clonidine and Decerebrate Posturing
clonidine has been researched along with Decerebrate Posturing in 101 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypertension is often present in the diabetic individual and it is known to aggravate the vascular complications associated with diabetes." | 5.29 | Opposite influences of hypertension and diabetes mellitus on pressor responses induced by different alpha-adrenoceptor agonists and angiotensin II in pithed rats. ( Beenen, OH; Mathy, MJ; Pfaffendorf, M; van Zwieten, PA, 1996) |
| "1 mg kg(-1), displaced the dose-response curve approximately six-fold to the right." | 1.33 | Postjunctional alpha1-adrenoceptors in the vasculature of the pithed mouse are of the alpha1A-subtype. ( Ibarra, M; López-Guerrero, JJ; Villalobos-Molina, R, 2005) |
| " After an acute, 1-day spinalization, there was no change in the antinociceptive dose-response function to clonidine, relative to intact rats." | 1.31 | Spinal transection increases the potency of clonidine on the tail-flick and hindlimb flexion reflexes. ( Advokat, C, 2002) |
| "Heart failure is associated with increased sympathetic nerve activity." | 1.30 | Decreased responsiveness of vascular postjunctional alpha1-, alpha2-adrenoceptors and neuropeptide Y1 receptors in rats with heart failure. ( Edvinsson, L; Feng, Q; Hedner, T; Lu, X; Sun, X, 1999) |
| "Hypertension is often present in the diabetic individual and it is known to aggravate the vascular complications associated with diabetes." | 1.29 | Opposite influences of hypertension and diabetes mellitus on pressor responses induced by different alpha-adrenoceptor agonists and angiotensin II in pithed rats. ( Beenen, OH; Mathy, MJ; Pfaffendorf, M; van Zwieten, PA, 1996) |
| " doses of efaroxan (mumol/kg) producing 2-fold shifts in dose-response curves for UK-14,304 at prejunctional cardiac alpha 2-adrenoceptors and postjunctional vascular alpha 2-adrenoceptors, and for cirazoline at postjunctional vascular alpha 1-adrenoceptors, were 0." | 1.28 | Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat. ( Berridge, TL; Doxey, JC; Roach, AG; Smith, CF, 1992) |
| "Treatment with captopril was found to attenuate pressor responses produced by the administration of either alpha 1- or alpha 2-adrenoceptor agonists, resulting in the displacement to the right of the agonist dose-response curves and significantly increasing the calculated ED50 values." | 1.28 | The interrelationship between the effects of captopril and nifedipine on pressor responses elicited by selective alpha-adrenoceptor agonists in the pithed rat preparation. ( Tabrizchi, R; Triggle, CR, 1992) |
| " The ED50 value for the dose-response curves to B-HT 920 and St587 were found to be significantly increased after the administration of staurosporine." | 1.28 | Effects of staurosporine on the pressor responses to alpha-adrenoceptor agonists in pithed rats: a comparison with nifedipine. ( Tabrizchi, R; Triggle, CR, 1991) |
| "Clonidine was used as an alpha 2-adrenoceptor agonist, and yohimbine and rauwolscine were used as antagonists." | 1.28 | Peripheral presynaptic and central effects of clonidine, yohimbine and rauwolscine on the sympathetic nervous system in rabbits. ( Hedler, L; Starke, K; Szabo, B, 1989) |
| "In pithed rats two recently-introduced beta-blockers, nipradilol and arotinolol, as well as labetalol shifted the pressor dose-response curve for phenylephrine to the right." | 1.27 | Alpha-blockade and vasodilatation induced by nipradilol, arotinolol and labetalol in pithed rats. ( Chin, WP; Imai, S; Nakagawa, Y; Nakahara, H, 1985) |
