clonidine has been researched along with Critical Illness in 24 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The α2 agonists, dexmedetomidine and clonidine, are used as sedative drugs during critical illness." | 9.01 | The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies. ( Baillie, JK; Edwardson, SA; Flanders, CA; Rocke, AS; Walsh, TS, 2019) |
| "Haloperidol and clonidine are commonly used to treat agitation in delirious intensive care unit (ICU) patients, but it is unclear whether these agents may shorten the duration of delirium." | 8.02 | Haloperidol, clonidine and resolution of delirium in critically ill patients: a prospective cohort study. ( Dijkstra-Kersten, SMA; Slooter, AJC; Smit, L; van der Jagt, M; Zaal, IJ, 2021) |
| "Nonselective beta blockade (BB) and clonidine may abrogate catecholamine-mediated persistent injury-associated anemia." | 7.88 | The effects of beta blockade and clonidine on persistent injury-associated anemia. ( Brakenridge, SC; Croft, CA; Efron, PA; Loftus, TJ; Mohr, AM; Moore, FA; Rosenthal, MD; Smith, RS, 2018) |
| "The α2 agonists, dexmedetomidine and clonidine, are used as sedative drugs during critical illness." | 5.01 | The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies. ( Baillie, JK; Edwardson, SA; Flanders, CA; Rocke, AS; Walsh, TS, 2019) |
| "Multimodal therapy encompasses a wide range of procedures and medications, including regional analgesia with continuous epidural or peripheral nerve block infusions, judicious opioids, acetaminophen, anti-inflammatory agents, anticonvulsants, ketamine, clonidine, mexiletine, antidepressants, and anxiolytics as options to treat or modulate pain at various sites of action." | 4.84 | The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism. ( Black, IH; Malchow, RJ, 2008) |
| "Haloperidol and clonidine are commonly used to treat agitation in delirious intensive care unit (ICU) patients, but it is unclear whether these agents may shorten the duration of delirium." | 4.02 | Haloperidol, clonidine and resolution of delirium in critically ill patients: a prospective cohort study. ( Dijkstra-Kersten, SMA; Slooter, AJC; Smit, L; van der Jagt, M; Zaal, IJ, 2021) |
| "Nonselective beta blockade (BB) and clonidine may abrogate catecholamine-mediated persistent injury-associated anemia." | 3.88 | The effects of beta blockade and clonidine on persistent injury-associated anemia. ( Brakenridge, SC; Croft, CA; Efron, PA; Loftus, TJ; Mohr, AM; Moore, FA; Rosenthal, MD; Smith, RS, 2018) |
| "Clonidine is an alternative to midazolam." | 2.79 | Prospective multicentre randomised, double-blind, equivalence study comparing clonidine and midazolam as intravenous sedative agents in critically ill children: the SLEEPS (Safety profiLe, Efficacy and Equivalence in Paediatric intensive care Sedation) st ( Boland, A; Gamble, C; Granville, H; McKay, A; Petrou, S; Spowart, C; Sutherland, A; Wolf, A, 2014) |
| " dosing range and to assess its cardiovascular effects." | 2.69 | Intravenous clonidine infusion in critically ill children: dose-dependent sedative effects and cardiovascular stability. ( Ambrose, C; Bevan, C; Howells, R; Jenkins, I; Murphy, P; Sale, S; Weir, P; Wolf, A, 2000) |
| "Clonidine dosages that have been assessed for discontinuing dexmedetomidine vary from 0." | 2.66 | Clonidine as a strategy for discontinuing dexmedetomidine sedation in critically ill patients: A narrative review. ( Attridge, RL; Christina Gutierrez, G; Glaess, SS, 2020) |
