clonidine has been researched along with Cardiovascular Stroke in 48 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study effects of long-term morphine-clofelin epidural analgesia and infusion of nitroglycerin on formation of the necrosis focus and the clinical course of acute myocardial infarction (MI)." | 9.11 | [Effect of long-term epidural analgesia and nitroglycerin infusion on formation of necrosis zone and clinical course of myocardial infarction]. ( Dzizinskiĭ, AA; Tumak, VN, 2004) |
| "To assess the hemodynamic effects of Clonidine in hypertensive patients (pts) with an acute myocardial infarction (AMI), we administered the drug to 12 such patients either in a single bolus (75--150 micrograms in 5 min - 8 pts) or by continuous infusion (0." | 8.76 | [Hemodynamic effects of intravenous clonidine in patients with acute myocardial infarction]. ( Foresti, A; Lotto, A; Massari, FM; Moglia, F, 1982) |
| "Abrupt withdrawal from clonidine therapy is a well-known cause of hyperadrenergic symptoms, but reports of acute myocardial infarction are extremely rare." | 7.72 | Acute myocardial infarction as a complication of clonidine withdrawal. ( Gifford, W; Goldberg, R; Kishineff, S; Simic, J, 2003) |
| "A 62-year-old white woman with stage 3 breast cancer metastatic to the spine and a history of hypertension received a combined injection of hydromorphone 48." | 7.70 | Hypertensive crisis and myocardial infarction following massive clonidine overdose. ( Frye, CB; Vance, MA, 2000) |
| "Intravenous clonidine was used to treat systolic hypertension (systolic blood pressure greater than 160 mm Hg) in 15 patients with acute myocardial infarction and documented sympathetic overactivity (high plasma norepinephrine)." | 7.67 | Central inhibition of sympathetic overdrive by clonidine in acute myocardial infarction with systolic hypertension. Haemodynamic study. ( Bernard, R; Liebens, I; Renard, M; Waterschoot, P, 1986) |
| "Status epilepticus has been increasingly associated with cardiac injury in both clinical and animal studies." | 5.40 | Cardiac electrographic and morphological changes following status epilepticus: effect of clonidine. ( Andreianova, AA; Goulton, CS; Harrison, JC; Kerr, DS; Read, MI; Sammut, IA, 2014) |
| "Neither aspirin nor clonidine had a significant effect on the primary 1-yr outcome, a composite of death or nonfatal myocardial infarction, with a 1-yr hazard ratio for aspirin of 1." | 5.34 | One-year Results of a Factorial Randomized Trial of Aspirin versus Placebo and Clonidine versus Placebo in Patients Having Noncardiac Surgery. ( Amir, M; Balasubramanian, K; Berwanger, O; Biccard, BM; Chan, MTV; Conen, D; Devereaux, PJ; Fleischmann, E; Forget, P; Gilron, I; Graham, M; Guyatt, G; Kumar, PA; Kurz, A; Lamy, A; Landoni, G; Leslie, K; Malaga, G; Manach, YL; Meyhoff, CS; Mrkobrada, M; Paniagua, P; Parlow, JL; Pettit, S; Popova, E; Sessler, DI; Sigamani, A; Srinathan, S; Torres, D; Turan, A; Villar, JC; Wang, CY; Whitlock, R; Xavier, D; Yusuf, S, 2020) |
| " ITC was delivered locally via catheter to the T2-T4 spinal segments and was dosed to reduce heart rate (HR) by >20% to 25%." | 5.33 | Intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine postinfarction heart failure model. ( Groh, WJ; Hildebrand, KR; Issa, ZF; Miller, JM; Rosenberger, J; Ujhelyi, MR; Zhou, X; Zipes, DP, 2005) |
