clonidine has been researched along with Cardiovascular Pregnancy Complications in 27 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A prospective, double-blind, randomized controlled trial was carried out, comparing alpha-methyldopa and clonidine hydrochloride in 100 pregnant women with hypertension." | 9.05 | Clonidine hydrochloride--a safe and effective antihypertensive agent in pregnancy. ( Child, A; Henderson-Smart, DJ; Horvath, JS; Korda, A; Phippard, A; Tiller, DJ, 1985) |
| "The objective of this study was to determine the pharmacokinetic parameters of clonidine during pregnancy compared with previously published data in nonpregnant subjects." | 7.75 | Clonidine pharmacokinetics in pregnancy. ( Buchanan, ML; Carr, DB; Easterling, TR; Hebert, MF; Mattison, DR; Nelson, WL; Risler, LJ; Shen, DD, 2009) |
| "Pharmacokinetics of clonidine were examined in ten women during pregnancy, in nine during nursing, and in the newborns of these women." | 7.67 | Pharmacokinetics of clonidine during pregnancy and nursing. ( Hartikainen-Sorri, AL; Heikkinen, JE; Koivisto, M, 1987) |
| "Eighty two hypertensive pregnant patients were treated with clonidine during the last trimester of pregnancy." | 7.67 | Clonidine in the treatment of hypertension during pregnancy. ( Kauppila, E; Punnonen, R; Tuimala, R, 1985) |
| " The mother took clonidine during pregnancy." | 7.66 | Roberts's syndrome and clonidine. ( Beshara, D; Levy, JM; Stoll, C, 1979) |
| "A prospective, double-blind, randomized controlled trial was carried out, comparing alpha-methyldopa and clonidine hydrochloride in 100 pregnant women with hypertension." | 5.05 | Clonidine hydrochloride--a safe and effective antihypertensive agent in pregnancy. ( Child, A; Henderson-Smart, DJ; Horvath, JS; Korda, A; Phippard, A; Tiller, DJ, 1985) |
| " It has also been used intravenously in phaeochromocytoma, tetanus, clonidine withdrawal, and as an adjunct to halothane to produce hypotensive anaesthesia." | 4.76 | Combined alpha- and beta-receptor inhibition in the treatment of hypertension. ( Prichard, BN, 1984) |
| "The objective of this study was to determine the pharmacokinetic parameters of clonidine during pregnancy compared with previously published data in nonpregnant subjects." | 3.75 | Clonidine pharmacokinetics in pregnancy. ( Buchanan, ML; Carr, DB; Easterling, TR; Hebert, MF; Mattison, DR; Nelson, WL; Risler, LJ; Shen, DD, 2009) |
| " The amniotic fluid norepinephrine concentration (mean +/- SD) in cases of hypertension treated with clonidine (0." | 3.67 | Amniotic fluid norepinephrine concentration as an indicator of fetal sympathetic nervous activity. Effect of pregnancy complications. ( Kauppila, A; Puolakka, J; Vuori, J, 1984) |
| "Pharmacokinetics of clonidine were examined in ten women during pregnancy, in nine during nursing, and in the newborns of these women." | 3.67 | Pharmacokinetics of clonidine during pregnancy and nursing. ( Hartikainen-Sorri, AL; Heikkinen, JE; Koivisto, M, 1987) |
| "Eighty two hypertensive pregnant patients were treated with clonidine during the last trimester of pregnancy." | 3.67 | Clonidine in the treatment of hypertension during pregnancy. ( Kauppila, E; Punnonen, R; Tuimala, R, 1985) |
| " The mother took clonidine during pregnancy." | 3.66 | Roberts's syndrome and clonidine. ( Beshara, D; Levy, JM; Stoll, C, 1979) |
| "Clonidine is an alpha-adrenergic agonist." | 2.38 | Fetal effects of maternally administered clonidine and angiotensin-converting enzyme inhibitors. ( Boutroy, MJ, 1989) |
