | 1 |
| Kharitonova, MV | 1 |
| Kravchenko, MS | 1 |
| Hymel, KA | 1 |
| Rickards, H | 1 |
| Cavanna, AE | 1 |
| Worrall, R | 1 |
| Chintawar, SD | 1 |
| Somani, RS | 1 |
| Kasture, VS | 1 |
| Kasture, SB | 1 |
| Rénéric, JP | 1 |
| Bouvard, M | 1 |
| Stinus, L | 1 |
| McGavin, CL | 1 |
| John, V | 1 |
| Musser, WS | 1 |
| Zeifang, F | 1 |
| Abel, R | 1 |
| Schiltenwolf, M | 1 |
| Leung, JS | 1 |
| Malatynska, E | 1 |
| Knapp, RJ | 1 |
| Kratochvil, CJ | 1 |
| Varley, C | 1 |
| Cummins, TK | 1 |
| Martin, A | 1 |
| Eriksson, E | 1 |
| Modigh, K | 3 |
| Paykel, ES | 3 |
| Fleminger, R | 1 |
| Watson, JP | 1 |
| Checkley, SA | 2 |
| Glass, IB | 2 |
| Shur, E | 1 |
| Sonnendecker, EW | 1 |
| Polakow, ES | 1 |
| Gerdes, L | 1 |
| Charney, DS | 1 |
| Heninger, GR | 1 |
| Sternberg, DE | 1 |
| Passarelli, F | 1 |
| Scotti de Carolis, A | 1 |
| Camí, J | 1 |
| de Torres, S | 1 |
| Solé, A | 1 |
| Guerra, D | 1 |
| Rodríguez, H | 1 |
| Ugena, B | 1 |
| Keup, W | 1 |
| Balldin, J | 1 |
| Edén, S | 1 |
| Granérus, AK | 1 |
| Wålinder, J | 1 |
| Lauritzen, C | 1 |
| Kostowski, W | 1 |
| Jimerson, DC | 1 |
| Post, RM | 1 |
| Stoddard, FJ | 1 |
| Gillin, JC | 1 |
| Bunney, WE | 1 |
| Christensen, NJ | 1 |
| Asakura, W | 1 |
| Matsumoto, K | 1 |
| Ohta, H | 1 |
| Watanabe, H | 1 |
| Halbreich, U | 1 |
| Piletz, JE | 1 |
| Carson, S | 1 |
| Halaris, A | 1 |
| Rojansky, N | 1 |
| Aulakh, CS | 1 |
| Hill, JL | 1 |
| Murphy, DL | 1 |
| Glassman, AH | 1 |
| Covey, LS | 1 |
| Dalack, GW | 1 |
| Stetner, F | 1 |
| Rivelli, SK | 1 |
| Fleiss, J | 1 |
| Cooper, TB | 1 |
| Prasad, A | 1 |
| Shotliff, K | 1 |
| Raber, JH | 1 |
| Shinar, C | 1 |
| Finkelstein, S | 1 |
| McCracken, JT | 1 |
| Martin, W | 1 |
| Bharucha, AE | 1 |
| Camilleri, M | 1 |
| Zinsmeister, AR | 1 |
| Hanson, RB | 1 |
| Callado, LF | 1 |
| Meana, JJ | 1 |
| Grijalba, B | 1 |
| Pazos, A | 1 |
| Sastre, M | 1 |
| García-Sevilla, JA | 1 |
| Harkin, A | 1 |
| Kelly, JP | 1 |
| McNamara, M | 1 |
| Connor, TJ | 1 |
| Dredge, K | 1 |
| Redmond, A | 1 |
| Leonard, BE | 1 |
| Abo-Zena, RA | 1 |
| Bobek, MB | 1 |
| Dweik, RA | 1 |
| Montgomery, AM | 1 |
| Grottick, AJ | 1 |
| Herberg, LJ | 1 |
| Srivastava, SK | 1 |
| Nath, C | 1 |
| Gerra, G | 1 |
| Zaimovic, A | 1 |
| Zambelli, U | 1 |
| Delsignore, R | 1 |
| Baroni, MC | 1 |
| Laviola, G | 1 |
| Macchia, T | 1 |
| Brambilla, F | 1 |
| Szabo, ST | 1 |
| Blier, P | 1 |
| Andrejak, M | 1 |
| Fournier, A | 1 |
| Hardin, JM | 1 |
| Coevoet, B | 1 |
| Lambrey, G | 1 |
| De Fremont, JF | 1 |
| Quichaud, J | 1 |
| Henning, M | 1 |
| Matussek, N | 1 |
| Gold, MS | 1 |
| Pottash, AL | 1 |
| Sweeney, DR | 1 |
| Kleber, HD | 1 |
