clonidine has been researched along with Chemical Dependence in 96 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study examines the efficacy of clonidine in smoking cessation and the influence of gender, history of major depression, and measures of nicotine dependence." | 9.07 | Smoking cessation, clonidine, and vulnerability to nicotine among dependent smokers. ( Cooper, TB; Covey, LS; Dalack, GW; Fleiss, J; Glassman, AH; Rivelli, SK; Stetner, F, 1993) |
| "Opioid detoxification is not an effective stand-alone treatment for heroin dependence but is nevertheless an essential step in the path to recovery." | 5.15 | Outpatient versus inpatient opioid detoxification: a randomized controlled trial. ( Day, E; Strang, J, 2011) |
| "Overall, the combination of Buprenorphine and Valproate seems to be a safe and promising method for treating multiple drug withdrawal symptoms." | 5.12 | Treatment of polydrug-using opiate dependents during withdrawal: towards a standardisation of treatment. ( Clausen, T; Isaksen, A; Kristensen, Ø; Lølandsmo, T; Vederhus, JK, 2006) |
| "This study examines the efficacy of clonidine in smoking cessation and the influence of gender, history of major depression, and measures of nicotine dependence." | 5.07 | Smoking cessation, clonidine, and vulnerability to nicotine among dependent smokers. ( Cooper, TB; Covey, LS; Dalack, GW; Fleiss, J; Glassman, AH; Rivelli, SK; Stetner, F, 1993) |
| "Clonidine poisoning usually causes depressed sensorium, hypotension, and bradycardia." | 4.76 | Clonidine overdose: report of six cases and review of the literature. ( Anderson, RJ; Crumpler, CP; Hart, GR; Lerman, MJ, 1981) |
| "A patient at a psychiatric hospital with a diagnosis of major depression and polysubstance abuse was administered a clonidine patch for opiate detoxification." | 3.68 | Clonidine patch ingestion in an adult. ( Finkelstein, S; Raber, JH; Shinar, C, 1993) |
| " Following her routine intravenous (IV) injection of solubilized pentazocine and tripelennamine tablets ("Ts and Blues"), the patient developed severe hypertension, a finding not characteristic of either drug alone or of the combination." | 3.67 | An acute hypertensive response after intravenous use of a new pentazocine formulation. ( Barrett, SM; Reinhart, S, 1985) |
| "Gabapentin is an important adjuvant to the management of opiate dependence both in acute detoxification as well as stabilisation phase." | 2.71 | Gabapentin in the management of pentazocine dependence: a potent analgesic--anticraving agent. ( Jain, MK; Kumar, P, 2003) |
| "Significant differences in levels of withdrawal symptoms were found on days 11, 13-15 and 17-20, symptoms resolving most rapidly in the 5-day lofexidine treatment group, whilst withdrawal responses in the 10-day lofexidine treatment group were intermediate between the 5-day lofexidine and standard methadone treatment conditions." | 2.69 | Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification. ( Bearn, J; Gossop, M; Strang, J, 1998) |
| " Neither the maximal clinical dosage of tizanidine (3 mg) nor twice that dosage (6 mg) induced any marked somatic or psychic symptoms compared with the placebo." | 2.66 | Effects of tizanidine in healthy volunteers: double-blind study compared with diazepam and a placebo. ( Igarashi, S; Yamamura, H; Yanagita, T, 1988) |
| "She had no significant withdrawal symptoms and hospitalization was brief." | 2.65 | Propoxyphene withdrawal with clonidine. ( Bohan, ME; Johnson, DA, 1983) |
