clonidine has been researched along with Chronic Insomnia in 19 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Clonidine is better than zopiclone for insomnia treatment in chronic pain patients." | 8.12 | Clonidine is better than zopiclone for insomnia treatment in chronic pain patients. ( Bamgbade, DO; Bamgbade, OA; Fadire, A; Mumporeze, L; Murphy-Akpieyi, O; Soni, NK; Tai-Osagbemi, J, 2022) |
| "Clonidine was effective in reducing sleep initiation latency and night awakening, to a less degree in improving attention deficits hyperactivity, mood instability and aggressiveness in this cohort of 19 children with ASD." | 6.73 | Use of clonidine in children with autism spectrum disorders. ( Gordon, E; Kang, N; Ming, X; Wagner, GC, 2008) |
| " Clonidine is better than zopiclone for insomnia treatment in chronic pain patients." | 4.12 | Clonidine is better than zopiclone for insomnia treatment in chronic pain patients. ( Bamgbade, DO; Bamgbade, OA; Fadire, A; Mumporeze, L; Murphy-Akpieyi, O; Soni, NK; Tai-Osagbemi, J, 2022) |
| "Clonidine was effective in reducing sleep initiation latency and night awakening, to a less degree in improving attention deficits hyperactivity, mood instability and aggressiveness in this cohort of 19 children with ASD." | 2.73 | Use of clonidine in children with autism spectrum disorders. ( Gordon, E; Kang, N; Ming, X; Wagner, GC, 2008) |
| " Clonidine, melatonin, L-theanine, eszopiclone and guanfacine were well tolerated with mild to moderate adverse events; zolpidem was associated with neuropsychiatric adverse effects." | 2.55 | Safety, Tolerability and Efficacy of Drugs for Treating Behavioural Insomnia in Children with Attention-Deficit/Hyperactivity Disorder: A Systematic Review with Methodological Quality Assessment. ( Anand, S; Besag, FMC; Chan, EW; Cortese, S; Tong, H; Wong, ICK, 2017) |
| "Clonidine reduced insomnia; and melatonin also exhibited a positive response, with reduced sleep latency, higher total sleep time, and higher sleep efficiency." | 2.49 | To sleep or not to sleep: a systematic review of the literature of pharmacological treatments of insomnia in children and adolescents with attention-deficit/hyperactivity disorder. ( Barrett, JR; Giaroli, G; Tracy, DK, 2013) |
| "Whether the additional PTSD and functional neurologic deficits were due to a direct effect of the lightning strike on the central nervous system or a secondary response is open to speculation." | 1.39 | Central hyperadrenergic state after lightning strike. ( Ahlskog, JE; Craft, JM; Gelfman, R; Kantor, B; Low, PA; Parsaik, AK; Seime, RJ; Sheldon, SH; Singer, W; Staab, JP, 2013) |
| " Mean administration of clonidine (on an "as-needed" basis) was 5 days (maximum 7 days), whilst the mean daily dosage ranged from 0." | 1.27 | [Clonidine for the treatment of heroin withdrawal syndrome]. ( Hermann, P; Presslich, O; Schanda, H, 1983) |
| "Finally it is suggested that insomnia and the loss of REM sleep may also contribute to the onset of the condition." | 1.27 | [Changes in the circadian rhythm of urinary cyclic adenosine monophosphate during the alcoholic withdrawal syndrome and related neurobiological correlations]. ( Cedaro, P; Di Piazza, V; Geatti, O; Lattuada, L; Marchetti, E; Nardoni, A, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Bamgbade, OA | 1 |
| Tai-Osagbemi, J | 1 |
| Bamgbade, DO | 1 |
| Murphy-Akpieyi, O | 1 |
| Fadire, A | 1 |
| Soni, NK | 1 |
| Mumporeze, L | 1 |
| Anand, S | 1 |
| Tong, H | 1 |
| Besag, FMC | 1 |
| Chan, EW | 1 |
| Cortese, S | 1 |
| Wong, ICK | 1 |
| Parsaik, AK | 1 |
| Ahlskog, JE | 1 |
| Singer, W | 1 |
| Gelfman, R | 1 |
| Sheldon, SH | 1 |
| Seime, RJ | 1 |
| Craft, JM | 1 |
| Staab, JP | 1 |
| Kantor, B | 1 |
| Low, PA | 1 |
| Barrett, JR | 1 |
| Tracy, DK | 1 |
| Giaroli, G | 1 |
| Efron, D | 1 |
| Lycett, K | 1 |
| Sciberras, E | 1 |
| Ghanizadeh, A | 1 |
| Heussler, H | 1 |
| Chan, P | 1 |
| Price, AM | 1 |
| Waters, K | 1 |
| Davey, MJ | 1 |
| Hiscock, H | 1 |
| Kratochvil, CJ | 2 |
| Lake, M | 1 |
| Pliszka, SR | 1 |
| Walkup, JT | 1 |
| Varley, C | 1 |
| Cummins, TK | 1 |
| Martin, A | 1 |
| Ming, X | 1 |
| Gordon, E | 1 |
| Kang, N | 1 |
| Wagner, GC | 1 |
| Schanda, H | 1 |
| Presslich, O | 1 |
| Hermann, P | 1 |
| Sovner, R | 1 |
| Horacek, HJ | 1 |
| Rubinstein, S | 1 |
| Silver, LB | 1 |
| Licamele, WL | 1 |
| Bhatara, VS | 1 |
| Kallepalli, BR | 1 |
| Misra, LK | 1 |
| Awadallah, S | 1 |
| Feikema, WJ | 1 |
| Cortelli, P | 1 |
| Parchi, P | 1 |
| Contin, M | 1 |
| Pierangeli, G | 1 |
| Avoni, P | 1 |
| Tinuper, P | 1 |
| Montagna, P | 1 |
| Baruzzi, A | 1 |
| Gambetti, PL | 1 |
| Lugaresi, E | 1 |
| Nardoni, A | 1 |
| Di Piazza, V | 1 |
| Marchetti, E | 1 |
| Geatti, O | 1 |
| Cedaro, P | 1 |
| Lattuada, L | 1 |
