Page last updated: 2024-10-25

clonidine and Cardiac Failure

clonidine has been researched along with Cardiac Failure in 59 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

ExcerptRelevanceReference
"This study examined the effects of low doses of intravenous clonidine on regional and global sympathetic nervous system activity in heart failure."9.10Regional sympathetic effects of low-dose clonidine in heart failure. ( Aggarwal, A; Esler, MD; Kaye, DM; Lambert, G; Morris, MJ, 2003)
"This randomized, double-blind, placebo-controlled study examines the effects of clonidine (a centrally acting sympathoinhibitor) on ventricular arrhythmias in 35 patients with congestive heart failure (CHF) by using the 24-h ambulatory electrocardiographic recording."9.08Suppressing sympathetic activation with clonidine on ventricular arrhythmias in congestive heart failure. ( Song, YC; Zhang, YH; Zhu, J, 1998)
"In this double-blind, placebo-controlled crossover study, we examined the effect of transdermal clonidine (given for 5 days) on autonomic control in 14 patients with mild to moderate congestive heart failure by heart rate variability analysis."9.08Sympathetic inhibition with clonidine improves autonomic balance in congestive heart failure. ( Jun, Z; Xian-qi, Y; You-cheng, S; You-hua, Z, 1997)
"The authors performed a randomized, double-blind, placebo-controlled trial to assess the tolerance and effects of chronic oral clonidine administration on the clinical status, exercise tolerance, and ventricular function of 10 male patients with chronic heart failure."9.06Acute and short-term effects of clonidine in heart failure. ( Giles, TD; Plauche, W; Quiroz, A; Rice, JC; Sander, GE; Thomas, MG, 1987)
"The case of a 59-year-old healthy woman is described, who developed an extreme sinus bradycardia (30/min) with chest pain and acute right heart failure associated with gastrointestinal symptoms and elevation of the liver enzymes while simultaneously taking tizanidine (Sirdalud), diclofenac (Voltaren), and rofecoxib (Vioxx)."7.73[Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)]. ( Bertoli, R; Caduff Janosa, P; Cerny, A; Kick, A; Moschovitis, G, 2005)
"In this patient with preoperative heart failure, clonidine was effective to treat bupivacaine induced conduction disturbances."7.72Successful resuscitation of serious bupivacaine intoxication in a patient with pre-existing heart failure. ( Allanic, L; Da Conceiçao, M; Fassassi, M; Favier, JC; Pitti, R; Steiner, T, 2003)
"We studied the effects of clonidine on cardiac sympathetic activity and left ventricular function in patients with congestive heart failure (CHF)."7.70Cardiac and systemic sympathetic activity in response to clonidine in human heart failure. ( Azevedo, ER; Newton, GE; Parker, JD, 1999)
"To determine whether alpha2-adrenergic-mediated sympathoinhibition was altered in chronic heart failure, sympathoinhibitory sensitivity was assessed using the alpha2-adrenergic agonist clonidine in 7 patients with heart failure and in 10 healthy control subjects."7.69Sympathoinhibitory response to clonidine is blunted in patients with heart failure. ( Belas, FJ; Blair, IA; He, HB; Lang, CC; Nelson, RA; Stein, CM; Wood, AJ; Wood, M, 1997)
"This study examined the interaction of chloroethylclonidine with alpha-adrenoceptor agonists in canine endothelium-denuded dorsal pedal artery and saphenous vein before (non-paced) and at end-stage heart failure which was induced by rapid ventricular pacing (250 bpm for no more than four weeks)."7.69Chloroethylclonidine and alpha-adrenoceptor agonist interaction in blood vessels following heart failure. ( Forster, C; Le Tran, Y, 1997)
" To study the influence of a specific sinus node inhibitor on myocardial function, alinidine was given to 10 patients with chronic congestive heart failure and stable sinus rhythm."7.68Hemodynamic effects of alinidine (ST 567) at rest and during exercise in patients with chronic congestive heart failure. ( Henze, E; Koenig, W; Stauch, M; Sund, M; Wanjura, D, 1990)
