clonidine has been researched along with Chronic Disease in 126 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonidine is frequently added to opioids in implantable intrathecal pumps for the management of chronic pain." | 9.11 | Stability of clonidine in clonidine-hydromorphone mixture from implanted intrathecal infusion pumps in chronic pain patients. ( Dunn, E; McCartney, C; Peng, P; Rudich, Z, 2004) |
| "To evaluate the effectiveness of intrathecal clonidine or clonidine/opioid admixture for the treatment of chronic pain states, a retrospective chart audit of 15 patients seen by the Pain Medicine and Neurosurgical Services was performed." | 9.10 | Long-term outcomes during treatment of chronic pain with intrathecal clonidine or clonidine/opioid combinations. ( Ackerman, LL; Follett, KA; Rosenquist, RW, 2003) |
| "The efficacy of the modified-release formulation of tizanidine (Sirdalud) was compared with placebo in a randomized, double-blind, parallel-group study of 138 women and 47 men, aged 18 to 79 years, with a history of chronic tension-type headache (IHS categories 2." | 9.09 | Modified-release formulation of tizanidine in chronic tension-type headache. ( Färkkilä, M; Havanka, H; Hedman, C; Kataja, M; Keränen, T; Murros, K; Peltola, J; Säkö, E, 2000) |
| " Women with pelvic pain of at least 6 months duration were eligible, and were randomized using a sealed envelope system to receive up to 600 mg lofexidine hydrochloride twice daily over 8 weeks or placebo." | 9.09 | Randomized placebo controlled trial of lofexidine hydrochloride for chronic pelvic pain in women. ( Anderson, D; Bradbury, L; Stones, RW, 2001) |
| "Twenty patients with chronic pain who previously had obtained analgesia from epidural clonidine and lignocaine agreed to participate in a double-blind crossover study of lumbar epidural clonidine (150 micrograms), lignocaine (40 mg) and the combination of clonidine (150 microgram) and lignocaine (40 mg), all drugs were given in a volume of 3 ml." | 9.08 | A double-blind randomised comparison of the effects of epidural clonidine, lignocaine and the combination of clonidine and lignocaine in patients with chronic pain. ( Glynn, C; O'Sullivan, K, 1996) |
| "Clonidine, but not placebo, caused pain relief, sedation, and decreased blood pressure and heart rate after bolus epidural injection." | 9.07 | Epidural clonidine treatment for refractory reflex sympathetic dystrophy. ( Eisenach, JC; Jackson, K; Rauck, RL; Southern, J; Young, LD, 1993) |
| "Imipramine improved the symptoms of patients with chest pain and normal coronary angiograms, possibly through a visceral analgesic effect." | 9.07 | Imipramine in patients with chest pain despite normal coronary angiograms. ( Black, BC; Cannon, RO; Geraci, MF; Gracely, RH; Mincemoyer, R; Quyyumi, AA; Smith, WB; Stine, AM; Uhde, TW; Waclawiw, MA, 1994) |
| "The efficacy of tizanidine in chronic tension-type headache was compared with placebo in a randomized, double-blind and cross-over study in 37 women aged 20 to 59 years with a history of headache for 7 months to 30 years (median 5 years)." | 9.07 | Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study. ( Fogelholm, R; Murros, K, 1992) |
| "The authors performed a randomized, double-blind, placebo-controlled trial to assess the tolerance and effects of chronic oral clonidine administration on the clinical status, exercise tolerance, and ventricular function of 10 male patients with chronic heart failure." | 9.06 | Acute and short-term effects of clonidine in heart failure. ( Giles, TD; Plauche, W; Quiroz, A; Rice, JC; Sander, GE; Thomas, MG, 1987) |
| "In a randomised double-blind study of 20 patients with chronic pain, epidural morphine 5 mg in 5 ml of saline was compared with epidural clonidine 150 micrograms in 5 ml of saline." | 9.06 | A double-blind comparison between epidural morphine and epidural clonidine in patients with chronic non-cancer pain. ( Dawson, D; Glynn, C; Sanders, R, 1988) |
| "A double-blind trial with two parallel groups was carried out to compare the antispastic effect and tolerability of a new muscle relaxant, tizanidine (DS 103-282), with those of baclofen in the treatment of spasticity due to multiple sclerosis." | 9.05 | A double-blind comparative trial of new muscle relaxant, tizanidine (DS 103-282), and baclofen in the treatment of chronic spasticity in multiple sclerosis. ( Muff, S; Smolenski, C; Smolenski-Kautz, S, 1981) |
| " In cobalt-induced epilepsy in the rat activity is associated with a cortical NA denervation." | 8.77 | Chronic cobalt-induced epilepsy: noradrenaline ionophoresis and adrenoceptor binding studies in the rat cerebral cortex. ( Bregman, B; Chauvel, P; Le Saux, F; Maurin, Y; Trottier, S, 1985) |
| "After lung contusion/hemorrhagic shock with chronic restraint stress, daily administration of clonidine restored bone marrow function and improved anemia." | 7.85 | Clonidine reduces norepinephrine and improves bone marrow function in a rodent model of lung contusion, hemorrhagic shock, and chronic stress. ( Alamo, IG; Efron, PA; Kannan, KB; Loftus, TJ; Mohr, AM; Ramos, H, 2017) |
| "Clonidine is a medication long used to treat hypertension, and it is still used in the treatment of refractory hypertension." | 7.71 | Clonidine-induced hypertension in a patient with a spinal lesion. ( Backo, AL; Clause, SL; Gibbs, KA; Triller, DM, 2002) |
| " We describe a case of chronic pain following SCI which failed to respond to a variety of approaches including intrathecal administration of morphine." | 7.69 | Intrathecal morphine and clonidine in the management of spinal cord injury pain: a case report. ( Cousins, MJ; Gray, M; Rutkowski, S; Siddall, PJ, 1994) |
| "The differential effects of the alpha-2 adrenergic agonist, clonidine, on blood pressure, renal sympathetic nerve activity (RSNA) and renal responses were investigated in conscious as well as anesthetized congestive heart failure (CHF) rats and normal control animals." | 7.68 | Effects of clonidine on renal sympathetic nerve activity, natriuresis and diuresis in chronic congestive heart failure rats. ( Carlsson, S; Feng, QP; Hedner, T; Thorén, P, 1992) |
| "Beta-endorphin (B-Ep), ACTH plasma levels and cortisol serum levels have been evaluated by RIA, in 27 patients suffering from essential blood hypertension and in 20 healthy control subjects." | 7.68 | [Plasma levels of beta-endorphin and ACTH and serum levels of cortisol in different stages of arterial hypertension before and after clonidine therapy]. ( Barletta, C; Scavo, D, 1990) |
| " To study the influence of a specific sinus node inhibitor on myocardial function, alinidine was given to 10 patients with chronic congestive heart failure and stable sinus rhythm." | 7.68 | Hemodynamic effects of alinidine (ST 567) at rest and during exercise in patients with chronic congestive heart failure. ( Henze, E; Koenig, W; Stauch, M; Sund, M; Wanjura, D, 1990) |
| " Clonidine, an alpha 2-adrenergic agonist, was used to treat three patients with "idiopathic" diabetic diarrhea after other treatments had failed: The volume of diarrhea declined significantly (p less than 0." | 7.67 | Treatment of diabetic diarrhea with clonidine. ( Chang, EB; Fedorak, RN; Field, M, 1985) |
| "Clonidine was administered by epidural injections with per os relay and long term therapeutic follow-up to 38 patients with deafferentation neurological sequellar pain either fully or partly intractable to classical pain treatments." | 7.67 | [Thoracolumbar or sacral epidural administration of clonidine in deafferentation pain: possibilities, limits and long-term follow-up]. ( Farcot, JM; Grasser, C; Mercky, F, 1989) |
| "The use of clonidine in the management of opiate abstinence is presented in a patient dependent upon levorphanol tartrate given for chronic pain." | 7.66 | The use of clonidine for management of opiate abstinence in a chronic pain patient. ( Bakris, GL; Cross, PD; Hammarsten, JE, 1982) |
| "Apraclonidine 1." | 6.69 | Reversal of intraocular pressure increases with 0.5% apraclonidine after dilated fundus examination in patients with chronic open-angle glaucoma. ( Chang, FW; Kolin, T; Nishimoto, JH; Tang, IH, 1999) |
