clonidine has been researched along with Complication, Intraoperative in 32 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the subgroup analysis, clonidine reduced the incidence of myocardial ischemia in patients undergoing cardiac and noncardiac surgery." | 8.81 | Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature. ( Kamae, I; Maekawa, M; Mikawa, K; Nishi, N; Nishina, K; Obara, H; Uesugi, T, 2002) |
| "Twenty-six patients undergoing ESS for chronic sinusitis and polyp removal were enrolled and randomly assigned to receive either oral clonidine or melatonin as preoperative premedication." | 5.19 | Improved quality of surgical field during endoscopic sinus surgery after clonidine premedication--a pilot study. ( Burduk, PK; Cywinski, JB; Kazmierczak, W; Kusza, K; Wawrzyniak, K, 2014) |
| " Our review, based on moderate-quality evidence, revealed that hypotension occurred frequently during the preoperative and postoperative periods, for both clonidine and dexmedetomidine." | 5.01 | Perioperative adverse events attributed to α2-adrenoceptor agonists in patients not at risk of cardiovascular events: systematic review and meta-analysis. ( Antunes, T; Demiri, M; Fletcher, D; Martinez, V, 2019) |
| " In the subgroup analysis, clonidine reduced the incidence of myocardial ischemia in patients undergoing cardiac and noncardiac surgery." | 4.81 | Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature. ( Kamae, I; Maekawa, M; Mikawa, K; Nishi, N; Nishina, K; Obara, H; Uesugi, T, 2002) |
| "Problem of clofellinum (clonidine) usage in premedication in aged persons with arterial hypertension is discussed." | 3.72 | [Arterial hypertension intraoperative management in aged patients by different premedication variants]. ( Proshchaev, KI, 2004) |
| "A patient with essential hypertension treated with clonidine developed accelerated acute clonidine withdrawal syndrome during coronary artery bypass surgery." | 3.66 | Accelerated acute clonidine withdrawal syndrome during coronary artery bypass surgery. A case report. ( O'Connor, DE, 1981) |
| "Propofol was started at 50 to 100 microg/kg/min, and after endotracheal intubation, clonidine infusion was started (6 to 20 microg/h)." | 2.70 | Remifentanil-clonidine-propofol versus sufentanil-propofol anesthesia for coronary artery bypass surgery. ( Dörges, V; Gerlach, K; Hüppe, M; Kraatz, E; Saager, L; Schmitz, A; Schmucker, P; Uhlig, T, 2002) |
| "Clonidine was associated with a significant (P < 0." | 2.69 | Clonidine and cardiac surgery: haemodynamic and metabolic effects, myocardial ischaemia and recovery. ( Buckland, MR; Bujor, MA; Davis, BB; Esmore, DS; Hall, J; Holdgaard, HO; Hunt, JO; McRae, R; Moloney, J; Morgan, DJ; Myles, PS, 1999) |
| "Nefopam has no influence on the extubation time (WMD 0." | 2.52 | Nefopam for the prevention of perioperative shivering: a meta-analysis of randomized controlled trials. ( Liu, M; Lv, M; Qu, W; Wang, X; Wang, Y, 2015) |
| "Caudal block is a safe procedure commonly used for pediatric perioperative analgesia." | 2.48 | [Pediatric caudal anesthesia : importance and aspects of safety concerns]. ( Mauch, J; Weiss, M, 2012) |
| "Awake regional anaesthesia for inguinal hernia repair in former preterm infants is suggested to avoid life-threatening respiratory complications known to occur after general anaesthesia." | 1.31 | Apnoea in a former preterm infant after caudal bupivacaine with clonidine for inguinal herniorrhaphy. ( Fellmann, C; Gerber, AC; Weiss, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.50) | 18.7374 |