| " The loss of the righting reflex induced by clonidine in the chicken was prevented by (+/-) and (+) S9871, as shown by a shift of the dose-response curve to clonidine to the right by both agents; on the contrary, (-) S9871 potentiated the sedation induced by clonidine." | 1.27 | Antagonistic effects of S9871 or (imidazolinyl-2)-2-dihydro 2,3 benzofurane and its stereoisomers on some central and peripheral actions of alpha 2-agonists. ( Joly, G; Mouillé, P; Schmitt, H, 1985) |
| " In addition, L-654,284 had better (5-6 times) oral bioavailability than RX 781094 or WY 26703." | 1.27 | L-654,284 a new potent and selective alpha 2-adrenoceptor antagonist. ( Baldwin, JJ; Clineschmidt, BV; Huff, JR; Lotti, VJ; Martin, GE; Pettibone, DJ; Randall, WC; Vacca, J, 1986) |
| "Rilmenidine (S 3341) is a new alpha 2 agonist, with antihypertensive properties." | 1.27 | Cardiovascular and central nervous system effects of rilmenidine (S 3341) in rats. ( Beau, B; Delbarre, G; Koenig-Berard, E; Labrid, C; Lhoste, F; Tierney, C, 1988) |
| "Naloxone was significantly more effective in spinalized rabbits whereas idazoxan had a much larger effect in non-spinalized animals." | 1.27 | Adrenergic and opioidergic modulation of a spinal reflex in the decerebrated rabbit. ( Clarke, RW; Ford, TW; Taylor, JS, 1988) |
| "Clonidine may prove to be a useful therapeutic adjunct in the treatment of spasticity." | 1.27 | Effect of clonidine on motoneuron excitability in spinalized rats. ( Bedard, PJ; Tremblay, LE, 1986) |
| " These data argue against desensitisation of peripheral presynaptic alpha 2-adrenoceptors by chronic administration of alpha 2-adrenoceptor agonist." | 1.27 | Chronic clonidine treatment produces desensitisation of post- but not presynaptic alpha 2-adrenoceptors. ( Finberg, JP; Kopin, IJ, 1987) |
| "When clonidine was given 1-3 months following the transection, at a time when the spinal cats had a stable and regular locomotor performance, the step length increased markedly, especially at low speeds." | 1.27 | The effects of clonidine and yohimbine on locomotion and cutaneous reflexes in the adult chronic spinal cat. ( Barbeau, H; Julien, C; Rossignol, S, 1987) |
| " In some of the pithed rats dose-response curves were constructed to exogenously administered noradrenaline (NA) and sympathetic nerve stimulation (SNS) through the pithing rod before and after the administration of an inhibitor of the neuronal uptake mechanism (desipramine, DMI, 0." | 1.27 | A low dietary sodium intake reduces neuronal noradrenaline release and the blood pressure in spontaneously hypertensive rats. ( Dahlöf, C; Gradin, K; Persson, B, 1986) |
| "Urapidil is a novel antihypertensive agent, chemically related to uracil." | 1.27 | Cardiovascular effects and interaction with adrenoceptors of urapidil. ( Beckeringh, JJ; de Jonge, A; Thoolen, MJ; Timmermans, PB; van Zwieten, PA; Wilffert, B, 1985) |
| " The dose-response curve to guanfacine for increase in blood pressure was shifted in a parallel fashion to the right by 1 mg/kg of yohimbine, an alpha 2-antagonist and by 1 mg/kg of phentolamine, a nonselective alpha 1- and alpha 2-antagonist." | 1.26 | [Effects of guanfacine on pre- and postsynaptic alpha-adrenoceptors studied in comparison with those of clonidine]. ( Chin, W; Imai, S; Nakagawa, Y, 1982) |
| " The vasodepressor effect of guanfacine was clearly dose-dependent, and was more marked when the initial level of the blood pressure was high, while that of clonidine was dose-dependent, only within a limited dosage range." | 1.26 | [Antihypertensive effect of guanfacine in rats]. ( Hamamura, M; Hashimoto, T; Imai, S; Kumada, M; Mitomi, A; Nakagawa, Y; Sakurai, H; Takeda, K, 1981) |
