clonidine has been researched along with Cerebral Palsy in 19 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Cerebral Palsy: A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare diazepam use, muscle spasm, analgesia, and side effects when clonidine or fentanyl are added to epidural bupivacaine in children with cerebral palsy after multilevel orthopaedic surgery." | 9.22 | Comparison of lumbar epidural bupivacaine with fentanyl or clonidine for postoperative analgesia in children with cerebral palsy after single-event multilevel surgery. ( Chalkiadis, GA; Dowden, SJ; Graham, HK; Low, J; Orsini, F; Penrose, S; Pirpiris, M; Sommerfield, D; Tay, M, 2016) |
| "Cerebral palsy is usually spastic, and baclofen, benzodiazepines and tizanidine are considered as oral treatments." | 9.13 | [Protocol for tizanidine use in infantile cerebral palsy]. ( Arroyo Riaño, O; Benavente Valdepeñas, A; Palazón García, R, 2008) |
| " Following botulinum toxin A treatment, clinical improvement led to the gradual reduction of baclofen or tizanidine dosing to one-third of the former dose." | 5.43 | Comparison of Efficacy and Side Effects of Oral Baclofen Versus Tizanidine Therapy with Adjuvant Botulinum Toxin Type A in Children With Cerebral Palsy and Spastic Equinus Foot Deformity. ( Aksoy, SN; Dai, AI; Demiryürek, AT, 2016) |
| "Clonidine is a frequently administered alpha2-adrenergic agonist which can decrease heart rate and blood pressure." | 5.34 | Cardiac arrest in a child with cerebral palsy undergoing sevoflurane induction of anesthesia after preoperative clonidine. ( Goldfinger, MM; Tripi, PA, 2007) |
| "To compare diazepam use, muscle spasm, analgesia, and side effects when clonidine or fentanyl are added to epidural bupivacaine in children with cerebral palsy after multilevel orthopaedic surgery." | 5.22 | Comparison of lumbar epidural bupivacaine with fentanyl or clonidine for postoperative analgesia in children with cerebral palsy after single-event multilevel surgery. ( Chalkiadis, GA; Dowden, SJ; Graham, HK; Low, J; Orsini, F; Penrose, S; Pirpiris, M; Sommerfield, D; Tay, M, 2016) |
| "Cerebral palsy is usually spastic, and baclofen, benzodiazepines and tizanidine are considered as oral treatments." | 5.13 | [Protocol for tizanidine use in infantile cerebral palsy]. ( Arroyo Riaño, O; Benavente Valdepeñas, A; Palazón García, R, 2008) |
| "For localized/segmental spasticity, botulinum toxin type A is established as an effective treatment to reduce spasticity in the upper and lower extremities." | 2.46 | Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child ( Aisen, M; Ashwal, S; Delgado, MR; Fehlings, DL; Hirtz, D; McLaughlin, J; Morrison, LA; Shrader, MW; Tilton, A; Vargus-Adams, J, 2010) |
| "While in some children, spasticity may adversely impact the motor abilities, in others, it may help maintain posture and ability to ambulate." | 2.43 | Pharmacologic interventions for reducing spasticity in cerebral palsy. ( Patel, DR; Soyode, O, 2005) |
| "Isolated dystonia or spasticity was infrequently seen, with a mixed picture of dystonia and spasticity ± choreoathetosis identified in 194/275 (70." | 1.51 | Pharmacological management of abnormal tone and movement in cerebral palsy. ( Amin, S; Basu, A; Cadwgan, J; Crowe, B; DeAlwis, Y; Devlin, A; Kumar, R; Lodh, R; Lumsden, DE; Lundy, CT; Mordekar, SR; Smith, M, 2019) |
| " Following botulinum toxin A treatment, clinical improvement led to the gradual reduction of baclofen or tizanidine dosing to one-third of the former dose." | 1.43 | Comparison of Efficacy and Side Effects of Oral Baclofen Versus Tizanidine Therapy with Adjuvant Botulinum Toxin Type A in Children With Cerebral Palsy and Spastic Equinus Foot Deformity. ( Aksoy, SN; Dai, AI; Demiryürek, AT, 2016) |