| 1990's | 10 (31.25) | 18.2507 |
| 2000's | 10 (31.25) | 29.6817 |
| 2010's | 8 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Demiri, M | 1 |
| Antunes, T | 1 |
| Fletcher, D | 1 |
| Martinez, V | 1 |
| Duncan, D | 1 |
| Sankar, A | 1 |
| Beattie, WS | 2 |
| Wijeysundera, DN | 2 |
| Wawrzyniak, K | 1 |
| Burduk, PK | 1 |
| Cywinski, JB | 1 |
| Kusza, K | 1 |
| Kazmierczak, W | 1 |
| Devereaux, PJ | 1 |
| Lv, M | 1 |
| Wang, X | 1 |
| Qu, W | 1 |
| Liu, M | 1 |
| Wang, Y | 1 |
| Aouad, MT | 1 |
| Moukaddem, FH | 1 |
| Akel, SR | 1 |
| Kanazi, GE | 1 |
| Garg, R | 1 |
| Rakesh, SV | 1 |
| Rajeev, S | 1 |
| Batra, YK | 1 |
| Rao, KL | 1 |
| Bender, JS | 1 |
| Yarwood, J | 1 |
| Bartholomew, K | 1 |
| Ramos, R | 1 |
| Ureña, A | 1 |
| Rivas, F | 1 |
| Macia, I | 1 |
| Rosado, G | 1 |
| Pequeño, S | 1 |
| Masuet, C | 1 |
| Badia, M | 1 |
| Miguel, M | 1 |
| Delgado, MA | 1 |
| Escobar, I | 1 |
| Moya, J | 1 |
| Mauch, J | 1 |
| Weiss, M | 2 |
| Fellmann, C | 1 |
| Gerber, AC | 1 |
| Gerlach, K | 1 |
| Uhlig, T | 1 |
| Hüppe, M | 1 |
| Kraatz, E | 1 |
| Saager, L | 1 |
| Schmitz, A | 1 |
| Dörges, V | 1 |
| Schmucker, P | 1 |
| Boussofara, M | 1 |
| Mtaallah, MH | 1 |
| Nefaa, MN | 1 |
| Kaddour, C | 1 |
| Proshchaev, KI | 1 |
| Talke, PO | 1 |
| Lobo, EP | 1 |
| Stapelfeldt, C | 1 |
| Brown, R | 1 |
| O'Connor, DE | 1 |
| Flacke, JW | 2 |
| Flacke, WE | 1 |
| Stühmeier, KD | 1 |
| Mainzer, B | 1 |
| Cierpka, J | 1 |
| Sandmann, W | 1 |
| Tarnow, J | 1 |
| Nishikawa, T | 1 |
| Quintin, L | 1 |
| de Kock, M | 1 |
| Ghignone, M | 1 |
| Joris, JL | 1 |
| Chiche, JD | 1 |
| Canivet, JL | 1 |
| Jacquet, NJ | 1 |
| Legros, JJ | 1 |
| Lamy, ML | 1 |
| Myles, PS | 1 |
| Hunt, JO | 1 |
| Holdgaard, HO | 1 |
| McRae, R | 1 |
| Buckland, MR | 1 |
| Moloney, J | 1 |
| Hall, J | 1 |
| Bujor, MA | 1 |
| Esmore, DS | 1 |
| Davis, BB | 1 |
| Morgan, DJ | 1 |
| Nishina, K | 1 |
| Mikawa, K | 1 |
| Uesugi, T | 1 |
| Obara, H | 1 |
| Maekawa, M | 1 |
| Kamae, I | 1 |
| Nishi, N | 1 |
| Chadha, R | 1 |
| Padmanabhan, V | 1 |
| Joseph, A | 1 |
| Mohandas, K | 1 |
| Bravo, EL | 1 |
| Johnson, VG | 1 |
| Romanoff, ME | 1 |
| Gombotz, H | 1 |
| Bonnet, F | 1 |
| Diallo, A | 1 |
| Catoire, P | 1 |
| Belon, M | 1 |
| Saada, M | 1 |
| Guilbaud, M | 1 |
| Stieglitz, P | 1 |
| Magioncalda, A | 1 |
| Setti, S | 1 |
| Cecchi, A | 1 |
| Tampoia, V | 1 |
| Bennio, M | 1 |
| Visani, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Intraoperative Goal-directed Blood Pressure Management and Dexmedetomidine on Outcomes of High-risk Patients After Major Abdominal Surgeries: a 2×2 Factorial Randomized Controlled Trial[NCT03933306] | Phase 4 | 496 participants (Actual) | Interventional | 2019-05-20 | Active, not recruiting | ||
| Effect of Pre-operative Oral Steroids on Blood Loss in Endoscopic Sinus Surgery for Chronic Rhinosinusitis Without Polyps[NCT05095961] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2023-03-31 | Withdrawn (stopped due to Technical difficulties encountered with recording intraoperative blood loss; unable to proceed with study.) | ||
| A Large, International, Placebo-controlled, Factorial Trial to Assess the Impact of Clonidine and Acetyl-salicylic Acid (ASA) in Patients Undergoing Noncardiac Surgery Who Are at Risk of a Perioperative Cardiovascular Event[NCT01082874] | Phase 3 | 10,010 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| Comparative Study Between Nefopam and Ondansteron for Prevention of Post Spinal Shivering. A Randomized Controlled Trial.[NCT04870541] | Phase 4 | 150 participants (Anticipated) | Interventional | 2020-12-01 | Recruiting | ||