| "Intraocular pressure was measured by a masked observer, using Goldmann applanation tonometry, before and 1 hour after the treatment." | 6.69 | Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures. ( Assalian, A; Chevrier, RL; Duperré, J; Lesk, MR, 1999) |
| "In patients with congestive heart failure, abnormal heart rate variability is a predictor of total mortality and sudden cardiac death." | 5.30 | Effect of clonidine on heart rate variability in congestive heart failure. ( Castellanos, A; Chakko, S; de Marchena, E; Diaz, P; Girgis, I; Jara, C; Myerburg, RJ, 1998) |
| "Twenty-six patients undergoing ESS for chronic sinusitis and polyp removal were enrolled and randomly assigned to receive either oral clonidine or melatonin as preoperative premedication." | 5.19 | Improved quality of surgical field during endoscopic sinus surgery after clonidine premedication--a pilot study. ( Burduk, PK; Cywinski, JB; Kazmierczak, W; Kusza, K; Wawrzyniak, K, 2014) |
| "A group of 44 patients undergoing FESS for chronic sinusitis and polyp removal were enrolled and randomly assigned to receive either oral clonidine or midazolam as preoperative premedication." | 5.17 | Premedication with clonidine before TIVA optimizes surgical field visualization and shortens duration of endoscopic sinus surgery - results of a clinical trial. ( Burduk, PK; Cywinski, JB; Kazmierczak, W; Kusza, K; Wawrzyniak, K, 2013) |
| "Clonidine is frequently added to opioids in implantable intrathecal pumps for the management of chronic pain." | 5.11 | Stability of clonidine in clonidine-hydromorphone mixture from implanted intrathecal infusion pumps in chronic pain patients. ( Dunn, E; McCartney, C; Peng, P; Rudich, Z, 2004) |
| "To evaluate the effectiveness of intrathecal clonidine or clonidine/opioid admixture for the treatment of chronic pain states, a retrospective chart audit of 15 patients seen by the Pain Medicine and Neurosurgical Services was performed." | 5.10 | Long-term outcomes during treatment of chronic pain with intrathecal clonidine or clonidine/opioid combinations. ( Ackerman, LL; Follett, KA; Rosenquist, RW, 2003) |
| " Women with pelvic pain of at least 6 months duration were eligible, and were randomized using a sealed envelope system to receive up to 600 mg lofexidine hydrochloride twice daily over 8 weeks or placebo." | 5.09 | Randomized placebo controlled trial of lofexidine hydrochloride for chronic pelvic pain in women. ( Anderson, D; Bradbury, L; Stones, RW, 2001) |
| "The efficacy of the modified-release formulation of tizanidine (Sirdalud) was compared with placebo in a randomized, double-blind, parallel-group study of 138 women and 47 men, aged 18 to 79 years, with a history of chronic tension-type headache (IHS categories 2." | 5.09 | Modified-release formulation of tizanidine in chronic tension-type headache. ( Färkkilä, M; Havanka, H; Hedman, C; Kataja, M; Keränen, T; Murros, K; Peltola, J; Säkö, E, 2000) |
| "2% topical medication or the replacement of apraclonidine with brimonidine resulted in a significant decrease in mean intraocular pressure from 20." | 5.09 | Long-term brimonidine therapy in glaucoma patients with apraclonidine allergy. ( Cha, SC; Glover, BK; Kim, C; Kim, YY; Nguyen, KD; Shin, DH, 1999) |
| "Twenty patients with chronic pain who previously had obtained analgesia from epidural clonidine and lignocaine agreed to participate in a double-blind crossover study of lumbar epidural clonidine (150 micrograms), lignocaine (40 mg) and the combination of clonidine (150 microgram) and lignocaine (40 mg), all drugs were given in a volume of 3 ml." | 5.08 | A double-blind randomised comparison of the effects of epidural clonidine, lignocaine and the combination of clonidine and lignocaine in patients with chronic pain. ( Glynn, C; O'Sullivan, K, 1996) |
| "The efficacy of tizanidine in chronic tension-type headache was compared with placebo in a randomized, double-blind and cross-over study in 37 women aged 20 to 59 years with a history of headache for 7 months to 30 years (median 5 years)." | 5.07 | Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study. ( Fogelholm, R; Murros, K, 1992) |
| "Imipramine improved the symptoms of patients with chest pain and normal coronary angiograms, possibly through a visceral analgesic effect." | 5.07 | Imipramine in patients with chest pain despite normal coronary angiograms. ( Black, BC; Cannon, RO; Geraci, MF; Gracely, RH; Mincemoyer, R; Quyyumi, AA; Smith, WB; Stine, AM; Uhde, TW; Waclawiw, MA, 1994) |
| "Clonidine, but not placebo, caused pain relief, sedation, and decreased blood pressure and heart rate after bolus epidural injection." | 5.07 | Epidural clonidine treatment for refractory reflex sympathetic dystrophy. ( Eisenach, JC; Jackson, K; Rauck, RL; Southern, J; Young, LD, 1993) |
| "Apraclonidine effectively lowers IOP associated with open-angle glaucoma or ocular hypertension; these pilot results will need to be confirmed by a larger pivotal study." | 5.07 | Comparison of apraclonidine and timolol in chronic open-angle glaucoma. A three-month study. ( Chuniaud, M; Demailly, P; Hitchings, RA; Nagasubramanian, S; Pannarale, MR; Parsons, DG; Pecori-Giraldi, J; Stodtmeister, R, 1993) |
| "The authors performed a randomized, double-blind, placebo-controlled trial to assess the tolerance and effects of chronic oral clonidine administration on the clinical status, exercise tolerance, and ventricular function of 10 male patients with chronic heart failure." | 5.06 | Acute and short-term effects of clonidine in heart failure. ( Giles, TD; Plauche, W; Quiroz, A; Rice, JC; Sander, GE; Thomas, MG, 1987) |
| "In a randomised double-blind study of 20 patients with chronic pain, epidural morphine 5 mg in 5 ml of saline was compared with epidural clonidine 150 micrograms in 5 ml of saline." | 5.06 | A double-blind comparison between epidural morphine and epidural clonidine in patients with chronic non-cancer pain. ( Dawson, D; Glynn, C; Sanders, R, 1988) |
| "A double-blind trial with two parallel groups was carried out to compare the antispastic effect and tolerability of a new muscle relaxant, tizanidine (DS 103-282), with those of baclofen in the treatment of spasticity due to multiple sclerosis." | 5.05 | A double-blind comparative trial of new muscle relaxant, tizanidine (DS 103-282), and baclofen in the treatment of chronic spasticity in multiple sclerosis. ( Muff, S; Smolenski, C; Smolenski-Kautz, S, 1981) |
| " In cobalt-induced epilepsy in the rat activity is associated with a cortical NA denervation." | 4.77 | Chronic cobalt-induced epilepsy: noradrenaline ionophoresis and adrenoceptor binding studies in the rat cerebral cortex. ( Bregman, B; Chauvel, P; Le Saux, F; Maurin, Y; Trottier, S, 1985) |
| "Following severe trauma, propranolol and clonidine abrogate persistent injury-associated anemia by modulating bone marrow cytokines, favoring effective erythropoiesis." | 3.91 | The effects of propranolol and clonidine on bone marrow expression of hematopoietic cytokines following trauma and chronic stress. ( Alamo, IG; Efron, PA; Kannan, KB; Loftus, TJ; Millar, JK; Miller, ES; Mohr, AM, 2019) |
| "After lung contusion/hemorrhagic shock with chronic restraint stress, daily administration of clonidine restored bone marrow function and improved anemia." | 3.85 | Clonidine reduces norepinephrine and improves bone marrow function in a rodent model of lung contusion, hemorrhagic shock, and chronic stress. ( Alamo, IG; Efron, PA; Kannan, KB; Loftus, TJ; Mohr, AM; Ramos, H, 2017) |
| "Clonidine is a medication long used to treat hypertension, and it is still used in the treatment of refractory hypertension." | 3.71 | Clonidine-induced hypertension in a patient with a spinal lesion. ( Backo, AL; Clause, SL; Gibbs, KA; Triller, DM, 2002) |
| "Previous short-term studies demonstrated that treatment with clonidine produced significant hemodynamic improvement in patients with congestive heart failure (CHF)." | 3.70 | Chronic sympathetic suppression in the treatment of chronic congestive heart failure. ( Argirakis, S; Gavras, H; Gavras, I; Handanis, S; Katsaros, C; Manolis, AJ; Olympios, C; Sifaki, M; Smirnioudis, N, 1998) |