| "Myocardial infarction was produced in 27 anesthetized dogs by ligating the left anterior descending (LAD) coronary artery proximal to the septal branch." | 5.29 | Electropharmacology of the bradycardic agents alinidine and zatebradine (UL-FS 49) in a conscious canine ventricular arrhythmia model of permanent coronary artery occlusion. ( Aidonidis, I; Brachmann, J; Kübler, W; Rizos, I; Stavridis, I; Toutouzas, P; Zacharoulis, A, 1995) |
| " Detailed analysis revealed undoubted correlation between the dosage and favourable dynamics of precordial mapping parameters." | 5.27 | Intravenous clonidine in acute myocardial infarction in men. ( Lada, W; Zochowski, RJ, 1984) |
| "Alinidine is a new sinus node inhibitor which does not interact with the beta adrenergic receptors." | 5.27 | Haemodynamic effects of alinidine, a specific sinus node inhibition, in patients with unstable angina or myocardial infarction. ( Hugenholtz, PG; Simoons, ML, 1984) |
| "Clonidine was administered intravenously in a dose of 5 micrograms/kg over a 5-min period." | 5.27 | Hemodynamic effects of clonidine in patients with acute myocardial infarction complicated by hypertension. ( Foresti, A; Lotto, A; Massari, FM, 1986) |
| "Clonidine was administered as a bolus injection of 1-2 micrograms/kg body weight and repeated every 1-3 h." | 5.27 | Intravenous clonidine treatment in acute myocardial infarction (with comparison to a nitroglycerin-treated and control group). ( Lada, W; Zochowski, RJ, 1986) |
| "Administration of low-dose clonidine in patients undergoing noncardiac surgery did not reduce the rate of the composite outcome of death or nonfatal myocardial infarction; it did, however, increase the risk of clinically important hypotension and nonfatal cardiac arrest." | 5.19 | Clonidine in patients undergoing noncardiac surgery. ( Alonso-Coello, P; Amir, M; Berwanger, O; Biccard, BM; Botto, F; Chan, MT; Chow, C; Chrolavicius, S; Cook, D; Devereaux, PJ; Eikelboom, J; Fleischmann, E; Forget, P; Gao, P; Garg, AX; Graham, M; Guyatt, G; Kearon, C; Kumar, PA; Kurz, A; Lamy, A; Le Manach, Y; Leslie, K; Lurati Buse, G; Malaga, G; Meyhoff, CS; Mizera, R; Mrkobrada, M; Paniagua, P; Parlow, JL; Pasin, L; Pettit, S; Pogue, J; Robinson, A; Rodseth, RN; Sessler, DI; Sigamani, A; Srinathan, S; Tiboni, M; Torres, D; Vanhelder, T; Villar, JC; Wang, CY; Whitlock, R; Xavier, D; Yusuf, S, 2014) |
| "To study effects of long-term morphine-clofelin epidural analgesia and infusion of nitroglycerin on formation of the necrosis focus and the clinical course of acute myocardial infarction (MI)." | 5.11 | [Effect of long-term epidural analgesia and nitroglycerin infusion on formation of necrosis zone and clinical course of myocardial infarction]. ( Dzizinskiĭ, AA; Tumak, VN, 2004) |
| "In a double-blind study, we examined the effects of early intravenous and continued oral administration of a beta-blocker (atenolol), a specific bradycardiac agent (alinidine) or placebo on left ventricular function, late coronary artery patency, infarct size, exercise capacity and incidence of arrhythmias." | 5.07 | Short-term effects of early intravenous treatment with a beta-adrenergic blocking agent or a specific bradycardiac agent in patients with acute myocardial infarction receiving thrombolytic therapy. ( Brzostek, T; Collen, D; Heidbüchel, H; Janssens, L; Lesaffre, E; Mortelmans, L; Scheys, I; Van de Werf, F; Wackers, FJ; Willems, GM, 1993) |