| Comparison of the Impacts of Prolonged Low-pressure and Standard-pressure Pneumoperitoneum on Myocardial and Pulmonary Injuries After Robot-assisted Surgery in the Trendelenburg Position: a Bi-center, Randomized Controlled Trial[NCT02600481] | 280 participants (Anticipated) | Interventional | 2016-01-31 | Not yet recruiting | |||
| Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/Paraganglioma[NCT01967576] | Phase 2 | 14 participants (Actual) | Interventional | 2013-10-19 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01082874)
Timeframe: 30 days
| Intervention | participants (Number) |
|---|---|
| Active Clonidine and Active ASA | 173 |
| Active Clonidine and Placebo ASA | 194 |
| Placebo Clonidine and Active ASA | 178 |
| Placebo Clonidine and Placebo ASA | 161 |
Here is the count of participants with serious and non-serious adverse events assessed by the Common Terminology Criteria in Adverse Events (CTCAE v4.0). A non-serious adverse event is any untoward medical occurrence. A serious adverse event is an adverse event or suspected adverse reaction that results in death, a life threatening adverse drug experience, hospitalization, disruption of the ability to conduct normal life functions, congenital anomaly/birth defect or important medical events that jeopardize the patient or subject and may require medical or surgical intervention to prevent one of the previous outcomes mentioned. (NCT01967576)
Timeframe: Date treatment consent signed to date off study, approximately 54 months and 29 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| 1/Arm 1-Axitinib | 14 |
PFS is defined as the duration of time from start of treatment to time of progression or death, whichever comes first. Disease progression was assessed by the Response Evaluation Criteria in Solid Tumors (RECIST) and is defined as at least a 20% increase in the sum of the diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study). In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm. (Note: the appearance of one or more new lesions is also considered progressions). (NCT01967576)
Timeframe: time from start of treatment to time of progression or death, up to 5 years and 9 months
| Intervention | months (Median) |
|---|---|
| 1/Arm 1-Axitinib | 7.7 |
Response was assessed by the Response Evaluation Criteria in Solid Tumors (RECIST). Partial Response (PR) is at least a 30% decrease in the sum of the diameters of target lesions, taking as reference the baseline sum diameters. Complete Response (CR) is disappearance of all target lesions. Any pathological lymph nodes (whether target or no-target) must have reduction in short axis to <10 mm. Stable Disease (SD) is neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD, taking as reference the smallest sum diameters while on study. Progressive Disease (PD) is at least a 20% increase in the sum of the diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study). (NCT01967576)
Timeframe: Patients were assessed every 12 weeks (+/- week) up to 40.6 months
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Confirmed Partial Response | Complete Response | Stable Disease | Progressive Disease | |
| 1/Arm 1-Axitinib | 5 | 0 | 5 | 2 |
9 reviews available for clonidine and Complication, Intraoperative
| Article | Year |
|---|---|
Perioperative adverse events attributed to α2-adrenoceptor agonists in patients not at risk of cardiovascular events: systematic review and meta-analysis.