"The differential effects of the alpha-2 adrenergic agonist, clonidine, on blood pressure, renal sympathetic nerve activity (RSNA) and renal responses were investigated in conscious as well as anesthetized congestive heart failure (CHF) rats and normal control animals."7.68Effects of clonidine on renal sympathetic nerve activity, natriuresis and diuresis in chronic congestive heart failure rats. ( Carlsson, S; Feng, QP; Hedner, T; Thorén, P, 1992)
"Clonidine withdrawal syndrome is described in a patient with heart failure and suspected cardiogenic shock."7.67Clonidine withdrawal syndrome in a patient with heart failure. ( Donker, AJ; van der Geest, S; van Dijk, RB, 1985)
"The effects of intravenous (IV) clonidine (150 micrograms) on the isolated forearm venous segment of ten patients with heart failure were studied."7.66The effect of intravenous clonidine hydrochloride on the isolated forearm venous segment in heart failure. ( Eilen, SD; Giles, TD; Quiroz, AC; Sander, GE, 1983)
"Fourteen patients with moderately severe congestive heart failure (CHF) were given clonidine orally (0."7.66Clonidine in congestive heart failure: a vasodilator with negative inotropic effects. ( Hermiller, JB; Leier, CV; Leithe, ME; Magorien, RD; Unverferth, DV, 1983)
"After intravenous bolus injections of clonidine HCl (150 micrograms) to 12 patients with congestive heart failure, peak effects appeared in 5 to 20 min."7.66Short-term effects of intravenous clonidine in congestive heart failure. ( Dillenkoffer, RL; Giles, TD; Iteld, BJ; Mautner, RK; Rognoni, PA, 1981)
"Thus, in congestive heart failure patients who are undergoing conventional drug treatment, chronic clonidine administration exerts marked sympathoinhibitory effects without adversely affecting cardiac functions and clinical state."6.70Effects of chronic clonidine administration on sympathetic nerve traffic and baroreflex function in heart failure. ( Bertinieri, G; Grassi, G; Mancia, G; Pierini, A; Seravalle, G; Turri, C, 2001)
" ITC was delivered locally via catheter to the T2-T4 spinal segments and was dosed to reduce heart rate (HR) by >20% to 25%."5.33Intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine postinfarction heart failure model. ( Groh, WJ; Hildebrand, KR; Issa, ZF; Miller, JM; Rosenberger, J; Ujhelyi, MR; Zhou, X; Zipes, DP, 2005)
"In patients with congestive heart failure, abnormal heart rate variability is a predictor of total mortality and sudden cardiac death."5.30Effect of clonidine on heart rate variability in congestive heart failure. ( Castellanos, A; Chakko, S; de Marchena, E; Diaz, P; Girgis, I; Jara, C; Myerburg, RJ, 1998)
"This study examined the effects of low doses of intravenous clonidine on regional and global sympathetic nervous system activity in heart failure."5.10Regional sympathetic effects of low-dose clonidine in heart failure. ( Aggarwal, A; Esler, MD; Kaye, DM; Lambert, G; Morris, MJ, 2003)
"In this double-blind, placebo-controlled crossover study, we examined the effect of transdermal clonidine (given for 5 days) on autonomic control in 14 patients with mild to moderate congestive heart failure by heart rate variability analysis."5.08Sympathetic inhibition with clonidine improves autonomic balance in congestive heart failure. ( Jun, Z; Xian-qi, Y; You-cheng, S; You-hua, Z, 1997)
"This randomized, double-blind, placebo-controlled study examines the effects of clonidine (a centrally acting sympathoinhibitor) on ventricular arrhythmias in 35 patients with congestive heart failure (CHF) by using the 24-h ambulatory electrocardiographic recording."5.08Suppressing sympathetic activation with clonidine on ventricular arrhythmias in congestive heart failure. ( Song, YC; Zhang, YH; Zhu, J, 1998)
"The authors performed a randomized, double-blind, placebo-controlled trial to assess the tolerance and effects of chronic oral clonidine administration on the clinical status, exercise tolerance, and ventricular function of 10 male patients with chronic heart failure."5.06Acute and short-term effects of clonidine in heart failure. ( Giles, TD; Plauche, W; Quiroz, A; Rice, JC; Sander, GE; Thomas, MG, 1987)