| " While medications for ADHD are generally well-tolerated, there are common, although less severe, as well as rare but severe adverse events AEs during treatment with ADHD drugs." | 2.49 | Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. ( Banaschewski, T; Buitelaar, J; Coghill, D; Cortese, S; Danckaerts, M; Dittmann, RW; Graham, J; Holtmann, M; Sergeant, J; Taylor, E, 2013) |
| "Clonidine's efficacy has been equivocal." | 2.38 | Cigarette smoking, nicotine addiction, and its pharmacologic treatment. ( D'Alonzo, GE; Lee, EW, 1993) |
| "In recent decades the pattern of substance use among patients admitted for detoxification has changed from predominantly single-substance use to simultaneous multi-substance use." | 1.43 | Standardised detoxification in cases of polydrug use. ( Clausen, T; Dunsæd, F; Høie, MM; Kristensen, Ø; Vederhus, JK, 2016) |
| "Clonidine influx was saturable, followed by Michaelis-Menten kinetics (K(m)=0." | 1.35 | Clonidine transport at the mouse blood-brain barrier by a new H+ antiporter that interacts with addictive drugs. ( André, P; Cisternino, S; Debray, M; Scherrmann, JM, 2009) |
| "Clonidine hydrochloride is an alpha(2)-adrenergic agonist commonly prescribed as an antihypertensive agent." | 1.32 | Intentional clonidine patch ingestion by 3 adults in a detoxification unit. ( Rapko, DA; Rastegar, DA, 2003) |
| "Clonidine use was assessed in 90 treatment-seeking, pregnant, opiate-abusing women using both self-report and urinalysis toxicology." | 1.30 | Illicit use of clonidine in opiate-abusing pregnant women. ( Anderson, F; Huggins, G; Lee, J; Paluzzi, P; Svikis, D, 1997) |
| "Clonidine is a rare, but important, atypical drug of abuse." | 1.29 | Atypical drug abuse: a case report involving clonidine. ( Dy, EC; Yates, WR, 1996) |
| "A polydrug abuser had been prescribed clonidine for hypertonia but ingested it for its sedative properties and for euphoria over a period of 6 years." | 1.29 | [Clonidine--potential dependence risk in psychiatric patients?]. ( Agelink, MW; Dammers, S; Zeit, T, 1996) |
| "Clonidine has been used to assist opiate detoxification in the past 10 years." | 1.28 | Two cases of clonidine abuse/dependence in methadone-maintained patients. ( Lauzon, P, 1992) |
| "Rilmenidine (S 3341) is a new agonist of alpha 2 adrenoceptors." | 1.27 | Effects of two alpha 2 agonists, rilmenidine and clonidine, on the morphine withdrawal syndrome and their potential addictive properties in rats. ( Koenig-Berard, E; Nadaud, D; Stinus, L; Tierney, C, 1988) |
| " These patients are best managed as outpatients with gradual dosage reduction over 4-12 weeks." | 1.27 | Management of benzodiazepine dependence. ( Lader, M; Moodley, P, 1986) |
| "Clonidine-naltrexone treatment should succeed with patients receiving methadone doses up to 50 mg/day, facilitate naltrexone maintenance, and apply to many clinical settings." | 1.27 | The combined use of clonidine and naltrexone as a rapid, safe, and effective treatment of abrupt withdrawal from methadone. ( Charney, DS; Heninger, GR; Kleber, HD, 1986) |
| "Morphine treatment was associated with an immediate (15-30 min) inhibition of gastric and colonic spiking activity and intestinal migrating myoelectric complex lasting 6 to 8 hr, followed by a partial recovery of gastric spiking activity while a permanent disorganized motility pattern persisted on the intestine." | 1.27 | Effects of centrally administered naloxone on gastrointestinal myoelectrical activity in morphine-dependent rats. ( Bueno, L; Primi, MP, 1987) |