| " The first group was used as control group (Control) (n = 20), in the second group subarachnoid hemorrhage was performed (SAH) (n = 20), in the third group Tizanidine was administered in addition to SAH (SAH + Tizanidine administration) (n = 20)." | 3.70 | The effect of tizanidine on chronic vasospasm in rats. ( Berkman, MK; Berkman, MZ; Erbengi, T; Iplikçioğlu, AC; San, T; Sav, A, 2000) |
| " We describe a case of chronic pain following SCI which failed to respond to a variety of approaches including intrathecal administration of morphine." | 3.69 | Intrathecal morphine and clonidine in the management of spinal cord injury pain: a case report. ( Cousins, MJ; Gray, M; Rutkowski, S; Siddall, PJ, 1994) |
| "The antinociceptive actions of morphine and tizanidine (an alpha 2-adrenergic agonist) administered intrathecally in a rat model of mononeuropathic pain were investigated." | 3.69 | A comparison of intrathecally administered narcotic and nonnarcotic analgesics for experimental chronic neuropathic pain. ( Dills, CV; Kim, DL; Leiphart, JW; Levy, RM; Zikel, OM, 1995) |
| " To study the influence of a specific sinus node inhibitor on myocardial function, alinidine was given to 10 patients with chronic congestive heart failure and stable sinus rhythm." | 3.68 | Hemodynamic effects of alinidine (ST 567) at rest and during exercise in patients with chronic congestive heart failure. ( Henze, E; Koenig, W; Stauch, M; Sund, M; Wanjura, D, 1990) |
| "The differential effects of the alpha-2 adrenergic agonist, clonidine, on blood pressure, renal sympathetic nerve activity (RSNA) and renal responses were investigated in conscious as well as anesthetized congestive heart failure (CHF) rats and normal control animals." | 3.68 | Effects of clonidine on renal sympathetic nerve activity, natriuresis and diuresis in chronic congestive heart failure rats. ( Carlsson, S; Feng, QP; Hedner, T; Thorén, P, 1992) |
| "Seventy consecutive patients with recurrent unexplained syncope were evaluated by use of an up-right tilt-table test for 45 minutes (with or without an infusion of isoproterenol) in an attempt to reproduce symptoms." | 3.68 | [Malignant vasovagal syncope: its diagnosis and therapeutic trial based on the orthostatism test (the tilt-table test)]. ( Campos Peris, JV; de la Morena, G; García García, J; Jaén Armand, E; López Candel, J; Martínez Sánchez, J; Picó Aracil, F; Ruiz Ros, JA; Salas, J; Sánchez Muñoz, JJ, 1993) |
| "Beta-endorphin (B-Ep), ACTH plasma levels and cortisol serum levels have been evaluated by RIA, in 27 patients suffering from essential blood hypertension and in 20 healthy control subjects." | 3.68 | [Plasma levels of beta-endorphin and ACTH and serum levels of cortisol in different stages of arterial hypertension before and after clonidine therapy]. ( Barletta, C; Scavo, D, 1990) |
| "Clonidine was administered by epidural injections with per os relay and long term therapeutic follow-up to 38 patients with deafferentation neurological sequellar pain either fully or partly intractable to classical pain treatments." | 3.67 | [Thoracolumbar or sacral epidural administration of clonidine in deafferentation pain: possibilities, limits and long-term follow-up]. ( Farcot, JM; Grasser, C; Mercky, F, 1989) |
| "To investigate the potential effect of Nicergoline, an alpha-adrenolytic drug, on negative symptoms in patients suffering from chronic schizophrenia, we administered this compound to 20 male chronic schizophrenics." | 3.67 | Clinical and biochemical effects of nicergoline in chronic schizophrenic patients. ( Ackenheil, M; Albus, M; Botschev, C; Müller-Spahn, F; Münch, U; Naber, D, 1986) |
| " Clonidine, an alpha 2-adrenergic agonist, was used to treat three patients with "idiopathic" diabetic diarrhea after other treatments had failed: The volume of diarrhea declined significantly (p less than 0." | 3.67 | Treatment of diabetic diarrhea with clonidine. ( Chang, EB; Fedorak, RN; Field, M, 1985) |
| "The effect of topically applied clonidine on aphthalmic arterial pressure was tested in three groups of open-angle glaucoma patients." | 3.66 | The response of ophthalmic arterial pressure to topically applied clonidine. ( Gramer, E; Krieglstein, GK, 1978) |
| "The use of clonidine in the management of opiate abstinence is presented in a patient dependent upon levorphanol tartrate given for chronic pain." | 3.66 | The use of clonidine for management of opiate abstinence in a chronic pain patient. ( Bakris, GL; Cross, PD; Hammarsten, JE, 1982) |
| "Chronic hypertension has been produced in mongrel dogs by the long-term oral administration of metyrapone (100 mg/kg per day)." | 3.65 | Multifactorial analysis of chronic hypertension induced by electrolyte-active steroids in trained, unanesthetized dogs. ( Bravo, EL; Dustan, HP; Tarazi, RC, 1977) |
| "Tizanidine was shown to be superior to placebo in reducing the overall headache index (P =." | 2.70 | Chronic daily headache prophylaxis with tizanidine: a double-blind, placebo-controlled, multicenter outcome study. ( Cantrell, DT; Lake, AE; Saper, JR; White, JR; Winner, PK, 2002) |
| "Clonidine is a centrally acting antihypertensive and has been prescribed widely for more than 20 years." | 2.69 | Clonidine does not potentiate the antipsychotic effects of neuroleptics in chronically ill patients. ( Bigelow, LB; El-Mallakh, RS; Elkashef, A; Hedges, S; Issa, F; Wyatt, RJ, 1998) |
| "Intraocular pressure was measured by a masked observer, using Goldmann applanation tonometry, before and 1 hour after the treatment." | 2.69 | Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures. ( Assalian, A; Chevrier, RL; Duperré, J; Lesk, MR, 1999) |
| "Apraclonidine 1." | 2.69 | Reversal of intraocular pressure increases with 0.5% apraclonidine after dilated fundus examination in patients with chronic open-angle glaucoma. ( Chang, FW; Kolin, T; Nishimoto, JH; Tang, IH, 1999) |
| "Treatment with clonidine markedly suppressed norepinephrine levels during exercise (matched peak exercise workload: control, 2137 +/- 187 versus clonidine, 1430 +/- 161 pg/mL), increased leg blood flow (control, 1." | 2.68 | Effect of sympathoinhibition on exercise performance in patients with heart failure. ( Chomsky, DB; Lang, CC; Rayos, GH; Wilson, JR; Wood, AJ, 1997) |
| " Alinidine was administered at a dosage of 30 mg 3 times a day." | 2.67 | Alinidine in chronic stable angina: the effect on diastolic perfusion time. ( Cinquegrana, G; Condorelli, M; Duilio, C; Ferro, G; Spadafora, M; Spinelli, L, 1990) |
| "Chronic diarrhea is a frequent and challenging problem in clinical medicine." | 2.48 | Functional diarrhea. ( Tack, J, 2012) |
| "Phenomenologically tics are differentiated as simple or complex, motor or vocal." | 2.44 | [Diagnosis and treatment of tics]. ( Topka, H, 2007) |
| "The prevalences of complex regional pain syndrome, phantom limb pain, chronic donor-site pain, and persistent pain following total joint arthroplasty are alarmingly high." | 2.44 | Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques. ( Buvanendran, A; Reuben, SS, 2007) |
| "Evidence on the treatment of tardive akathisia is unsatisfactory." | 2.41 | Managing antipsychotic-induced acute and chronic akathisia. ( Fleischhacker, WW; Miller, CH, 2000) |
| "Mexiletine was used in an open-label study to evaluate its effectiveness in the treatment of this disorder." | 2.38 | Successful treatment for phantom pain. ( Davis, RW, 1993) |
| "Chronic migraine is an important public health problem." | 1.36 | Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials. ( D'Amico, D, 2010) |
| "Such episodes (known as autonomic dysreflexia) are thought to result from the loss of descending baroreflex inhibition and/or plasticity within the spinal cord." | 1.32 | Tail arteries from chronically spinalized rats have potentiated responses to nerve stimulation in vitro. ( Brock, JA; McLachlan, EM; Yeoh, M, 2004) |
| "The technique of controlled hypotonia was developed for adequate management of anesthesia in endonasal microsurgical interventions on the paranasal sinuses in patients with chronic rhinosinusitis." | 1.31 | [The use of controlled hypotonia in endonasal microsurgical interventions on the paranasal sinuses in patients with chronic rhinosinusitis]. ( Iurchenko, LV; Zakharov, GP, 2000) |