"The effects of prazosin, clonidine, and indoramin on central and regional hemodynamic parameters and left ventricular performance were analyzed in a congestive heart failure population to compare the pharmacodynamic responses to different levels of alpha-adrenergic interruption in this condition."5.06Hemodynamic responses to different levels of alpha-adrenergic interruption in congestive heart failure. ( Good, AP; Leier, CV; Unverferth, DV, 1988)
" It has also been used intravenously in phaeochromocytoma, tetanus, clonidine withdrawal, and as an adjunct to halothane to produce hypotensive anaesthesia."4.76Combined alpha- and beta-receptor inhibition in the treatment of hypertension. ( Prichard, BN, 1984)
"The case of a 59-year-old healthy woman is described, who developed an extreme sinus bradycardia (30/min) with chest pain and acute right heart failure associated with gastrointestinal symptoms and elevation of the liver enzymes while simultaneously taking tizanidine (Sirdalud), diclofenac (Voltaren), and rofecoxib (Vioxx)."3.73[Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)]. ( Bertoli, R; Caduff Janosa, P; Cerny, A; Kick, A; Moschovitis, G, 2005)
"In this patient with preoperative heart failure, clonidine was effective to treat bupivacaine induced conduction disturbances."3.72Successful resuscitation of serious bupivacaine intoxication in a patient with pre-existing heart failure. ( Allanic, L; Da Conceiçao, M; Fassassi, M; Favier, JC; Pitti, R; Steiner, T, 2003)
" Clonidine, an imidazoline and adrenergic agonist with high selectivity for the alpha-2 adrenoceptor, has been shown to reduce generalized sympathetic activity in heart failure after parenteral administration."3.71Evidence for functional presynaptic alpha-2 adrenoceptors and their down-regulation in human heart failure. ( Aggarwal, A; Esler, MD; Kaye, DM; Socratous, F, 2001)
"Previous short-term studies demonstrated that treatment with clonidine produced significant hemodynamic improvement in patients with congestive heart failure (CHF)."3.70Chronic sympathetic suppression in the treatment of chronic congestive heart failure. ( Argirakis, S; Gavras, H; Gavras, I; Handanis, S; Katsaros, C; Manolis, AJ; Olympios, C; Sifaki, M; Smirnioudis, N, 1998)
"We studied the effects of clonidine on cardiac sympathetic activity and left ventricular function in patients with congestive heart failure (CHF)."3.70Cardiac and systemic sympathetic activity in response to clonidine in human heart failure. ( Azevedo, ER; Newton, GE; Parker, JD, 1999)
"This study examined the interaction of chloroethylclonidine with alpha-adrenoceptor agonists in canine endothelium-denuded dorsal pedal artery and saphenous vein before (non-paced) and at end-stage heart failure which was induced by rapid ventricular pacing (250 bpm for no more than four weeks)."3.69Chloroethylclonidine and alpha-adrenoceptor agonist interaction in blood vessels following heart failure. ( Forster, C; Le Tran, Y, 1997)
"To determine whether alpha2-adrenergic-mediated sympathoinhibition was altered in chronic heart failure, sympathoinhibitory sensitivity was assessed using the alpha2-adrenergic agonist clonidine in 7 patients with heart failure and in 10 healthy control subjects."3.69Sympathoinhibitory response to clonidine is blunted in patients with heart failure. ( Belas, FJ; Blair, IA; He, HB; Lang, CC; Nelson, RA; Stein, CM; Wood, AJ; Wood, M, 1997)
"The differential effects of the alpha-2 adrenergic agonist, clonidine, on blood pressure, renal sympathetic nerve activity (RSNA) and renal responses were investigated in conscious as well as anesthetized congestive heart failure (CHF) rats and normal control animals."3.68Effects of clonidine on renal sympathetic nerve activity, natriuresis and diuresis in chronic congestive heart failure rats. ( Carlsson, S; Feng, QP; Hedner, T; Thorén, P, 1992)
" To study the influence of a specific sinus node inhibitor on myocardial function, alinidine was given to 10 patients with chronic congestive heart failure and stable sinus rhythm."3.68Hemodynamic effects of alinidine (ST 567) at rest and during exercise in patients with chronic congestive heart failure. ( Henze, E; Koenig, W; Stauch, M; Sund, M; Wanjura, D, 1990)