| "Hypertension in pregnancy has implications for both maternal and fetal welfare." | 2.37 | Hypertension in pregnancy. Pathophysiology and management. ( Lubbe, WF, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (85.19) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Buchanan, ML | 1 |
| Easterling, TR | 1 |
| Carr, DB | 1 |
| Shen, DD | 1 |
| Risler, LJ | 1 |
| Nelson, WL | 1 |
| Mattison, DR | 1 |
| Hebert, MF | 1 |
| Moodley, J | 1 |
| Richter, R | 1 |
| Lubbe, WF | 1 |
| Prichard, BN | 1 |
| Fleming, SE | 1 |
| Horvath, JS | 4 |
| Korda, A | 3 |
| Puolakka, J | 1 |
| Kauppila, A | 1 |
| Vuori, J | 1 |
| Berkowitz, RL | 2 |
| Cellina, G | 1 |
| Lo Cicero, G | 1 |
| Montanari, C | 1 |
| Barbato, M | 1 |
| Brina, A | 1 |
| Radev, R | 1 |
| Redman, CW | 1 |
| Walters, WA | 1 |
| Yudkin, JS | 1 |
| Shekhtman, MM | 1 |
| Volpin, EA | 1 |
| Turenko, AI | 1 |
| Zamanskaia, EM | 1 |
| Stoll, C | 1 |
| Levy, JM | 1 |
| Beshara, D | 1 |
| Heilmann, L | 1 |
| Kurz, E | 1 |
| Mellina, IM | 1 |
| Tarakhovskiĭ, ML | 1 |
| Gutman, LB | 1 |
| Zaĭtseva, NE | 1 |
| Phippard, AF | 1 |
| Fischer, WE | 1 |
| Child, AG | 1 |
| Korda, AR | 1 |
| Henderson-Smart, D | 2 |
| Duggin, GG | 2 |
| Tiller, DJ | 3 |
| Boutroy, MJ | 1 |
| Kreisberg, GA | 1 |
| Diamant, S | 1 |
| Diamant, YZ | 1 |
| Atlas, D | 1 |
| Chervenak, FA | 1 |
| Huisjes, HJ | 1 |
| Hadders-Algra, M | 1 |
| Touwen, BC | 1 |
| Ng-Wing Tin, L | 1 |
| Frelon, JH | 1 |
| Beauté, Y | 1 |
| Pellerin, M | 1 |
| Guillaumin, JP | 1 |
| Bazin, C | 1 |
| Hartikainen-Sorri, AL | 1 |
| Heikkinen, JE | 1 |
| Koivisto, M | 1 |
| Tuimala, R | 1 |
| Punnonen, R | 1 |
| Kauppila, E | 1 |
| Phippard, A | 2 |
| Henderson-Smart, DJ | 1 |
| Child, A | 2 |
| Hall, BM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Transversus Abdominis Plane (TAP) Block for Cesarean Section[NCT01015807] | 90 participants (Actual) | Interventional | 2009-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Determine which of three different TAP formulations (Placebo, TAP, Clo-TAP) has the most beneficial effect on the postoperative area of hyperalgesia 48hrs after the start of the cesarean section. The smaller the area of WHA, assessed in cm2, the better the outcome. Area sizes may range from 0 to any size. (NCT01015807)
Timeframe: 48hrs after CS
| Intervention | cm^2 (Mean) |
|---|---|
| Placebo | 1.07 |
| TAP (Bupi) | 1.27 |
| Clo-TAP (Bupi + Clon) | 0.74 |
7 reviews available for clonidine and Cardiovascular Pregnancy Complications
| Article | Year |
|---|---|
The management of hypertension in pregnancy: A review.
Topics: Acute Disease; Adrenergic beta-Antagonists; Anesthesia, Epidural; Anesthesia, Obstetrical; Anticoagu | 1980 |
Hypertension in pregnancy. Pathophysiology and management.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Calcium Channel Blockers; Captopril; Clon | 1984 |
Combined alpha- and beta-receptor inhibition in the treatment of hypertension.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia; Antihyp | 1984 |
Anti-hypertensive drugs in the pregnant patient.
Topics: Antihypertensive Agents; Chronic Disease; Clonidine; Diazoxide; Diuretics; Female; Fetus; Furosemide | 1980 |
The use of antihypertensive drugs in hypertension in pregnancy.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Clonidine; Diazoxide; Diuretic | 1977 |
Fetal effects of maternally administered clonidine and angiotensin-converting enzyme inhibitors.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Clonidine; Female; Fetus; Humans; Hypertension; Mat | 1989 |
Hypertension in pregnancy.