| Redmond, DE | 1 |
| Sandifer, MG | 1 |
| Roberts, JA | 1 |
| Zweifler, AJ | 1 |
| Esler, M | 1 |
| Arushanian, EB | 1 |
| Beĭer, EV | 1 |
| Coupland, N | 1 |
| Glue, P | 1 |
| Nutt, DJ | 1 |
| Fogelholm, R | 1 |
| Murros, K | 1 |
| Hewlett, WA | 1 |
| Vinogradov, S | 1 |
| Agras, WS | 1 |
| Brohée, D | 1 |
| Charles, G | 1 |
| Machowski, R | 1 |
| Schittecatte, M | 1 |
| Piro, P | 1 |
| Wilmotte, J | 1 |
| Kennes, B | 1 |
| Mitchell, P | 1 |
| Smythe, G | 1 |
| Parker, G | 1 |
| Wilhelm, K | 1 |
| Brodaty, H | 1 |
| Boyce, P | 1 |
| Hickie, I | 1 |
| Andorn, AC | 1 |
| Hascoët, M | 1 |
| Bourin, M | 1 |
| Bradwejn, J | 1 |
| Pavcovich, LA | 1 |
| Ramirez, OA | 1 |
| Lechin, F | 2 |
| van der Dijs, B | 2 |
| Vitelli-Florez, G | 1 |
| Lechin-Baez, S | 1 |
| Azocar, J | 1 |
| Cabrera, A | 2 |
| Lechin, A | 1 |
| Jara, H | 1 |
| Lechin, M | 1 |
| Gomez, F | 2 |
| Ansseau, M | 1 |
| Hollingsworth, PJ | 1 |
| Koella, WP | 1 |
| Simson, PG | 2 |
| Weiss, JM | 2 |
| Hoffman, LJ | 1 |
| Ambrose, MJ | 1 |
| Theodorou, AE | 2 |
| Hale, AS | 2 |
| Davies, SL | 2 |
| Katona, CL | 2 |
| Yamaguchi, Y | 2 |
| Horton, RW | 2 |
| Kelly, JS | 2 |
| Corn, TH | 1 |
| Thompson, C | 1 |
| Franey, C | 1 |
| Arendt, J | 1 |
| Tunnicliffe, C | 1 |
| Parale, MP | 1 |
| Kulkarni, SK | 1 |
| Giannini, AJ | 1 |
| Pascarzi, GA | 1 |
| Loiselle, RH | 1 |
| Price, WA | 1 |
| Giannini, MC | 1 |
| Amat, J | 1 |
| Lechin, AE | 1 |
| Lechin, ME | 1 |
| Arocha, L | 1 |
| Jiménez, V | 1 |
| Hughes, JR | 1 |
| Siever, LJ | 1 |
| Coccaro, EF | 1 |
| Benjamin, E | 1 |
| Rubinstein, K | 1 |
| Davis, KL | 1 |
| Simpson, FO | 1 |
| Amery, AK | 1 |
| Bossaert, H | 1 |
| Fagard, RH | 1 |
| Verstraete, M | 1 |
| Schwarz, D | 1 |
| Michel, D | 1 |
| Strian, F | 1 |
| Stensrud, P | 1 |
| Sjaastad, O | 1 |
| Raftos, J | 1 |
| Bauer, GE | 1 |
| Lewis, RG | 1 |
| Stokes, GS | 1 |
| Mitchell, AS | 1 |
| Young, AA | 1 |
| Maclachlan, I | 1 |
7 reviews available for clonidine and Depression
| Article | Year |
|---|---|
Dominant-submissive behavior as models of mania and depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bipolar Disorder; Clonidine; Depression; Disease M | 2005 |
Depression, alpha 2-receptors and sex hormones: neuroendocrine studies in rat.
Topics: Animals; Antidepressive Agents; Apomorphine; Carbidopa; Castration; Clonidine; Depression; Dihydrote | 1984 |
Psychiatric side effects of antihypertensive drugs other than reserpine.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Anxiety; Bethanidine; Clonidine; Debrisoquin; | 1982 |
Challenge tests: assessment of the noradrenergic and GABA systems in depression and anxiety disorders.