| "Clonidine is a frequently administered alpha2-adrenergic agonist which can decrease heart rate and blood pressure." | 1.34 | Cardiac arrest in a child with cerebral palsy undergoing sevoflurane induction of anesthesia after preoperative clonidine. ( Goldfinger, MM; Tripi, PA, 2007) |
| " Secondary objectives included determining correlations between dosage and age, injury type, location of spasticity, comorbid seizures, or concomitant antispasticity medications." | 1.33 | Oral baclofen and clonidine for treatment of spasticity in children. ( Haase, M; Habersang, R; Lubsch, L; Luedtke, S, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Bohn, E | 1 |
| Goren, K | 1 |
| Switzer, L | 1 |
| Falck-Ytter, Y | 1 |
| Fehlings, D | 1 |
| Arshad, MF | 1 |
| Ahmad, E | 1 |
| Biddanda, AN | 1 |
| Sharif, M | 1 |
| Lumsden, DE | 1 |
| Crowe, B | 1 |
| Basu, A | 1 |
| Amin, S | 1 |
| Devlin, A | 1 |
| DeAlwis, Y | 1 |
| Kumar, R | 1 |
| Lodh, R | 1 |
| Lundy, CT | 1 |
| Mordekar, SR | 1 |
| Smith, M | 1 |
| Cadwgan, J | 1 |
| Dai, AI | 2 |
| Aksoy, SN | 1 |
| Demiryürek, AT | 1 |
| Chalkiadis, GA | 2 |
| Sommerfield, D | 1 |
| Low, J | 1 |
| Orsini, F | 1 |
| Dowden, SJ | 1 |
| Tay, M | 1 |
| Penrose, S | 1 |
| Pirpiris, M | 1 |
| Graham, HK | 1 |
| Wasay, M | 1 |
| Awan, S | 1 |
| Delgado, MR | 1 |
| Hirtz, D | 1 |
| Aisen, M | 1 |
| Ashwal, S | 1 |
| Fehlings, DL | 1 |
| McLaughlin, J | 1 |
| Morrison, LA | 1 |
| Shrader, MW | 1 |
| Tilton, A | 1 |
| Vargus-Adams, J | 1 |
| Chung, CY | 1 |
| Chen, CL | 1 |
| Wong, AM | 1 |
| Patel, DR | 1 |
| Soyode, O | 1 |
| Lubsch, L | 1 |
| Habersang, R | 1 |
| Haase, M | 1 |
| Luedtke, S | 1 |
| Goldfinger, MM | 1 |
| Tripi, PA | 1 |
| Skinner, AV | 1 |
| Feron, FJ | 1 |
| Hendriksen, JG | 1 |
| Nicolai, J | 1 |
| Vles, JS | 1 |
| Palazón García, R | 1 |
| Benavente Valdepeñas, A | 1 |
| Arroyo Riaño, O | 1 |
| Knutsson, E | 1 |
| Shumilina, AP | 1 |
| Guzeva, VI | 1 |
| Skoromets, AA | 1 |
| Maksimov, OG | 1 |
| Secheĭko, MV | 1 |
| Andriĭchuk, EL | 1 |
| Brin, IL | 1 |
| Kurenkov, AL | 1 |
| Gotlib, VIa | 1 |
| Autti-Rämö, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Radial Extracorporeal Shock Wave Therapy for Management of Spasticity in Patients With Cerebral Palsy[NCT05702606] | 73 participants (Actual) | Interventional | 2021-06-10 | Completed | |||
| Sensory-Motor Rehabilitation Post Stroke[NCT02369770] | 140 participants (Anticipated) | Interventional | 2019-04-26 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for clonidine and Cerebral Palsy
| Article | Year |
|---|---|
Pharmacological and neurosurgical interventions for individuals with cerebral palsy and dystonia: a systematic review update and meta-analysis.
Topics: Baclofen; Botulinum Toxins; Cerebral Palsy; Clonidine; Deep Brain Stimulation; Dystonia; Humans; Inj | 2021 |
Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child
Topics: Adolescent; Botulinum Toxins, Type A; Cerebral Palsy; Child; Clonidine; Diazepam; Humans; Muscle Rel | 2010 |
Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child
Topics: Adolescent; Botulinum Toxins, Type A; Cerebral Palsy; Child; Clonidine; Diazepam; Humans; Muscle Rel | 2010 |
Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child
Topics: Adolescent; Botulinum Toxins, Type A; Cerebral Palsy; Child; Clonidine; Diazepam; Humans; Muscle Rel | 2010 |
Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child
Topics: Adolescent; Botulinum Toxins, Type A; Cerebral Palsy; Child; Clonidine; Diazepam; Humans; Muscle Rel | 2010 |
Pharmacotherapy of spasticity in children with cerebral palsy.