| "In patients with congestive heart failure, abnormal heart rate variability is a predictor of total mortality and sudden cardiac death." | 1.30 | Effect of clonidine on heart rate variability in congestive heart failure. ( Castellanos, A; Chakko, S; de Marchena, E; Diaz, P; Girgis, I; Jara, C; Myerburg, RJ, 1998) |
| "Clonidine was more potent in CCI then in CFA rats in reducing the response to cold." | 1.30 | The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models. ( Franssen, M; Goff, JR; Janni, G; Jasmin, L; Kohan, L, 1998) |
| "Tizanidine (TZD) is an alpha-2-adrenergic drug with potential spinal analgesic action and could be a substitute or additive for intrathecal (i." | 1.30 | Distribution, tolerability and tissue compatibility of intrathecal tizanidine in the sheep. ( Loew, M; Ochs, G; Tonn, J; Toyka, K, 1998) |
| "The atipamezole-induced increase in LC activity and blood pressure was significantly attenuated by pretreatment with DGG (200 micrograms i." | 1.29 | The role of excitatory amino acids in the expression of precipitated acute and chronic clonidine withdrawal: an in vivo voltammetric study in the rat locus coeruleus. ( Duggan, S; Hong, M; Jhamandas, K; Milne, B, 1994) |
| "This led to successfully oral treatment of the orthostatic hypotension with clonidine 150 micrograms bd and midodrine 10 mg bd." | 1.28 | Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report. ( Arias, A; Berlan, M; Montastruc, JL; Rascol, A; Senard, JM; Tran, MA, 1991) |
| "Treatment with chlorpromazine (CPZ) for 2 weeks further decreased the Bmax for both ligands." | 1.27 | Platelet alpha 2-adrenergic receptors in schizophrenic patients before and after phenothiazine treatment. ( Rice, HE; Rosen, J; Silk, KR; Smith, CB, 1984) |
| "Clonidine was given once daily by gavage on an increasing dose schedule of 50 micrograms/kg for 4 weeks, followed by 100 micrograms/kg for 8 weeks and finally 200 micrograms/kg for 6 weeks." | 1.27 | Effect of clonidine on the progression of chronic renal disease in partially nephrectomized rats. ( Fettman, MJ; Tan, AA; Wilke, WL, 1987) |
| "Clonidine hydrochloride was administered to ten patients in an inpatient setting after abrupt discontinuation of chronic methadone hydrochloride administration." | 1.26 | Opiate withdrawal using clonidine. A safe, effective, and rapid nonopiate treatment. ( Gold, MS; Kleber, HD; Pottash, AC; Sweeney, DR, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (26.19) | 18.7374 |
| 1990's | 51 (40.48) | 18.2507 |
| 2000's | 30 (23.81) | 29.6817 |
| 2010's | 12 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loftus, TJ | 2 |
| Miller, ES | 1 |
| Millar, JK | 1 |
| Kannan, KB | 2 |
| Alamo, IG | 2 |
| Efron, PA | 2 |
| Mohr, AM | 2 |
| Leavitt, K | 1 |
| Običan, S | 1 |
| Yankowitz, J | 1 |
| Escamilla, Y | 2 |
| Cardesín, A | 2 |
| Samara, L | 1 |
| López, S | 1 |
| Izquierdo, A | 1 |
| Fradera, M | 1 |
| Vives, R | 1 |
| Bernal-Sprekelsen, M | 2 |
| Pontes, C | 2 |
| Wawrzyniak, K | 2 |
| Kusza, K | 2 |
| Cywinski, JB | 2 |
| Burduk, PK | 2 |
| Kazmierczak, W | 2 |
| Rosell, R | 1 |
| Marco, J | 1 |
| Escobar, MJ | 1 |
| Duffell, LD | 1 |
| Brown, GL | 1 |
| Mirbagheri, MM | 1 |
| Ramos, H | 1 |
| D'Amico, D | 1 |
| Williams, BS | 1 |
| Wong, D | 1 |
| Amin, S | 1 |
| Fuchigami, T | 1 |
| Kakinohana, O | 1 |
| Hefferan, MP | 1 |
| Lukacova, N | 1 |
| Marsala, S | 1 |
| Platoshyn, O | 1 |
| Sugahara, K | 1 |
| Yaksh, TL | 1 |
| Marsala, M | 1 |
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| Backo, AL | 1 |
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| Lechin, F | 2 |
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| van der Dijs, B | 2 |
| Ackerman, LL | 1 |
| Follett, KA | 1 |
| Rosenquist, RW | 1 |
| Moufarrege, G | 1 |
| Frank, E | 1 |
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| Kawamura, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Study of Influence of Surgical Pleth Index Guided Total Intravenous Anaesthesia (TIVA) or Volatile Anaesthesia Using Sevoflurane or Desflurane on the Intraoperative Blood Loss During Functional Endoscopic Sinus Surgery[NCT03417180] | 120 participants (Anticipated) | Interventional | 2018-09-01 | Recruiting | |||
| Comparative Study of Influence of Total Intravenous Anaesthesia (TIVA) and Volatile Anaesthesia Using Sevoflurane or Desflurane on the Intraoperative Blood Loss During Functional Endoscopic Sinus Surgery[NCT03417206] | 120 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | |||
| Comparative Study of Influence of Different Techniques of Remifentanil Titration During Functional Endoscopic Sinus Surgery Under Total Intravenous Anaesthesia (TIVA)[NCT03389763] | 105 participants (Actual) | Interventional | 2016-06-01 | Completed | |||
| Effect of Pre-operative Oral Steroids on Blood Loss in Endoscopic Sinus Surgery for Chronic Rhinosinusitis Without Polyps[NCT05095961] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2023-03-31 | Withdrawn (stopped due to Technical difficulties encountered with recording intraoperative blood loss; unable to proceed with study.) | ||
| Pain Measurement in Healthy Volunteers[NCT00001597] | 40 participants | Observational | 1997-03-31 | Completed | |||
| Psychophysiological Interactions in Non-Cardiac Chest Pain[NCT00005575] | Phase 3 | 0 participants | Interventional | 1999-01-31 | Completed | ||
| WISE Ancillary Study Data Analyses: Efficacy of Hormone Replacement on Myocardial Ischemia in Postmenopausal Women With Normal/Minimal Coronary Artery Disease: Data Analysis[NCT00600106] | 37 participants (Actual) | Interventional | 1999-12-31 | Completed | |||
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| Management of Chronic Pain in Rehabilitation Project II Management of Chronic Pain in Persons With Amputation[NCT00006427] | Phase 4 | 125 participants | Interventional | 1996-08-31 | Completed | ||
| Clinical Trial of Etanercept (TNF-α Blocker) for Treatment of Blast-Induced Tinnitus[NCT04066348] | Phase 2 | 310 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury[NCT03602014] | Phase 4 | 22 participants (Actual) | Interventional | 2018-06-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Endothelial dysfunction refers to altered vasoactive, anticoagulant, and anti-inflammatory properties of endothelium, and dysregulated vascular growth remodeling that results from a loss of nitric oxide (NO) bioactivity in the endothelium. Brachial Artery Reactivity Testing (BART), high-frequency ultrasonographic imaging of the brachial artery, evaluates flow-mediated vasodilation (FMD), an endothelium-dependent function. The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of endothelial dysfunction.~Flow-mediated vasodilation is typically expressed as the change in post-stimulus diameter as a percentage of the baseline diameter [diameter after cuff deflation - baseline diameter / baseline diameter) x 100]." (NCT00600106)
Timeframe: Baseline
| Intervention | percentage of pre-stimulus diameter (Mean) |
|---|---|
| Hormone Replacement Therapy | 8.2 |
| Placebo | 8.8 |
"Endothelial dysfunction refers to altered vasoactive, anticoagulant, and anti-inflammatory properties of endothelium, and dysregulated vascular growth remodeling that results from a loss of nitric oxide (NO) bioactivity in the endothelium. Brachial Artery Reactivity Testing (BART), high-frequency ultrasonographic imaging of the brachial artery, evaluates flow-mediated vasodilation (FMD), an endothelium-dependent function. The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of vasomotor function.~Flow-mediated vasodilation is typically expressed as the change in post-stimulus diameter as a percentage of the baseline diameter [diameter after cuff deflation - baseline diameter / baseline diameter) x 100]." (NCT00600106)
Timeframe: 12 weeks
| Intervention | percentage of pre-stimulus diameter (Mean) |
|---|---|
| Hormone Replacement Therapy | 8.8 |
| Placebo | 7.3 |
