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clonidine and Complex Regional Pain Syndromes

clonidine has been researched along with Complex Regional Pain Syndromes in 10 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Complex Regional Pain Syndromes: Conditions characterized by pain involving an extremity or other body region, HYPERESTHESIA, and localized autonomic dysfunction following injury to soft tissue or nerve. The pain is usually associated with ERYTHEMA; SKIN TEMPERATURE changes, abnormal sudomotor activity (i.e., changes in sweating due to altered sympathetic innervation) or edema. The degree of pain and other manifestations is out of proportion to that expected from the inciting event. Two subtypes of this condition have been described: type I; (REFLEX SYMPATHETIC DYSTROPHY) and type II; (CAUSALGIA). (From Pain 1995 Oct;63(1):127-33)

Research Excerpts

ExcerptRelevanceReference
"To evaluate the efficacy of intravenous regional anesthesia (IVRA) with clonidine in patients with a previous history of complex regional pain syndrome (CRPS) who are undergoing upper extremity hand surgery."9.11Surgery on the affected upper extremity of patients with a history of complex regional pain syndrome: the use of intravenous regional anesthesia with clonidine. ( Faruqi, S; Kilaru, PA; Reuben, SS; Rosenthal, EA; Steinberg, RB, 2004)
"Evidence suggests that complex regional pain syndrome (CRPS) is a manifestation of microvascular dysfunction."5.43A Novel Compound Analgesic Cream (Ketamine, Pentoxifylline, Clonidine, DMSO) for Complex Regional Pain Syndrome Patients. ( Russo, MA; Santarelli, DM, 2016)
"To evaluate the efficacy of intravenous regional anesthesia (IVRA) with clonidine in patients with a previous history of complex regional pain syndrome (CRPS) who are undergoing upper extremity hand surgery."5.11Surgery on the affected upper extremity of patients with a history of complex regional pain syndrome: the use of intravenous regional anesthesia with clonidine. ( Faruqi, S; Kilaru, PA; Reuben, SS; Rosenthal, EA; Steinberg, RB, 2004)
" We prospectively evaluated the use of four anesthetic techniques (general anesthesia, axillary block, and IV regional anesthesia [IVRA] with lidocaine with or without clonidine) for patients undergoing fasciectomy for Dupuytren's contracture."3.73The incidence of complex regional pain syndrome after fasciectomy for Dupuytren's contracture: a prospective observational study of four anesthetic techniques. ( Dixon, D; Faruqi, S; Madabhushi, L; Pristas, R; Reuben, SS; Wenner, S, 2006)
"Chronic pain may be accompanied by hyperalgesia and allodynia, and analgesic interventions may reduce these hypersensitivity phenomena."2.80Intrathecal clonidine and adenosine: effects on pain and sensory processing in patients with chronic regional pain syndrome. ( Eisenach, JC; North, J; Rauck, RL, 2015)
"The prevalences of complex regional pain syndrome, phantom limb pain, chronic donor-site pain, and persistent pain following total joint arthroplasty are alarmingly high."2.44Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques. ( Buvanendran, A; Reuben, SS, 2007)
"Evidence suggests that complex regional pain syndrome (CRPS) is a manifestation of microvascular dysfunction."1.43A Novel Compound Analgesic Cream (Ketamine, Pentoxifylline, Clonidine, DMSO) for Complex Regional Pain Syndrome Patients. ( Russo, MA; Santarelli, DM, 2016)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (50.00)29.6817
2010's5 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Herring, EZ1
Frizon, LA1
Hogue, O1
Mejia, JU1
Rosenquist, R1
Bolash, RB1
Machado, AG1
Nagel, SJ1
Drummond, PD1
Morellini, N1
Finch, PM1
Birklein, F1
Knudsen, LF1
Rauck, RL1
North, J1
Eisenach, JC1
Russo, MA1
Santarelli, DM1
Dizdarevic, A1
Bremer, N1
Reuben, SS3
Rosenthal, EA1
Steinberg, RB1
Faruqi, S2
Kilaru, PA1
Pristas, R1
Dixon, D1
Madabhushi, L1
Wenner, S1
Chen, LC1
Wong, CS1
Huh, BK1
Huang, YS1
Yang, CP1
Yeh, CC1
Wu, CT1
Giri, S1
Nixdorf, D1
Buvanendran, A1