Topics: Baclofen; Benzodiazepines; Cerebral Palsy; Child; Clonidine; Dantrolene; Humans; Muscle Spasticity; | 2011 |
Pharmacologic interventions for reducing spasticity in cerebral palsy.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Age Factors; Anti-Infective Agents, Local; Baclofen | 2005 |
[Treatment of spasticity].
Topics: Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Clonidine; Humans; Injections, Spinal; Muscle Re | 1999 |
5 trials available for clonidine and Cerebral Palsy
| Article | Year |
|---|---|
Comparison of lumbar epidural bupivacaine with fentanyl or clonidine for postoperative analgesia in children with cerebral palsy after single-event multilevel surgery.
Topics: Analgesics; Bupivacaine; Cerebral Palsy; Child; Clonidine; Drug Therapy, Combination; Female; Fentan | 2016 |
Botulinum toxin type A with oral baclofen versus oral tizanidine: a nonrandomized pilot comparison in patients with cerebral palsy and spastic equinus foot deformity.
Topics: Administration, Oral; Adolescent; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Chi-Square Dis | 2008 |
[Protocol for tizanidine use in infantile cerebral palsy].
Topics: Cerebral Palsy; Child; Child, Preschool; Clonidine; Drug Administration Schedule; Female; Humans; In | 2008 |
[The use of sirdalud in the treatment of spasticity in infantile cerebral palsy].
Topics: Adolescent; Anticonvulsants; Cerebral Palsy; Child; Child, Preschool; Clonidine; Dose-Response Relat | 1999 |
[The use of sirdalud in cerebral palsy in children].
Topics: Adolescent; Cerebral Palsy; Child; Clonidine; Dose-Response Relationship, Drug; Electromyography; Fe | 1999 |
9 other studies available for clonidine and Cerebral Palsy
| Article | Year |
|---|---|
Status dystonicus: a diagnosis delayed.
Topics: Administration, Intravenous; Adrenergic alpha-2 Receptor Agonists; Adult; Cerebral Palsy; Clonidine; | 2018 |
Pharmacological management of abnormal tone and movement in cerebral palsy.
Topics: Adolescent; Baclofen; Botulinum Toxins; Cerebral Palsy; Child; Child Health Services; Child, Prescho | 2019 |
Comparison of Efficacy and Side Effects of Oral Baclofen Versus Tizanidine Therapy with Adjuvant Botulinum Toxin Type A in Children With Cerebral Palsy and Spastic Equinus Foot Deformity.
Topics: Administration, Oral; Adolescent; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Child; Child, | 2016 |
Oral baclofen and clonidine for treatment of spasticity in children.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Agonists; Adult; Age Factors; Baclofen; Brain Inj | 2006 |
Cardiac arrest in a child with cerebral palsy undergoing sevoflurane induction of anesthesia after preoperative clonidine.
Topics: Adrenergic alpha-Agonists; Anesthesia, General; Anesthetics, Inhalation; Cerebral Palsy; Child, Pres | 2007 |
Clinically unrecognized intravascular placement of epidural catheter in a child--an argument for the use of radio-opaque contrast?
Topics: Adrenergic Agonists; Analgesia, Epidural; Analgesics; Anesthetics, Local; Blood Pressure; Bupivacain | 2007 |
New-onset seizures: a possible association with clonidine?
Topics: Adrenergic alpha-Agonists; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Cerebral | 2008 |
Analysis of gait and isokinetic movements for evaluation of antispastic drugs or physical therapies.
Topics: Cerebral Palsy; Clonidine; Electromyography; Gait; Humans; Motor Neurons; Muscle Contraction; Muscle | 1983 |
[Sirdalud in the practice of the pediatric neurologist].
Topics: Adolescent; Cerebral Palsy; Child; Clonidine; Drug Evaluation; Humans; Muscle Relaxants, Central; Mu | 1997 |