| "Clonidine is an alpha-2 selective adrenergic agonist that may have a role in optimizing current sedation practices in the pediatric and adult critically ill populations by potentially minimizing exposure to other sedative agents." | 2.52 | Clonidine for sedation in the critically ill: a systematic review and meta-analysis (protocol). ( Alhazzani, W; Belley-Coté, E; Burry, L; D'Aragon, F; Duffett, M; Jing Wang, G; Karachi, T; Perri, D; Rochwerg, B; Wunsch, H, 2015) |
| " Advantages, potential side effects, and dosing for multiple modes of delivery are discussed." | 2.43 | Long-term use of clonidine in a critically-ill infant. ( Lowery, R; Polaner, DM; Zuk, J, 2005) |
| "Clonidine is a sedative-sparing agent and this can help reduce complications associated with prolonged use of opioids and benzodiazepines." | 1.72 | Use of continuous infusion of clonidine for sedation in critically ill infants and children. ( Bourdon, O; Dauger, S; Deho, A; Prot-Labarthe, S; Sadozai, L, 2022) |
| " Our objectives were to describe clonidine dosing regimens used for sedation and analgesia in critically ill adults, the associated adverse effects (i." | 1.62 | High-versus low-dose clonidine for sedation and analgesia in critically ill adults: A retrospective cohort study. ( Burry, L; Cheung, A; Coleman, B; Guenette, M; Purivatra, E, 2021) |
| "Clonidine is an α2-agonist that is commonly used for sedation in the intensive care unit." | 1.56 | In vivo Elimination of Clonidine by Continuous Venovenous Hemofiltration in Critically Ill Patients. ( Arbouw, M; Bles, C; de Meijer, AR; Kruisdijk-Gerritsen, A; Nassikovker, P; van den Oever, HLA; van Steveninck, FAL; Zeeman, M, 2020) |
| "Clonidine was a common part of up to two-thirds of the regimens." | 1.33 | Practice of sedation and analgesia in German intensive care units: results of a national survey. ( Fischer, M; Franck, M; Martin, J; Parsch, A; Spies, C; Wernecke, KD, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 11 (45.83) | 24.3611 |
| 2020's | 8 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Sadozai, L | 1 |
| Prot-Labarthe, S | 1 |
| Bourdon, O | 1 |
| Dauger, S | 1 |
| Deho, A | 1 |
| Flanders, CA | 1 |
| Rocke, AS | 1 |
| Edwardson, SA | 1 |
| Baillie, JK | 1 |
| Walsh, TS | 1 |
| de Castro, REV | 1 |
| Martins, RSO | 1 |
| Prata-Barbosa, A | 1 |
| de Magalhães-Barbosa, MC | 1 |
| van den Oever, HLA | 1 |
| Zeeman, M | 1 |
| Nassikovker, P | 1 |
| Bles, C | 1 |
| van Steveninck, FAL | 1 |
| de Meijer, AR | 1 |
| Kruisdijk-Gerritsen, A | 1 |
| Arbouw, M | 1 |
| Glaess, SS | 1 |
| Attridge, RL | 1 |
| Christina Gutierrez, G | 1 |
| Petitjeans, F | 1 |
| Martinez, JY | 1 |
| Danguy des Déserts, M | 1 |
| Leroy, S | 1 |
| Quintin, L | 1 |
| Escarment, J | 1 |
| Lankadeva, YR | 1 |
| Shehabi, Y | 1 |
| Deane, AM | 1 |
| Plummer, MP | 1 |
| Bellomo, R | 1 |
| May, CN | 1 |
| Smit, L | 1 |
| Dijkstra-Kersten, SMA | 1 |
| Zaal, IJ | 1 |
| van der Jagt, M | 1 |
| Slooter, AJC | 1 |
| Purivatra, E | 1 |
| Guenette, M | 1 |
| Coleman, B | 1 |
| Cheung, A | 1 |
| Burry, L | 3 |
| Wang, JG | 1 |
| Belley-Coté, E | 2 |
| Duffett, M | 3 |
| Karachi, T | 2 |
| Perri, D | 2 |
| Alhazzani, W | 2 |
| D'Aragon, F | 2 |
| Wunsch, H | 2 |
| Rochwerg, B | 2 |
| Gagnon, DJ | 1 |
| Fontaine, GV | 1 |
| Riker, RR | 1 |
| Fraser, GL | 1 |
| Loftus, TJ | 1 |
| Rosenthal, MD | 1 |
| Croft, CA | 1 |
| Smith, RS | 1 |
| Moore, FA | 1 |