Topics: Anxiety; Clonidine; Depression; gamma-Aminobutyric Acid; Growth Hormone; Humans; Hydrocortisone; Nor | 1992 |
[Biological markers of depression].
Topics: Antidepressive Agents; Apomorphine; Clonidine; Contingent Negative Variation; Depression; Dexamethas | 1986 |
CNS-related (side-)effects of beta-blockers with special reference to mechanisms of action.
Topics: Adrenergic beta-Antagonists; Amphetamine; Animals; Anxiety; Blood-Brain Barrier; Central Nervous Sys | 1985 |
[Clonidine (Catapresan) in prevention of migraine].
Topics: Clonidine; Depression; Fatigue; Humans; Migraine Disorders; Placebos; Time Factors | 1973 |
10 trials available for clonidine and Depression
| Article | Year |
|---|---|
Predictors of outcome for short-term medically supervised opioid withdrawal during a randomized, multicenter trial of buprenorphine-naloxone and clonidine in the NIDA clinical trials network drug and alcohol dependence.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Anxiety; Buprenorphine; Clonidine; Data Interpretation, Stat | 2009 |
[Possible conservative treatment methods for patients with spinal claudication].
Topics: Aged; Analgesics; Clonidine; Cognitive Behavioral Therapy; Combined Modality Therapy; Complementary | 2003 |
Psycho-endocrine differences and correlations in symptomatic and asymptomatic climacteric women - the possible role of prolactin.
Topics: Adult; Anxiety; Climacteric; Clonidine; Depression; Estradiol; Estrogens, Conjugated (USP); Female; | 1981 |
Smoking cessation, clonidine, and vulnerability to nicotine among dependent smokers.
Topics: Adolescent; Adult; Aged; Clonidine; Depression; Double-Blind Method; Female; Follow-Up Studies; Huma | 1993 |
Adrenergic modulation of human colonic motor and sensory function.
Topics: Adrenergic Agents; Adult; Anxiety; Blood Pressure; Clonidine; Colon; Depression; Female; Gastrointes | 1997 |
Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study.
Topics: Adult; Analgesics; Chronic Disease; Clonidine; Depression; Dose-Response Relationship, Drug; Double- | 1992 |
Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder.
Topics: Adult; Analysis of Variance; Anxiety; Clomipramine; Clonazepam; Clonidine; Depression; Double-Blind | 1992 |
Comparison of clonidine and lithium in the treatment of mania.
Topics: Adult; Bipolar Disorder; Clinical Trials as Topic; Clonidine; Depression; Double-Blind Method; Human | 1986 |
Clonidine versus methyldopa. A double blind cross-over study comparing side effects of clonidine and methyldopa administered together with chlorthalidone at a dosage producing the same blood pressure lowering effect.
Topics: Antihypertensive Agents; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Clonidine; Consti | 1972 |
[Depressive effects during treatment with antihypertensive drugs (author's transl)].
Topics: Age Factors; Clinical Trials as Topic; Clonidine; Depression; Dose-Response Relationship, Drug; Drug | 1973 |
71 other studies available for clonidine and Depression
| Article | Year |
|---|---|
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholin | 2018 |
Synthesis and biological evaluation of imidazoline derivatives as potential CNS and CVS agents.
Topics: Animals; Antihypertensive Agents; Central Nervous System Agents; Depression; Female; Hypertension; I | 2020 |
Lycopene and Chrysin through Mitigation of Neuroinflammation and Oxidative Stress Exerted Antidepressant Effects in Clonidine-Induced Depression-like Behavior in Rats.
Topics: Animals; Antidepressive Agents; Antioxidants; Clonidine; Depression; Flavonoids; Lycopene; Neuroinfl | 2023 |
Anxiolytic-like effects of an mGluR 5 antagonist and a mGluR 2/3 agonist, and antidepressant-like effects of an mGluR 7 agonist in the chick social separation stress test, a dual-drug screening model of treatment-resistant depression.
Topics: Anti-Anxiety Agents; Antidepressive Agents; Clonidine; Depression; Drug Evaluation, Preclinical; Exe | 2023 |
Antidepressant-Like Effect of the Endogenous Neuroprotective Amine, 1MeTIQ in Clonidine-Induced Depression: Behavioral and Neurochemical Studies in Rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Biogenic Monoamines; Brain; Brain Che | 2017 |
Effects of indole-3-carbinol on clonidine-induced neurotoxicity in rats: Impact on oxidative stress, inflammation, apoptosis and monoamine levels.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Biogenic Monoamines; Brain; Clonidine; D | 2014 |
Comparative Evaluation of Partial α2 -Adrenoceptor Agonist and Pure α2 -Adrenoceptor Antagonist on the Behavioural Symptoms of Withdrawal after Chronic Alcohol Administration in Mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Alcoholism; Animals; Anxiety; Be | 2016 |
Medical Approach to the Management of Traumatized Refugees.