| "To assess the hemodynamic effects of Clonidine in hypertensive patients (pts) with an acute myocardial infarction (AMI), we administered the drug to 12 such patients either in a single bolus (75--150 micrograms in 5 min - 8 pts) or by continuous infusion (0." | 4.76 | [Hemodynamic effects of intravenous clonidine in patients with acute myocardial infarction]. ( Foresti, A; Lotto, A; Massari, FM; Moglia, F, 1982) |
| "Abrupt withdrawal from clonidine therapy is a well-known cause of hyperadrenergic symptoms, but reports of acute myocardial infarction are extremely rare." | 3.72 | Acute myocardial infarction as a complication of clonidine withdrawal. ( Gifford, W; Goldberg, R; Kishineff, S; Simic, J, 2003) |
| "Bradycardia was induced in rats by administering alinidine via osmotic pumps beginning 1 day after coronary artery ligation." | 3.72 | Bradycardia induces angiogenesis, increases coronary reserve, and preserves function of the postinfarcted heart. ( Christensen, LP; Lei, L; Tomanek, RJ; Weiss, RM; Zheng, W; Zhou, R, 2004) |
| "A 62-year-old white woman with stage 3 breast cancer metastatic to the spine and a history of hypertension received a combined injection of hydromorphone 48." | 3.70 | Hypertensive crisis and myocardial infarction following massive clonidine overdose. ( Frye, CB; Vance, MA, 2000) |
| "Clonidine is a centrally acting antihypertensive agent used in the management of essential hypertension." | 3.67 | Reversal of clonidine toxicity by naloxone. ( Getzug, T; Murphy, W; Niemann, JT, 1986) |
| "Intravenous clonidine was used to treat systolic hypertension (systolic blood pressure greater than 160 mm Hg) in 15 patients with acute myocardial infarction and documented sympathetic overactivity (high plasma norepinephrine)." | 3.67 | Central inhibition of sympathetic overdrive by clonidine in acute myocardial infarction with systolic hypertension. Haemodynamic study. ( Bernard, R; Liebens, I; Renard, M; Waterschoot, P, 1986) |
| "We investigated prospectively the arrhythmia incidence in 244 patients with AMI receiving alteplase and a double-blind randomized adjunctive therapy with intravenous atenolol, alinidine, or placebo." | 2.67 | Significance of arrhythmias during the first 24 hours of acute myocardial infarction treated with alteplase and effect of early administration of a beta-blocker or a bradycardiac agent on their incidence. ( Ballet, A; Ector, H; Heidbüchel, H; Tack, J; Van de Werf, F; Vanneste, L, 1994) |
| "Status epilepticus has been increasingly associated with cardiac injury in both clinical and animal studies." | 1.40 | Cardiac electrographic and morphological changes following status epilepticus: effect of clonidine. ( Andreianova, AA; Goulton, CS; Harrison, JC; Kerr, DS; Read, MI; Sammut, IA, 2014) |
| " ITC was delivered locally via catheter to the T2-T4 spinal segments and was dosed to reduce heart rate (HR) by >20% to 25%." | 1.33 | Intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine postinfarction heart failure model. ( Groh, WJ; Hildebrand, KR; Issa, ZF; Miller, JM; Rosenberger, J; Ujhelyi, MR; Zhou, X; Zipes, DP, 2005) |
| "Heart failure is associated with increased sympathetic nerve activity." | 1.30 | Decreased responsiveness of vascular postjunctional alpha1-, alpha2-adrenoceptors and neuropeptide Y1 receptors in rats with heart failure. ( Edvinsson, L; Feng, Q; Hedner, T; Lu, X; Sun, X, 1999) |