" On this basis, functional and therapeutical regimen of regression of cardiac hypertrophy (prazosin, clonidine, nifedipine) are analyzed in concentric as well as in excentric hypertrophy in patients with arterial hypertension."3.67[Progression and regression of heart hypertrophy in arterial hypertension: pathophysiology and clinical aspects]. ( Strauer, BE, 1985)
"Clonidine withdrawal syndrome is described in a patient with heart failure and suspected cardiogenic shock."3.67Clonidine withdrawal syndrome in a patient with heart failure. ( Donker, AJ; van der Geest, S; van Dijk, RB, 1985)
"After intravenous bolus injections of clonidine HCl (150 micrograms) to 12 patients with congestive heart failure, peak effects appeared in 5 to 20 min."3.66Short-term effects of intravenous clonidine in congestive heart failure. ( Dillenkoffer, RL; Giles, TD; Iteld, BJ; Mautner, RK; Rognoni, PA, 1981)
"Fourteen patients with moderately severe congestive heart failure (CHF) were given clonidine orally (0."3.66Clonidine in congestive heart failure: a vasodilator with negative inotropic effects. ( Hermiller, JB; Leier, CV; Leithe, ME; Magorien, RD; Unverferth, DV, 1983)
"The effects of intravenous (IV) clonidine (150 micrograms) on the isolated forearm venous segment of ten patients with heart failure were studied."3.66The effect of intravenous clonidine hydrochloride on the isolated forearm venous segment in heart failure. ( Eilen, SD; Giles, TD; Quiroz, AC; Sander, GE, 1983)
"Thus, in congestive heart failure patients who are undergoing conventional drug treatment, chronic clonidine administration exerts marked sympathoinhibitory effects without adversely affecting cardiac functions and clinical state."2.70Effects of chronic clonidine administration on sympathetic nerve traffic and baroreflex function in heart failure. ( Bertinieri, G; Grassi, G; Mancia, G; Pierini, A; Seravalle, G; Turri, C, 2001)
" In this situation, alpha 2-agonists reduce sympathetic activity and improve hemodynamic parameters of cardiac function; both acute and chronic administration of alpha 2-AR have been demonstrated to reduce serum catecholamine levels, heart rate, and arterial blood pressure, and to improve exercise performance."2.66Alpha-adrenergic mechanisms in the pathophysiology of left ventricular heart failure--an analysis of their role in systolic and diastolic dysfunction. ( Giles, TD; Quiroz, AC; Sander, GE; Thomas, MG, 1986)
"Congestive heart failure is a complex clinical syndrome characterized by striking abnormalities of the autonomic nervous system."2.37The autonomic nervous system in congestive heart failure. ( Cohn, JN; Francis, GS, 1986)
" ITC was delivered locally via catheter to the T2-T4 spinal segments and was dosed to reduce heart rate (HR) by >20% to 25%."1.33Intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine postinfarction heart failure model. ( Groh, WJ; Hildebrand, KR; Issa, ZF; Miller, JM; Rosenberger, J; Ujhelyi, MR; Zhou, X; Zipes, DP, 2005)
"Clonidine is a valuable adjunct for conscious sedation and can be used safely for sympathicolysis, even in patients with aortic stenosis."1.31Difficult airway management in a patient with severe aortic stenosis, coronary artery disease, and heart failure. ( Kulka, PJ; Tryba, M; Zenz, M, 2002)
"In patients with congestive heart failure, abnormal heart rate variability is a predictor of total mortality and sudden cardiac death."1.30Effect of clonidine on heart rate variability in congestive heart failure. ( Castellanos, A; Chakko, S; de Marchena, E; Diaz, P; Girgis, I; Jara, C; Myerburg, RJ, 1998)
"Heart failure was induced in Sprague-Dawley rats by coronary artery ligation."1.30Decreased responsiveness of vascular postjunctional alpha1-, alpha2-adrenoceptors and neuropeptide Y1 receptors in rats with heart failure. ( Edvinsson, L; Feng, Q; Hedner, T; Lu, X; Sun, X, 1999)
" The dose-response curve in CHF was shifted to the right with a pD2 value of 5."1.29Vascular alpha-2 adrenoceptor function is decreased in rats with congestive heart failure. ( Bergdahl, A; Edvinsson, L; Feng, QP; Hedner, T; Lu, XR; Sun, XY, 1996)
"Patients with chronic congestive heart failure (CHF) are known to have elevated plasma concentrations of norepinephrine."1.27Platelet alpha 2 adrenoreceptors in chronic congestive heart failure. ( Smith, CB; Tobes, M; Weiss, RJ; Wertz, CE, 1983)

