Page last updated: 2024-10-25

clonidine and Constricted Pupil

clonidine has been researched along with Constricted Pupil in 10 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

ExcerptRelevanceReference
"Apraclonidine (0."5.33The sensitivity and specificity of 0.5% apraclonidine in the diagnosis of oculosympathetic paresis. ( Acaroglu, G; Firat, E; Kansu, T; Kavuncu, S; Koc, F, 2005)
"Instillation of apraclonidine 1% in healthy subjects causes relative miosis, which is most pronounced after 30-60 min."5.15Apraclonidine and my pupil. ( Cambron, M; Crevits, L; Maertens, H, 2011)
" Clonidine did not significantly reduce the mydriatic effects of MDMA, although it produced miosis when administered alone."4.88Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex. ( Hysek, CM; Liechti, ME, 2012)
"The authors report a clinical case of clonidine poisoning in a 20-month-old child."4.79[Coma with miosis and bradycardia]. ( Matos, LD; Porfírio, H, 1994)
"Apraclonidine (0."1.33The sensitivity and specificity of 0.5% apraclonidine in the diagnosis of oculosympathetic paresis. ( Acaroglu, G; Firat, E; Kansu, T; Kavuncu, S; Koc, F, 2005)
"Clonidine is an antihypertensive agent with central and peripheral alpha-2 adrenergic effects."1.28Pediatric clonidine intoxications. ( Bamshad, MJ; Wasserman, GS, 1990)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's4 (40.00)29.6817
2010's4 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Slattery, A1
Liebelt, E1
Gaines, LA1
Bohnsack, BL1
Parker, JW1
Kwon, HJ1
Kim, HY1
Cambron, M1
Maertens, H1
Crevits, L1
Shin, RK1
Cheek, AG1
Hysek, CM1
Liechti, ME1
Osterhoudt, KC1
Koc, F1
Kavuncu, S1
Kansu, T1
Acaroglu, G1
Firat, E1
Porfírio, H1
Matos, LD1
Bamshad, MJ1
Wasserman, GS1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacological Interaction Between Duloxetine and 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy): Pharmacodynamics (PD) and Pharmacokinetics (PK)[NCT00990067]Phase 116 participants (Actual)Interventional2009-11-30Completed
Pharmacological Interaction Between Reboxetine and 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy): Pharmacological Effects and Pharmacokinetics[NCT00886886]Phase 116 participants (Actual)Interventional2009-04-30Completed
Pharmacological Interaction Between Clonidine and 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)[NCT01136278]Phase 116 participants (Actual)Interventional2010-07-31Completed
Interactive Effects of Doxazosin and 3,4-Methylenedioxymethamphetamine (MDMA) in Healthy Subjects[NCT01386177]Phase 116 participants (Actual)Interventional2011-07-31Completed
"Effects of Carvedilol on the Cardiovascular and Subjective Response to MDMA (3,4-Methylenedioxymethamphetamine, Ecstasy)"[NCT01270672]16 participants (Actual)Interventional2011-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for clonidine and Constricted Pupil

ArticleYear
Common ocular effects reported to a poison control center after systemic absorption of drugs in therapeutic and toxic doses.
    Current opinion in ophthalmology, 2014, Volume: 25, Issue:6

    Topics: Amphetamines; Analgesics, Opioid; Clonidine; Dextromethorphan; Humans; Miosis; Mydriasis; Nystagmus,

2014
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
[Coma with miosis and bradycardia].
    Acta medica portuguesa, 1994, Volume: 7, Issue:3

    Topics: Bradycardia; Clonidine; Coma; Diagnosis, Differential; Emergencies; Female; Humans; Infant; Miosis;

1994

Trials

1 trial available for clonidine and Constricted Pupil

ArticleYear
Apraclonidine and my pupil.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2011, Volume: 21, Issue:5

    Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Clonidine; Female; Humans; Male; Miosis; Pupil; Time Fa

2011

Other Studies

6 other studies available for clonidine and Constricted Pupil

ArticleYear
Positive apraclonidine test within two weeks of onset of Horner syndrome caused by carotid artery dissection.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2008, Volume: 28, Issue:3

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Carotid Artery, Internal; Ca

2008
A pharmacologic pupillary test in the diagnosis of diabetic autonomic neuropathy.
    Korean journal of ophthalmology : KJO, 2009, Volume: 23, Issue:4

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Diabetic Nephropathies; Diagnosis, Differential;

2009
Teaching NeuroImages: Positive apraclonidine test in Horner syndrome.
    Neurology, 2011, May-17, Volume: 76, Issue:20

    Topics: Adrenergic alpha-Agonists; Adult; Blepharoptosis; Clonidine; Diskectomy; Female; Horner Syndrome; Hu

2011
No sympathy for a boy with obtundation.
    Pediatric emergency care, 2004, Volume: 20, Issue:6

    Topics: Child, Preschool; Clonidine; Diagnosis, Differential; Humans; Male; Miosis; Narcotics; Poisoning; Re

2004
The sensitivity and specificity of 0.5% apraclonidine in the diagnosis of oculosympathetic paresis.
    The British journal of ophthalmology, 2005, Volume: 89, Issue:11

    Topics: Adrenergic alpha-Agonists; Adult; Anisocoria; Blepharoptosis; Clonidine; Diabetic Neuropathies; Fema

2005
Pediatric clonidine intoxications.
    Veterinary and human toxicology, 1990, Volume: 32, Issue:3

    Topics: Clonidine; Humans; Infant; Infant, Newborn; Male; Miosis; Naloxone; Respiratory Distress Syndrome, N

1990