| "Clonidine (Catapres) is a safe and effective agent for detoxification of selected opiate addicts." | 1.27 | Opiate and cocaine dependencies. Techniques to help counter the rising tide. ( Gold, MS; Pottash, AC; Washton, AM, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (47.92) | 18.7374 |
| 1990's | 29 (30.21) | 18.2507 |
| 2000's | 11 (11.46) | 29.6817 |
| 2010's | 9 (9.38) | 24.3611 |
| 2020's | 1 (1.04) | 2.80 |
| Authors | Studies |
|---|---|
| Jain, S | 1 |
| Gupta, T | 1 |
| Nebhinani, N | 1 |
| Singhai, K | 1 |
| Suthar, N | 1 |
| Paino, M | 1 |
| Aletraris, L | 1 |
| Roman, PM | 1 |
| Toledano, D | 1 |
| Tassin, JP | 1 |
| Gisquet-Verrier, P | 1 |
| Slattery, A | 1 |
| Liebelt, E | 1 |
| Gaines, LA | 1 |
| Cummins Jacklin, E | 1 |
| Boughner, E | 1 |
| Kent, K | 1 |
| Kwiatkowski, D | 1 |
| MacDonald, T | 1 |
| Leri, F | 1 |
| Woody, G | 1 |
| Dunsæd, F | 1 |
| Kristensen, Ø | 2 |
| Vederhus, JK | 2 |
| Clausen, T | 2 |
| Høie, MM | 1 |
| André, P | 1 |
| Debray, M | 1 |
| Scherrmann, JM | 1 |
| Cisternino, S | 1 |
| Rutten, K | 1 |
| Van Der Kam, EL | 1 |
| De Vry, J | 1 |
| Bruckmann, W | 1 |
| Tzschentke, TM | 1 |
| Day, E | 1 |
| Strang, J | 2 |
| Cortese, S | 1 |
| Holtmann, M | 1 |
| Banaschewski, T | 1 |
| Buitelaar, J | 1 |
| Coghill, D | 1 |
| Danckaerts, M | 1 |
| Dittmann, RW | 1 |
| Graham, J | 1 |
| Taylor, E | 1 |
| Sergeant, J | 1 |
| Rapko, DA | 1 |
| Rastegar, DA | 1 |
| Kumar, P | 1 |
| Jain, MK | 1 |
| Zullino, DF | 1 |
| Eskenasy, AC | 1 |
| Beeson, J | 1 |
| Wolraich, ML | 1 |
| Wibbelsman, CJ | 1 |
| Brown, TE | 1 |
| Evans, SW | 1 |
| Gotlieb, EM | 1 |
| Knight, JR | 1 |
| Ross, EC | 1 |
| Shubiner, HH | 1 |
| Wender, EH | 1 |
| Wilens, T | 1 |
| Bartlett, D | 1 |
| Lølandsmo, T | 1 |
| Isaksen, A | 1 |
| Ozaki, S | 1 |
| Collier, HO | 2 |
| Tucker, JF | 1 |
| Gold, MS | 8 |
| Pottash, AC | 2 |
| Kleber, HD | 8 |
| Cerdeño Impuesto, V | 1 |
| Johnson, DA | 1 |
| Bohan, ME | 1 |
| Dackis, CA | 2 |
| Emmett-Oglesby, MW | 1 |
| Spencer, DG | 1 |
| Lewis, MW | 1 |
| Lal, H | 1 |
| Bouteiller, J | 1 |
| Ciaccheri, M | 1 |
| Dolara, A | 1 |
| Manetti, A | 1 |
| Botti, P | 1 |
| Zorn, M | 1 |
| Peruzzi, S | 1 |
| Schaut, J | 1 |
| Schnoll, SH | 1 |
| Pottash, AL | 3 |
| Annitto, W | 1 |
| Rawson, RA | 2 |
| Washton, AM | 2 |
| Resnick, RB | 1 |
| Tennant, FS | 1 |
| Keup, W | 1 |
| Jasinski, DR | 1 |
| Haertzen, CA | 1 |
| Henningfield, JE | 1 |
| Johnson, RE | 1 |
| Makhzoumi, HM | 1 |
| Miyasato, K | 1 |
| Anderson, RJ | 1 |
| Hart, GR | 1 |
| Crumpler, CP | 1 |
| Lerman, MJ | 1 |
| Cuthbert, NJ | 1 |
| Francis, DL | 1 |
| Hjelt, K | 1 |
| Fetrow, CW | 1 |
| Hoyt, JW | 1 |
| White, TM | 1 |
| Glassman, AH | 1 |
| Covey, LS | 1 |
| Dalack, GW | 1 |
| Stetner, F | 1 |
| Rivelli, SK | 1 |
| Fleiss, J | 1 |
| Cooper, TB | 1 |
| Raber, JH | 1 |
| Shinar, C | 1 |
| Finkelstein, S | 1 |
| Conway, T | 1 |
| Balson, A | 1 |
| Miller, NS | 1 |
| Cocores, JA | 1 |
| Lee, EW | 1 |
| D'Alonzo, GE | 1 |
| Seivewright, NA | 1 |
| Greenwood, J | 1 |
| Sarlis, NJ | 1 |
| Caticha, O | 1 |
| Anderson, JL | 1 |
| Kablitz, C | 1 |
| Shihab, FS | 1 |
| Dy, EC | 1 |
| Yates, WR | 1 |
| Agelink, MW | 1 |
| Dammers, S | 1 |
| Zeit, T | 1 |
| Roerig, SC | 1 |
| Howse, KM | 1 |
| Aley, KO | 1 |
| Levine, JD | 1 |
| McCann, MJ | 1 |
| Miotto, K | 1 |
| Huber, A | 1 |
| Shoptaw, S | 1 |
| Ling, W | 1 |
| Rumball, D | 1 |
| Williams, J | 1 |