Research

Studies (59)

TimeframeStudies, this research(%)All Research%
pre-199026 (44.07)18.7374
1990's20 (33.90)18.2507
2000's11 (18.64)29.6817
2010's2 (3.39)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Middlekauff, HR1
Verity, MA1
Horwich, TB1
Fonarow, GC1
Hamilton, MA1
Shieh, P1
Moorman, AJ1
Stratton, JR1
Levy, WC1
Lechin, F1
Lechin, M1
van der Dijs, B1
Favier, JC1
Da Conceiçao, M1
Fassassi, M1
Allanic, L1
Steiner, T1
Pitti, R1
Aggarwal, A2
Esler, MD2
Morris, MJ1
Lambert, G1
Kaye, DM2
Detsky, ME1
Azevedo, ER2
Parker, JD2
Kick, A1
Bertoli, R1
Moschovitis, G1
Caduff Janosa, P1
Cerny, A1
Issa, ZF1
Ujhelyi, MR1
Hildebrand, KR1
Zhou, X1
Rosenberger, J1
Groh, WJ1
Miller, JM1
Zipes, DP1
Houston, MC1
Koller, H1
Prager, H1
Prichard, BN1
Opie, LH1
Weiss, RJ1
Tobes, M1
Wertz, CE1
Smith, CB1
Hayduk, K1
Brandt, D2
Akhmedkhanov, SSh2
Pomerantsev, VP1
Vasiuk, IuA2
Quiroz, AC2
Eilen, SD1
Sander, GE3
Giles, TD5
Hermiller, JB1
Magorien, RD2
Leithe, ME1
Unverferth, DV3
Leier, CV3
Iteld, BJ1
Mautner, RK1
Rognoni, PA1
Dillenkoffer, RL1
Manolis, AJ3
Olympios, C3
Sifaki, M3
Handanis, S3
Bresnahan, M2
Gavras, I3
Gavras, H3
Sacchetti, A1
McCabe, J1
Torres, M1
Harris, RL1
Rabinovitch, MA1
Rose, CP1
Schwab, AJ1
Fitchett, DH1
Honos, GN1
Stewart, JA1
Chen, LF1
Castilla, EP1
Gomez, AA1
Abrahamowicz, M1
Feng, QP4
Bergdahl, A1
Lu, XR1
Sun, XY1
Edvinsson, L2
Hedner, T5
Cokkinos, D1
Nishikawa, T1
You-hua, Z1
You-cheng, S1
Jun, Z1
Xian-qi, Y1
Lang, CC1
Stein, CM1
Nelson, RA1
He, HB1
Belas, FJ1
Blair, IA1
Wood, M1
Wood, AJ1
Le Tran, Y1
Forster, C1
Girgis, I1
Chakko, S1
de Marchena, E1
Jara, C1
Diaz, P1
Castellanos, A1
Myerburg, RJ1
Zhang, YH1
Zhu, J1
Song, YC1
Smirnioudis, N1
Argirakis, S1
Katsaros, C1
Newton, GE1
Feng, Q1
Sun, X1
Lu, X1
Coats, AJ1
Zhang, Y1
Cheng, Z1
Socratous, F1
Grassi, G1
Turri, C1
Seravalle, G1
Bertinieri, G1
Pierini, A1
Mancia, G1
Kulka, PJ1
Tryba, M1
Zenz, M1
Sterz, H1
Enenkel, W1
Ban, M1
Matsuno, T1
Ogawa, K1
Satake, T1
Carlsson, S2
Thorén, P2
Hedner, J1
Pettersson, A1
Manmontri, A1
MacLeod, SM1
Koenig, W1
Stauch, M1
Sund, M1
Wanjura, D1
Henze, E1
Motz, W1
Strauer, BE2
Urbaszek, W1
Graf, B1
Francis, GS1
Cohn, JN1
Thomas, MG2
Good, AP1
Yin, HQ1
Chen, DG1
Shen, BR1
Wang, RM1
Liu, YL1
Quiroz, A1
Rice, JC1
Plauche, W1
Ren, JH1
van der Geest, S1
van Dijk, RB1
Donker, AJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Clonidine and the Skeletal Myopathy of Heart Failure[NCT00858845]Phase 411 participants (Actual)Interventional2008-05-31Completed
Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System[NCT03109795]Phase 430 participants (Actual)Interventional2017-04-10Terminated (stopped due to Funding ended)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Citrate Synthase Activity as an Estimate of Mitochondrial Activity

