clonidine has been researched along with Childhood Tic Disorders in 35 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To ascertain whether the incidence of clonidine poisoning in children has increased given the probable increase in clonidine use for treatment of childhood behavioural disorders." | 7.70 | Clonidine poisoning--an emerging problem: epidemiology, clinical features, management and preventative strategies. ( Duncan, A; Erickson, SJ, 1998) |
| "Clonidine is an alpha-adrenergic agonist which may alleviate emerging symptoms in Tourette syndrome, an observation that has fueled speculation regarding involvement of stress-sensitive central noradrenergic systems in this disorder." | 7.69 | Predictors of clonidine response in Tourette syndrome: implications and inferences. ( Jackson, LA; Lichter, DG, 1996) |
| "To ascertain whether the incidence of clonidine poisoning in children has increased given the probable increase in clonidine use for treatment of childhood behavioural disorders." | 3.70 | Clonidine poisoning--an emerging problem: epidemiology, clinical features, management and preventative strategies. ( Duncan, A; Erickson, SJ, 1998) |
| "Clonidine is an alpha-adrenergic agonist which may alleviate emerging symptoms in Tourette syndrome, an observation that has fueled speculation regarding involvement of stress-sensitive central noradrenergic systems in this disorder." | 3.69 | Predictors of clonidine response in Tourette syndrome: implications and inferences. ( Jackson, LA; Lichter, DG, 1996) |
| " The dosage of the clonidine adhesive patch was 1." | 2.73 | Randomized double-blind multicentre placebo-controlled clinical trial of the clonidine adhesive patch for the treatment of tic disorders. ( Du, YS; Jiao, FY; Li, HF; Ma, SW; Su, LY; Vance, A; Wang, HM; Wang, MJ; Wu, JB; Yu, DL; Zhong, YQ, 2008) |
| "Lofexidine appears to be a safe and effective treatment for children with tic disorders and ADHD." | 2.71 | A placebo-controlled study of lofexidine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. ( Mair, A; Niederhofer, H; Staffen, W, 2003) |
| " In one study, tics limited further dosage increases of methylphenidate." | 2.58 | Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders. ( Osland, ST; Pringsheim, T; Steeves, TD, 2018) |
| "Desipramine and placebo were similar on "all-cause treatment discontinuation" (RD -0." | 2.50 | Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents. ( Castells, X; Ehimare, UP; Otasowie, J; Smith, CH, 2014) |
| " While medications for ADHD are generally well-tolerated, there are common, although less severe, as well as rare but severe adverse events AEs during treatment with ADHD drugs." | 2.49 | Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. ( Banaschewski, T; Buitelaar, J; Coghill, D; Cortese, S; Danckaerts, M; Dittmann, RW; Graham, J; Holtmann, M; Sergeant, J; Taylor, E, 2013) |
| "Clonidine was associated with markedly higher clinical efficacy vs." | 1.91 | Efficacy of clonidine in the treatment of children with tic disorder co-morbid with attention deficit hyperactivity disorder. ( Hu, B; Huang, XH; Wang, GL; Yuan, Y; Zeng, KD; Zhang, W, 2023) |
| "Clonidine hydrochloride was more effective than placebo in the treatment of an atypical tic disorder (1) in a single case study using an A-B-A design." | 1.27 | Clonidine in a case of atypical tic disorder. ( Haskell, EL; Joffe, R, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (25.71) | 18.7374 |
| 1990's | 7 (20.00) | 18.2507 |
| 2000's | 11 (31.43) | 29.6817 |
| 2010's | 7 (20.00) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Zeng, KD | 1 |
| Wang, GL | 1 |
| Yuan, Y | 1 |
| Zhang, W | 1 |
| Huang, XH | 1 |
| Hu, B | 1 |
| Wang, S | 1 |
| Wei, YZ | 1 |
| Yang, J | 1 |
| Zhou, Y | 1 |
| Zheng, Y | 1 |
| Guo, JM | 1 |
| Shi, XX | 1 |
| Yang, SW | 1 |
| Qian, QF | 1 |
| Huang, Y | 1 |
| Xie, YQ | 1 |
| Ou, P | 1 |
| French, KE | 1 |
| Wilson, MH | 1 |
| Revington, PJ | 1 |
| Osland, ST | 1 |
| Steeves, TD | 1 |
| Pringsheim, T | 2 |
| Otasowie, J | 1 |
| Castells, X | 1 |
| Ehimare, UP | 1 |
| Smith, CH | 1 |
| Du, YS | 1 |
| Li, HF | 1 |
| Vance, A | 1 |
| Zhong, YQ | 2 |
| Jiao, FY | 1 |
| Wang, HM | 1 |