Inducible myocardial ischemia measured by P-31 gated magnetic resonance cardiac spectroscopy (MRS) is reported as change (∆) in PCr/ATP ratio, with isometric submaximal handgrip stress. PCr/ATP ratio defined as (stress-[average of rest and recovery periods]) / average of rest and recover periods X 100, and expressed as % mean ± SD. For this trial, myocardial ischemia was pre-specified as a fall in quantitative PCR/ATP ratio >20% from rest, and a lower value is considered indicative of greater ischemia. (NCT00600106)
Timeframe: 12 weeks
| Intervention | percent change in PCR/ATP ratio (Mean) |
|---|---|
| Hormone Replacement Therapy | -7.7 |
| Placebo | 1.1 |
Inducible myocardial ischemia measured by P-31 gated magnetic resonance cardiac spectroscopy (MRS) is reported as change (∆) in PCr/ATP ratio, with isometric submaximal handgrip stress. PCr/ATP ratio defined as (stress-[average of rest and recovery periods]) / average of rest and recover periods X 100, and expressed as % mean ± SD. For this trial, myocardial ischemia was pre-specified as a fall in quantitative PCR/ATP ratio >20% from rest, and a lower value is considered indicative of greater ischemia. (NCT00600106)
Timeframe: Baseline
| Intervention | percent changed in PCR/ATP ratio (Mean) |
|---|---|
| Hormone Replacement Therapy | -13.8 |
| Placebo | -7.0 |
"Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain.~In electrocardiography, the ST segment connects the QRS complex and the T wave and has duration of 80 to 120 ms. It should be essentially level with the PR and TP segment. The normal ST segment has a slight upward concavity. Flat, downsloping, or depressed ST segment may indicate coronary ishcemia. Positive treadmill exercise stress test (>1.0 mm horizontal / downsloping or >1.5 upsloping ST segment depression measured 0.08 msec after the J point)." (NCT00600106)
Timeframe: Baseline
| Intervention | mm (Mean) |
|---|---|
| Hormone Replacement Therapy | -0.79 |
| Placebo | -0.79 |
Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain. (NCT00600106)
Timeframe: Baseline
| Intervention | metabolism equivalents (Mean) |
|---|---|
| Hormone Replacement Therapy | 6.1 |
| Placebo | 5.8 |
Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain. (NCT00600106)
Timeframe: Exit (12 weeks)
| Intervention | metabolism equivalents (Mean) |
|---|---|
| Hormone Replacement Therapy | 6.1 |
| Placebo | 5.4 |
Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain. A MET is defined as the resting metabolic rate, that is, the amount or oxygen consumet at rest, sitting quietly in a chair, approximately 3.5 ml O2 / kg / min (1.2 kcallmin for a 70-kg person). As such, work at METs requires twice the resting metabolism or 7.0 ml O2/kg/min, and so on. (NCT00600106)
Timeframe: Baseline
| Intervention | metabolism equivalents (Mean) |
|---|---|
| Hormone Replacement Therapy | 5.4 |
| Placebo | 5.4 |
Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain. A MET is defined as the resting metabolic rate, that is, the amount or oxygen consumet at rest, sitting quietly in a chair, approximately 3.5 ml O2 / kg / min (1.2 kcallmin for a 70-kg person). As such, work at METs requires twice the resting metabolism or 7.0 ml O2/kg/min, and so on. (NCT00600106)
Timeframe: Exit at 12 weeks
| Intervention | metabolism equivalents (Mean) |
|---|---|
| Hormone Replacement Therapy | 6.1 |
| Placebo | 5.4 |
"Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain.~In electrocardiography, the ST segment connects the QRS complex and the T wave and has duration of 80 to 120 ms. It should be essentially level with the PR and TP segment. The normal ST segment has a slight upward concavity. Flat, downsloping, or depressed ST segment may indicate coronary ishcemia. Positive treadmill exercise stress test (>1.0 mm horizontal / downsloping or >1.5 upsloping ST segment depression measured 0.08 msec after the J point)." (NCT00600106)
Timeframe: Exit (12 weeks)
| Intervention | mm (Mean) |
|---|---|
| Hormone Replacement Therapy | -1.05 |
| Placebo | -0.63 |
"Quality of life assessed by cardiac symptoms and psychological questionnaires (SF 36 scale - Short Form Health Survey) The SF-36 includes one multi-item scale that assesses eight health concepts: 1) limitations in physical activities because of health problems; 2) limitations in social activities because of physical or emotional problems; 3) limitations in usual role activities because of physical health problems; 4) bodily pain; 5) general mental health (psychological distress and well-being); 6) limitations in usual role activities because of emotional problems; 7) vitality (energy and fatigue); and 8) general health perceptions.~Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability." (NCT00600106)
Timeframe: 12 weeks
| Intervention | units on a scale (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Physical functioning | Role-physical | Role-emotional | Bodily pain | General health | Mental health | Vitality | Social functioning | |
| Hormone Replacement Therapy | 59.4 | 58.8 | 76.5 | 54.5 | 55.2 | 66.4 | 35.6 | 59.4 |
| Placebo | 44.4 | 25.0 | 66.7 | 41.5 | 57.2 | 69.3 | 41.2 | 56.1 |
"Quality of life assessed by cardiac symptoms and psychological questionnaires (SF 36 scale - Short Form Health Survey) The SF-36 includes one multi-item scale that assesses eight health concepts: 1) limitations in physical activities because of health problems; 2) limitations in social activities because of physical or emotional problems; 3) limitations in usual role activities because of physical health problems; 4) bodily pain; 5) general mental health (psychological distress and well-being); 6) limitations in usual role activities because of emotional problems; 7) vitality (energy and fatigue); and 8) general health perceptions.~Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability." (NCT00600106)
Timeframe: Baseline
| Intervention | units on a scale (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Physical functioning | Role-physical | Role-emotional | Bodily pain | General health | Mental health | Vitality | Social functioning | |
| Hormone Replacement Therapy | 60.8 | 54.2 | 70.3 | 53.3 | 55.4 | 66.7 | 35.6 | 59.4 |
| Placebo | 43.8 | 37.3 | 66.7 | 42.1 | 57.4 | 65.7 | 42.9 | 53.2 |
Quality of life assessed by menopausal symptoms and psychological questionnaires (NCT00600106)
Timeframe: 12 weeks
| Intervention | percent of participants (Number) | ||||
|---|---|---|---|---|---|
| Hot flushes or flashing | Poor memory | Change in sexual desire | Vaginal dryness | Avoiding intimacy | |
| Hormone Replacement Therapy | 41 | 59 | 35 | 35 | 24 |
| Placebo | 89 | 78 | 67 | 67 | 56 |
Quality of life assessed by menopausal symptoms and psychological questionnaires (NCT00600106)
Timeframe: Baseline
| Intervention | percent of participants (Number) | ||||
|---|---|---|---|---|---|
| Hot flushes or flashing | Poor memory | Change in sexual desire | Vaginal dryness | Avoiding intimacy | |
| Hormone Replacement Therapy | 89 | 76 | 50 | 44 | 39 |
| Placebo | 68 | 53 | 37 | 58 | 37 |
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
19 reviews available for clonidine and Chronic Disease
| Article | Year |
|---|---|
Treatment and Prevention of Hypertensive Disorders During Pregnancy.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Aspirin; Calcium Channel Blockers; Chronic Dis | 2019 |
Functional diarrhea.
Topics: Antidepressive Agents, Tricyclic; Antidiarrheals; Bismuth; Carbon; Cholestyramine Resin; Chronic Dis | 2012 |
[Sensory disorder and clinical care in painful diabetic neuropathy].
Topics: Antidepressive Agents; Capsaicin; Carbamazepine; Chronic Disease; Clonidine; Diabetic Neuropathies; | 2002 |
Spinal agents for acute pain management.
Topics: Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Chronic Disease; C | 2004 |
Intra-articular injections.
Topics: Acute Disease; Adrenal Cortex Hormones; Anesthetics, Local; Arthralgia; Chronic Disease; Clonidine; | 2007 |
Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Anesthetics, Local; Anima | 2007 |
[Diagnosis and treatment of tics].
Topics: Adolescent; Adult; Age Factors; Antipsychotic Agents; Child; Child, Preschool; Chronic Disease; Clin | 2007 |
[Alpha2-adrenergic receptors in the dorsal horn of the spinal cord--their function and the descending inhibitory systems].
