clonidine has been researched along with Cardiomegaly in 19 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " It was found that in a part of patients the long-term administration of antihypertensive drugs led to an increased accumulation of kynurenine as a manifestation of pyridoxal-5-phosphate deficiency." | 5.28 | Increased blood kynurenine level as a factor inhibiting the therapeutic effect of antihypertensive agents in combined long-term treatment of essential hypertension. ( Liepinja, DJ; Rudzite, VK; Silava, AK; Vitols, AV, 1990) |
| " On this basis, functional and therapeutical regimen of regression of cardiac hypertrophy (prazosin, clonidine, nifedipine) are analyzed in concentric as well as in excentric hypertrophy in patients with arterial hypertension." | 3.67 | [Progression and regression of heart hypertrophy in arterial hypertension: pathophysiology and clinical aspects]. ( Strauer, BE, 1985) |
| " Clonidine (6 mg of base/l of water) was given as drinking fluid to normotensive rats or rats with established or early hypertension." | 3.66 | Effect of chronic clonidine treatment and its abrupt cessation on mean blood pressure of rats with a normal or an elevated blood pressure. ( Atkinson, J; Boillat, N; Kirchertz, EJ; Pera-Bally, R; Peters-Haefeli, L, 1979) |
| " Twenty-one patients with concentric LVH (thickness of interventricular septum, IVS, and left posterior wall, LPW, above 11 mm) were given a 2D and M-mode echocardiogram before (pre) and 12 and 24 weeks, respectively, after therapy was initiated (mean oral cl dosage 150 micrograms; nf, 30 mg/day)." | 2.66 | Effects of clonidine and nifedipine on left ventricular hypertrophy and muscle mass in hypertensive patients. ( Brückner, S; Kleine, P; Meissner, E; von Bruchhausen, V, 1987) |
| "Pretreatment with efaroxan (a selective I(1)-imidazoline receptor antagonist) or rauwolscine (a selective alpha(2)-adrenoceptor antagonist) inhibited the moxonidine-induced increases in ANP secretion and interstitial ANP concentration and decrease in pulse pressure." | 1.32 | Augmentation of moxonidine-induced increase in ANP release by atrial hypertrophy. ( Cao, C; Kang, CW; Kim, SH; Kim, SZ, 2004) |
| " It was found that in a part of patients the long-term administration of antihypertensive drugs led to an increased accumulation of kynurenine as a manifestation of pyridoxal-5-phosphate deficiency." | 1.28 | Increased blood kynurenine level as a factor inhibiting the therapeutic effect of antihypertensive agents in combined long-term treatment of essential hypertension. ( Liepinja, DJ; Rudzite, VK; Silava, AK; Vitols, AV, 1990) |
| " Chronic administration of propranolol to SHR for three consecutive weeks by Alzet minipump reduced systolic arterial pressure but did not reverse the indices of myocardial hypertrophy." | 1.26 | Effect of chronic administration of clonidine and propranolol on the myocardium of spontaneously hypertensive rats. ( Greenberg, S; Wilborn, WM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (68.42) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thomas, L | 1 |
| Gasser, B | 1 |
| Bousquet, P | 1 |
| Monassier, L | 1 |
| Cao, C | 1 |
| Kang, CW | 1 |
| Kim, SZ | 1 |
| Kim, SH | 1 |
| Menard, J | 1 |
| Michel, JB | 1 |
| Dussaule, JC | 1 |
| Alhenc-Gelas, F | 1 |
| Corvol, P | 1 |
| Motz, W | 3 |
| Ippisch, R | 1 |
| Strauer, BE | 4 |
| Ricciardelli, B | 1 |
| De Luca, N | 1 |
| Volpe, M | 1 |
| Veniero, AM | 1 |
| De Simone, A | 1 |
| Cuocolo, A | 1 |
| Rosiello, G | 1 |
| Trimarco, B | 1 |
| Condorelli, M | 1 |
| Ishise, S | 2 |
| Pegram, BL | 2 |
| Frohlich, ED | 2 |
| Greenberg, S | 1 |
| Wilborn, WM | 1 |
| Fazio, S | 1 |
| Sabatini, D | 1 |
| Cittadini, A | 1 |
| Santomauro, M | 1 |
| Merola, B | 1 |
| Biondi, B | 1 |
| Colao, A | 1 |
| Lombardi, G | 1 |
| Saccà, L | 1 |
| Satia, MC | 1 |
| Damani, RR | 1 |
| Goyal, RK | 1 |
| Mier, K | 1 |
| Kemken, D | 1 |
| Katus, HA | 1 |
| Richardt, G | 1 |
| Kurz, T | 1 |
| Atkinson, J | 1 |
| Boillat, N | 1 |
| Pera-Bally, R | 1 |
| Peters-Haefeli, L | 1 |
| Kirchertz, EJ | 1 |
| Rudzite, VK | 1 |
| Vitols, AV | 1 |
| Liepinja, DJ | 1 |
| Silava, AK | 1 |
| Ferder, L | 1 |
| Inserra, F | 1 |
| Medina, F | 1 |
| Timio, M | 1 |
| Venanzi, S | 1 |
| Gentili, S | 1 |
| Ronconi, M | 1 |
| Del Re, G | 1 |
| Del Vita, M | 1 |
| Kleine, P | 1 |
| Meissner, E | 1 |
| von Bruchhausen, V | 1 |
| Brückner, S | 1 |
| Klepzig, M | 1 |
1 trial available for clonidine and Cardiomegaly
| Article | Year |
|---|---|
Effects of clonidine and nifedipine on left ventricular hypertrophy and muscle mass in hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Cardiomegaly; Clonidine; Echocardiography; Female; Heart; Heart Rate; H | 1987 |
18 other studies available for clonidine and Cardiomegaly
| Article | Year |
|---|---|
Hemodynamic and cardiac anti-hypertrophic actions of clonidine in Goldblatt one-kidney, one-clip rats.