Topics: Adrenergic beta-Antagonists; Animals; Chronic Disease; Clonidine; Diuretics; Female; Humans; Hydrala | 1985 |
3 trials available for clonidine and Cardiovascular Pregnancy Complications
| Article | Year |
|---|---|
[Treatment of the hypertensive syndrome with hemiton and isobarin in certain diseases of pregnant women].
Topics: Blood Pressure; Clinical Trials as Topic; Clonidine; Drug Evaluation; Female; Guanethidine; Humans; | 1977 |
Early blood pressure control improves pregnancy outcome in primigravid women with mild hypertension.
Topics: Adult; Birth Weight; Blood Pressure; Clonidine; Double-Blind Method; Drug Administration Schedule; D | 1991 |
Clonidine hydrochloride--a safe and effective antihypertensive agent in pregnancy.
Topics: Adult; Apgar Score; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female | 1985 |
17 other studies available for clonidine and Cardiovascular Pregnancy Complications
| Article | Year |
|---|---|
Clonidine pharmacokinetics in pregnancy.
Topics: Adrenergic alpha-Agonists; Adult; Area Under Curve; Clonidine; Female; Half-Life; Humans; Hypertensi | 2009 |
[Antihypertensive therapy in pregnancy].
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Clonidine; Female; Humans; Hydralazine; Hydro | 1982 |
Errors in the measurement of blood pressure.
Topics: Blood Pressure Determination; Cardiac Catheterization; Clonidine; False Negative Reactions; Female; | 1983 |
Amniotic fluid norepinephrine concentration as an indicator of fetal sympathetic nervous activity. Effect of pregnancy complications.
Topics: Amniotic Fluid; Clonidine; Female; Humans; Hypertension; Kidney Diseases; Norepinephrine; Pregnancy; | 1984 |
[The effect of clonidine on cardiocirculatory function in the treatment of hypertension in pregnancy].
Topics: Adult; Clonidine; Female; Hemodynamics; Humans; Hypertension; Pregnancy; Pregnancy Complications, Ca | 1981 |
[The use of clofelin for the treatment of arterial hypertension and for the anesthesia of labor].
Topics: Adrenergic alpha-Agonists; Adult; Anesthesia, Obstetrical; Antihypertensive Agents; Clonidine; Cysti | 1997 |
Review: the significance and management of raised blood pressure in pregnancy.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Chlormethiazole; Clonidine; Diazepam; D | 1979 |
Withdrawal of clonidine.
Topics: Adult; Clonidine; Female; Humans; Hypertension; Male; Middle Aged; Pregnancy; Pregnancy Complication | 1977 |
Roberts's syndrome and clonidine.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Cleft Lip; Cleft Palate; Clonidine; Diazepam; | 1979 |
[The therapy of the hypertensive form of late gestosis (author's transl)].
Topics: Adult; Cardiac Output; Clonidine; Female; Humans; Hypertension; Placenta; Pre-Eclampsia; Pregnancy; | 1978 |
[The characteristics of treating hypertension with clofelin in pregnant women].
Topics: Adult; Clonidine; Discriminant Analysis; Drug Evaluation; Female; Hemodynamics; Humans; Hypertension | 1991 |
Raised levels of an endogenous nonadrenergic substance in the serum of pregnancy-induced hypertension patients.
Topics: Adult; Clonidine; Female; Humans; Hypertension; Parity; Placenta; Pre-Eclampsia; Pregnancy; Pregnanc | 1987 |
Is clonidine a behavioural teratogen in the human?
Topics: Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Clonidine; Dose-Response Rel | 1986 |
[Clonidine and treatment of arterial hypertension in the pregnant woman].
Topics: Adult; Clonidine; Female; Humans; Hypertension; Pregnancy; Pregnancy Complications, Cardiovascular | 1986 |
Pharmacokinetics of clonidine during pregnancy and nursing.
Topics: Amniotic Fluid; Breast Feeding; Clonidine; Female; Fetal Blood; Humans; Hypertension; Infant, Newbor | 1987 |
Clonidine in the treatment of hypertension during pregnancy.
Topics: Adult; Clonidine; Female; Fetal Death; Humans; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Com | 1985 |
Hypertension in pregnancy. A study of 142 women presenting before 32 weeks' gestation.
Topics: Antihypertensive Agents; Clonidine; Diazoxide; Female; Humans; Hydralazine; Hypertension; Infant Mor | 1985 |