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics; Animals; Brain-Derived Neur | 2007 |
Treatment of renal hypertension.
Topics: Adrenergic beta-Antagonists; Chronic Disease; Clonidine; Diuretics; Drug Therapy, Combination; Glome | 1980 |
Anti-hypertensive drugs in the pregnant patient.
Topics: Antihypertensive Agents; Chronic Disease; Clonidine; Diazoxide; Diuretics; Female; Fetus; Furosemide | 1980 |
Successful treatment for phantom pain.
Topics: Administration, Cutaneous; Aged; Chronic Disease; Clonidine; Drug Therapy, Combination; Female; Huma | 1993 |
Aquadynia: noradrenergic pain induced by bathing and responsive to clonidine.
Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Baths; Chronic Disease; Clonidine; Female; Human | 1998 |
[Headache and chronic sleep deprivation: an often missed relationship in children and also in adults].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Caffeine; Central Nervous System Stimulants; Child; Ch | 1999 |
Managing antipsychotic-induced acute and chronic akathisia.
Topics: Acute Disease; Akathisia, Drug-Induced; Amantadine; Antipsychotic Agents; Benzodiazepines; Cholinerg | 2000 |
Recent advances in the treatment of hypertension.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Chronic Disease; Clonidine; Diazoxide; Drug Th | 1977 |
Detoxification of nonopiate drugs in the chronic pain setting and clonidine opiate detoxification.
Topics: Analgesics; Chronic Disease; Clonidine; Humans; Pain; Substance Withdrawal Syndrome | 1992 |
Clonidine: old friend--new guises.
Topics: Analgesics; Anesthetics; Cardiovascular System; Chronic Disease; Clonidine; Drug Synergism; Humans; | 1990 |
Hypertension in pregnancy.
Topics: Adrenergic beta-Antagonists; Animals; Chronic Disease; Clonidine; Diuretics; Female; Humans; Hydrala | 1985 |
Chronic cobalt-induced epilepsy: noradrenaline ionophoresis and adrenoceptor binding studies in the rat cerebral cortex.
Topics: Animals; Cerebral Cortex; Chronic Disease; Clonidine; Cobalt; Dihydroalprenolol; Epilepsy; Iontophor | 1985 |
37 trials available for clonidine and Chronic Disease
| Article | Year |
|---|---|
Randomized clinical trial to compare the efficacy to improve the quality of surgical field of hypotensive anesthesia with clonidine or dexmedetomidine during functional endoscopic sinus surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia; Blood Loss, Surgical; Chronic Disease; Clonidine; | 2019 |
Premedication with clonidine before TIVA optimizes surgical field visualization and shortens duration of endoscopic sinus surgery - results of a clinical trial.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Blood Loss, Surgical; Chronic Disease; Clonidine; | 2013 |
Improved quality of surgical field during endoscopic sinus surgery after clonidine premedication--a pilot study.
Topics: Adult; Arterial Pressure; Chronic Disease; Clonidine; Endoscopy; Female; Heart Rate; Hemodynamics; H | 2014 |
Interventions to Reduce Spasticity and Improve Function in People With Chronic Incomplete Spinal Cord Injury: Distinctions Revealed by Different Analytical Methods.
Topics: Analysis of Variance; Cervical Vertebrae; Chronic Disease; Clonidine; Data Interpretation, Statistic | 2015 |
Chronic daily headache prophylaxis with tizanidine: a double-blind, placebo-controlled, multicenter outcome study.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Chronic Disease; Clonidine; Double-Blind Method; Femal | 2002 |
Long-term outcomes during treatment of chronic pain with intrathecal clonidine or clonidine/opioid combinations.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Chronic Disease; Clonidine; Drug The | 2003 |
Stability of clonidine in clonidine-hydromorphone mixture from implanted intrathecal infusion pumps in chronic pain patients.
Topics: Analgesics; Chronic Disease; Clonidine; Complex Mixtures; Drug Combinations; Drug Stability; Drug St | 2004 |
Combination of tizanidine and amitriptyline in the prophylaxis of chronic tension-type headache: evaluation of efficacy and impact on quality of life.
Topics: Adult; Amitriptyline; Analgesics; Chronic Disease; Clonidine; Drug Therapy, Combination; Female; Hea | 2006 |
A double-blind comparative trial of new muscle relaxant, tizanidine (DS 103-282), and baclofen in the treatment of chronic spasticity in multiple sclerosis.
Topics: Adult; Aged; Baclofen; Chronic Disease; Clinical Trials as Topic; Clonidine; Double-Blind Method; Fe | 1981 |
[The efficacy of sirdalud in the drug therapy of pain in the spine].
Topics: Acute Disease; Adult; Aged; Analgesics; Back Pain; Chronic Disease; Clonidine; Female; Humans; Male; | 1994 |
Noradrenergic and dopaminergic interrelation in schizophrenia.
Topics: Adolescent; Adult; Apomorphine; Arousal; Chronic Disease; Clonidine; Dopamine; Growth Hormone; Human | 1994 |
Oral clonidine for heart rate control in chronic atrial fibrillation.
Topics: Administration, Oral; Aged; Atrial Fibrillation; Chronic Disease; Clonidine; Female; Hemodynamics; H | 1993 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double- | 1994 |
Epidural clonidine treatment for refractory reflex sympathetic dystrophy.
Topics: Adult; Analgesics; Blood Pressure; Chronic Disease; Clonidine; Heart Rate; Humans; Injections, Epidu | 1993 |
Comparison of apraclonidine and timolol in chronic open-angle glaucoma. A three-month study.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Clonidine; Double-Blind Method; Drug Administration | 1993 |
A double-blind randomised comparison of the effects of epidural clonidine, lignocaine and the combination of clonidine and lignocaine in patients with chronic pain.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Analgesia, Epidural; Anesthetics, Local; Chronic Disease; Cl | 1996 |
[The treatment of the phantom pain syndrome with tizanidine].
Topics: Adult; Aged; Analgesics; Chronic Disease; Clonidine; Double-Blind Method; Female; Humans; Male; Midd | 1997 |
Effect of sympathoinhibition on exercise performance in patients with heart failure.
Topics: Cardiomyopathy, Dilated; Chronic Disease; Clonidine; Coronary Disease; Exercise; Exercise Test; Hemo | 1997 |
Polydipsia in chronic psychiatric patients: therapeutic trials of clonidine and enalapril.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antipsychotic Agents; Chronic Disease; Clonid | 1998 |
Short-term clinical trial evaluating the efficacy of the combination of apraclonidine 0.5% solution and betaxolol 0.25% suspension.
Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Betaxolol; Chronic | 1997 |
Clonidine does not potentiate the antipsychotic effects of neuroleptics in chronically ill patients.
Topics: Adjuvants, Pharmaceutic; Adrenergic alpha-Agonists; Adult; Antipsychotic Agents; Chronic Disease; Cl | 1998 |
Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Anterior Eye Segment; Brimonidine Tartrat | 1999 |
Long-term brimonidine therapy in glaucoma patients with apraclonidine allergy.
Topics: Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Chronic Disease; Clonidine; Drug Hypersensiti | 1999 |
Reversal of intraocular pressure increases with 0.5% apraclonidine after dilated fundus examination in patients with chronic open-angle glaucoma.
Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Chronic Disease; Clonidine; Double-Blind Method; | 1999 |
Modified-release formulation of tizanidine in chronic tension-type headache.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Chronic Disease; Clonidine; Delayed-Action Preparations; Dou | 2000 |
Randomized placebo controlled trial of lofexidine hydrochloride for chronic pelvic pain in women.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Anti-Inflammatory Agents, Non-Steroidal; Body Mass Index; | 2001 |
Effects of clonidine in schizophrenic patients with primary polydipsia: three single case studies.
Topics: Adrenergic alpha-Agonists; Adult; Analysis of Variance; Chronic Disease; Clonidine; Dose-Response Re | 2002 |
Continuous intrathecal clonidine administration for the treatment of neuropathic pain.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Analgesics; Analgesics, Opioid; Buprenorphine; Chronic Disea | 2000 |
[Clinical trial of the preparation clofazolin used intravenously].
Topics: Adolescent; Adult; Aged; Blood Pressure; Chronic Disease; Clinical Trials as Topic; Clonidine; Drug | 1978 |
[Clonidine as ointment (author's transl)].
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Clonidine; Drug Evaluation; Female; Glaucoma | 1976 |
Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study.
Topics: Adult; Analgesics; Chronic Disease; Clonidine; Depression; Dose-Response Relationship, Drug; Double- | 1992 |
Clonidine in acute and chronic pain.
