clonidine has been researched along with Cocaine-Related Disorders in 14 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Environmental cues can elicit robust cocaine reward memories, contributing to relapse to cocaine abuse." | 3.91 | Clonidine, an α2 adrenergic receptor agonist, disrupts reconsolidation of a cocaine-paired environmental memory. ( Denny, RR; Unterwald, EM, 2019) |
| " Two dosing regimens for lofexedine were investigated: 0." | 2.79 | Assessment of safety, cardiovascular and subjective effects after intravenous cocaine and lofexidine. ( Anderson, A; Chen, CY; De La Garza, R; Dib, E; Galloway, GP; Haile, CN; Hawkins, RY; Kahn, R; Lao, G; Mahoney, JJ; Mendelson, J; Mojsiak, J; Newton, TF, 2014) |
| "Clonidine was effective in reducing stress-induced (and, at a higher dose, cue-induced) craving in a pattern consistent with preclinical findings, although this was significant on only one of several measures." | 2.76 | Clonidine blocks stress-induced craving in cocaine users. ( Epstein, DH; Ghitza, UE; Heishman, SJ; Jobes, ML; Phillips, KA; Preston, KL, 2011) |
| "Treatment of cocaine addiction includes anti-craving agents, dopamine agonists or blocking agents, antidepressants, and treatment of co-morbid psychiatric disorders, but all with mixed results." | 2.42 | Pharmacologic treatments for heroin and cocaine dependence. ( Kleber, HD, 2003) |
| "Lofexidine did not produce any observable side effects during or after treatment." | 1.39 | Differential effects of acute and chronic treatment with the α2-adrenergic agonist, lofexidine, on cocaine self-administration in rhesus monkeys. ( Fivel, PA; Kohut, SJ; Mello, NK, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (71.43) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Denny, RR | 1 |
| Unterwald, EM | 1 |
| Kohut, SJ | 1 |
| Fivel, PA | 1 |
| Mello, NK | 1 |
| De La Garza, R | 1 |
| Galloway, GP | 1 |
| Newton, TF | 1 |
| Mendelson, J | 1 |
| Haile, CN | 1 |
| Dib, E | 1 |
| Hawkins, RY | 1 |
| Chen, CY | 1 |
| Mahoney, JJ | 1 |
| Mojsiak, J | 1 |
| Lao, G | 1 |
| Anderson, A | 1 |
| Kahn, R | 1 |
| Brown, ZJ | 1 |
| Tribe, E | 1 |
| D'souza, NA | 1 |
| Erb, S | 2 |
| Jobes, ML | 1 |
| Ghitza, UE | 1 |
| Epstein, DH | 1 |
| Phillips, KA | 1 |
| Heishman, SJ | 1 |
| Preston, KL | 1 |
| Vanderschuren, LJ | 1 |
| Beemster, P | 1 |
| Schoffelmeer, AN | 1 |
| Kleber, HD | 1 |
| Lee, B | 1 |
| Tiefenbacher, S | 1 |
| Platt, DM | 3 |
| Spealman, RD | 3 |
| Baumann, MH | 1 |
| Milchanowski, AB | 1 |
| Rothman, RB | 1 |
| Durst, P | 1 |
| Palazzolo, J | 1 |
| Peyrelong, JP | 1 |
| Berger, M | 1 |
| Chalabreysse, M | 1 |
| Billiard, M | 1 |
| Vialle, A | 1 |
| Rowlett, JK | 2 |
| Valdez, GR | 1 |
| Rüedi-Bettschen, D | 1 |
| Hitchcott, PK | 1 |
| Rajabi, H | 1 |
| Mueller, D | 1 |
| Shaham, Y | 2 |
| Stewart, J | 1 |
| Highfield, D | 1 |
| Yap, J | 1 |
| Grimm, JW | 1 |
| Shalev, U | 1 |
1 review available for clonidine and Cocaine-Related Disorders
| Article | Year |
|---|---|
Pharmacologic treatments for heroin and cocaine dependence.
Topics: Buprenorphine; Clonidine; Cocaine-Related Disorders; Comorbidity; Heroin Dependence; Humans; Mental | 2003 |
2 trials available for clonidine and Cocaine-Related Disorders
| Article | Year |
|---|---|
Assessment of safety, cardiovascular and subjective effects after intravenous cocaine and lofexidine.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Behavior, Addictive; Blood Pressure; Clonid | 2014 |
Clonidine blocks stress-induced craving in cocaine users.
Topics: Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Adult; Clonidine; Cocaine-Related Disord | 2011 |
11 other studies available for clonidine and Cocaine-Related Disorders
| Article | Year |
|---|---|
Clonidine, an α2 adrenergic receptor agonist, disrupts reconsolidation of a cocaine-paired environmental memory.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Cocaine; Cocaine-Rela | 2019 |
Differential effects of acute and chronic treatment with the α2-adrenergic agonist, lofexidine, on cocaine self-administration in rhesus monkeys.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Behavior, Animal; Catheterization, Peripheral; Clonid | 2013 |
Interaction between noradrenaline and corticotrophin-releasing factor in the reinstatement of cocaine seeking in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Addictive; Behavior, Ani | 2009 |
On the role of noradrenaline in psychostimulant-induced psychomotor activity and sensitization.
Topics: Amphetamine-Related Disorders; Animals; Central Nervous System Stimulants; Clonidine; Cocaine; Cocai | 2003 |
Pharmacological blockade of alpha2-adrenoceptors induces reinstatement of cocaine-seeking behavior in squirrel monkeys.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Behavior, Ad | 2004 |
Evidence for alterations in alpha2-adrenergic receptor sensitivity in rats exposed to repeated cocaine administration.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Cocaine; Cocaine-Related Disorders; Corticoste | 2004 |
[Methadone and sleep apnea syndrome].
Topics: Adult; Brain; Clonidine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Drug Administr | 2005 |
Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Animals; Behavior, Addictive; Be | 2007 |
Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms.
Topics: Animals; Behavior, Addictive; Benzofurans; Clonidine; Cocaine-Related Disorders; Corticotropin-Relea | 2007 |
Alpha-2 adrenergic receptor agonists block stress-induced reinstatement of cocaine seeking.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Catheterization; Clonidine | 2000 |
Repeated lofexidine treatment attenuates stress-induced, but not drug cues-induced reinstatement of a heroin-cocaine mixture (speedball) seeking in rats.
Topics: Adrenergic alpha-Agonists; Animals; Body Weight; Clonidine; Cocaine-Related Disorders; Conditioning, | 2001 |