| "Myocardial infarction was produced in 27 anesthetized dogs by ligating the left anterior descending (LAD) coronary artery proximal to the septal branch." | 1.29 | Electropharmacology of the bradycardic agents alinidine and zatebradine (UL-FS 49) in a conscious canine ventricular arrhythmia model of permanent coronary artery occlusion. ( Aidonidis, I; Brachmann, J; Kübler, W; Rizos, I; Stavridis, I; Toutouzas, P; Zacharoulis, A, 1995) |
| " Detailed analysis revealed undoubted correlation between the dosage and favourable dynamics of precordial mapping parameters." | 1.27 | Intravenous clonidine in acute myocardial infarction in men. ( Lada, W; Zochowski, RJ, 1984) |
| "Alinidine is a new sinus node inhibitor which does not interact with the beta adrenergic receptors." | 1.27 | Haemodynamic effects of alinidine, a specific sinus node inhibition, in patients with unstable angina or myocardial infarction. ( Hugenholtz, PG; Simoons, ML, 1984) |
| "Clonidine was administered intravenously in a dose of 5 micrograms/kg over a 5-min period." | 1.27 | Hemodynamic effects of clonidine in patients with acute myocardial infarction complicated by hypertension. ( Foresti, A; Lotto, A; Massari, FM, 1986) |
| "Clonidine was administered as a bolus injection of 1-2 micrograms/kg body weight and repeated every 1-3 h." | 1.27 | Intravenous clonidine treatment in acute myocardial infarction (with comparison to a nitroglycerin-treated and control group). ( Lada, W; Zochowski, RJ, 1986) |
| "Alinidine appears to be a safe drug for reduction of heart rate in patients with unstable angina and acute myocardial infarction." | 1.27 | Effect of ST-567 (a specific bradycardiac agent) in patients with unstable angina and myocardial infarction. ( Simoons, ML, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (37.50) | 18.7374 |
| 1990's | 7 (14.58) | 18.2507 |
| 2000's | 9 (18.75) | 29.6817 |
| 2010's | 12 (25.00) | 24.3611 |
| 2020's | 2 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Kuptsova, AM | 1 |
| Bugrov, RK | 1 |
| Ziyatdinova, NI | 1 |
| Zefirov, TL | 1 |
| Sessler, DI | 3 |
| Conen, D | 1 |
| Leslie, K | 3 |
| Yusuf, S | 3 |
| Popova, E | 2 |
| Graham, M | 2 |
| Kurz, A | 2 |
| Villar, JC | 3 |
| Mrkobrada, M | 3 |
| Sigamani, A | 3 |
| Biccard, BM | 3 |
| Meyhoff, CS | 3 |
| Parlow, JL | 3 |
| Guyatt, G | 3 |
| Xavier, D | 3 |
| Chan, MTV | 2 |
| Kumar, PA | 3 |
| Forget, P | 2 |
| Malaga, G | 2 |
| Fleischmann, E | 3 |
| Amir, M | 2 |
| Torres, D | 2 |
| Wang, CY | 2 |
| Paniagua, P | 2 |
| Berwanger, O | 2 |
| Srinathan, S | 2 |
| Landoni, G | 2 |
| Manach, YL | 1 |
| Whitlock, R | 3 |
| Lamy, A | 3 |
| Balasubramanian, K | 1 |
| Gilron, I | 1 |
| Turan, A | 1 |
| Pettit, S | 2 |
| Devereaux, PJ | 4 |
| Graham, MM | 1 |
| Cook, DJ | 1 |
| Tandon, V | 1 |
| Alvarez-Garcia, J | 1 |
| Painter, TW | 1 |
| Le Manach, Y | 2 |
| Aphang-Lam, M | 1 |
| Cata, JP | 1 |
| Gao, P | 2 |
| Terblanche, NCS | 1 |
| Ramana, PV | 1 |
| Jamieson, KA | 1 |
| Bessissow, A | 1 |
| Mendoza, GR | 1 |
| Ramirez, S | 1 |
| Diemunsch, PA | 1 |
| Duncan, D | 1 |
| Sankar, A | 1 |
| Beattie, WS | 2 |
| Wijeysundera, DN | 2 |
| Read, MI | 1 |
| Andreianova, AA | 1 |
| Harrison, JC | 1 |
| Goulton, CS | 1 |
| Sammut, IA | 1 |
| Kerr, DS | 1 |
| Vaishnava, P | 1 |
| Eagle, KA | 1 |
| Alonso-Coello, P | 2 |
| Robinson, A | 1 |
| Garg, AX | 1 |
| Rodseth, RN | 1 |
| Botto, F | 1 |
| Lurati Buse, G | 1 |
| Chan, MT | 1 |
| Tiboni, M | 1 |
| Cook, D | 1 |
| Eikelboom, J | 1 |
| Mizera, R | 1 |
| Vanhelder, T | 1 |
| Pasin, L | 1 |
| Pogue, J | 1 |
| Kearon, C | 1 |
| Chow, C | 1 |
| Chrolavicius, S | 1 |
| Geach, T | 1 |
| Treschan, TA | 1 |
| Kienbaum, P | 1 |
| Mitka, M | 1 |