| Brakenridge, SC | 1 |
| Efron, PA | 1 |
| Mohr, AM | 1 |
| Mavropoulos, G | 1 |
| Minguet, G | 1 |
| Brichant, JF | 1 |
| Choong, K | 1 |
| Foster, J | 1 |
| Cheng, J | 1 |
| Meade, MO | 1 |
| Menon, K | 1 |
| Cook, DJ | 1 |
| Chen, K | 1 |
| Lu, Z | 1 |
| Xin, YC | 1 |
| Cai, Y | 1 |
| Chen, Y | 1 |
| Pan, SM | 1 |
| Wolf, A | 2 |
| McKay, A | 1 |
| Spowart, C | 1 |
| Granville, H | 1 |
| Boland, A | 1 |
| Petrou, S | 1 |
| Sutherland, A | 1 |
| Gamble, C | 1 |
| Jing Wang, G | 1 |
| Mokhtari, M | 1 |
| Sistanizad, M | 1 |
| Farasatinasab, M | 1 |
| Capino, AC | 1 |
| Miller, JL | 2 |
| Johnson, PN | 2 |
| Malchow, RJ | 1 |
| Black, IH | 1 |
| Honey, BL | 1 |
| Benefield, RJ | 1 |
| Martin, J | 1 |
| Parsch, A | 1 |
| Franck, M | 1 |
| Wernecke, KD | 1 |
| Fischer, M | 1 |
| Spies, C | 1 |
| Lowery, R | 1 |
| Zuk, J | 1 |
| Polaner, DM | 1 |
| Ambrose, C | 1 |
| Sale, S | 1 |
| Howells, R | 1 |
| Bevan, C | 1 |
| Jenkins, I | 1 |
| Weir, P | 1 |
| Murphy, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| New Approaches to Pediatric Sedation: Adjunctive Clonidine in the Sedation of Mechanically Ventilated Children (NAPS Pilot Trial)[NCT00959062] | Phase 4 | 50 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| The Use of Transcranial Focused Ultrasound for the Treatment of Neurodegenerative Dementias[NCT04250376] | 100 participants (Anticipated) | Interventional | 2017-11-27 | Enrolling by invitation | |||
| Lymphatic System Health in Alzheimer's Disease[NCT04205539] | Phase 1 | 0 participants (Actual) | Interventional | 2021-12-10 | Withdrawn (stopped due to Pending COVID-19 pandemic) | ||
| Comparison of Ultrasound Guided Femoral Nerve Blockade and Standard Parenteral Opioid Pain Management Alone in Patients With Hip Fracture in the Emergency Department[NCT02381717] | 60 participants (Anticipated) | Interventional | 2015-08-31 | Recruiting | |||
| Managing Acute Pain in Critically Ill Non-communicative Palliative Care Patients[NCT02127086] | 377 participants (Actual) | Interventional | 2015-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for clonidine and Critical Illness
| Article | Year |
|---|---|
The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Critical Illness; Dexmedetomidine; Disease | 2019 |
Clonidine as a strategy for discontinuing dexmedetomidine sedation in critically ill patients: A narrative review.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Clonidine; Critical Illness; Dexmedetomidine; Dose-Resp | 2020 |
A Centrally Acting Antihypertensive, Clonidine, Sedates Patients Presenting With Acute Respiratory Distress Syndrome Evoked by Severe Acute Respiratory Syndrome-Coronavirus 2.
Topics: Adult; Aged; Antihypertensive Agents; Clonidine; Conscious Sedation; Coronavirus Infections; COVID-1 | 2020 |
Emerging benefits and drawbacks of α
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Clonidine; Critical Illness; Dexmed | 2021 |
Clonidine for sedation in the critically ill: a systematic review and meta-analysis.
Topics: Clonidine; Critical Illness; Humans; Hypnotics and Sedatives; Hypotension; Intensive Care Units; Len | 2017 |
Repurposing Valproate, Enteral Clonidine, and Phenobarbital for Comfort in Adult ICU Patients: A Literature Review with Practical Considerations.
Topics: Administration, Oral; Administration, Sublingual; Adult; Clonidine; Critical Illness; Drug Repositio | 2017 |
[Alpha-2 adrenoreceptor agonists in anaesthesia and intensive care medicine].