| "Pretreatment with piperoxane (10 mg/kg) antagonized this effect but pretreatment with phentolamine (10 mg/kg) did not." | 1.26 | Effects of clonidine on habituation and sensitization of acoustic startle in normal, decerebrate and locus coeruleus lesioned rats. ( Aghajanian, GK; Cedarbaum, JM; Davis, M; Gendelman, DS, 1977) |
| "Clonidine 100 mug/kg was given to conscious and to decerebrated rats." | 1.25 | Effects of pentobarbitone and decerebration on the clonidine-induced circulatory changes. ( Trolin, G, 1975) |
Research
Studies (101)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 58 (57.43) | 18.7374 |
| 1990's | 34 (33.66) | 18.2507 |
| 2000's | 9 (8.91) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Monroy-Ordoñez, EB | 1 |
| Villalón, CM | 2 |
| Cobos-Puc, LE | 1 |
| Márquez-Conde, JA | 1 |
| Sánchez-López, A | 1 |
| Centurión, D | 2 |
| Bouyer, LJ | 1 |
| Rossignol, S | 5 |
| Li, Y | 1 |
| Harvey, PJ | 1 |
| Li, X | 1 |
| Bennett, DJ | 2 |
| López-Guerrero, JJ | 1 |
| Ibarra, M | 1 |
| Villalobos-Molina, R | 1 |
| Barthélemy, D | 1 |
| Leblond, H | 1 |
| Provencher, J | 2 |
| Albarrán-Juárez, JA | 1 |
| Lozano-Cuenca, J | 1 |
| Pertz, HH | 1 |
| Görnemann, T | 1 |
| Nakagawa, Y | 3 |
| Chin, W | 1 |
| Imai, S | 3 |
| Demichel, P | 1 |
| Gomond, P | 1 |
| Roquebert, J | 1 |
| Timmermans, PB | 6 |
| Thoolen, MJ | 6 |
| Mathy, MJ | 4 |
| Wilffert, B | 6 |
| De Jonge, A | 6 |
| Van Zwieten, PA | 8 |
| Matthews, WD | 1 |
| Demarinis, RM | 1 |
| Hieble, JP | 1 |
| Doods, HN | 1 |
| Ishii, K | 1 |
| Kato, R | 1 |
| Zomlefer, MR | 1 |
| Blanchette, G | 1 |
| Cavero, I | 1 |
| Lefevre-Borg, F | 1 |
| Lhoste, F | 2 |
| Sabatier, C | 1 |
| Richer, C | 2 |
| Giudicelli, JF | 1 |
| Takeda, K | 1 |
| Hashimoto, T | 1 |
| Sakurai, H | 1 |
| Mitomi, A | 1 |
| Hamamura, M | 1 |
| Kumada, M | 1 |
| Medvedev, OS | 1 |
| Vylegzhanin, AG | 1 |
| Matsievskiĭ, DD | 1 |
| Takahashi, T | 1 |
| Luo, L | 1 |
| Wiesenfeld-Hallin, Z | 4 |
| Ono, H | 3 |
| Fukushima, C | 1 |
| Fukuda, H | 3 |
| Gulati, A | 1 |
| Rebello, S | 1 |
| Vargas, HM | 1 |
| Zhou, L | 1 |
| Gorman, AJ | 1 |
| Moorman, SJ | 1 |
| Whalen, LR | 1 |
| Angel, I | 1 |
| Grosset, A | 1 |
| Perrault, G | 1 |
| Schoemaker, H | 1 |
| Langer, SZ | 1 |
| Nakamura, T | 2 |
| Tanabe, M | 2 |
| Kozuka, M | 1 |
| Iwata, N | 2 |
| Xu, XJ | 3 |
| Wikberg, JE | 1 |
| Andell, S | 1 |
| Hao, JX | 1 |
| Bartfai, T | 1 |
| Prieto, P | 1 |
| Carrón, R | 1 |
| Montero, MJ | 1 |
| Morán, A | 1 |
| Román, LS | 1 |
| Beenen, OH | 1 |
| Pfaffendorf, M | 1 |
| Nomura, S | 1 |
| Sunagane, N | 1 |
| Uruno, T | 1 |
| Kubota, K | 1 |
| De Serres, SJ | 1 |
| Stein, RB | 1 |
| Alvarez-Guerra, M | 1 |
| Bertholom, N | 1 |
| Garay, RP | 1 |
| Szabo, B | 3 |
| Bock, C | 1 |
| Nordheim, U | 1 |
| Niederhoffer, N | 1 |
| Feng, Q | 1 |
| Sun, X | 1 |
| Lu, X | 1 |
| Edvinsson, L | 1 |
| Hedner, T | 1 |
| Marcoux, J | 1 |
| Rives, JE | 1 |
| Bernard, DG | 1 |
| Advokat, C | 1 |
| Kobinger, W | 4 |
| Pichler, L | 4 |
| Davis, M | 1 |
| Cedarbaum, JM | 1 |
| Aghajanian, GK | 1 |
| Gendelman, DS | 1 |
| Tadepalli, AS | 1 |
| Mills, E | 1 |
| Miller, S | 1 |
| Van Der Burg, J | 1 |
| Van Der Meché, F | 1 |
| Maj, J | 2 |
| Palider, W | 1 |
| Baran, L | 1 |
| Trolin, G | 1 |
| Pompeiano, O | 3 |
| Ma, S | 1 |
| Long, JP | 1 |
| Bhatnagar, RK | 1 |
| Serdiuchenko, IIa | 1 |
| Koropova, GE | 1 |
| Shcherbinina, MB | 1 |
| Berridge, TL | 1 |
| Doxey, JC | 1 |
| Roach, AG | 1 |
| Smith, CF | 1 |
| Puke, MJC | 1 |
| Tabrizchi, R | 2 |
| Triggle, CR | 2 |
| Pearson, KG | 1 |
| Jiang, W | 1 |
| Ramirez, JM | 1 |
| Kaneko, T | 1 |
| Tonohiro, T | 1 |
| Kehne, JH | 1 |
| Ketteler, HJ | 1 |
| Kane, JM | 1 |
| McCloskey, TC | 1 |
| Senyah, Y | 1 |
| Palfreyman, MG | 1 |
| Gomez, RE | 1 |
| Ernsberger, P | 1 |
| Feinland, G | 1 |
| Reis, DJ | 1 |
| Rabloczky, G | 1 |