| Cegarra-Sanmartin, V | 1 |
| Paniagua-Iglesias, P | 1 |
| de Nadal Clanchet, M | 1 |
| Plou, P | 1 |
| Mata Mena, E | 1 |
| Fernández-Riveira, C | 1 |
| García del Valle, S | 1 |
| Tena Blanco, B | 1 |
| Sabaté Tenas, S | 1 |
| Font Gual, A | 1 |
| Maestre Hittinger, ML | 1 |
| González Rodríguez, R | 1 |
| Locatelli, A | 1 |
| Musumeci, G | 1 |
| Rossini, R | 1 |
| Fumagalli, S | 1 |
| Del Medico, M | 1 |
| Montano, N | 1 |
| Naik, JS | 1 |
| Simic, J | 1 |
| Kishineff, S | 1 |
| Goldberg, R | 1 |
| Gifford, W | 1 |
| Tumak, VN | 2 |
| Dzizinskiĭ, AA | 2 |
| Lei, L | 1 |
| Zhou, R | 1 |
| Zheng, W | 1 |
| Christensen, LP | 2 |
| Weiss, RM | 2 |
| Tomanek, RJ | 2 |
| Dedkov, EI | 1 |
| Issa, ZF | 1 |
| Ujhelyi, MR | 1 |
| Hildebrand, KR | 1 |
| Zhou, X | 1 |
| Rosenberger, J | 1 |
| Groh, WJ | 1 |
| Miller, JM | 1 |
| Zipes, DP | 1 |
| Houston, MC | 1 |
| Borokhova, IA | 1 |
| Zochowski, RJ | 2 |
| Lada, W | 2 |
| Simoons, ML | 2 |
| Hugenholtz, PG | 1 |
| Foresti, A | 2 |
| Massari, FM | 2 |
| Moglia, F | 1 |
| Lotto, A | 2 |
| Bender, F | 1 |
| Tsuchida, A | 1 |
| Liu, Y | 1 |
| Liu, GS | 1 |
| Cohen, MV | 1 |
| Downey, JM | 1 |
| Heidbüchel, H | 2 |
| Tack, J | 1 |
| Vanneste, L | 1 |
| Ballet, A | 1 |
| Ector, H | 1 |
| Van de Werf, F | 2 |
| Janssens, L | 1 |
| Brzostek, T | 1 |
| Mortelmans, L | 1 |
| Wackers, FJ | 1 |
| Willems, GM | 1 |
| Lesaffre, E | 1 |
| Scheys, I | 1 |
| Collen, D | 1 |
| Aidonidis, I | 1 |
| Brachmann, J | 1 |
| Rizos, I | 1 |
| Zacharoulis, A | 1 |
| Stavridis, I | 1 |
| Toutouzas, P | 1 |
| Kübler, W | 1 |
| Hudson, PA | 1 |
| Rose, JS | 1 |
| Feng, Q | 1 |
| Sun, X | 1 |
| Lu, X | 1 |
| Edvinsson, L | 1 |
| Hedner, T | 1 |
| Zhang, Y | 1 |
| Cheng, Z | 1 |
| Frye, CB | 1 |
| Vance, MA | 1 |
| Birkenhäger, WH | 1 |
| Kho, TL | 1 |
| Kolsters, G | 1 |
| Schalekamp, MA | 1 |
| Wester, A | 1 |
| Zaal, GA | 1 |
| Berge, KH | 1 |
| Lanier, WL | 1 |
| Zaĭtsev, AA | 1 |
| Ignatov, IuD | 1 |
| Kuznetsova, OIu | 1 |
| Mikhaĭlovich, VA | 1 |
| Ruksin, VV | 1 |
| Harron, DW | 1 |
| Shanks, RG | 1 |
| Reichhalter, R | 1 |
| Lillie, C | 1 |
| Kobinger, W | 1 |
| Feldstein, JS | 1 |
| Niemann, JT | 1 |
| Getzug, T | 1 |
| Murphy, W | 1 |
| Stangeland, L | 1 |
| Grong, K | 1 |
| Vik-Mo, H | 1 |
| Andersen, KS | 1 |
| Lekven, J | 1 |
| Renard, M | 1 |
| Liebens, I | 1 |
| Waterschoot, P | 1 |
| Bernard, R | 1 |
| Bauer, GE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Large, International, Placebo-controlled, Factorial Trial to Assess the Impact of Clonidine and Acetyl-salicylic Acid (ASA) in Patients Undergoing Noncardiac Surgery Who Are at Risk of a Perioperative Cardiovascular Event[NCT01082874] | Phase 3 | 10,010 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| Impact of Intraoperative Goal-directed Blood Pressure Management and Dexmedetomidine on Outcomes of High-risk Patients After Major Abdominal Surgeries: a 2×2 Factorial Randomized Controlled Trial[NCT03933306] | Phase 4 | 496 participants (Actual) | Interventional | 2019-05-20 | Active, not recruiting | ||
| Effect of Target Intraoperative Blood Pressure on the Incidence of Post-operative Cognitive Dysfunction in Patients Aged 75 and Older Undergoing General Anesthesia for Non-cardiac Surgery: an International Multicenter Randomized Controlled Trial[NCT02428062] | Phase 2/Phase 3 | 1,812 participants (Anticipated) | Interventional | 2014-10-31 | Suspended (stopped due to Pending Pilot study results evaluation) | ||