Topics: Adult; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Clonidine; Depression; Dreams; Dru | 2016 |
Modelling the anxiety-depression continuum in chicks.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Chickens; Chlordiaze | 2009 |
Insomnia, night terror, and depression related to clonidine in attention-deficit/hyperactivity disorder.
Topics: Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Central Nervous System Sti | 2008 |
Prolonged delirium after quetiapine overdose.
Topics: Adolescent; Antipsychotic Agents; Cholinergic Antagonists; Clonidine; Cytochrome P-450 CYP3A; Deliri | 2010 |
When is a phaeo not a phaeo? Depression in an adolescent leading to a phaeochromocytoma-like biochemical profile.
Topics: Adolescent; Adrenal Gland Neoplasms; Catecholamines; Clonidine; Depression; Humans; Male; Pheochromo | 2011 |
Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine, d-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anxiety; Apomorphine; Arecoline; Clonidine; Depression; D | 2011 |
Pharmacological reversal of cognitive bias in the chick anxiety-depression model.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antidepressive Agents; Anxiety; Bias; Chickens; Clo | 2012 |
Treatment practices in Tourette syndrome: the European perspective.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety; Aripiprazole; Atomoxetine Hydrochloride | 2012 |
Nootropic activity of Albizzia lebbeck in mice.
Topics: Albizzia; Animals; Avoidance Learning; Behavior, Animal; Brain Chemistry; Catalepsy; Clonidine; Depr | 2002 |
In the rat forced swimming test, chronic but not subacute administration of dual 5-HT/NA antidepressant treatments may produce greater effects than selective drugs.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Second-Gene | 2002 |
Levetiracetam as a treatment for tardive dyskinesia: a case report.
Topics: Adrenergic alpha-Agonists; Anticonvulsants; Antidepressive Agents; Chronic Disease; Clonidine; Depre | 2003 |
Suicides in general hospitals.
Topics: Adrenergic beta-Antagonists; Analgesics; Anti-Infective Agents, Urinary; Antipsychotic Agents; Cloni | 2004 |
Less is more: inpatient management of a child with complex pharmacotherapy.
Topics: Aggression; Amphetamines; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Depressio | 2006 |
Central alpha 2-adrenoceptor function in depression.
Topics: Clonidine; Depression; Growth Hormone; Humans; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1982 |
Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of oral yohimbine.
Topics: Adult; Analysis of Variance; Antidepressive Agents; Anxiety; Blood Pressure; Clonidine; Depression; | 1982 |
Effects of chronic treatment with imipramine, trazodone and electroshock on the behavioural and electroencephalographic modifications induced by clonidine in the rat.
Topics: Animals; Behavior, Animal; Brain; Clonidine; Depression; Disease Models, Animal; Electroencephalogra | 1983 |
[Cardiovascular and neuropsychologic changes during detoxification of heroin addicts with clonidine].
Topics: Anxiety; Blood Pressure; Clonidine; Depression; Heart Rate; Heroin Dependence; Humans; Inactivation, | 1984 |
[Clonidine in opiate withdrawal. II. Potential side-effects].
Topics: Aggression; Anxiety; Clonidine; Depression; Humans; Narcotics; Opioid-Related Disorders; Psychoses, | 1982 |
Electroconvulsive therapy and receptor sensitivity.
Topics: Animals; Apomorphine; Catecholamines; Clonidine; Depression; Electroconvulsive Therapy; Growth Hormo | 1981 |
[Treatment of menopausal symptoms with low doses of clonidine (author's transl)].
Topics: Blood Pressure; Climacteric; Clonidine; Depression; Female; Genital Diseases, Female; Headache; Hear | 1982 |
Brain noradrenergic neurons, their interactions and role in the action of antidepressive drugs.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Clonidine; Depression; Humans; Mood Disorde | 1982 |
Preliminary trial of the noradrenergic agonist clonidine in psychiatric patients.
