Page last updated: 2024-10-25

clonidine and Dehydration

clonidine has been researched along with Dehydration in 9 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Dehydration: The condition that results from excessive loss of water from a living organism.

Research Excerpts

Excerpt	Relevance	Reference
"), and a 24 hour dehydration were attenuated by acute IP administration of graded doses of the central and peripheral alpha 2-adrenergic agonist, clonidine."	7.66	Antidipsogenic effect of clonidine on angiotensin II-, hypertonic saline-, pilocarpine- and dehydration-induced water intakes. ( Fregly, MJ; Greenleaf, JE; Kelleher, DL, 1981)
"Pretreatment with prazosin (40 nmol) abolished the antidipsogenic action of an 80-nmol dose of phenylephrine (11."	1.29	Clonidine and phenylephrine injected into the lateral preoptic area reduce water intake in dehydrated rats. ( Callera, JC; Camargo, LA; De Luca Júnior, LA; Menani, JV; Renzi, A; Saad, WA, 1993)

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (44.44)	18.7374
1990's	4 (44.44)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (11.11)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Moss, JR	1
Cofer, S	1
Hersey, S	1
Goudy, S	1
Werkhaven, J	1
Swanson, E	1
Mantle, C	1
Stowell, N	1
Byrne, D	1
Wang, L	1
Labadie, R	1
Selmi, W	1
Matricardi, L	1
Fregly, MJ	1
Kelleher, DL	1
Greenleaf, JE	1
Callera, JC	1
Camargo, LA	3
De Luca Júnior, LA	3
Menani, JV	4
Renzi, A	3
Saad, WA	3
Sato, MA	1
Yada, MM	1
De-Luca Júnior, LA	1
Humphreys, MH	1
Reid, IA	1
Chou, LY	1
Ferrari, AC	1
Kawasaki, H	1
Takasaki, K	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Pediatric Tonsillectomy Pain Reduction Study, a Randomized, Placebo Controlled, Double-Blind Clinical Trial Using Clonidine and Local Anesthetics[NCT00678379]			Phase 3	120 participants (Actual)	Interventional	2008-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Median Number of Pain Medication Doses

The median number of intravenous fentanyl doses administered in the PACU due to pain (NCT00678379)
Timeframe: in recovery room

Intervention	number of doses (Median)
Normal Saline	3.0
Lidocaine (1%) + Bupivacaine 0.5%	3
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	3

Total Number of Post-operative Doses of Analgesics.

The total number of intravenous fentanyl doses given PACU which will be compared between the three randomized groups (arms) (NCT00678379)
Timeframe: Post-operative thru day 7

Intervention	number of doses (Median)
Normal Saline	12
Lidocaine (1%) + Bupivacaine 0.5%	12
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	14

Total Time Until Discharge From Hospital.

(NCT00678379)
Timeframe: Day of Surgery

Intervention	minutes (Median)
Normal Saline	122
Lidocaine (1%) + Bupivacaine 0.5%	111
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	120

Mean Visual Analog Scale Pain Number.

Visual analog pain scale range is 0-10 with 0=no pain and 10 = worst pain ever (NCT00678379)
Timeframe: in recovery room; post-operative days 1,3,5 & 7

Intervention	pain score (Mean)
	In recovery room	day 1	day 3	day 5	day 7
Lidocaine (1%) + Bupivacaine 0.5%	3	4	2.5	2	2
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	3	5	3	3	2
Normal Saline	3	3	3	3	2.5

Number and Percent of Participants Able to Tolerate a Regular Diet

The number and percent of patients whose post-operative diet has to a regular diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Intervention	Participants (Count of Participants)
	post-op day 1	post-op day 3	post op day 5	post op day 7
Lidocaine (1%) + Bupivacaine 0.5%	4	8	18	26
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	1	12	14	22
Normal Saline	7	18	21	24

Number and Percent of Participants Able to Tolerate Only a Soft Diet

The number and percent of patients whose post-operative diet has only advanced to a soft diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Intervention	Participants (Count of Participants)
	post-op day 1	post-op day 3	post op day 5	post op day 7
Lidocaine (1%) + Bupivacaine 0.5%	22	26	17	10
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	26	18	18	14
Normal Saline	26	18	13	13

Number and Percent of Participants Able to Tolerate Only Liquids

The number and percent of patients whose post-operative diet has advanced to liquids only on post-op days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Intervention	Participants (Count of Participants)
	post-op day 1	post-op day 3	post op day 5	post op day 7
Lidocaine (1%) + Bupivacaine 0.5%	33	13	10	11
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	30	23	19	10
Normal Saline	16	8	13	6

Reviews

2 reviews available for clonidine and Dehydration

Article	Year
[Side effects of hypotensive agents]. Minerva medica, 1982, Oct-06, Volume: 73, Issue:38 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Benzothiadiazines; Bradycardia; Clonidine; Deh	1982
Multifactorial control of water and saline intake: role of alpha 2-adrenoceptors. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1997, Volume: 30, Issue:4 Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dehydration; Drinking; Norepinephrine; Receptors, Adr	1997

Trials

1 trial available for clonidine and Dehydration

Article	Year
Comparison of clonidine, local anesthetics, and placebo for pain reduction in pediatric tonsillectomy. Archives of otolaryngology--head & neck surgery, 2011, Volume: 137, Issue:6 Topics: Adenoids; Adolescent; Age Factors; Analgesics; Anesthetics, Local; Bupivacaine; Child; Child, Presch	2011

Other Studies

6 other studies available for clonidine and Dehydration

Article	Year
Antidipsogenic effect of clonidine on angiotensin II-, hypertonic saline-, pilocarpine- and dehydration-induced water intakes. Brain research bulletin, 1981, Volume: 7, Issue:6 Topics: Angiotensin II; Animals; Clonidine; Dehydration; Drinking; Female; Pilocarpine; Rats; Rats, Inbred S	1981
Clonidine and phenylephrine injected into the lateral preoptic area reduce water intake in dehydrated rats. Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:1 Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A	1993
Antagonism of clonidine injected intracerebroventricularly in different models of salt intake. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1996, Volume: 29, Issue:12 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon	1996
Suppression of antidiuretic hormone secretion by clonidine in the anesthetized dog. Kidney international, 1975, Volume: 7, Issue:6 Topics: Animals; Blood Pressure; Clonidine; Dehydration; Depression, Chemical; Diuresis; Dogs; Glomerular Fi	1975
Clonidine and phenylephrine injected into the lateral hypothalamus inhibits water intake in rats. Brain research, 1990, Jul-02, Volume: 522, Issue:1 Topics: Angiotensin II; Animals; Clonidine; Dehydration; Drinking; Eating; Hypothalamic Area, Lateral; In Vi	1990
Effect of water deprivation on the centrally-mediated hypertensive response to clonidine in freely moving, normotensive rats. Life sciences, 1987, May-11, Volume: 40, Issue:19 Topics: Animals; Blood Pressure; Clonidine; Dehydration; Hypertension; Injections, Intravenous; Injections,	1987