| Effect of Ivabradine on Heart Rate and Hemodynamics in Patients With Stage D Heart Failure (HF)/Cardiogenic Shock on Dobutamine Treatment[NCT03387605] | Phase 4 | 40 participants (Anticipated) | Interventional | 2018-03-15 | Recruiting | ||
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01082874)
Timeframe: 30 days
| Intervention | participants (Number) |
|---|---|
| Active Clonidine and Active ASA | 173 |
| Active Clonidine and Placebo ASA | 194 |
| Placebo Clonidine and Active ASA | 178 |
| Placebo Clonidine and Placebo ASA | 161 |
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
6 reviews available for clonidine and Cardiovascular Stroke
| Article | Year |
|---|---|
Alpha-2 adrenergic agonists for the prevention of cardiac complications among adults undergoing surgery.
Topics: Adrenergic alpha-Agonists; Clonidine; Dexmedetomidine; Heart Diseases; Humans; Imidazoles; Intraoper | 2018 |
Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: a meta-analysis.
Topics: Adrenergic alpha-Agonists; Arrhythmias, Cardiac; Cardiac Surgical Procedures; Clonidine; Dexmedetomi | 2003 |
Abrupt cessation of treatment in hypertension: consideration of clinical features, mechanisms, prevention and management of the discontinuation syndrome.
Topics: Acute Disease; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Bethanidine; Blood Pressure; Cloni | 1981 |
[Significance of free fatty acid levels in evaluating the severity of myocardial infarction and the efficacy of drug therapy].
Topics: Acute Disease; Arrhythmias, Cardiac; Catecholamines; Clonidine; Fatty Acids, Nonesterified; Follow-U | 1984 |
[Hemodynamic effects of intravenous clonidine in patients with acute myocardial infarction].
Topics: Adult; Clonidine; Female; Hemodynamics; Humans; Hypertension; Injections, Intravenous; Male; Middle | 1982 |
Pharmacology, clinical pharmacology and potential therapeutic uses of the specific bradycardiac agent alinidine.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Clonidine; Coronary Disease; Drug Evaluation; | 1985 |
11 trials available for clonidine and Cardiovascular Stroke
| Article | Year |
|---|---|
One-year Results of a Factorial Randomized Trial of Aspirin versus Placebo and Clonidine versus Placebo in Patients Having Noncardiac Surgery.
Topics: Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clonidine; Female; Follow-Up Stu | 2020 |
Aspirin in Patients With Previous Percutaneous Coronary Intervention Undergoing Noncardiac Surgery.
Topics: Aged; Antihypertensive Agents; Aspirin; Biomarkers; Clonidine; Drug Administration Schedule; Drug Th | 2018 |
Clonidine in patients undergoing noncardiac surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Female; Humans; Hypotension; Kaplan-Meier Est | 2014 |
Clonidine in patients undergoing noncardiac surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Female; Humans; Hypotension; Kaplan-Meier Est | 2014 |
Clonidine in patients undergoing noncardiac surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Female; Humans; Hypotension; Kaplan-Meier Est | 2014 |
Clonidine in patients undergoing noncardiac surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Clonidine; Female; Humans; Hypotension; Kaplan-Meier Est | 2014 |
Rationale and design of the PeriOperative ISchemic Evaluation-2 (POISE-2) trial: an international 2 × 2 factorial randomized controlled trial of acetyl-salicylic acid vs. placebo and clonidine vs. placebo in patients undergoing noncardiac surgery.