| Wang, MJ | 1 |
| Su, LY | 1 |
| Yu, DL | 1 |
| Ma, SW | 1 |
| Wu, JB | 1 |
| Doja, A | 1 |
| Gorman, D | 1 |
| McKinlay, D | 1 |
| Day, L | 1 |
| Billinghurst, L | 1 |
| Carroll, A | 1 |
| Dion, Y | 1 |
| Luscombe, S | 1 |
| Steeves, T | 1 |
| Sandor, P | 1 |
| Cortese, S | 1 |
| Holtmann, M | 1 |
| Banaschewski, T | 2 |
| Buitelaar, J | 1 |
| Coghill, D | 1 |
| Danckaerts, M | 1 |
| Dittmann, RW | 1 |
| Graham, J | 1 |
| Taylor, E | 1 |
| Sergeant, J | 1 |
| Listernick, R | 1 |
| Niederhofer, H | 2 |
| Staffen, W | 1 |
| Mair, A | 1 |
| Kano, Y | 1 |
| Roessner, V | 1 |
| Rothenberger, A | 1 |
| Coffey, B | 1 |
| Wieland, N | 1 |
| Zhou, WZ | 1 |
| Hu, WG | 1 |
| Sears, J | 1 |
| Patel, NC | 1 |
| Gillies, DR | 1 |
| Forsythe, WI | 1 |
| Leckman, JF | 2 |
| Cohen, DJ | 2 |
| Haskell, EL | 1 |
| Joffe, R | 1 |
| Wilens, TE | 1 |
| Spencer, T | 1 |
| Biederman, J | 1 |
| Wozniak, J | 1 |
| Connor, D | 1 |
| Singer, HS | 1 |
| Lichter, DG | 1 |
| Jackson, LA | 1 |
| Erickson, SJ | 1 |
| Duncan, A | 1 |
| Newcorn, JH | 1 |
| Schulz, K | 1 |
| Harrison, M | 1 |
| DeBellis, MD | 1 |
| Udarbe, JK | 1 |
| Halperin, JM | 1 |
| Kofoed, L | 1 |
| Tadepalli, G | 1 |
| Oesterheld, JR | 1 |
| Awadallah, S | 1 |
| Shapiro, R | 1 |
| Yochelson, MR | 1 |
| David, RG | 1 |
| Riddle, MA | 1 |
| Jankovic, J | 1 |
| van de Wetering, BJ | 1 |
| Cohen, AP | 1 |
| Minderaa, RB | 1 |
| Roos, RA | 1 |
| van Woerkom, TC | 1 |
| Troung, DD | 1 |
| Bressman, S | 1 |
| Shale, H | 1 |
| Fahn, S | 1 |
| Caine, ED | 1 |
| McBride, MC | 1 |
| Chiverton, P | 1 |
| Bamford, KA | 1 |
| Rediess, S | 1 |
| Shiao, J | 1 |
| Erenberg, G | 2 |
| Cruse, RP | 1 |
| Rothner, AD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Behavioral Therapy for Children and Adolescents With Tourette Syndrome: A Randomized Controlled Trial in Taiwan[NCT03621059] | 46 participants (Actual) | Interventional | 2015-01-01 | Completed | |||
| Finalizing and Testing an Online Therapist Training and Assistance Program to Facilitate Implementation of Comprehensive Behavioral Intervention for Tic Disorders[NCT05547854] | 234 participants (Anticipated) | Interventional | 2023-06-27 | Recruiting | |||
| Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.[NCT06069323] | 80 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for clonidine and Childhood Tic Disorders
| Article | Year |
|---|---|
Clonidine adhesive patch for the treatment of tic disorders: A systematic review and meta-analysis.
Topics: Administration, Cutaneous; Adrenergic alpha-2 Receptor Agonists; Clonidine; Humans; Tic Disorders | 2017 |
Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders.
Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervou | 2018 |
Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Central | 2014 |
Canadian guidelines for the evidence-based treatment of tic disorders: pharmacotherapy.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Antipsychotic Agents; Canada; Child; Clonidine; Evidenc | 2012 |
Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents.
Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Blood Pressure | 2013 |
[Chronic tic disorders--chronic mortor or vocal tic disorders and de la Tourette's syndrome].
Topics: Adolescent; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous Sy | 2003 |
[Therapy of tic-disorders].
Topics: Antipsychotic Agents; Behavior Therapy; Benzamides; Child; Clonidine; Combined Modality Therapy; Hum | 2004 |
Treatment of multiple tics and the Tourette syndrome.
Topics: Adolescent; Antipsychotic Agents; Benztropine; Child; Child, Preschool; Clonidine; Haloperidol; Huma | 1984 |
Recent advances in Gilles de la Tourette syndrome: implications for clinical practice and future research.
Topics: Adolescent; Age Factors; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Compulsive | 1983 |
Tic disorders.
Topics: Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child; Child | 1993 |
Alpha 2 adrenergic agonists. Neurochemistry, efficacy, and clinical guidelines for use in children.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Anxiety Disorders; Attention Defici | 1998 |
Pharmacotherapy of Tourette's syndrome and associated disorders.