| Hunyor, SN | 1 |
| Hansson, L | 1 |
| Harrison, TS | 1 |
| Hoobler, SW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Lemborexant vs Zopiclone vs Clonidine for Insomnia Treatment in Chronic Pain Patients[NCT05618002] | 150 participants (Anticipated) | Observational | 2022-11-08 | Recruiting | |||
| An Observational Study Investigating the Experience of Patients Undergoing Active Insomnia Clinical Trials[NCT05978271] | 500 participants (Anticipated) | Observational | 2024-08-31 | Not yet recruiting | |||
| Follow-up Studies of PS and OSAHS in Chinese Children[NCT02447614] | 500 participants (Actual) | Observational [Patient Registry] | 2014-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for clonidine and Chronic Insomnia
| Article | Year |
|---|---|
Safety, Tolerability and Efficacy of Drugs for Treating Behavioural Insomnia in Children with Attention-Deficit/Hyperactivity Disorder: A Systematic Review with Methodological Quality Assessment.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Eszopiclone; Glutamates; Guanfacine | 2017 |
To sleep or not to sleep: a systematic review of the literature of pharmacological treatments of insomnia in children and adolescents with attention-deficit/hyperactivity disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Glutamates; Humans; Pyr | 2013 |
Pharmacological management of treatment-induced insomnia in ADHD.
Topics: Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimula | 2005 |
[Headache and chronic sleep deprivation: an often missed relationship in children and also in adults].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Caffeine; Central Nervous System Stimulants; Child; Ch | 1999 |
2 trials available for clonidine and Chronic Insomnia
| Article | Year |
|---|---|
Use of sleep medication in children with ADHD.
Topics: Adolescent; Anxiety Disorders; Attention Deficit and Disruptive Behavior Disorders; Attention Defici | 2014 |
Use of clonidine in children with autism spectrum disorders.
Topics: Adolescent; Adrenergic alpha-Agonists; Aggression; Attention Deficit Disorder with Hyperactivity; At | 2008 |
13 other studies available for clonidine and Chronic Insomnia
| Article | Year |
|---|---|
Clonidine is better than zopiclone for insomnia treatment in chronic pain patients.
Topics: Adult; Azabicyclo Compounds; Chronic Pain; Clonidine; Cross-Over Studies; Humans; Hypnotics and Seda | 2022 |
Central hyperadrenergic state after lightning strike.
Topics: Activities of Daily Living; Adrenergic alpha-Agonists; Anxiety; Arrhythmias, Cardiac; Autonomic Nerv | 2013 |
Insomnia, night terror, and depression related to clonidine in attention-deficit/hyperactivity disorder.
Topics: Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Central Nervous System Sti | 2008 |
Pharmacological and non-pharmacological management of sleep disturbance in children: an Australian Paediatric Research Network survey.
Topics: Adult; Aged; Anxiety Disorders; Australia; Behavior Therapy; Child; Clonidine; Comorbidity; Dose-Res | 2013 |
Less is more: inpatient management of a child with complex pharmacotherapy.
Topics: Aggression; Amphetamines; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Depressio | 2006 |
[Clonidine for the treatment of heroin withdrawal syndrome].
Topics: 2-Hydroxyphenethylamine; Clonidine; Dose-Response Relationship, Drug; Doxepin; Drug Administration S | 1983 |
Thioridazine withdrawal-induced behavioral deterioration treated with clonidine: two case reports.
Topics: Administration, Cutaneous; Anxiety Disorders; Bipolar Disorder; Clonidine; Dose-Response Relationshi | 1995 |
Extended-release clonidine for sleep disorders.
Topics: Adolescent; Arousal; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Delayed-Action | 1994 |
Clonidine for stimulant-related sleep problems.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Dextroamphetamine; Drug Therapy, Co | 1994 |
A possible clonidine-trazodone-dextroamphetamine interaction in a 12-year-old boy.
Topics: Antihypertensive Agents; Bradycardia; Central Nervous System Stimulants; Child; Clonidine; Conscious | 1996 |
Cardiovascular dysautonomia in fatal familial insomnia.
Topics: Adult; Autonomic Nervous System; Blood Pressure; Cardiovascular System; Clonidine; Dysautonomia, Fam | 1991 |
[Changes in the circadian rhythm of urinary cyclic adenosine monophosphate during the alcoholic withdrawal syndrome and related neurobiological correlations].
Topics: Adult; Alcoholism; Circadian Rhythm; Clonidine; Cyclic AMP; Female; Humans; Piracetam; Sleep Initiat | 1985 |
Effects of clonidine withdrawal: possible mechanisms and suggestions for management.
Topics: Blood Pressure; Catecholamines; Clonidine; Epinephrine; Heart Rate; Humans; Hypertension; Injections | 1973 |