Topics: Aged; Aspirin; Clonidine; Double-Blind Method; Female; Humans; Intraoperative Complications; Male; M | 2014 |
[Perioperative acetylsalicylic acid and clonidine in noncardiac surgery patients (POISE-2 trial)].
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Clo | 2015 |
[The POISE-2 Aspirin trial].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clonidine; Dose-Response Relationship, Drug; Human | 2015 |
[The POISE-2 Clonidine trial].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clonidine; Dose-Response Relationship, Drug; Doubl | 2015 |
[Clinical course of acute myocardial infarction and left ventricular function in long-term epidural analgesia].
Topics: Analgesia, Epidural; Analgesics; Analgesics, Opioid; Clonidine; Female; Humans; Injections, Intraven | 2004 |
[Effect of long-term epidural analgesia and nitroglycerin infusion on formation of necrosis zone and clinical course of myocardial infarction].
Topics: Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Case-Control Studies; Clonidine; | 2004 |
Significance of arrhythmias during the first 24 hours of acute myocardial infarction treated with alteplase and effect of early administration of a beta-blocker or a bradycardiac agent on their incidence.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atenolol; Clonidine; Double-Blind Method; Electrocardi | 1994 |
Short-term effects of early intravenous treatment with a beta-adrenergic blocking agent or a specific bradycardiac agent in patients with acute myocardial infarction receiving thrombolytic therapy.
Topics: Adult; Aged; Arrhythmias, Cardiac; Atenolol; Cardiovascular Agents; Clonidine; Double-Blind Method; | 1993 |
31 other studies available for clonidine and Cardiovascular Stroke
| Article | Year |
|---|---|
Delayed Consequences of Experimental Myocardial Infarction: Functional Responses to Stimulation of α2-Adrenoreceptors in the Isolated Heart.
Topics: Animals; Clonidine; Heart; Heart Rate; Hemodynamics; Myocardial Contraction; Myocardial Infarction; | 2022 |
Cardiac electrographic and morphological changes following status epilepticus: effect of clonidine.
Topics: Animals; Clonidine; Double-Blind Method; Electrocardiography; Heart; Male; Myocardial Infarction; My | 2014 |
The yin and yang of perioperative medicine.
Topics: Adrenergic alpha-2 Receptor Agonists; Aspirin; Clonidine; Female; Humans; Hypotension; Male; Myocard | 2014 |
Surgery: Low-dose aspirin and clonidine--no benefit during surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Aspirin; Clonidine; Female; Humans; Hypotension; Male; Myocard | 2014 |
[Comments on: perioperative administration of clonidine or aspirin].
Topics: Adrenergic alpha-2 Receptor Agonists; Aspirin; Clonidine; Female; Humans; Hypotension; Male; Myocard | 2014 |
Myocardial infarction risks remain for patients undergoing noncardiac elective surgery.
Topics: Antihypertensive Agents; Aspirin; Clonidine; Elective Surgical Procedures; Humans; Myocardial Infarc | 2014 |
Acute myocardial infarction as a complication of clonidine withdrawal.
Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Clonidine; Electrocardiography; Female; Humans; | 2003 |
Bradycardia induces angiogenesis, increases coronary reserve, and preserves function of the postinfarcted heart.
Topics: Angiopoietin-1; Angiopoietin-2; Animals; Bradycardia; Cardiovascular Agents; Clonidine; Coronary Ves | 2004 |
Reduction of heart rate by chronic beta1-adrenoceptor blockade promotes growth of arterioles and preserves coronary perfusion reserve in postinfarcted heart.
Topics: Adrenergic beta-Antagonists; Animals; Arterioles; Atenolol; Cardiac Output; Clonidine; Coronary Vess | 2005 |
Intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine postinfarction heart failure model.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Disease Models, Animal; Dogs; Electro | 2005 |
Intravenous clonidine in acute myocardial infarction in men.
Topics: Adult; Aged; Angina Pectoris; Clonidine; Creatine Kinase; Dose-Response Relationship, Drug; Electroc | 1984 |
Haemodynamic effects of alinidine, a specific sinus node inhibition, in patients with unstable angina or myocardial infarction.