Reviews

1 review available for clonidine and Complex Regional Pain Syndromes

ArticleYear
Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques.
    The Journal of bone and joint surgery. American volume, 2007, Volume: 89, Issue:6

    Topics: Acetaminophen; Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Anesthetics, Local; Anima

2007

Trials

2 trials available for clonidine and Complex Regional Pain Syndromes

ArticleYear
Intrathecal clonidine and adenosine: effects on pain and sensory processing in patients with chronic regional pain syndrome.
    Pain, 2015, Volume: 156, Issue:1

    Topics: Adenosine; Adult; Analgesics; Chronic Pain; Clonidine; Complex Regional Pain Syndromes; Cross-Over S

2015
Surgery on the affected upper extremity of patients with a history of complex regional pain syndrome: the use of intravenous regional anesthesia with clonidine.
    Journal of clinical anesthesia, 2004, Volume: 16, Issue:7

    Topics: Anesthesia, Conduction; Anesthetics, Combined; Anesthetics, Intravenous; Clonidine; Complex Regional

2004

Other Studies

7 other studies available for clonidine and Complex Regional Pain Syndromes

ArticleYear
Long-term Outcomes Using Intrathecal Drug Delivery Systems in Complex Regional Pain Syndrome.
    Pain medicine (Malden, Mass.), 2019, 03-01, Volume: 20, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; A

2019
Complex regional pain syndrome: intradermal injection of phenylephrine evokes pain and hyperalgesia in a subgroup of patients with upregulated α1-adrenoceptors on dermal nerves.
    Pain, 2018, Volume: 159, Issue:11

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Clonidine;

2018
A Novel Compound Analgesic Cream (Ketamine, Pentoxifylline, Clonidine, DMSO) for Complex Regional Pain Syndrome Patients.
    Pain practice : the official journal of World Institute of Pain, 2016, Volume: 16, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Analgesics; Anesthetics, Dissociative; Anti-Infective Agents, Loca

2016
Cervical Spinal Cord Stimulation with Concomitant Serotonin Norepinephrine Reuptake Inhibitor Therapy Leading to the Serotonin Syndrome.
    Pain medicine (Malden, Mass.), 2017, 06-01, Volume: 18, Issue:6

    Topics: Adult; Analgesics; Cervical Vertebrae; Clonidine; Complex Regional Pain Syndromes; Diclofenac; Drug

2017
The incidence of complex regional pain syndrome after fasciectomy for Dupuytren's contracture: a prospective observational study of four anesthetic techniques.
    Anesthesia and analgesia, 2006, Volume: 102, Issue:2

    Topics: Aged; Anesthesia; Anesthesia, Conduction; Anesthesia, General; Anesthesia, Intravenous; Arm; Axilla;

2006
Repeated lumbar sympathetic blockade with lidocaine and clonidine attenuates pain in complex regional pain syndrome type 1 patients--a report of two cases.
    Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2006, Volume: 44, Issue:2

    Topics: Adult; Autonomic Nerve Block; Clonidine; Complex Regional Pain Syndromes; Humans; Lidocaine; Lumbosa

2006
Sympathetically maintained pain presenting first as temporomandibular disorder, then as parotid dysfunction.
    Journal (Canadian Dental Association), 2007, Volume: 73, Issue:2

    Topics: Adrenergic alpha-Agonists; Adult; Anesthetics, Local; Autonomic Nervous System Diseases; Bupivacaine

2007