| Jaszlits, L | 1 |
| Horváth, E | 1 |
| Dabiré, H | 2 |
| Horn, E | 2 |
| d'Ascanio, P | 2 |
| Rawlow, A | 1 |
| King, RG | 1 |
| Bouhelal, R | 1 |
| Loubatières-Mariani, MM | 1 |
| Mir, AK | 1 |
| Smyth, DD | 1 |
| Blandford, DE | 1 |
| Li, P | 1 |
| Penner, SB | 1 |
| Nakahara, H | 1 |
| Chin, WP | 1 |
| Jonkman, FA | 2 |
| Man, PW | 1 |
| Breurkes, R | 1 |
| Murata, K | 1 |
| Nakagawa, I | 1 |
| Kumeta, Y | 1 |
| Kitahata, LM | 1 |
| Collins, JG | 1 |
| Szemeredi, K | 2 |
| Zukowska-Grojec, Z | 3 |
| Bagdy, G | 2 |
| Fekete, MI | 1 |
| Kopin, IJ | 4 |
| Galeano, C | 1 |
| Corcos, J | 1 |
| Carmel, M | 1 |
| Jubelin, B | 1 |
| Hedler, L | 3 |
| Starke, K | 3 |
| Skuza, G | 1 |
| Sowińska, H | 1 |
| Nowak, G | 1 |
| Schomburg, ED | 1 |
| Steffens, H | 1 |
| Savola, JM | 1 |
| Puurunen, J | 1 |
| Ruskoaho, H | 1 |
| Kärki, NT | 1 |
| Joly, G | 1 |
| Mouillé, P | 2 |
| Schmitt, H | 3 |
| van den Berg, G | 1 |
| Qian, JQ | 1 |
| Dausse, JP | 1 |
| Fournier, B | 1 |
| Cardot, A | 1 |
| Meyer, P | 1 |
| Skarsfeldt, T | 1 |
| Hyttel, J | 1 |
| Pettibone, DJ | 2 |
| Clineschmidt, BV | 2 |
| Lotti, VJ | 2 |
| Martin, GE | 1 |
| Huff, JR | 2 |
| Randall, WC | 1 |
| Vacca, J | 2 |
| Baldwin, JJ | 1 |
| Chen, DF | 1 |
| Bianchetti, M | 1 |
| Wiesendanger, M | 1 |
| Koenig-Berard, E | 1 |
| Tierney, C | 1 |
| Beau, B | 1 |
| Delbarre, G | 1 |
| Labrid, C | 1 |
| Hucker, HB | 1 |
| Sweeney, BM | 1 |
| Reiss, DR | 1 |
| Lis, EV | 1 |
| Clarke, RW | 1 |
| Ford, TW | 1 |
| Taylor, JS | 1 |
| Ruffolo, RR | 1 |
| Messick, K | 1 |
| Ensinger, H | 1 |
| Majewski, H | 1 |
| Haass, M | 1 |
| Goldstein, DS | 1 |
| Sanders, KH | 1 |
| Kilian, U | 1 |
| Kolassa, N | 1 |
| Schoetensack, W | 1 |
| Tremblay, LE | 1 |
| Bedard, PJ | 1 |
| Rawłów, A | 1 |
| Górka, Z | 1 |
| Finberg, JP | 1 |
| Franz, DN | 1 |
| Peterson, RG | 1 |
| Madsen, PW | 1 |
| Sangdee, C | 1 |
| Conway, BA | 1 |
| Hultborn, H | 1 |
| Kiehn, O | 1 |
| Mintz, I | 1 |
| Hill, J | 1 |
| Barbeau, H | 1 |
| Julien, C | 1 |
| Stampacchia, G | 1 |
| Zhao, ZQ | 1 |
| Duggan, AW | 1 |
| Matsumoto, K | 1 |
| Kato, K | 1 |
| Kato, F | 1 |
| Miyamoto, M | 1 |
| Mori, T | 1 |
| Oka, J | 1 |
| Gradin, K | 1 |
| Dahlöf, C | 1 |
| Persson, B | 1 |
| Gutkind, JS | 1 |
| Kazanietz, M | 1 |
| Enero, MA | 1 |
| Beckeringh, JJ | 1 |
| Fenard, S | 1 |
| Klevans, LR | 1 |
| Kepner, K | 1 |
| Kovacs, JL | 1 |
Reviews
1 review available for clonidine and Decerebrate Posturing
| Article | Year |
|---|---|
Locus coeruleus and dorsal pontine reticular influences on the gain of vestibulospinal reflexes.
Topics: Action Potentials; Animals; Carbachol; Cats; Cholinergic Fibers; Clonidine; Decerebrate State; Drug | 1991 |
Other Studies
100 other studies available for clonidine and Decerebrate Posturing
| Article | Year |
|---|---|
Evidence that some imidazoline derivatives inhibit peripherally the vasopressor sympathetic outflow in pithed rats.
Topics: Adrenergic alpha-Agonists; Agmatine; Animals; Antihypertensive Agents; Azepines; Blood Pressure; Blo | 2008 |
Contribution of cutaneous inputs from the hindpaw to the control of locomotion. II. Spinal cats.
Topics: Adrenergic alpha-Agonists; Animals; Biomechanical Phenomena; Cats; Clonidine; Decerebrate State; Den | 2003 |
Spastic long-lasting reflexes of the chronic spinal rat studied in vitro.
Topics: Adrenergic alpha-Agonists; Animals; Biogenic Monoamines; Clonidine; Decerebrate State; Dose-Response | 2004 |
Postjunctional alpha1-adrenoceptors in the vasculature of the pithed mouse are of the alpha1A-subtype.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Caro | 2005 |
Nonlocomotor and locomotor hindlimb responses evoked by electrical microstimulation of the lumbar cord in spinalized cats.