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia; Clonidine; Critical Care; Critical Illness; Dexmed | 2014 |
Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Bradycardia; Clonidine; Conscious Sedation; Critical Il | 2015 |
Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Bradycardia; Clonidine; Conscious Sedation; Critical Il | 2015 |
Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Bradycardia; Clonidine; Conscious Sedation; Critical Il | 2015 |
Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Bradycardia; Clonidine; Conscious Sedation; Critical Il | 2015 |
Clonidine for sedation in the critically ill: a systematic review and meta-analysis (protocol).
Topics: Adrenergic alpha-2 Receptor Agonists; Clonidine; Conscious Sedation; Critical Care; Critical Illness | 2015 |
Clonidine for Sedation and Analgesia and Withdrawal in Critically Ill Infants and Children.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Child; Clonidine; Critical Illness; Dose-Response | 2016 |
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste | 2008 |
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste | 2008 |
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste | 2008 |
The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anti-Inflammatory Agents, Non-Ste | 2008 |
Alpha2-receptor agonists for treatment and prevention of iatrogenic opioid abstinence syndrome in critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Child; Clonidine; Critical I | 2009 |
Long-term use of clonidine in a critically-ill infant.
Topics: Analgesics; Clonidine; Critical Illness; Fatal Outcome; Follow-Up Studies; Hemangioma; Humans; Infan | 2005 |
4 trials available for clonidine and Critical Illness
| Article | Year |
|---|---|
Clonidine in the sedation of mechanically ventilated children: a pilot randomized trial.
Topics: Adolescent; Algorithms; Child; Child, Preschool; Clonidine; Critical Illness; Double-Blind Method; F | 2014 |
Prospective multicentre randomised, double-blind, equivalence study comparing clonidine and midazolam as intravenous sedative agents in critically ill children: the SLEEPS (Safety profiLe, Efficacy and Equivalence in Paediatric intensive care Sedation) st
Topics: Adolescent; Child; Child, Preschool; Clonidine; Conscious Sedation; Cost-Benefit Analysis; Critical | 2014 |
Antipyretic Effect of Clonidine in Intensive Care Unit Patients: A Nested Observational Study.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Aged, 80 and over; Antipyretics; Case-Control Stu | 2017 |
Intravenous clonidine infusion in critically ill children: dose-dependent sedative effects and cardiovascular stability.
Topics: Adrenergic alpha-Agonists; Analgesics; Child; Child, Preschool; Clonidine; Conscious Sedation; Criti | 2000 |
7 other studies available for clonidine and Critical Illness
| Article | Year |
|---|---|
Use of continuous infusion of clonidine for sedation in critically ill infants and children.
Topics: Bradycardia; Child, Preschool; Clonidine; Critical Care; Critical Illness; Female; Humans; Hypnotics | 2022 |
Clonidine Doses For Sedation in the PICU.
Topics: Analgesics; Child; Clonidine; Critical Illness; Humans; Hypnotics and Sedatives; Intensive Care Unit | 2020 |
In vivo Elimination of Clonidine by Continuous Venovenous Hemofiltration in Critically Ill Patients.
Topics: Adult; Clonidine; Continuous Renal Replacement Therapy; Critical Illness; Female; Humans; Male; Meta | 2020 |
Haloperidol, clonidine and resolution of delirium in critically ill patients: a prospective cohort study.
Topics: Clonidine; Cohort Studies; Critical Illness; Delirium; Haloperidol; Humans; Intensive Care Units; Pr | 2021 |
High-versus low-dose clonidine for sedation and analgesia in critically ill adults: A retrospective cohort study.
Topics: Adult; Aged; Analgesia; Analgesics, Opioid; Clonidine; Critical Illness; Dose-Response Relationship, | 2021 |
The effects of beta blockade and clonidine on persistent injury-associated anemia.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Age Factors; Anemia; Blood Loss, | 2018 |
Practice of sedation and analgesia in German intensive care units: results of a national survey.
Topics: Analgesia; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Clonidine; Critical Illness; Data In | 2005 |