| Anderson, F | 1 |
| Paluzzi, P | 1 |
| Lee, J | 1 |
| Huggins, G | 1 |
| Svikis, D | 1 |
| Bearn, J | 1 |
| Gossop, M | 1 |
| Lerner, AG | 1 |
| Finkel, B | 1 |
| Oyffe, I | 1 |
| Merenzon, I | 1 |
| Sigal, M | 1 |
| Markowitz, JS | 1 |
| Myrick, H | 1 |
| Hiott, W | 1 |
| Dennison, SJ | 2 |
| Dehpour, AR | 1 |
| Sadr, SS | 1 |
| Azizi, MR | 1 |
| Namiranian, K | 1 |
| Farahani, M | 1 |
| Javidan, AN | 1 |
| Sawyer, MG | 1 |
| Rey, JM | 1 |
| Graetz, BW | 1 |
| Clark, JJ | 1 |
| Baghurst, PA | 1 |
| Armbruster, H | 1 |
| Vetter, W | 1 |
| Reck, G | 1 |
| Beckerhoff, R | 1 |
| Siegenthaler, W | 1 |
| Redmond, DE | 3 |
| Barolin, GS | 1 |
| Yudkin, JS | 1 |
| Sweeney, DR | 2 |
| Meyer, DR | 1 |
| El-Azhary, R | 1 |
| Bierer, DW | 1 |
| Hanson, SK | 1 |
| Robbins, MS | 1 |
| Sparber, SB | 1 |
| Annexton, M | 1 |
| Poyner, TF | 1 |
| Gennery, BA | 1 |
| Vasey, RH | 1 |
| Done, C | 1 |
| Silverstone, P | 1 |
| Sharp, T | 1 |
| Jiang, Z | 1 |
| Lauzon, P | 1 |
| Ammer, H | 1 |
| Nice, L | 1 |
| Lang, J | 1 |
| Schulz, R | 1 |
| Pini, LA | 1 |
| Sternieri, E | 1 |
| Ferretti, C | 1 |
| Sopelana, P | 1 |
| Bautista, L | 1 |
| Diéguez, A | 1 |
| Muga, R | 1 |
| Tor, J | 1 |
| Purschke, R | 1 |
| Torrens, M | 1 |
| San, L | 2 |
| Peri, JM | 1 |
| Olle, JM | 1 |
| Preston, KL | 1 |
| Bigelow, GE | 1 |
| Liebson, IA | 1 |
| Mannelli, P | 1 |
| Janiri, L | 1 |
| De Marinis, M | 1 |
| Tempesta, E | 1 |
| Green, JJ | 1 |
| Cordes, DH | 1 |
| Poser, W | 1 |
| van der Laan, JW | 1 |
| Hillen, FC | 1 |
| Tierney, C | 1 |
| Nadaud, D | 1 |
| Koenig-Berard, E | 1 |
| Stinus, L | 1 |
| Esposito, E | 1 |
| Kruszewska, A | 1 |
| Ossowska, G | 1 |
| Samanin, R | 1 |
| Yanagita, T | 1 |
| Yamamura, H | 1 |
| Igarashi, S | 1 |
| Vining, E | 1 |
| Kosten, TR | 1 |
| Kaneto, H | 1 |
| Kaneda, H | 1 |
| Kawatani, S | 1 |
| Moodley, P | 1 |
| Lader, M | 1 |
| Charney, DS | 1 |
| Heninger, GR | 1 |
| Linder, R | 1 |
| Garcia, A | 1 |
| Svensson, TH | 1 |
| Primi, MP | 1 |
| Bueno, L | 1 |
| Miller, L | 1 |
| Reinhart, S | 1 |
| Barrett, SM | 1 |
| Camí, J | 1 |
| de Torres, S | 1 |
| Solé, A | 1 |
| Guerra, D | 1 |
| Ugena, B | 1 |
| Siegel, EG | 1 |
| Bonfiglio, JF | 1 |
| Ritschel, WA | 1 |
| Fant, W | 1 |
| Regli, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.[NCT06069323] | 80 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| Treatment of Polydrug-Using Opiate Dependents During Withdrawal[NCT00367874] | Phase 4 | 12 participants | Interventional | 2003-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for clonidine and Chemical Dependence
| Article | Year |
|---|---|
Common ocular effects reported to a poison control center after systemic absorption of drugs in therapeutic and toxic doses.
Topics: Amphetamines; Analgesics, Opioid; Clonidine; Dextromethorphan; Humans; Miosis; Mydriasis; Nystagmus, | 2014 |
Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents.
Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Blood Pressure | 2013 |
Attention-deficit/hyperactivity disorder among adolescents: a review of the diagnosis, treatment, and clinical implications.
Topics: Adolescent; Antidepressive Agents; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hypera | 2005 |
[Drug dependence syndrome as a side effect of medical drug use].
Topics: Central Nervous System Agents; Clonidine; Flumazenil; Humans; Naloxone; Psychotherapy, Group; Self-H | 2007 |
Sites and mechanisms of dependence in the myenteric plexus of guinea pig ileum.