Topics: Adrenergic alpha-Agonists; Animals; Biomechanical Phenomena; Cats; Clonidine; Decerebrate State; Ele | 2006 |
Pharmacological profile of the clonidine-induced inhibition of vasodepressor sensory outflow in pithed rats: correlation with alpha(2A/2C)-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Blood Vessels; Cal | 2008 |
[Effects of guanfacine on pre- and postsynaptic alpha-adrenoceptors studied in comparison with those of clonidine].
Topics: Adrenalectomy; Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Clonidine; Decerebrate S | 1982 |
alpha-Adrenoceptor blocking properties of raubasine in pithed rats.
Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Blood Pressure; Clonidine; Decerebrate State; Elect | 1982 |
Sgd 101/75 is distinguished from other selective alpha 1-adrenoceptor agonists by the inhibition of its pressor responses by calcium entry blockade and vasodilatation in pithed rats and cats.
Topics: Adrenergic alpha-Agonists; Albuterol; Animals; Blood Pressure; Calcium Channel Blockers; Cats; Cloni | 1983 |
Alpha 1-adrenoceptor-mediated vasoconstriction in vivo to enantiomers of SK & F 89748-A.
Topics: Adrenergic alpha-Agonists; Animals; Binding, Competitive; Blood Pressure; Cats; Clonidine; Decerebra | 1984 |
Development of tolerance to alpha-2 adrenergic agonists in the vascular system of the rat after chronic treatment with clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Decerebrate State; Drug Tolerance; Ma | 1984 |
Electromyographic study of lumbar back muscles during locomotion in acute high decerebrate and in low spinal cats.
Topics: Animals; Cats; Clonidine; Decerebrate State; Electromyography; Locomotion; Motor Activity; Muscles; | 1984 |
Pharmacological, hemodynamic and autonomic nervous system mechanisms responsible for the blood pressure and heart rate lowering effects of pergolide in rats.
Topics: Adrenalectomy; Animals; Antiparkinson Agents; Autonomic Nervous System; Blood Pressure; Clonidine; D | 1984 |
[Antihypertensive effect of guanfacine in rats].
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Consciousness; Decerebrate | 1981 |
[Effect of clonidine and naloxone in somatovegetative responses in decerebrate cats].
Topics: Animals; Autonomic Nervous System; Blood Pressure; Cardiac Output; Cats; Clonidine; Decerebrate Stat | 1981 |
[Alpha adrenergic mechanism on the reflex micturition in the male decerebrate dog].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Decerebrate State; Dogs | 1993 |
Low-dose intrathecal clonidine releases tachykinins in rat spinal cord.
Topics: Animals; Biphenyl Compounds; Clonidine; Decerebrate State; Hypnotics and Sedatives; Injections, Spin | 1993 |
Effect of the centrally acting muscle relaxant tizanidine on spinal reflexes: involvement of descending noradrenergic systems.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 1993 |
Role of adrenergic mechanisms in the pressor effect of diaspirin cross-linked hemoglobin.
Topics: Adrenal Medulla; Adrenalectomy; Adrenergic beta-Antagonists; Animals; Aspirin; Blood Pressure; Cardi | 1994 |
Role of vascular alpha-1 adrenoceptor subtypes in the pressor response to sympathetic nerve stimulation in the pithed rat.
Topics: Animals; Blood Pressure; Blood Vessels; Clonidine; Decerebrate State; Dioxanes; Electric Stimulation | 1994 |
A model system to determine the effects of specific neurotransmitters on segmental reflexes in the spinal cord of the rat.
Topics: Animals; Clonidine; Decerebrate State; Dopamine; Electromyography; Electrophysiology; Female; Hindli | 1993 |
In vivo pharmacological profile of SL 84.0418, a new selective, peripherally active alpha 2-adrenoceptor antagonist.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Blood Pressure; Bri | 1993 |
Local cerebral glucose utilization in rats with decerebrate rigidity and effects of centrally acting muscle relaxants, diazepam and tizanidine.
Topics: Animals; Cerebellar Nuclei; Clonidine; Decerebrate State; Deoxyglucose; Diazepam; Glucose; Male; Mus | 1993 |
The effect of intrathecal guanfacine and clonidine on the flexor reflex in rats with intact and sectioned sciatic nerves.
Topics: Analgesia; Animals; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Female; Guanfaci | 1993 |
The effects of intrathecal galanin message-associated peptide (GMAP) on the flexor reflex in rats.
Topics: Analgesics, Opioid; Animals; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Female; | 1995 |
MR-14134, a new benzothiazepine with central hypotensive action.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Antihypertensive Agents; Binding, Competitive; Bl | 1995 |
Opposite influences of hypertension and diabetes mellitus on pressor responses induced by different alpha-adrenoceptor agonists and angiotensin II in pithed rats.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Azepines; Blood Glucose; Blood Pressure; Brimoni | 1996 |
Characteristics of depression by clonidine of the pressor response to alpha 1-adrenoceptor agonists in pithed rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agon | 1996 |
Regulation of soleus muscle spindle sensitivity in decerebrate and spinal cats during postural and locomotor activities.