(NCT00858845)
Timeframe: Baseline, 3 months

Interventionmicromole/min/wet weight (Mean)
Clonidine Patch-0.3
Placebo0.07

Change in Muscle Sympathetic Nerve Activity

Muscle sympathetic nerve activity was measured as bursts sympathetic nerve activity per minute. (NCT00858845)
Timeframe: Baseline, 3 months

Interventionbursts/min (Mean)
Clonidine Patch-4.3
Placebo4.4

Change in Proportion of Type 1 Fibers

Fibers were typed as I or II according to presence of myosin heavy chain. (NCT00858845)
Timeframe: Baseline, 3 months

Interventionpercentage of fibers (Mean)
Clonidine Patch-4.6
Placebo-5.6

Reviews

8 reviews available for clonidine and Cardiac Failure

ArticleYear
Abrupt cessation of treatment in hypertension: consideration of clinical features, mechanisms, prevention and management of the discontinuation syndrome.
    American heart journal, 1981, Volume: 102, Issue:3 Pt 1

    Topics: Acute Disease; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Bethanidine; Blood Pressure; Cloni

1981
Combined alpha- and beta-receptor inhibition in the treatment of hypertension.
    Drugs, 1984, Volume: 28 Suppl 2

    Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia; Antihyp

1984
[Therapy of hypertensive crisis].
    Wiener medizinische Wochenschrift (1946), 1980, May-31, Volume: 130, Issue:10

    Topics: Acute Disease; Bed Rest; Cardiac Glycosides; Clonidine; Diazoxide; Dihydralazine; Diuretics; Heart F

1980
[Preoperative evaluation of patients with heart dysfunction and preanesthetic medication].
    Masui. The Japanese journal of anesthesiology, 1996, Volume: 45 Suppl

    Topics: Adrenergic alpha-Agonists; Anesthesia, General; Clonidine; Coronary Disease; Heart Failure; Heart Fu