Topics: Acetylcholine; Adenosine; Animals; Clonidine; Cyclic AMP; Guinea Pigs; Humans; Ileum; In Vitro Techn | 1984 |
[Narcotic withdrawal syndrome. Therapeutic methods].
Topics: Acupuncture Therapy; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Analgesia; Brain; Centr | 1982 |
New insights and treatments: opiate withdrawal and cocaine addiction.
Topics: Brain Chemistry; Clonidine; Cocaine; Dopamine; Humans; Methadone; Naltrexone; Norepinephrine; Substa | 1984 |
Clonidine overdose: report of six cases and review of the literature.
Topics: Adolescent; Adult; Atropine; Bradycardia; Child, Preschool; Clonidine; Dopamine; Female; Humans; Hyp | 1981 |
Nicotine dependence: diagnosis, chemistry, and pharmacologic treatments.
Topics: Acetates; Acetic Acid; Administration, Cutaneous; Adolescent; Chewing Gum; Clonidine; Female; Humans | 1993 |
Cigarette smoking, nicotine addiction, and its pharmacologic treatment.
Topics: Chewing Gum; Clonidine; Costs and Cost Analysis; Humans; Nicotine; Polymethacrylic Acids; Polyvinyls | 1993 |
What is important in drug misuse treatment?
Topics: Buprenorphine; Clonidine; Humans; Methadone; Naltrexone; Narcotic Antagonists; Substance Withdrawal | 1996 |
12 trials available for clonidine and Chemical Dependence
| Article | Year |
|---|---|
Outpatient versus inpatient opioid detoxification: a randomized controlled trial.
Topics: Analgesics, Opioid; Clonidine; Female; Heroin; Heroin Dependence; Humans; Inpatients; Male; Methadon | 2011 |
Gabapentin in the management of pentazocine dependence: a potent analgesic--anticraving agent.
Topics: Acetates; Amines; Analgesics; Analgesics, Opioid; Anti-Anxiety Agents; Clonidine; Cyclohexanecarboxy | 2003 |
Treatment of polydrug-using opiate dependents during withdrawal: towards a standardisation of treatment.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Buprenorphine; Carbamazepine; Clonidi | 2006 |
Propoxyphene withdrawal with clonidine.
Topics: Clinical Trials as Topic; Clonidine; Dextropropoxyphene; Female; Hospitalization; Humans; Middle Age | 1983 |
Smoking cessation, clonidine, and vulnerability to nicotine among dependent smokers.
Topics: Adolescent; Adult; Aged; Clonidine; Depression; Double-Blind Method; Female; Follow-Up Studies; Huma | 1993 |
Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Clonidine; Dose-Response Relationship, Drug; D | 1998 |
Clonidine blocks acute opiate-withdrawal symptoms.
Topics: Acute Disease; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Evaluation; Follow-Up | 1978 |
Dapiprazole compared with clonidine and a placebo in detoxification of opiate addicts.
Topics: Adolescent; Adult; Blood Chemical Analysis; Clonidine; Double-Blind Method; Female; Humans; Liver Fu | 1991 |
Cocaine abuse among heroin addicts in Spain.
Topics: Adolescent; Adult; Clonidine; Cocaine; Cross-Cultural Comparison; Cross-Sectional Studies; Female; H | 1991 |
Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity.
Topics: Anesthetics, Local; Antipsychotic Agents; Clonidine; Follow-Up Studies; Heroin Dependence; Humans; M | 1989 |
Effects of tizanidine in healthy volunteers: double-blind study compared with diazepam and a placebo.
Topics: Adult; Blood Pressure; Clonidine; Diazepam; Double-Blind Method; Heart Rate; Humans; Male; Placebos; | 1988 |
[Treatment of vascular headaches].
Topics: Adrenergic beta-Antagonists; Carbamazepine; Cerebrovascular Disorders; Clonidine; Ergotamine; Female | 1973 |
73 other studies available for clonidine and Chemical Dependence
| Article | Year |
|---|---|
Therapeutic challenges in comorbid obsessive compulsive disorder with substance use.
Topics: Adrenergic alpha-2 Receptor Agonists; Clonazepam; Clonidine; Combined Modality Therapy; Fluoxetine; | 2018 |
The use of off-label medications in substance abuse treatment programs.
Topics: Accreditation; Adrenergic alpha-2 Receptor Agonists; Anticonvulsants; Antiemetics; Baclofen; Clonidi | 2020 |
Traumatic stress in rats induces noradrenergic-dependent long-term behavioral sensitization: role of individual differences and similarities with dependence on drugs of abuse.
