clonidine and Cardiovascular Diseases

clonidine has been researched along with Cardiovascular Diseases in 22 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Research

Studies (22)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Change in Ambulatory Diastolic Blood Pressure

The change in diastolic blood pressure as measured by 24 hour ambulatory monitoring at 6 months as compared to from baseline. (NCT01628198)
Timeframe: baseline and 6 months

Mean Change in Ambulatory Systolic Blood Pressure

The change in systolic blood pressure as measured by 24 hour ambulatory monitoring at 6 months as compared to from baseline. (NCT01628198)
Timeframe: baseline and 6 months

Anti-hypertensive Medications

The total number of anti-hypertensive medications at baseline, 6 months, and 12 months (NCT01628198)
Timeframe: Baseline, 6 months, 12 months

Blood Urea Nitrogen

A blood urea nitrogen (BUN) test measures the amount of nitrogen in blood that comes from the waste product urea. Urea is made when protein is broken down in the body. Urea is made in the liver and passed out in the urine. (NCT01628198)
Timeframe: baseline, 6 months, 12 months

Creatinine

Creatinine measures the level of the waste product in the body. The amount of creatinine in the blood depends partly on the amount of muscle tissue you have. Men generally have higher creatinine levels than women.Normal levels of creatinine in the blood are approximately 0.6 to 1.2 milligrams (mg) per deciliter (dL) in adult males and 0.5 to 1.1 milligrams per deciliter in adult females. High levels of creatinine indicates kidney impairment. (NCT01628198)
Timeframe: baseline, 6 months, 12 months

Office Diastolic BP

Different time points office diastolic blood pressure measurements (NCT01628198)
Timeframe: baseline, 6 month, 12 months

Office Systolic BP

Different time points office systolic blood pressure measurements (NCT01628198)
Timeframe: baseline, 6 month, 12 months

Renal Aortic Ratio

Renal artery blood flow as measured by Renal Aortic Ratio (RAR) = Peak systolic Velocity renal artery / Peak Systolic Velocity Aorta. A >60% stenosis is reported when there is a >3.5:1 Renal to Aortic Ratio. (NCT01628198)
Timeframe: Baseline and 12 months

Renal Artery Dimensions

Dimensions of renal artery, right and left (NCT01628198)
Timeframe: baseline and 12 months

Resistive Index

Renal artery blood flow as measured by Resistive Index. RI = (peak systolic velocity - end diastolic velocity ) / peak systolic velocity. the normal value is ~ 0.60, with 0.70 being around the upper limits of normal (NCT01628198)
Timeframe: Baseline and 12 months

Change in Blood Pressure After Intrathecal Injection of Clonidine.

"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection

Changes in Visual Analogue Scale (VAS) Ratings of Sedation and Sensation of Dry Mouth Reported by the Subjects, Pre and 1 Hour Post Injection

Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.

Likert Scale Pain Rating

Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.

Reviews

14 reviews available for clonidine and Cardiovascular Diseases

Trials

3 trials available for clonidine and Cardiovascular Diseases

Other Studies

6 other studies available for clonidine and Cardiovascular Diseases