clonidine has been researched along with Cardiac Hypertrophy in 19 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| " It was found that in a part of patients the long-term administration of antihypertensive drugs led to an increased accumulation of kynurenine as a manifestation of pyridoxal-5-phosphate deficiency." | 5.28 | Increased blood kynurenine level as a factor inhibiting the therapeutic effect of antihypertensive agents in combined long-term treatment of essential hypertension. ( Liepinja, DJ; Rudzite, VK; Silava, AK; Vitols, AV, 1990) |
| " On this basis, functional and therapeutical regimen of regression of cardiac hypertrophy (prazosin, clonidine, nifedipine) are analyzed in concentric as well as in excentric hypertrophy in patients with arterial hypertension." | 3.67 | [Progression and regression of heart hypertrophy in arterial hypertension: pathophysiology and clinical aspects]. ( Strauer, BE, 1985) |
| " Clonidine (6 mg of base/l of water) was given as drinking fluid to normotensive rats or rats with established or early hypertension." | 3.66 | Effect of chronic clonidine treatment and its abrupt cessation on mean blood pressure of rats with a normal or an elevated blood pressure. ( Atkinson, J; Boillat, N; Kirchertz, EJ; Pera-Bally, R; Peters-Haefeli, L, 1979) |
| " Twenty-one patients with concentric LVH (thickness of interventricular septum, IVS, and left posterior wall, LPW, above 11 mm) were given a 2D and M-mode echocardiogram before (pre) and 12 and 24 weeks, respectively, after therapy was initiated (mean oral cl dosage 150 micrograms; nf, 30 mg/day)." | 2.66 | Effects of clonidine and nifedipine on left ventricular hypertrophy and muscle mass in hypertensive patients. ( Brückner, S; Kleine, P; Meissner, E; von Bruchhausen, V, 1987) |
| "Pretreatment with efaroxan (a selective I(1)-imidazoline receptor antagonist) or rauwolscine (a selective alpha(2)-adrenoceptor antagonist) inhibited the moxonidine-induced increases in ANP secretion and interstitial ANP concentration and decrease in pulse pressure." | 1.32 | Augmentation of moxonidine-induced increase in ANP release by atrial hypertrophy. ( Cao, C; Kang, CW; Kim, SH; Kim, SZ, 2004) |
| " It was found that in a part of patients the long-term administration of antihypertensive drugs led to an increased accumulation of kynurenine as a manifestation of pyridoxal-5-phosphate deficiency." | 1.28 | Increased blood kynurenine level as a factor inhibiting the therapeutic effect of antihypertensive agents in combined long-term treatment of essential hypertension. ( Liepinja, DJ; Rudzite, VK; Silava, AK; Vitols, AV, 1990) |
| " Chronic administration of propranolol to SHR for three consecutive weeks by Alzet minipump reduced systolic arterial pressure but did not reverse the indices of myocardial hypertrophy." | 1.26 | Effect of chronic administration of clonidine and propranolol on the myocardium of spontaneously hypertensive rats. ( Greenberg, S; Wilborn, WM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (68.42) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thomas, L | 1 |
| Gasser, B | 1 |
| Bousquet, P | 1 |
| Monassier, L | 1 |
| Cao, C | 1 |
| Kang, CW | 1 |
| Kim, SZ | 1 |
| Kim, SH | 1 |
| Menard, J | 1 |
| Michel, JB | 1 |
| Dussaule, JC | 1 |
| Alhenc-Gelas, F | 1 |
| Corvol, P | 1 |
| Motz, W | 3 |
| Ippisch, R | 1 |
| Strauer, BE | 4 |
| Ricciardelli, B | 1 |
| De Luca, N | 1 |
| Volpe, M | 1 |
| Veniero, AM | 1 |
| De Simone, A | 1 |
| Cuocolo, A | 1 |
| Rosiello, G | 1 |
| Trimarco, B | 1 |
| Condorelli, M | 1 |
| Ishise, S | 2 |
| Pegram, BL | 2 |
| Frohlich, ED | 2 |
| Greenberg, S | 1 |
| Wilborn, WM | 1 |
| Fazio, S | 1 |
| Sabatini, D | 1 |
| Cittadini, A | 1 |
| Santomauro, M | 1 |
| Merola, B | 1 |
| Biondi, B | 1 |
| Colao, A | 1 |
| Lombardi, G | 1 |
| Saccà, L | 1 |
| Satia, MC | 1 |
| Damani, RR | 1 |
| Goyal, RK | 1 |
| Mier, K | 1 |
| Kemken, D | 1 |
| Katus, HA | 1 |
| Richardt, G | 1 |
| Kurz, T | 1 |
| Atkinson, J | 1 |
| Boillat, N | 1 |
| Pera-Bally, R | 1 |
| Peters-Haefeli, L | 1 |
| Kirchertz, EJ | 1 |
| Rudzite, VK | 1 |
| Vitols, AV | 1 |
| Liepinja, DJ | 1 |
| Silava, AK | 1 |
| Ferder, L | 1 |
| Inserra, F | 1 |
| Medina, F | 1 |
| Timio, M | 1 |
| Venanzi, S | 1 |
| Gentili, S | 1 |
| Ronconi, M | 1 |
| Del Re, G | 1 |
| Del Vita, M | 1 |
| Kleine, P | 1 |
| Meissner, E | 1 |
| von Bruchhausen, V | 1 |
| Brückner, S | 1 |
| Klepzig, M | 1 |
1 trial available for clonidine and Cardiac Hypertrophy
| Article | Year |
|---|---|
Effects of clonidine and nifedipine on left ventricular hypertrophy and muscle mass in hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Cardiomegaly; Clonidine; Echocardiography; Female; Heart; Heart Rate; H | 1987 |
18 other studies available for clonidine and Cardiac Hypertrophy
| Article | Year |
|---|---|
Hemodynamic and cardiac anti-hypertrophic actions of clonidine in Goldblatt one-kidney, one-clip rats.