Topics: Action Potentials; Afferent Pathways; Animals; Cats; Clonidine; Decerebrate State; Electrophysiology | 1996 |
Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha 1A-adrenoceptor subtype in the rat.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; An | 1999 |
Mechanism of the sympathoinhibition produced by the clonidine-like drugs rilmenidine and moxonidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepi | 1999 |
Decreased responsiveness of vascular postjunctional alpha1-, alpha2-adrenoceptors and neuropeptide Y1 receptors in rats with heart failure.
Topics: Adrenergic alpha-Agonists; Animals; Atrial Natriuretic Factor; Autonomic Fibers, Preganglionic; Azep | 1999 |
Initiating or blocking locomotion in spinal cats by applying noradrenergic drugs to restricted lumbar spinal segments.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cats; Clonidine; Decerebrate State | 2000 |
Alpha2 adrenergic receptors and the central control of breathing in the cane toad, Bufo marinus.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Bufo marinus; Clon | 2001 |
Spinal transection increases the potency of clonidine on the tail-flick and hindlimb flexion reflexes.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; | 2002 |
Pharmacological characterization of B-HT 933 (2-amino-6-ethyl-4,5,7,8,-tetrahydro-6H-oxazolo-[5,4-d]-azepindihydrochloride) as a hypotensive agent of the "clonidine-type".
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Azepines; Cardiac Output; Cats; Central | 1977 |
The central modulatory effect of clonidine on the cardiodepressor reflex after suppression of synthesis and storage of noradrenaline.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Animals; Blood Pressure; Brain; Clonidine; Decerebrate | 1975 |
Localization in the CNA of adrenoceptors which facilitate a cardioinhibitory reflex.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Animals; Blood Pressure; Cerebellum; Clonidine; Decereb | 1975 |
Effects of clonidine on habituation and sensitization of acoustic startle in normal, decerebrate and locus coeruleus lesioned rats.
Topics: Acoustic Stimulation; Animals; Cerebral Ventricles; Clonidine; Decerebrate State; Drug Interactions; | 1977 |
Contribution of supracollicular structures of the brain to the central depression of cardiovascular function by clonidine.
Topics: Animals; Brain; Carotid Arteries; Cats; Cerebral Aqueduct; Clonidine; Decerebrate State; Depression, | 1978 |
Locomotion in the cat: basic programmes of movement.
Topics: 5-Hydroxytryptophan; Animals; Cats; Clonidine; Decerebrate State; Forelimb; Gait; Hindlimb; Levodopa | 1975 |
The effects of serotonergic and antiserotonergic drugs on the flexor reflex of spinal rat: a proposed model to evaluate the action on the central serotonin receptor.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anthracenes; Clonidine; Cyproheptadine; Decerebrate State | 1976 |
Effects of pentobarbitone and decerebration on the clonidine-induced circulatory changes.
Topics: Animals; Blood Pressure; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Drug Intera | 1975 |
Noradrenergic and cholinergic modulations of corticocerebellar activity modify the gain of vestibulospinal reflexes.
Topics: Animals; Cats; Cerebellum; Cerebral Cortex; Clonidine; Decerebrate State; Isoproterenol; Methoxamine | 1992 |
Further studies on central actions of nitroglycerin and lack of evidence for nitroglycerin interacting on [3H]clonidine binding sites in cortex membranes.
Topics: Animals; Binding Sites; Blood Pressure; Brain; Clonidine; Decerebrate State; Heart Rate; Injections, | 1992 |
[Segmental reflexes after sciatic nerve damage in rats given thyroxine].
Topics: Animals; Clonidine; Decerebrate State; Female; Injections, Intraperitoneal; Propranolol; Rats; Refle | 1992 |
Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Blood Glucose; Brimonidine Tartrate; Clonidine; | 1992 |
The depressive effect of intrathecal clonidine on the spinal flexor reflex is enhanced after sciatic nerve section in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Axons; Blood Pressure; Clonidine; Decerebrate State; Female; | 1992 |
The interrelationship between the effects of captopril and nifedipine on pressor responses elicited by selective alpha-adrenoceptor agonists in the pithed rat preparation.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Blood Pressure; Captopril; Clonidine; Decerebrate Stat | 1992 |
The use of naloxone to facilitate the generation of the locomotor rhythm in spinal cats.
Topics: Animals; Cats; Clonidine; Decerebrate State; Electromyography; Motor Activity; Naloxone; Physical St | 1992 |
The pharmacological properties of CS-722, a newly synthesized centrally acting muscle relaxant.
Topics: Animals; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Electroencephalography; Evo | 1992 |
MDL 27,531 reduces spontaneous hindlimb contractions in rats with chronic transections of the spinal cord.
Topics: Animals; Anticonvulsants; Clonidine; Decerebrate State; Hindlimb; Male; Muscle Contraction; Muscle T | 1992 |
Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area.
Topics: Animals; Antihypertensive Agents; Benzazepines; Binding, Competitive; Blood Pressure; Brain Stem; Cl | 1991 |
GYKI-12743 a new postsynaptic vascular alpha-adrenoceptor antagonist.
Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Blood Pressure; Clonidine; Decerebrate State; Dioxa | 1991 |
Effects of staurosporine on the pressor responses to alpha-adrenoceptor agonists in pithed rats: a comparison with nifedipine.
Topics: Adrenergic alpha-Agonists; Alkaloids; Animals; Azepines; Blood Pressure; Clonidine; Decerebrate Stat | 1991 |
Implication of the central nervous system in the systemic and regional hemodynamics of two centrally acting hypotensive drugs, flesinoxan and clonidine, in the rat.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Central Nervous System | 1991 |
A novel in vivo test for drugs affecting central serotonergic and adrenergic systems.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Albuterol; Animals; Cl | 1990 |
Investigation of the mechanism(s) of 8-OH-DPAT-mediated inhibition of plasma insulin in spontaneously hypertensive rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Blood Glucose; Blood Pressure; Clonidin | 1990 |
Comparison of renal and vascular alpha 2-adrenoceptor sensitivity to clonidine in the rat.
Topics: Anesthesia; Animals; Blood Pressure; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; | 1990 |
Alpha-blockade and vasodilatation induced by nipradilol, arotinolol and labetalol in pithed rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Clonidine; Decer | 1985 |
Beta 2-adrenoceptor antagonists intensify clonidine withdrawal syndrome in conscious rats.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Clonidine; Decerebrate State; Dose-Response Re | 1989 |
Intrathecal clonidine suppresses noxiously evoked activity of spinal wide dynamic range neurons in cats.
Topics: Analgesics; Animals; Blood Pressure; Cats; Clonidine; Decerebrate State; Drug Combinations; Female; | 1989 |
Opposite effects of chronic cortisol treatment on pre- and postsynaptic actions of clonidine in pithed rats.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Blood Pressure; Body Weight; Clonidine; Decerebrate St | 1989 |
Action of clonidine on micturitional reflexes in decerebrate cats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cats; Central Nervous System; Clon | 1989 |
Peripheral presynaptic and central effects of clonidine, yohimbine and rauwolscine on the sympathetic nervous system in rabbits.
Topics: Animals; Blood Pressure; Brain; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Fema | 1989 |
Pharmacological properties of EXP 561, a potential antidepressant drug.
Topics: Aggression; Amphetamine; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Blood Pressu | 1987 |
The effect of DOPA and clonidine on reflex pathways from group II muscle afferents to alpha-motoneurones in the cat.
Topics: Action Potentials; Animals; Cats; Clonidine; Decerebrate State; Dihydroxyphenylalanine; Electric Sti | 1988 |
Peripheral cardiovascular alpha- and beta-adrenergic effects of some hypotensive and bradycardic arylalkyl imidazole derivatives in the rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Cardiovascular System; Clonidi | 1985 |
Antagonistic effects of S9871 or (imidazolinyl-2)-2-dihydro 2,3 benzofurane and its stereoisomers on some central and peripheral actions of alpha 2-agonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Benzofurans; Blood Press | 1985 |
Inhibitory effect of alpha-1 adrenoceptor stimulation on cardiac sympathetic neurotransmission in pithed normotensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Decerebrate State; Ethanolamines; Heart; Heart Rate; | 1986 |
Central and peripheral effects of S 3341 [(N-dicyclopropylmethyl)-amino-2-oxazoline] in animal models.
Topics: Adrenergic alpha-Agonists; Animals; Binding, Competitive; Blood Pressure; Brain; Cats; Clonidine; De | 1986 |
Pharmacological properties of the enantiomers of idazoxan: possible separation between their alpha-adrenoceptor blocking effects.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Blood Pressure; Cerebral Cortex; Chicke | 1986 |
The St 587-induced flexor reflex in pithed rats: a model to evaluate central alpha 1-receptor blocking properties.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Binding, Competitive; Clonidine; Decere | 1986 |
L-654,284 a new potent and selective alpha 2-adrenoceptor antagonist.
Topics: Adrenergic alpha-Antagonists; Animals; Cattle; Cerebral Cortex; Clonidine; Decerebrate State; Dihydr | 1986 |
Dopamine1 receptor agonist and alpha-2 adrenoceptor antagonist effects of fenoldopam in rabbits.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Clonidine; Decerebrate State; Desipramine; Domp | 1986 |
The adrenergic agonist tizanidine has differential effects on flexor reflexes of intact and spinalized rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Clonidine; Decerebrate State; Dose-Response | 1987 |
Cardiovascular and central nervous system effects of rilmenidine (S 3341) in rats.
Topics: Adrenalectomy; Adrenergic alpha-Agonists; Anesthesia; Animals; Blood Pressure; Catecholamines; Centr | 1988 |
A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Blood-Brain Barrier; Callitrichinae; Cl | 1988 |
Adrenergic and opioidergic modulation of a spinal reflex in the decerebrated rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Decerebrate State; Dioxanes; Dioxins; Dose-Respons | 1988 |
Evaluation of the alpha-1 and alpha-2 adrenoceptor-mediated effects of a series of dimethoxy-substituted tolazoline derivatives in the cardiovascular system of the pithed rat.