Topics: Animals; Antihypertensive Agents; Cardiomegaly; Clonidine; Hemodynamics; Hypertension, Renovascular; | 2003 |
Augmentation of moxonidine-induced increase in ANP release by atrial hypertrophy.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Atrial Fu | 2004 |
Potentials and limitations of angiotensin converting enzyme inhibition in the treatment of hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Cardiomegaly; Clonidine; | 1984 |
The role of clonidine in hypertensive heart disease. Influence on myocardial contractility and left ventricular afterload.
Topics: Animals; Blood Pressure; Cardiomegaly; Clonidine; Dose-Response Relationship, Drug; Hypertension; Ma | 1983 |
[Effects of long-term treatment with various antihypertensive drugs on the cardiac mass and on the hemodynamics of patients with essential arterial hypertension].
Topics: Adult; Cardiac Output; Cardiomegaly; Clonidine; Echocardiography; Heart; Humans; Hypertension; Methy | 1983 |
Disparate effects of methyldopa and clonidine on cardiac mass and haemodynamics in rats.
Topics: Animals; Body Weight; Cardiomegaly; Clonidine; Hemodynamics; Hypertension; Methyldopa; Myocardium; O | 1980 |
Effect of methyldopa, clonidine, and hydralazine on cardiac mass and haemodynamics in Wistar Kyoto and spontaneously hypertensive rats.
Topics: Animals; Cardiomegaly; Clonidine; Heart; Hemodynamics; Hydralazine; Hypertension; Methyldopa; Organ | 1982 |
Effect of chronic administration of clonidine and propranolol on the myocardium of spontaneously hypertensive rats.
Topics: Animals; Body Water; Cardiomegaly; Clonidine; Glycosaminoglycans; Heart; Hypertension; Muscle Protei | 1982 |
[Cardiac effects of GH].
Topics: Acromegaly; Adult; Cardiomegaly; Clonidine; Echocardiography, Doppler; Female; Growth Hormone; Growt | 1993 |
Beneficial effects of clonidine in streptozotocin-induced diabetes and DOCA-hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cardiomegaly; Clonidine; Desoxycorticosterone; D | 1997 |
Adrenergic activation of cardiac phospholipase D: role of alpha(1)-adrenoceptor subtypes.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; Clonidine; Dioxane | 2002 |
Effect of chronic clonidine treatment and its abrupt cessation on mean blood pressure of rats with a normal or an elevated blood pressure.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Clonidine; Female; Hypertension; Kidney; Organ S | 1979 |
Increased blood kynurenine level as a factor inhibiting the therapeutic effect of antihypertensive agents in combined long-term treatment of essential hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cardiac Volume; Cardiomegaly; Clonidine; Drug Therap | 1990 |
Safety aspects of long-term antihypertensive therapy (10 years) with clonidine.
Topics: Adult; Blood Pressure; Cardiomegaly; Cholesterol; Clonidine; Drug Therapy, Combination; Electrocardi | 1987 |
Reversal of left ventricular hypertrophy after one-year treatment with clonidine: relationship between echocardiographic findings, blood pressure, and urinary catecholamines.
Topics: Adult; Blood Pressure; Cardiomegaly; Clonidine; Echocardiography; Epinephrine; Female; Follow-Up Stu | 1987 |
Regression of cardiac hypertrophy: experimental and clinical results.
Topics: Animals; Cardiomegaly; Clonidine; Enalapril; Humans; Hypertension; Nifedipine; Prazosin; Rats; Rats, | 1987 |
[What is safe in the therapy of hypertensive heart disease?].
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Animal | 1985 |
[Progression and regression of heart hypertrophy in arterial hypertension: pathophysiology and clinical aspects].
Topics: Blood Pressure; Cardiac Volume; Cardiomegaly; Cardiomyopathy, Hypertrophic; Clonidine; Coronary Circ | 1985 |