Topics: Adrenergic alpha-2 Receptor Agonists; Bradycardia; Clonidine; Dexmedetomidine; Humans; Hypotension; | 2019 |
Alpha-2 adrenergic agonists for the prevention of cardiac complications among adults undergoing surgery.
Topics: Adrenergic alpha-Agonists; Clonidine; Dexmedetomidine; Heart Diseases; Humans; Imidazoles; Intraoper | 2018 |
Nefopam for the prevention of perioperative shivering: a meta-analysis of randomized controlled trials.
Topics: Analgesics, Non-Narcotic; Anesthesia; Clonidine; Humans; Intraoperative Complications; Nefopam; Rand | 2015 |
Alpha-2 adrenergic agonists for the prevention of cardiac complications among patients undergoing surgery.
Topics: Adrenergic alpha-Agonists; Clonidine; Dexmedetomidine; Heart Diseases; Humans; Imidazoles; Intraoper | 2009 |
[Pediatric caudal anesthesia : importance and aspects of safety concerns].
Topics: Adjuvants, Anesthesia; Anesthesia, Caudal; Anesthesia, Conduction; Anesthetics, Local; Child; Child, | 2012 |
[Clonidine and anesthesia].
Topics: Adrenergic alpha-Agonists; Analgesia; Analgesics; Analgesics, Non-Narcotic; Anesthesia; Anesthetics, | 2004 |
[Preoperative evaluation of patients with heart dysfunction and preanesthetic medication].
Topics: Adrenergic alpha-Agonists; Anesthesia, General; Clonidine; Coronary Disease; Heart Failure; Heart Fu | 1996 |
Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature.
Topics: Adrenergic alpha-Agonists; Clinical Trials as Topic; Clonidine; Humans; Intraoperative Complications | 2002 |
[Management of peroperative hypertensive crises].
Topics: Adrenergic beta-Antagonists; Anesthesia, General; Calcium Channel Blockers; Clonidine; Coronary Dise | 1988 |
7 trials available for clonidine and Complication, Intraoperative
| Article | Year |
|---|---|
Improved quality of surgical field during endoscopic sinus surgery after clonidine premedication--a pilot study.
Topics: Adult; Arterial Pressure; Chronic Disease; Clonidine; Endoscopy; Female; Heart Rate; Hemodynamics; H | 2014 |
Rationale and design of the PeriOperative ISchemic Evaluation-2 (POISE-2) trial: an international 2 × 2 factorial randomized controlled trial of acetyl-salicylic acid vs. placebo and clonidine vs. placebo in patients undergoing noncardiac surgery.
Topics: Aged; Aspirin; Clonidine; Double-Blind Method; Female; Humans; Intraoperative Complications; Male; M | 2014 |
Remifentanil-clonidine-propofol versus sufentanil-propofol anesthesia for coronary artery bypass surgery.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Aged; Analgesics, Opioid; Anesthesia Recovery Peri | 2002 |
Small, oral dose of clonidine reduces the incidence of intraoperative myocardial ischemia in patients having vascular surgery.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Blood Pressure; Clo | 1996 |
Hemodynamic changes induced by laparoscopy and their endocrine correlates: effects of clonidine.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Carbon Dioxide; Catecholamines; Cholecystectomy, Laparoscopi | 1998 |
Clonidine and cardiac surgery: haemodynamic and metabolic effects, myocardial ischaemia and recovery.