Topics: Animals; Behavior, Animal; Clonidine; Dextroamphetamine; Hypothalamo-Hypophyseal System; Male; Motor | 2013 |
Memory of a drug lapse: Role of noradrenaline.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Animals; Basolateral | 2015 |
Clonidine: new use of an old medication to reduce stress-related substance use.
Topics: Clonidine; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 2016 |
Standardised detoxification in cases of polydrug use.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Anticonvulsants; Clonidine; Cohort St | 2016 |
Clonidine transport at the mouse blood-brain barrier by a new H+ antiporter that interacts with addictive drugs.
Topics: Analgesics; Animals; Antiporters; Biological Transport; Blood-Brain Barrier; Brain; Clonidine; Diphe | 2009 |
The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates conditioned place preference induced by various addictive and non-addictive drugs in rats.
Topics: Animals; Brain; Buspirone; Choice Behavior; Clonidine; Cocaine; Conditioning, Classical; Dose-Respon | 2011 |
Intentional clonidine patch ingestion by 3 adults in a detoxification unit.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Alcoholic Intoxication; Alprazolam; Antihype | 2003 |
High-dose tizanidine abuse.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Female; Humans; Muscle Relaxants, Central; Spasm; Subst | 2003 |
The vague OD. The symptomatic patient with an unknown exposure.
Topics: Adult; Cholinergic Agents; Clonidine; Diagnosis, Differential; Drug Overdose; Education, Continuing; | 2006 |
Outpatient clonidine detoxification.
Topics: Clonidine; Humans; Methadone; Outpatients; Patients; Substance Withdrawal Syndrome; Substance-Relate | 1981 |
Bioassay of subjective effects associated with benzodiazepine withdrawal in animals: a novel direction in dependence research.
Topics: Animals; Benzodiazepinones; Biological Assay; Clonidine; Conditioning, Operant; Diazepam; Discrimina | 1984 |
[Considerations in assisting drug addicts in a psychiatric department].
Topics: Clonidine; Humans; Psychiatric Department, Hospital; Socioeconomic Factors; Substance Withdrawal Syn | 1984 |
A-V block by an overdose of Clonidine.
Topics: Adult; Clonidine; Female; Heart Block; Humans; Substance-Related Disorders | 1983 |
Four cases of clonidine abuse.
Topics: Adult; Clonidine; Female; Humans; Male; Opioid-Related Disorders; Substance Withdrawal Syndrome; Sub | 1983 |
The dexamethasone suppression test for major depression among opiate addicts.
Topics: Adult; Clonidine; Depressive Disorder; Dexamethasone; Heroin Dependence; Humans; Hydrocortisone; Met | 1984 |
Clonidine hydrochloride detoxification from methadone treatments: the value of naltrexone aftercare.
Topics: Adolescent; Clonidine; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Opium; Subs | 1981 |
[Clonidine in opiate withdrawal. III. Pros and cons of administration].
Topics: Clonidine; Humans; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome; Substance-Rel | 1982 |
Progress report of the NIDA Addiction Research Center.
Topics: Analgesics; Buprenorphine; Chlordiazepoxide; Clonidine; Diazepam; Humans; Morphine; National Institu | 1982 |
Clonidine dependence in the guinea-pig isolated ileum.
Topics: Animals; Clonidine; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Mus | 1981 |
[Clonidine (Catapressan) prescription for substance abusers].
Topics: Clonidine; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1981 |
Clonidine patch: reservoir for abuse.
Topics: Administration, Cutaneous; Adult; Clonidine; Heroin Dependence; Humans; Male; Mastication; Poisoning | 1994 |
Clonidine patch ingestion in an adult.
Topics: Administration, Cutaneous; Adult; Clonidine; Depression; Drug Overdose; Humans; Male; Substance-Rela | 1993 |
Concomitant abuse of clonidine and heroin.
Topics: Adult; Clonidine; Female; Heroin Dependence; Humans; Substance Withdrawal Syndrome; Substance-Relate | 1993 |
Hyperadrenergic state following acute withdrawal from clonidine used at supratherapeutic doses.
Topics: Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Clonidine; Humans; Male; Substance Withdr | 1996 |
Atypical drug abuse: a case report involving clonidine.
Topics: Adult; Antihypertensive Agents; Clonidine; Diagnosis, Differential; Humans; Male; Substance-Related | 1996 |
[Clonidine--potential dependence risk in psychiatric patients?].
Topics: Antihypertensive Agents; Arousal; Clonidine; Dose-Response Relationship, Drug; Euphoria; Female; Hum | 1996 |
Omega-agatoxin IVA blocks spinal morphine/clonidine antinociceptive synergism.