Topics: Adult; Bipolar Disorder; Blood Pressure; Clonidine; Depression; Dose-Response Relationship, Drug; Do | 1980 |
Adrenergic mechanisms in selected diseases: arterial hypertension, duodenal ulcer, primary depressive illness, malignant tumors, and ketotic hypoglycemia.
Topics: Adult; Blood Pressure; Child; Clonidine; Depression; Duodenal Ulcer; Epinephrine; Female; Gastrins; | 1980 |
Monoamine depletion attenuates the REM sleep deprivation-induced increase in clonidine response in the forced swimming test.
Topics: Adrenergic alpha-2 Receptor Antagonists; alpha-Methyltyrosine; Animals; Biogenic Monoamines; Brain C | 1994 |
Increased imidazoline and alpha 2 adrenergic binding in platelets of women with dysphoric premenstrual syndromes.
Topics: Adrenergic alpha-Agonists; Adult; Blood Platelets; Clonidine; Depression; Depressive Disorder; Femal | 1993 |
Lithium treatment restores clonidine's effect in an animal model of depression.
Topics: Animals; Clonidine; Depression; Disease Models, Animal; Drug Synergism; Growth Hormone; Lithium Carb | 1994 |
Depression and chronic clonidine therapy.
Topics: Aged; Aged, 80 and over; Clonidine; Depression; Drug Administration Schedule; Female; Humans | 1993 |
Clonidine patch ingestion in an adult.
Topics: Administration, Cutaneous; Adult; Clonidine; Depression; Drug Overdose; Humans; Male; Substance-Rela | 1993 |
Clonidine side effect.
Topics: Adrenergic alpha-Agonists; Aggression; Autistic Disorder; Child; Clonidine; Depression; Humans; Male | 1997 |
Selective increase of alpha2A-adrenoceptor agonist binding sites in brains of depressed suicide victims.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Autoradiography; Binding, Competitiv | 1998 |
Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Analgesics; Animals; Antidepressive Agents; Body T | 1999 |
Hypertensive urgency induced by an interaction of mirtazapine and clonidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Antidepressive Agents; Antihypertens | 2000 |
Rapid recovery of self-stimulation responding from depression by clozapine is prevented by the alpha 2-adrenoceptor agonist, clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Antipsychotic Agents; Clonidine; Clozapine; Depression; Dose-Res | 1999 |
The differential effects of calcium channel blockers in the behavioural despair test in mice.
Topics: Animals; Antidepressive Agents; Calcium Channel Blockers; Clomipramine; Clonidine; Cyproheptadine; D | 2000 |
Neuroendocrine correlates of depression in abstinent heroin-dependent subjects.
Topics: Adrenergic alpha-Agonists; Adult; Analysis of Variance; Biomarkers; Brain; Bromocriptine; Case-Contr | 2000 |
Effect of the selective noradrenergic reuptake inhibitor reboxetine on the firing activity of noradrenaline and serotonin neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Adrenergic alpha-Agonists; Adrenergic Upt | 2001 |
[Suppression of the antihypertensive effect of clonidine by the simultaneous intake of a tricyclic antidepressive agent. Practical problem in the treatment of a depressed hypertensive patient].
Topics: Adrenergic beta-Antagonists; Adult; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Clomi | 1977 |
Adverse reactions to antihypertensive drug therapy: central nervous system.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Brain; Clonidine; Depression; Humans; Hypnotic | 1979 |
Electroconvulsive shock and postsynaptic catecholamine effects: increased psychomotor stimulant action of apomorphine and clonidine in reserpine pretreated mice by repeated ECS.
Topics: Animals; Apomorphine; Brain; Catecholamines; Clonidine; Depression; Electroshock; Humans; Male; Mice | 1975 |
[Neuroendocrinological studies of affective disorders (author's transl)].
Topics: Amphetamines; Circadian Rhythm; Clonidine; Depression; Depression, Chemical; Dexamethasone; Growth H | 1978 |
Rapid opiate detoxification: clinical evidence of antidepressant and antipanic effects of opiates.
Topics: Adult; Anxiety; Clonidine; Depression; Drug Therapy, Combination; Fear; Humans; Imipramine; Male; Me | 1979 |
The hypertensive psychiatric patient: pharmacologic problems.
Topics: Antihypertensive Agents; Clonidine; Depression; Diuretics; Drug Interactions; Guanethidine; Humans; | 1978 |
Drugs for hypertension.
Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Depression; Diuretics; Drug Combinations; Dru | 1977 |
Dixarit (clonidine hydrochloride) and depression.