Topics: Attention Deficit Disorder with Hyperactivity; Clonidine; Female; Haloperidol; Humans; Male; Mental | 1992 |
Recent advances in the management of tics.
Topics: Antipsychotic Agents; Clonidine; Humans; Receptors, Dopamine; Tic Disorders; Tourette Syndrome | 1986 |
6 trials available for clonidine and Childhood Tic Disorders
| Article | Year |
|---|---|
[Efficacy of clonidine transdermal patch in treatment of moderate to severe tic disorders in children].
Topics: Child; Child, Preschool; Clonidine; Female; Haloperidol; Humans; Male; Severity of Illness Index; Ti | 2017 |
Randomized double-blind multicentre placebo-controlled clinical trial of the clonidine adhesive patch for the treatment of tic disorders.
Topics: Administration, Cutaneous; Adolescent; Adrenergic alpha-Agonists; Child; China; Clonidine; Dose-Resp | 2008 |
A placebo-controlled study of lofexidine in the treatment of children with tic disorders and attention deficit hyperactivity disorder.
Topics: Adolescent; Adrenergic Agonists; Analysis of Variance; Attention Deficit Disorder with Hyperactivity | 2003 |
[Randomized double-blind controlled study on treatment of tic disorders in children with transcutaneous patch of clonidine].
Topics: Administration, Cutaneous; Adolescent; Antihypertensive Agents; Child; Clonidine; Double-Blind Metho | 2007 |
Treatment of ADHD in children with tics: a randomized controlled trial.
Topics: Adolescent; Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Central Nervou | 2002 |
Clonazepam, haloperidol, and clonidine in tic disorders.
Topics: Child; Clinical Trials as Topic; Clonazepam; Clonidine; Drug Therapy, Combination; Dyskinesia, Drug- | 1988 |
16 other studies available for clonidine and Childhood Tic Disorders
| Article | Year |
|---|---|
Efficacy of clonidine in the treatment of children with tic disorder co-morbid with attention deficit hyperactivity disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Clonidine; | 2023 |
Chronic recurrent dislocation of the temporomandibular joint secondary to a complex facial tic disorder.
Topics: Adolescent; Botulinum Toxins, Type A; Clonidine; Combined Modality Therapy; Counseling; Humans; Join | 2017 |
A nine-year-old girl with new-onset tics.
Topics: Antipsychotic Agents; Child; Chorea; Clonidine; Diagnosis, Differential; Female; Humans; Obsessive-C | 2003 |
Tics, anxiety, and possible PANDAS in an adolescent.
Topics: Adolescent; Adrenergic alpha-Agonists; Antidepressive Agents, Second-Generation; Anxiety; Autoimmune | 2007 |
Development of tics in a thirteen-year-old male following atomoxetine use.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Anticonvulsants; Atomoxetine Hydrochloride; Attention Defi | 2008 |
Clonidine in a case of atypical tic disorder.
Topics: Child; Clonidine; Female; Humans; Tic Disorders | 1984 |
Combined pharmacotherapy: an emerging trend in pediatric psychopharmacology.
Topics: Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Benzodiazepines; Child Psychiatry; | 1995 |
Predictors of clonidine response in Tourette syndrome: implications and inferences.
Topics: Adolescent; Adrenergic alpha-Agonists; Age Factors; Attention Deficit Disorder with Hyperactivity; C | 1996 |
Clonidine poisoning--an emerging problem: epidemiology, clinical features, management and preventative strategies.
Topics: Attention Deficit Disorder with Hyperactivity; Charcoal; Child; Child Behavior Disorders; Child, Pre | 1998 |
Case series: clonidine has no systematic effects on PR or QTc intervals in children.
Topics: Adolescent; Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Central Nervou | 1999 |
New-onset tic disorder following acute hemorrhage of an arteriovenous malformation.
Topics: Acute Disease; Adolescent; Adrenergic alpha-Agonists; Cerebral Hemorrhage; Clonidine; Craniotomy; Di | 2000 |
[Therapy of tic disorders apparently of organic origin in a multi-morbid 5-year-old patient with lofexidine (Britlofex) and clonidine (Catapressan)].
Topics: Affective Symptoms; Aggression; Attention Deficit Disorder with Hyperactivity; Brain Damage, Chronic | 2001 |
[Gilles de la Tourette syndrome].
Topics: Adolescent; Adult; Antipsychotic Agents; Child; Clonidine; Compulsive Behavior; Female; Humans; Male | 1988 |
Tourette's syndrome in Monroe County school children.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior; Child; Child, Preschool; Clonid | 1988 |
Pharmacologic therapy of tics in childhood.
Topics: Adolescent; Adult; Child; Clonazepam; Clonidine; Haloperidol; Humans; Pimozide; Tic Disorders; Toure | 1988 |
The natural history of Tourette syndrome: a follow-up study.
Topics: Adaptation, Psychological; Adolescent; Adolescent Behavior; Adult; Aging; Clonidine; Fluphenazine; F | 1987 |