Topics: Analgesics, Opioid; Animals; Calcium Channel Blockers; Clonidine; Drug Synergism; Drug Tolerance; Li | 1996 |
Multiple receptors involved in peripheral alpha 2, mu, and A1 antinociception, tolerance, and withdrawal.
Topics: Adenosine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagon | 1997 |
The Nathan B. Eddy Award Lecture: "A passion to improve treatment".
Topics: Clonidine; Humans; Methadone; Narcotic Antagonists; Substance-Related Disorders | 1996 |
Outpatient non-opioid detoxification for opioid withdrawal. Who is likely to benefit?
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Ambulatory Care Facilities; Clonidine; Female; GABA Mo | 1997 |
Rapid opiate detoxification. Assessment is needed to exclude certain patients before detoxification.
Topics: Adrenergic alpha-Agonists; Clonidine; Humans; Naltrexone; Narcotic Antagonists; Narcotics; Substance | 1997 |
Illicit use of clonidine in opiate-abusing pregnant women.
Topics: Adult; Antihypertensive Agents; Case-Control Studies; Clonidine; Female; Humans; Opioid-Related Diso | 1997 |
Clonidine treatment for hallucinogen persisting perception disorder.
Topics: Adult; Clonidine; Hallucinogens; Humans; Lysergic Acid Diethylamide; Male; Perceptual Disorders; Sub | 1998 |
Clonidine dependence.
Topics: Antihypertensive Agents; Clonidine; Female; Humans; Middle Aged; Substance-Related Disorders | 1997 |
Clonidine abuse among opiate addicts.
Topics: Adult; Antihypertensive Agents; Clonidine; Female; Heroin Dependence; Humans; Male; Methadone; Middl | 2001 |
Lithium inhibits the development of physical dependence to clonidine in mice.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Clonidine; Injections, Intraperitoneal; | 2002 |
Use of medication by young people with attention-deficit/hyperactivity disorder.
Topics: Adolescent; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Australia; Central | 2002 |
Severe arterial hypertension caused by chronical abuse of a topical mineralocorticoid.
Topics: Adult; Aldosterone; Clonidine; Drug Combinations; Drug Therapy, Combination; Female; Fluprednisolone | 1975 |
Clonidine in opiate withdrawal.
Topics: Clonidine; Humans; Male; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders | 1978 |
[Drug therapy for headache: (author's transl)].
Topics: Analgesics; Anti-Inflammatory Agents; Antidepressive Agents; Clonidine; Dihydroergotamine; Ergotamin | 1977 |
Clonidine withdrawal syndrome in Tanzania--a substantial risk.
Topics: Adult; Clonidine; Female; Humans; Hypertension; Long-Term Care; Male; Middle Aged; Substance Withdra | 1978 |
Decreased serum prolactin in opiate withdrawal and dopaminergic hyperactivity.
Topics: Clonidine; Humans; Methadone; Narcotics; Prolactin; Receptors, Dopamine; Substance Withdrawal Syndro | 1979 |
Rapid opiate detoxification: clinical evidence of antidepressant and antipanic effects of opiates.
Topics: Adult; Anxiety; Clonidine; Depression; Drug Therapy, Combination; Fear; Humans; Imipramine; Male; Me | 1979 |
Tolerance and dependence after chronic administration of clonidine to the rat.
Topics: Animals; Clonidine; Conditioning, Operant; Drug Tolerance; Humans; Male; Naloxone; Rats; Substance W | 1977 |
Clonidine may relieve opiate withdrawal symptoms.
Topics: Clonidine; Humans; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders | 1978 |
Management in cases of clonidine overdosage.
Topics: Adolescent; Atropine; Blood Pressure; Bradycardia; Clonidine; Diuresis; Female; Humans; Hypotension; | 1976 |
Mr R: a case study of withdrawal.
Topics: Alcoholism; Clonidine; Cocaine; Humans; Male; Methadone; Middle Aged; Neurologic Examination; Opioid | 1992 |
Effect of naloxone-precipitated morphine withdrawal on noradrenaline release in rat hippocampus in vivo.
Topics: Animals; Chromatography, High Pressure Liquid; Clonidine; Dialysis; Electrochemistry; Hippocampus; L | 1992 |
[Iatrogenic addiction of pethidine: clinical feature and experience of detoxification].
Topics: Adult; Clonidine; Female; Humans; Iatrogenic Disease; Male; Meperidine; Methadone; Substance-Related | 1992 |
Two cases of clonidine abuse/dependence in methadone-maintained patients.
Topics: Clonidine; Dose-Response Relationship, Drug; Female; Heroin Dependence; HIV Seropositivity; Humans; | 1992 |
Regulation of G proteins by chronic opiate and clonidine treatment in the guinea pig myenteric plexus.