Topics: Adrenergic alpha-Agonists; Aged; Anesthetics, Intravenous; Clonidine; Coronary Artery Bypass; Creati | 1999 |
Oral clonidine pretreatment for haemodynamic stability during craniotomy.
Topics: Administration, Oral; Adult; Clonidine; Craniotomy; Female; Humans; Hypertension; Intraoperative Com | 1992 |
16 other studies available for clonidine and Complication, Intraoperative
| Article | Year |
|---|---|
Respiratory failure in a former preterm infant following high spinal anesthesia with bupivacaine and clonidine.
Topics: Adrenergic alpha-Agonists; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; Humans; I | 2008 |
Be vigilant during use of intrathecal clonidine in former preterm infants.
Topics: Analgesics; Anesthesia, Spinal; Clonidine; Humans; Infant; Infant, Newborn; Infant, Premature; Injec | 2009 |
Cephalad migration of intrathecal clonidine in an infant undergoing bilateral herniorrhaphy.
Topics: Adrenergic alpha-Agonists; Clonidine; Hernia, Inguinal; Humans; Infant; Injections, Spinal; Intraope | 2009 |
Systemic effects of topical ophthalmic agents.
Topics: Adrenergic alpha-Agonists; Child; Clonidine; Humans; Intraoperative Complications; Ophthalmic Soluti | 2010 |
Impact of T3 thoracoscopic sympathectomy on pupillary function: a cause of partial Horner's syndrome?
Topics: Adolescent; Adult; Clonidine; Equipment Design; Horner Syndrome; Humans; Hyperhidrosis; Intraoperati | 2012 |
Apnoea in a former preterm infant after caudal bupivacaine with clonidine for inguinal herniorrhaphy.
Topics: Anesthesia, Caudal; Anesthetics, Combined; Apnea; Bupivacaine; Clonidine; Hernia, Inguinal; Humans; | 2002 |
[Arterial hypertension intraoperative management in aged patients by different premedication variants].
Topics: Aged; Antihypertensive Agents; Clonidine; Female; Humans; Hypertension; Intraoperative Complications | 2004 |
Intraoperative clonidine administration to neurosurgical patients.
Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Clonidine; Humans; Intraoperative Complicatio | 2005 |
Accelerated acute clonidine withdrawal syndrome during coronary artery bypass surgery. A case report.
Topics: Acute Disease; Clonidine; Coronary Artery Bypass; Humans; Hypertension; Hypotension; Intraoperative | 1981 |
Clonidine prevention of myocardial ischemia during cardiac surgery: will this change outcome?
Topics: Bradycardia; Cardiac Output; Cardiac Pacing, Artificial; Clonidine; Coronary Artery Bypass; Heart; H | 1993 |
Safety of alpha2-agonists?
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Hemodynamics; Humans; Hypotension; Intraoperative Com | 1998 |
Pheochromocytoma: new concepts and future trends.
Topics: Acidosis, Lactic; Adrenal Gland Neoplasms; Adult; Animals; Antihypertensive Agents; Antineoplastic C | 1991 |
Case 2--1991. A 50-year-old man undergoing a right thoracotomy experiences unexpected intraoperative hypotension due to a drug interaction.
Topics: Blood Pressure; Captopril; Clonidine; Drug Interactions; Heart Rate; Humans; Hypotension; Intraopera | 1991 |
[Sinus node inhibitors in coronary surgery].
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clonidine; Coronary Artery Bypass; Female; Heart | 1990 |
[Incidence of tourniquet pain from spinal anesthesia with a combination of bupivacaine and clonidine].
Topics: Anesthesia, Spinal; Bupivacaine; Clonidine; Drug Combinations; Humans; Intraoperative Complications; | 1989 |
[Use of clonidine in the prevention of intraoperative hypertensive crisis. Study on cardiopathic and hypertensive patients subjected to cataract surgery under local anesthesia].
Topics: Aged; Anesthesia, Local; Cataract Extraction; Clonidine; Female; Heart Diseases; Humans; Hypertensio | 1986 |