Topics: Animals; Antihypertensive Agents; Cardiomegaly; Clonidine; Hemodynamics; Hypertension, Renovascular; | 2003 |
Augmentation of moxonidine-induced increase in ANP release by atrial hypertrophy.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Atrial Fu | 2004 |
Potentials and limitations of angiotensin converting enzyme inhibition in the treatment of hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Cardiomegaly; Clonidine; | 1984 |
The role of clonidine in hypertensive heart disease. Influence on myocardial contractility and left ventricular afterload.
Topics: Animals; Blood Pressure; Cardiomegaly; Clonidine; Dose-Response Relationship, Drug; Hypertension; Ma | 1983 |
[Effects of long-term treatment with various antihypertensive drugs on the cardiac mass and on the hemodynamics of patients with essential arterial hypertension].
Topics: Adult; Cardiac Output; Cardiomegaly; Clonidine; Echocardiography; Heart; Humans; Hypertension; Methy | 1983 |
Disparate effects of methyldopa and clonidine on cardiac mass and haemodynamics in rats.
Topics: Animals; Body Weight; Cardiomegaly; Clonidine; Hemodynamics; Hypertension; Methyldopa; Myocardium; O | 1980 |
Effect of methyldopa, clonidine, and hydralazine on cardiac mass and haemodynamics in Wistar Kyoto and spontaneously hypertensive rats.
Topics: Animals; Cardiomegaly; Clonidine; Heart; Hemodynamics; Hydralazine; Hypertension; Methyldopa; Organ | 1982 |
Effect of chronic administration of clonidine and propranolol on the myocardium of spontaneously hypertensive rats.
Topics: Animals; Body Water; Cardiomegaly; Clonidine; Glycosaminoglycans; Heart; Hypertension; Muscle Protei | 1982 |
[Cardiac effects of GH].
Topics: Acromegaly; Adult; Cardiomegaly; Clonidine; Echocardiography, Doppler; Female; Growth Hormone; Growt | 1993 |
Beneficial effects of clonidine in streptozotocin-induced diabetes and DOCA-hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cardiomegaly; Clonidine; Desoxycorticosterone; D | 1997 |
Adrenergic activation of cardiac phospholipase D: role of alpha(1)-adrenoceptor subtypes.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; Clonidine; Dioxane | 2002 |
Effect of chronic clonidine treatment and its abrupt cessation on mean blood pressure of rats with a normal or an elevated blood pressure.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Clonidine; Female; Hypertension; Kidney; Organ S | 1979 |
Increased blood kynurenine level as a factor inhibiting the therapeutic effect of antihypertensive agents in combined long-term treatment of essential hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cardiac Volume; Cardiomegaly; Clonidine; Drug Therap | 1990 |
Safety aspects of long-term antihypertensive therapy (10 years) with clonidine.
Topics: Adult; Blood Pressure; Cardiomegaly; Cholesterol; Clonidine; Drug Therapy, Combination; Electrocardi | 1987 |
Reversal of left ventricular hypertrophy after one-year treatment with clonidine: relationship between echocardiographic findings, blood pressure, and urinary catecholamines.
Topics: Adult; Blood Pressure; Cardiomegaly; Clonidine; Echocardiography; Epinephrine; Female; Follow-Up Stu | 1987 |
Regression of cardiac hypertrophy: experimental and clinical results.
Topics: Animals; Cardiomegaly; Clonidine; Enalapril; Humans; Hypertension; Nifedipine; Prazosin; Rats; Rats, | 1987 |
[What is safe in the therapy of hypertensive heart disease?].
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Animal | 1985 |
[Progression and regression of heart hypertrophy in arterial hypertension: pathophysiology and clinical aspects].
Topics: Blood Pressure; Cardiac Volume; Cardiomegaly; Cardiomyopathy, Hypertrophic; Clonidine; Coronary Circ | 1985 |