Topics: Adult; Clonidine; Depression; Female; Humans | 1977 |
Factors influencing the choice of antihypertensive agents.
Topics: Age Factors; Aldosterone; Cerebrovascular Disorders; Clonidine; Depression; Diabetes Complications; | 1976 |
[The antidepressive properties of anaprilin].
Topics: Animals; Antidepressive Agents; Clonidine; Depression; Disease Models, Animal; Dose-Response Relatio | 1992 |
Growth hormone response to clonidine and cortisol secretion pattern predict changes in peripheral blood lymphocyte subsets in major depressive patients.
Topics: Adult; Clonidine; Depression; Dexamethasone; Female; Growth Hormone; Humans; Hydrocortisone; Lymphoc | 1992 |
Growth hormone and other hormonal responses to clonidine in melancholic and nonmelancholic depressed subjects and controls.
Topics: Adrenocorticotropic Hormone; Adult; Blood Pressure; Clonidine; Depression; Depressive Disorder; Fema | 1991 |
The low affinity component of [3H]clonidine binding is absent in the prefrontal cortex of presumptive suicide victims.
Topics: Cell Membrane; Cerebral Cortex; Clonidine; Depression; Humans; Kinetics; Receptors, Adrenergic, alph | 1991 |
Behavioral models in mice. Implication of the alpha noradrenergic system.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Depression; Dioxanes; Hydroxamic | 1991 |
Time course effects of uncontrollable stress in locus coeruleus neuronal activity.
Topics: Animals; Avoidance Learning; Clonidine; Depression; Electroshock; Locus Coeruleus; Male; Neurons; Ra | 1991 |
Psychoneuroendocrinological and immunological parameters in cancer patients: involvement of stress and depression.
Topics: Adult; Aged; Antibodies, Monoclonal; Catecholamines; Clonidine; Depression; Female; Hormones; Humans | 1990 |
Chronic treatment with cholinesterase inhibitors increases alpha 2-adrenoceptors in rat brain.
Topics: Animals; Brain; Cholinesterase Inhibitors; Clonidine; Depression; Histocytochemistry; Isoflurophate; | 1988 |
Reversal of behavioral depression by infusion of an alpha-2 adrenergic agonist into the locus coeruleus.
Topics: Animals; Clonidine; Depression; Electroshock; Locus Coeruleus; Male; Piperoxan; Rats; Receptors, Adr | 1986 |
Platelet high affinity adrenoceptor binding sites labelled with the agonist [3H]UK-14,304, in depressed patients and matched controls.
Topics: Adult; Blood Platelets; Brimonidine Tartrate; Clonidine; Depression; Female; Humans; Kinetics; Male; | 1986 |
Neuroendocrine and other studies of the mechanism of antidepressant action of desipramine.
Topics: Animals; Blood Pressure; Clonidine; Depression; Desipramine; Growth Hormone; Humans; Melatonin; Phen | 1986 |
Depression in an animal model: focus on the locus ceruleus.
Topics: Action Potentials; Animals; Anxiety; Behavior, Animal; Clonidine; Depression; Electroshock; Locus Co | 1986 |
Platelet radioligand binding and neuroendocrine challenge tests in depression.
Topics: Adult; Binding Sites; Blood Platelets; Blood Pressure; Clonidine; Depression; Female; Growth Hormone | 1986 |
Clonidine--induced behavioural despair in mice: reversal by antidepressants.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Azepines; Clonidine; Depression; D | 1986 |
Definite and sustained improvement with pimozide of two patients with severe trigeminal neuralgia. Some neurochemical, neurophysiological and neuroendocrinological findings.
Topics: Aged; Clonidine; Colon; Depression; Female; Gastrointestinal Motility; Humans; Male; Middle Aged; No | 1988 |
Clonidine, depression, and smoking cessation.
Topics: Behavior Therapy; Clonidine; Depression; Humans; Nicotine; Smoking | 1988 |
Adrenergic and serotonergic receptor responsiveness in depression.
Topics: Clonidine; Depression; Fenfluramine; Growth Hormone; Humans; Middle Aged; Norepinephrine; Prolactin; | 1986 |
Editorial: Hypertension and depression and their treatment.
Topics: Animals; Antidepressive Agents; Antihypertensive Agents; Clonidine; Depression; Humans; Hypertension | 1973 |
Clonidine in the treatment of severe hypertension.
Topics: Adult; Anesthesia, General; Cerebrovascular Disorders; Clonidine; Coronary Disease; Depression; Huma | 1973 |