Topics: Animals; Blood Pressure; Brimonidine Tartrate; Clonidine; Decerebrate State; Dose-Response Relations | 1985 |
Neuronal and postjunctional components in the blood pressure effects of dopamine and bromocriptine in rabbits.
Topics: Anesthesia; Animals; Benzazepines; Blood Pressure; Bromocriptine; Clonidine; Decerebrate State; Desi | 1985 |
Effects of the irreversible alpha-adrenoceptor antagonists phenoxybenzamine and benextramine on the effectiveness of nifedipine in inhibiting alpha 1- and alpha 2-adrenoceptor mediated vasoconstriction in pithed rats.
Topics: Animals; Azepines; Clonidine; Cystamine; Decerebrate State; Diastole; Dose-Response Relationship, Dr | 1985 |
Differential inhibition of alpha adrenoceptor-mediated pressor responses by rat atrial natriuretic peptide in the pithed rat.
Topics: Adrenergic alpha-Antagonists; Animals; Atrial Natriuretic Factor; Blood Pressure; Clonidine; Decereb | 1985 |
Influence of urapidil on alpha- and beta-adrenoreceptors in pithed rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Decerebrate State; Dose-Response Relati | 1985 |
Effect of clonidine on motoneuron excitability in spinalized rats.
Topics: Animals; Anterior Horn Cells; Clonidine; Decerebrate State; Depression, Chemical; Efferent Pathways; | 1986 |
Involvement of postsynaptic alpha 1- and alpha 2-adrenoceptors in the flexor reflex activity in the spinal rats.
Topics: Animals; Clonidine; Clozapine; Decerebrate State; Male; Norepinephrine; Prazosin; Rats; Rats, Inbred | 1986 |
Chronic clonidine treatment produces desensitisation of post- but not presynaptic alpha 2-adrenoceptors.
Topics: Animals; Blood Pressure; Body Weight; Catecholamines; Clonidine; Decerebrate State; Dose-Response Re | 1987 |
Enhancement of central transmission to sympathetic preganglionic neurons by phosphodiesterase inhibitors and its prevention by clonidine.
Topics: Animals; Catecholamines; Cats; Clonidine; Decerebrate State; Female; Ganglia; Male; Neurons; Phospho | 1987 |
Plateau potentials in alpha-motoneurones induced by intravenous injection of L-dopa and clonidine in the spinal cat.
Topics: Action Potentials; Animals; Cats; Clonidine; Decerebrate State; Levodopa; Membrane Potentials; Motor | 1988 |
Evidence for a direct peripheral effect of clonidine on the norepinephrine release in vivo in pithed rats.
Topics: Animals; Blood Pressure; Clonidine; Decerebrate State; Male; Norepinephrine; Peripheral Nerves; Rats | 1988 |
The effects of clonidine and yohimbine on locomotion and cutaneous reflexes in the adult chronic spinal cat.
Topics: Animals; Cats; Clonidine; Decerebrate State; Electromyography; Gait; Locomotion; Reflex; Skin; Skin | 1987 |
Effects of local injection of the alpha 2-adrenergic agonist clonidine into the locus coeruleus complex on the gain of vestibulospinal and cervicospinal reflexes in decerebrate cats.
Topics: Animals; Cats; Clonidine; Decerebrate State; Electromyography; Functional Laterality; Locus Coeruleu | 1987 |
Clonidine and the hyper-responsiveness of dorsal horn neurones following morphine withdrawal in the spinal cat.
Topics: Animals; Cats; Clonidine; Decerebrate State; Ganglia, Spinal; Injections; Injections, Intravenous; M | 1987 |
Effects of tizanidine, a centrally acting muscle relaxant, on motor systems.
Topics: Animals; Cerebral Cortex; Chlorpromazine; Clonidine; Decerebrate State; Diazepam; Male; Membranes; M | 1986 |
A low dietary sodium intake reduces neuronal noradrenaline release and the blood pressure in spontaneously hypertensive rats.
Topics: Animals; Catecholamines; Clonidine; Decerebrate State; Diet, Sodium-Restricted; Electric Stimulation | 1986 |
Cardiovascular effects of alpha-adrenergic drugs: differences between clonidine and guanabenz.
Topics: Animals; Blood Pressure; Brain; Clonidine; Decerebrate State; Dopamine; Female; Guanabenz; Guanidine | 1986 |
Cardiovascular effects and interaction with adrenoceptors of urapidil.
Topics: Animals; Antihypertensive Agents; Binding, Competitive; Cats; Clonidine; Decerebrate State; Female; | 1985 |
Evidence for direct alpha-adrenoceptor stimulation of effector neurons in cardiovascular centers by clonidine.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Angiotensin II; Animals; Blood Pressure; Card | 1974 |
Localization of the site of the central sympatho-inhibitory action of 1-Dopa in dogs and cats.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Blood Pressure; Brain Stem; Carbidopa; Cats; | 1973 |
Role of forebrain in clonidine-induced suppression of cardiovascular responses.
Topics: Animals; Blood Pressure; Brain; Cats; Clonidine; Decamethonium Compounds; Decerebrate State; Electri | 1973 |