Topics: Adult; Aged; Angina Pectoris; Angina, Unstable; Cardiac Output; Cardiovascular Agents; Clonidine; Fe | 1984 |
Acute hypertensive crises.
Topics: Acute Disease; Adult; Aged; Clonidine; Diazoxide; Heart Block; Humans; Hypertension; Injections, Int | 1980 |
alpha 1-adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals | 1994 |
Electropharmacology of the bradycardic agents alinidine and zatebradine (UL-FS 49) in a conscious canine ventricular arrhythmia model of permanent coronary artery occlusion.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzazepines; Blood Pressure; Cardiotonic Age | 1995 |
Real-time ultrasound guided internal jugular vein catheterization in the emergency department.
Topics: Catheterization, Central Venous; Clonidine; Drug Overdose; Emergency Service, Hospital; Female; Huma | 1997 |
Decreased responsiveness of vascular postjunctional alpha1-, alpha2-adrenoceptors and neuropeptide Y1 receptors in rats with heart failure.
Topics: Adrenergic alpha-Agonists; Animals; Atrial Natriuretic Factor; Autonomic Fibers, Preganglionic; Azep | 1999 |
Sympathetic inhibition with clonidine prolongs survival in experimental chronic heart failure.
Topics: Animals; Blood Pressure; Chronic Disease; Clonidine; Disease Models, Animal; Heart Failure; Heart Ra | 2000 |
Hypertensive crisis and myocardial infarction following massive clonidine overdose.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Breast Neoplasms; Clonidine; Drug Overdose; Drug Ther | 2000 |
Haemodynamic setting of essential hypertension as a guide to management.
Topics: Antihypertensive Agents; Arteries; Blood Pressure; Cardiac Output; Clonidine; Diazoxide; Diuretics; | 1975 |
Myocardial infarction accompanying acute clonidine withdrawal in a patient without a history of ischemic coronary artery disease.
Topics: Aged; Clonidine; Electrocardiography; Female; Humans; Hypertension; Myocardial Infarction; Substance | 1991 |
Hemodynamic effects of clonidine in patients with acute myocardial infarction complicated by hypertension.
Topics: Adult; Aged; Clonidine; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Myocardial In | 1986 |
Intravenous clonidine treatment in acute myocardial infarction (with comparison to a nitroglycerin-treated and control group).
Topics: Adult; Aged; Arrhythmias, Cardiac; Catecholamines; Clonidine; Female; Humans; Male; Middle Aged; Myo | 1986 |
[The use of clofelin in the acute period of myocardial infarct].
Topics: Aged; Aged, 80 and over; Clonidine; Hemodynamics; Humans; Middle Aged; Myocardial Infarction; Pain | 1989 |
Effect of ST-567 (a specific bradycardiac agent) in patients with unstable angina and myocardial infarction.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Anti-Arrhythmia Agents; Clonidine; H | 1987 |
Effects of alinidine on survival and infarct size in rats with coronary artery occlusion.
Topics: Animals; Blood Pressure; Clonidine; Heart Rate; Male; Myocardial Infarction; Rats | 1988 |
Hypertensive emergencies.
Topics: Adrenal Gland Neoplasms; Angina Pectoris; Antihypertensive Agents; Aortic Aneurysm; Aortic Dissectio | 1986 |
Reversal of clonidine toxicity by naloxone.
Topics: Accidents, Traffic; Aged; Clonidine; Female; Humans; Hypertension; Hypotension; Myocardial Infarctio | 1986 |
Is reduced cardiac performance the only mechanism for myocardial infarct size reduction during beta adrenergic blockade?
Topics: Animals; Autoradiography; Cardiac Output; Cats; Clonidine; Disease Models, Animal; Heart Rate; Myoca | 1986 |
Central inhibition of sympathetic overdrive by clonidine in acute myocardial infarction with systolic hypertension. Haemodynamic study.
Topics: Aged; Blood Pressure; Cardiac Output; Catecholamines; Clonidine; Female; Hemodynamics; Humans; Hyper | 1986 |
Treatment of hypertension in the elderly.
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Cerebrovascular Disorders; Clonidine; Di | 1974 |