Topics: Acute Disease; Chronic Disease; Clonidine; Female; Humans; Pain | 1992 |
Pharmacological characterization of tardive akathisia.
Topics: Administration, Oral; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Arousal; Atenolol; Benztr | 1990 |
Alinidine in chronic stable angina: the effect on diastolic perfusion time.
Topics: Angina Pectoris; Cardiovascular Agents; Chronic Disease; Clonidine; Diastole; Double-Blind Method; E | 1990 |
A double-blind comparison between epidural morphine and epidural clonidine in patients with chronic non-cancer pain.
Topics: Adult; Aged; Chronic Disease; Clonidine; Double-Blind Method; Female; Humans; Injections, Spinal; Ma | 1988 |
Acute and short-term effects of clonidine in heart failure.
Topics: Administration, Oral; Adult; Aged; Blood Pressure; Chronic Disease; Clinical Trials as Topic; Clonid | 1987 |
[Influence of clonidine on intraocular pressure and pupillary diameter].
Topics: Analysis of Variance; Chronic Disease; Clonidine; Glaucoma; Humans; Intraocular Pressure; Ophthalmic | 1972 |
70 other studies available for clonidine and Chronic Disease
| Article | Year |
|---|---|
The effects of propranolol and clonidine on bone marrow expression of hematopoietic cytokines following trauma and chronic stress.
Topics: Anemia; Animals; Biomarkers; Bone Marrow; Chronic Disease; Clonidine; Contusions; Cytokines; Drug Th | 2019 |
Hypotensive anaesthesia and bleeding during endoscopic sinus surgery: an observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anesthesia, General; Blo | 2014 |
Hypotensive anaesthesia and bleeding during endoscopic sinus surgery: an observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anesthesia, General; Blo | 2014 |
Hypotensive anaesthesia and bleeding during endoscopic sinus surgery: an observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anesthesia, General; Blo | 2014 |
Hypotensive anaesthesia and bleeding during endoscopic sinus surgery: an observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anesthesia, General; Blo | 2014 |
Hypotensive anaesthesia and bleeding during endoscopic sinus surgery: an observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anesthesia, General; Blo | 2014 |
Hypotensive anaesthesia and bleeding during endoscopic sinus surgery: an observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anesthesia, General; Blo | 2014 |
Hypotensive anaesthesia and bleeding during endoscopic sinus surgery: an observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anesthesia, General; Blo | 2014 |
Hypotensive anaesthesia and bleeding during endoscopic sinus surgery: an observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anesthesia, General; Blo | 2014 |
Hypotensive anaesthesia and bleeding during endoscopic sinus surgery: an observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anesthesia, General; Blo | 2014 |
Clonidine reduces norepinephrine and improves bone marrow function in a rodent model of lung contusion, hemorrhagic shock, and chronic stress.
Topics: Animals; Bone Marrow; Chronic Disease; Clonidine; Contusions; Disease Models, Animal; Granulocyte Co | 2017 |
Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials.
Topics: Amines; Analgesics; Chronic Disease; Clonidine; Cyclohexanecarboxylic Acids; Diagnosis, Differential | 2010 |
Case scenario: self-extraction of intrathecal pump medication with a concomitant intrathecal granulomatous mass.
Topics: Acetaminophen; Administration, Cutaneous; Adult; Analgesics; Analgesics, Non-Narcotic; Analgesics, O | 2011 |
Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia.
Topics: Animals; Chronic Disease; Clonidine; Disease Models, Animal; Male; Muscle Relaxants, Central; Neural | 2011 |
Clonidine-induced hypertension in a patient with a spinal lesion.
Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Chronic Disease; Clonidine; Fructose; Humans; Hype | 2002 |
Plasma catecholamines and chronic congestive heart failure.
Topics: Adrenal Glands; Catecholamines; Chronic Disease; Clonidine; Diagnostic Techniques, Cardiovascular; D | 2002 |
Eosinophilic exudative pleural effusion after initiation of tizanidine treatment: a case report.
Topics: Adult; Analgesics; Chronic Disease; Clonidine; Eosinophilia; Humans; Low Back Pain; Male; Pleural Ef | 2003 |
Levetiracetam as a treatment for tardive dyskinesia: a case report.
Topics: Adrenergic alpha-Agonists; Anticonvulsants; Antidepressive Agents; Chronic Disease; Clonidine; Depre | 2003 |
Tail arteries from chronically spinalized rats have potentiated responses to nerve stimulation in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Autonomic Dysreflexia; C | 2004 |
Mechanisms of analgesic action of neurotropin on chronic pain in adjuvant-induced arthritic rat: roles of descending noradrenergic and serotonergic systems.
Topics: Administration, Oral; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Analges | 2005 |
Repeated nerve blocks with clonidine, fentanyl and bupivacaine for trigeminal neuralgia.
Topics: Anesthetics; Bupivacaine; Chronic Disease; Clonidine; Electric Stimulation; Fentanyl; Humans; Nerve | 2006 |
Sympathetically maintained pain presenting first as temporomandibular disorder, then as parotid dysfunction.
Topics: Adrenergic alpha-Agonists; Adult; Anesthetics, Local; Autonomic Nervous System Diseases; Bupivacaine | 2007 |
Platelet alpha 2-adrenergic receptors in schizophrenic patients before and after phenothiazine treatment.
Topics: Adult; Blood Platelets; Chlorpromazine; Chronic Disease; Clonidine; Humans; Kinetics; Male; Norepine | 1984 |
Preliminary trial of clonidine treatment in two patients suffering from chronic schizophrenia.
Topics: Adult; Antipsychotic Agents; Chronic Disease; Clonidine; Humans; Male; Psychiatric Status Rating Sca | 1980 |
Clonidine-induced growth hormone secretion in chronic schizophrenia.
Topics: Adult; Antipsychotic Agents; Chronic Disease; Clonidine; Growth Hormone; Humans; Male; Receptors, Ad | 1983 |
Epidural clonidine.
Topics: Chronic Disease; Clonidine; Drug Therapy, Combination; Humans; Male; Middle Aged; Morphine; Pain | 1984 |
[High blood pressure maintaining mechanisms in chronic one-kidney, one clip and two-kidney, one clip hypertensive rats. II. Roles of the sympathetic nervous system and renin-angiotensin system].
Topics: Animals; Blood Pressure; Chronic Disease; Clonidine; Female; Hypertension, Renovascular; Kidney; Rat | 1983 |
Clonidine as analgesic.
Topics: Chronic Disease; Clonidine; Female; Humans; Middle Aged; Pain | 1983 |
[Characteristics of the action of gemiton, adelfan and dopegit on cerebral circulation in arterial hypertension].
Topics: Aged; Antihypertensive Agents; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disea | 1984 |
The use of clonidine for management of opiate abstinence in a chronic pain patient.
Topics: Adult; Chronic Disease; Clonidine; Humans; Levorphanol; Male; Opioid-Related Disorders; Pain; Substa | 1982 |
Opiate withdrawal using clonidine. A safe, effective, and rapid nonopiate treatment.
Topics: Brain; Chronic Disease; Clonidine; Diastole; Drug Evaluation; Humans; Male; Opioid-Related Disorders | 1980 |
Clozapine-induced hypersalivation and the alpha 2 adrenoceptor.
Topics: Antipsychotic Agents; Chronic Disease; Clonidine; Clozapine; Dose-Response Relationship, Drug; Drug | 1995 |
Intrathecal morphine and clonidine in the management of spinal cord injury pain: a case report.
Topics: Adult; Chronic Disease; Clonidine; Drug Therapy, Combination; Humans; Infusion Pumps; Injections, Sp | 1994 |
mu-Opioid receptor and alpha 2-adrenoceptor agonist binding sites in the postmortem brain of heroin addicts.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Amino Acid Sequence; Analgesics; Brain Chemistry; Chron | 1994 |
The role of excitatory amino acids in the expression of precipitated acute and chronic clonidine withdrawal: an in vivo voltammetric study in the rat locus coeruleus.
Topics: Acute Disease; Animals; Catechols; Chronic Disease; Clonidine; Electrophysiology; Excitatory Amino A | 1994 |
A comparison of intrathecally administered narcotic and nonnarcotic analgesics for experimental chronic neuropathic pain.
Topics: Analgesics; Animals; Chronic Disease; Clonidine; Dose-Response Relationship, Drug; Humans; Injection | 1995 |
A case of narcotic bowel syndrome successfully treated with clonidine.
