clonidine has been researched along with Cerebral Infarction in 5 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
| Excerpt | Relevance | Reference |
|---|---|---|
| "When clonidine therapy was initiated, the patient responded rapidly with both subjective and objective improvements in her spasticity." | 1.28 | Clonidine in the treatment of brainstem spasticity. Case report. ( Sandford, PR; Sawasky, KB; Spengler, SE, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Y | 1 |
| Schrader, J | 1 |
| Diener, HC | 1 |
| Lüders, S | 1 |
| Momo, K | 1 |
| Doki, K | 1 |
| Hosono, H | 1 |
| Homma, M | 1 |
| Kohda, Y | 1 |
| Afonso Pérez, E | 1 |
| Pego Reigosa, R | 1 |
| Lancho Seco, A | 1 |
| Brañas Fernández, F | 1 |
| Sandford, PR | 1 |
| Spengler, SE | 1 |
| Sawasky, KB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I-II Clinical Trial to Determine the Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia[NCT01862250] | Phase 1/Phase 2 | 13 participants (Actual) | Interventional | 2013-10-03 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Intravenous morphine (mg/kg) was given. The standard dose is 0.05 mg/kg per dose (NCT01862250)
Timeframe: Up to 2 days
| Intervention | mg/kg (Median) |
|---|---|
| Clonidine Infants With HIE | 0.02 |
Babies were assessed after administration of clonidine for the presence or absence of shivering. (NCT01862250)
Timeframe: 48hrs
| Intervention | Participants (Count of Participants) |
|---|---|
| Clonidine Infants With HIE | 0 |
"Trough clonidine blood levels were measured after 4-7 doses of clonidine were given intravenously with a dosing interval of every 8 hrs. Mean and standard deviation (SD) of the number of doses given prior to levels being drawn was 5.3 (mean) and 0.37 (SD).~Time after last dose before measurement was 9hrs (mean) and 2.7hrs (SD)." (NCT01862250)
Timeframe: 3 days
| Intervention | ng/ml (Median) |
|---|---|
| Clonidine Infants With HIE | 0.6 |
Following 2 hours of therapeutic hypothermia, the temperature of the thermo-blanket is adjusted up half degree per hour allowing passive rewarming until 36.5 degrees is reached (NCT01862250)
Timeframe: Beginning at 72 hours up to 12 hours
| Intervention | Hours (Median) |
|---|---|
| Clonidine Infants With HIE | 8.7 |
1 review available for clonidine and Cerebral Infarction
| Article | Year |
|---|---|
[Tizanidine-induced toxic hepatitis].
Topics: Aged; Cerebral Infarction; Chemical and Drug Induced Liver Injury; Clonidine; Drug Therapy, Combinat | 1999 |
4 other studies available for clonidine and Cerebral Infarction
| Article | Year |
|---|---|
Clonidine preconditioning decreases infarct size and improves neurological outcome from transient forebrain ischemia in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2004 |
[Treating high blood pressure in acute stroke].
Topics: Acute Disease; Adrenergic alpha-Agonists; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Conve | 2004 |
Drug interaction of tizanidine and fluvoxamine.
Topics: Adrenergic alpha-Agonists; Aged; Antidepressive Agents, Second-Generation; Body Temperature; Cerebra | 2004 |
Clonidine in the treatment of brainstem spasticity. Case report.
Topics: Adult; Baclofen; Cerebral Infarction; Clonidine; Female; Humans; Medulla Oblongata; Muscle Spasticit | 1992 |