Topics: Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Clonidine; Dose-Response Relationship, Drug | 1991 |
[Factors affecting the course of hospital detoxication of drug addicts].
Topics: Adult; Cannabis; Clonidine; Cocaine; Evaluation Studies as Topic; Female; Guanfacine; Heroin Depende | 1991 |
[Drug addiction and detoxication units].
Topics: Adult; Ambulatory Care; Clonidine; Female; Guanfacine; Heroin Dependence; Hospital Units; Humans; Ma | 1991 |
[Perioperative risk caused by alcohol and/or drug abuse. Which therapy?].
Topics: Adrenergic beta-Antagonists; Alcoholism; Anti-Anxiety Agents; Benzodiazepines; Chlormethiazole; Clon | 1990 |
Self-administration of clonidine, oxazepam, and hydromorphone by patients undergoing methadone detoxification.
Topics: Adult; Clonidine; Drug Administration Schedule; Humans; Hydromorphone; Male; Methadone; Opioid-Relat | 1985 |
Transdermal clonidine therapy and nicotine withdrawal.
Topics: Administration, Cutaneous; Adult; Aged; Clonidine; Female; Humans; Nicotine; Substance-Related Disor | 1989 |
[Dependence on nicotine in chewing gum].
Topics: Adult; Chewing Gum; Clonidine; Humans; Male; Nicotine; Smoking Prevention; Substance-Related Disorde | 1989 |
The potentiation of morphine-withdrawal jumping by clonidine is antagonized by m-chlorophenylpiperazine and not by haloperidol.
Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Behavior, Animal; Clonidine; Dopamine Antagonists; | 1986 |
Effects of two alpha 2 agonists, rilmenidine and clonidine, on the morphine withdrawal syndrome and their potential addictive properties in rats.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Clonidine; Male; Morphine; Oxazoles; Rats; Rat | 1988 |
Noradrenergic and behavioural effects of naloxone injected in the locus coeruleus of morphine-dependent rats and their control by clonidine.
Topics: Animals; Behavior, Animal; Clonidine; Locus Coeruleus; Male; Methoxyhydroxyphenylglycol; Morphine; N | 1987 |
Clinical utility of rapid clonidine-naltrexone detoxification for opioid abusers.
Topics: Adult; Clinical Protocols; Clonidine; Drug Therapy, Combination; Female; Heroin; Humans; Male; Naltr | 1988 |
Pharmacological characterization of alcohol and barbital physical dependence in mice.
Topics: Animals; Atropine; Barbital; Barbiturates; Clonidine; Ethanol; Male; Mice; Muscimol; Propranolol; Su | 1987 |
Management of benzodiazepine dependence.
Topics: Barbiturates; Benzodiazepines; Clonidine; Humans; Prognosis; Propranolol; Substance Withdrawal Syndr | 1986 |
The combined use of clonidine and naltrexone as a rapid, safe, and effective treatment of abrupt withdrawal from methadone.
Topics: Adult; Blood Pressure; Clonidine; Drug Administration Schedule; Drug Therapy, Combination; Female; H | 1986 |
[Clonidine--a new possibility in the treatment of drug addicts].
Topics: Adult; Alcoholism; Clonidine; Female; Humans; Substance-Related Disorders | 1986 |
Effects of centrally administered naloxone on gastrointestinal myoelectrical activity in morphine-dependent rats.
Topics: Animals; Atropine; Clonidine; Digestive System; Electrophysiology; Enkephalin, Leucine; Gastrointest | 1987 |
Tourette syndrome and drug addiction.
Topics: Clonidine; Humans; Substance-Related Disorders; Tourette Syndrome | 1985 |
Opiate and cocaine dependencies. Techniques to help counter the rising tide.
Topics: Ambulatory Care; Blood Pressure; Clonidine; Cocaine; Drug Tolerance; Hospitalization; Humans; Opioid | 1985 |
An acute hypertensive response after intravenous use of a new pentazocine formulation.
Topics: Adult; Clonidine; Female; Humans; Hypertension; Injections, Intravenous; Pentazocine; Substance-Rela | 1985 |
Efficacy of clonidine and of methadone in the rapid detoxification of patients dependent on heroin.
Topics: Adolescent; Adult; Analysis of Variance; Anxiety; Blood Pressure; Clonidine; Double-Blind Method; Dr | 1985 |
Investigation of clonidine and lofexidine for the treatment of barbiturate withdrawal in mice.
Topics: Animals; Barbiturates; Clonidine; Male; Mice; Mice, Inbred DBA; Seizures; Substance Withdrawal Syndr | 1985 |