Topics: Abdominal Pain; Adult; Analgesics, Opioid; Chronic Disease; Clonidine; Female; Humans; Substance Wit | 1994 |
The stability of mixtures of morphine hydrochloride, bupivacaine hydrochloride, and clonidine hydrochloride in portable pump reservoirs for the management of chronic pain syndromes.
Topics: Bupivacaine; Chronic Disease; Clonidine; Drug Combinations; Drug Stability; Humans; Infusion Pumps; | 1994 |
Should epidural clonidine be used for reflex sympathetic dystrophy?
Topics: Analgesia, Epidural; Chronic Disease; Clonidine; Humans; Pain; Reflex Sympathetic Dystrophy | 1994 |
[The clofelin and nifedipine treatment of hypertensive crises in elderly patients].
Topics: Aged; Chronic Disease; Clonidine; Drug Therapy, Combination; Female; Hemodynamics; Humans; Hypertens | 1993 |
[Malignant vasovagal syncope: its diagnosis and therapeutic trial based on the orthostatism test (the tilt-table test)].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Chronic Disease; Clonidine; Female; Heart Functio | 1993 |
[An acute pharmacological test in predicting the efficacy of hypotensive therapy].
Topics: Adult; Aged; Antihypertensive Agents; Chronic Disease; Clonidine; Drug Evaluation; Hemodynamics; Hum | 1992 |
Interactions of the cardiac chronotropic effects of rilmenidine with the autonomic nervous system in conscious dogs: comparison with clonidine.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Atropine; Blood Pressure; Chronic Dis | 1996 |
What you need to know: addiction--cough mixture.
Topics: Acute Disease; Adrenergic alpha-Agonists; Antitussive Agents; Chronic Disease; Clonidine; Codeine; D | 1997 |
Clinical experience with apraclonidine 0.5%.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Child; Chronic Disease; Cloni | 1997 |
Pain management with spinal and epidural analgesia.
Topics: Acute Disease; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; C | 1997 |
[The treatment of tension headache with sirdalud].
Topics: Adult; Chronic Disease; Clonidine; Drug Evaluation; Female; Humans; Male; Muscle Relaxants, Central; | 1997 |
The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Behavior, Animal; Chronic Disease; Clonidine; Cold | 1998 |
Distribution, tolerability and tissue compatibility of intrathecal tizanidine in the sheep.
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Animals; Behavior, A | 1998 |
Effect of clonidine on heart rate variability in congestive heart failure.
Topics: Adrenergic alpha-Agonists; Blood Pressure; Chronic Disease; Clonidine; Death, Sudden, Cardiac; Elect | 1998 |
Chronic sympathetic suppression in the treatment of chronic congestive heart failure.
Topics: Administration, Oral; Catecholamines; Chronic Disease; Clonidine; Echocardiography; Electrocardiogra | 1998 |
Brain-derived TNFalpha: involvement in neuroplastic changes implicated in the conscious perception of persistent pain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Chronic Disease; Clonidine; | 2000 |
Sympathetic inhibition with clonidine prolongs survival in experimental chronic heart failure.
Topics: Animals; Blood Pressure; Chronic Disease; Clonidine; Disease Models, Animal; Heart Failure; Heart Ra | 2000 |
[The use of controlled hypotonia in endonasal microsurgical interventions on the paranasal sinuses in patients with chronic rhinosinusitis].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Chronic Disease; Clonidine; Humans; Microsurgery | 2000 |
The effect of tizanidine on chronic vasospasm in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Chronic Disease; Clonidine; Disease Models, Animal; F | 2000 |
Treatment of chronic hypertension with intravenous enalaprilat and transdermal clonidine.
Topics: Administration, Cutaneous; Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; | 2001 |
Abrogation of alpha-adrenergic vasoactivity in chronically inflamed rat knee joints.
Topics: Administration, Topical; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonis | 2001 |
Low-dose tizanidine with nonsteroidal anti-inflammatory drugs for detoxification from analgesic rebound headache.
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Clonidine; Dose-R | 2002 |
The response of ophthalmic arterial pressure to topically applied clonidine.
Topics: Blood Pressure; Chronic Disease; Clonidine; Glaucoma; Humans; Ophthalmic Artery | 1978 |
Combined clonidine and hydralazine therapy in severe and refractory hypertension.
Topics: Adult; Blood Pressure; Chronic Disease; Clonidine; Drug Evaluation; Drug Therapy, Combination; Femal | 1977 |
Multifactorial analysis of chronic hypertension induced by electrolyte-active steroids in trained, unanesthetized dogs.
Topics: Acebutolol; Aldosterone; Animals; Chronic Disease; Clonidine; Corticosterone; Diet, Sodium-Restricte | 1977 |
Effects of clonidine on renal sympathetic nerve activity, natriuresis and diuresis in chronic congestive heart failure rats.
Topics: Animals; Atrial Natriuretic Factor; Chronic Disease; Clonidine; Diuresis; Epinephrine; Heart Failure | 1992 |
Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report.
Topics: Blood Pressure; Chronic Disease; Clonidine; Efferent Pathways; Humans; Hypotension, Orthostatic; Mal | 1991 |
Intrathecal administration of clonidine suppresses autotomy, a behavioral sign of chronic pain in rats after sciatic nerve section.
Topics: Animals; Chronic Disease; Clonidine; Disease Models, Animal; Humans; Injections, Spinal; Male; Nails | 1991 |
Clonidine in chronic headaches.
Topics: Chronic Disease; Clonidine; Headache; Humans | 1991 |
Unusual complications of the treatment of chronic spinal arachnoiditis.
Topics: Aged; Analgesia, Epidural; Arachnoiditis; Chronic Disease; Clonidine; Female; Humans; Injections; Li | 1990 |
[Plasma levels of beta-endorphin and ACTH and serum levels of cortisol in different stages of arterial hypertension before and after clonidine therapy].
Topics: Adrenocorticotropic Hormone; Adult; Aged; beta-Endorphin; Blood Pressure; Chronic Disease; Clonidine | 1990 |
Hemodynamic effects of alinidine (ST 567) at rest and during exercise in patients with chronic congestive heart failure.
Topics: Aged; Anti-Arrhythmia Agents; Blood Pressure; Chronic Disease; Clonidine; Exercise; Female; Heart Fa | 1990 |
[Thoracolumbar or sacral epidural administration of clonidine in deafferentation pain: possibilities, limits and long-term follow-up].
Topics: Chronic Disease; Clonidine; Follow-Up Studies; Humans; Injections, Epidural; Pain; Spinal Cord Injur | 1989 |
Effect of clonidine on the progression of chronic renal disease in partially nephrectomized rats.
Topics: Animals; Blood Pressure; Chronic Disease; Clonidine; Creatinine; Enalapril; Heart; Kidney; Kidney Di | 1987 |
[Treatment with Pharmachim's Chlophazolin of hypertension and symptomatic hypertonia].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Chronic Disease; | 1986 |
Endorphin patterns within the headache spectrum disorders.
Topics: Adrenocorticotropic Hormone; Adult; beta-Endorphin; Chronic Disease; Clonidine; Cluster Headache; De | 1985 |
[Analgesia with an implanted device for repetitive intrathecal injections of morphine].
Topics: Adolescent; Adult; Aged; Aspirin; Chronic Disease; Clonidine; Drug Tolerance; Humans; Injections, Sp | 1985 |
Role of stress in the exacerbation of chronic illness: effects of clonidine administration on blood pressure and plasma norepinephrine, cortisol, growth hormone and prolactin concentrations.
Topics: Arousal; Blood Pressure; Chronic Disease; Clonidine; Depressive Disorder; Dopamine; Epinephrine; Fem | 1987 |
Clinical and biochemical effects of nicergoline in chronic schizophrenic patients.
Topics: Adult; Chronic Disease; Clonidine; Epinephrine; Ergolines; Growth Hormone; Humans; Male; Middle Aged | 1986 |
Treatment of diabetic diarrhea with clonidine.
Topics: Chronic Disease; Clonidine; Diabetes Mellitus, Type 1; Diarrhea; Feces; Humans; Substance Withdrawal | 1985 |
[Letter: Glaucoma and clonidine. A new therapeutic possibility].
Topics: Chronic Disease; Clonidine; Drug Tolerance; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressur | 1974 |
[Clonidin for the treatment of glaucoma in general ophthalmic practice].
Topics: Chronic Disease; Clonidine; Glaucoma; Humans; Hypotension; Male; Professional Practice; Vertigo | 1973 |