1996
[New aspects in the treatment of acute cardiac insufficiency].
    Wiener medizinische Wochenschrift (1946), 1978, May-15, Volume: 128, Issue:9

    Topics: Adrenergic beta-Antagonists; Clonidine; Diazoxide; Digitalis Glycosides; Diuretics; Droperidol; Fent

1978
[Cardiac therapy in the old patient].
    Wiener medizinische Wochenschrift (1946), 1979, Oct-10, Volume: 129, Issue:18

    Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Body Water; Calcium; Clonidine; Digitalis Glycos

1979
Centrally acting sympatholytic agents in the treatment of congestive heart failure. A review of the literature.
    Drugs, 1990, Volume: 40, Issue:2

    Topics: Bromocriptine; Clinical Trials as Topic; Clonidine; Guanabenz; Heart Failure; Humans; Methyldopa; Sy

1990
The autonomic nervous system in congestive heart failure.
    Annual review of medicine, 1986, Volume: 37

    Topics: Adrenergic beta-Antagonists; Alprazolam; Animals; Autonomic Nervous System; Benzodiazepines; Blood V

1986

Trials

11 trials available for clonidine and Cardiac Failure

ArticleYear
Intact skeletal muscle mitochondrial enzyme activity but diminished exercise capacity in advanced heart failure patients on optimal medical and device therapy.
    Clinical research in cardiology : official journal of the German Cardiac Society, 2013, Volume: 102, Issue:8

    Topics: Biopsy; Case-Control Studies; Clonidine; Double-Blind Method; Exercise Tolerance; Female; Heart Fail

2013
Clonidine therapy in patients with heart failure improves exercise efficiency, functional class and symptoms.
    International journal of cardiology, 2011, Aug-04, Volume: 150, Issue:3

    Topics: Antihypertensive Agents; Clonidine; Double-Blind Method; Exercise; Exercise Test; Heart Failure; Hum

2011
Regional sympathetic effects of low-dose clonidine in heart failure.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 41, Issue:3

    Topics: Aged; Brain; Clonidine; Dose-Response Relationship, Drug; Heart; Heart Failure; Hemodynamics; Humans

2003
Suppressing sympathetic activation in congestive heart failure. A new therapeutic strategy.
    Hypertension (Dallas, Tex. : 1979), 1995, Volume: 26, Issue:5

    Topics: Administration, Oral; Adult; Aged; Clonidine; Female; Heart Failure; Hemodynamics; Humans; Male; Mid

1995
Combined sympathetic suppression and angiotensin-converting enzyme inhibition in congestive heart failure.
    Hypertension (Dallas, Tex. : 1979), 1997, Volume: 29, Issue:1 Pt 2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Clonidine; Drug Therapy, Combination; Female; H

1997
Sympathetic inhibition with clonidine improves autonomic balance in congestive heart failure.
    International journal of cardiology, 1997, Apr-18, Volume: 59, Issue:2

    Topics: Administration, Cutaneous; Adrenergic Agonists; Adult; Aged; Autonomic Nervous System; Clonidine; Cr

1997
Suppressing sympathetic activation with clonidine on ventricular arrhythmias in congestive heart failure.
    International journal of cardiology, 1998, Volume: 65, Issue:3

    Topics: Adult; Aged; Cardiovascular Physiological Phenomena; Chi-Square Distribution; Clonidine; Double-Blin

1998
Effects of chronic clonidine administration on sympathetic nerve traffic and baroreflex function in heart failure.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:2

    Topics: Baroreflex; Blood Pressure; Clonidine; Double-Blind Method; Female; Heart Failure; Heart Rate; Human

2001
Alpha-adrenergic mechanisms in the pathophysiology of left ventricular heart failure--an analysis of their role in systolic and diastolic dysfunction.
    Journal of molecular and cellular cardiology, 1986, Volume: 18 Suppl 5

    Topics: Adrenergic alpha-Antagonists; Autonomic Nervous System; Central Nervous System; Clinical Trials as T

1986
Hemodynamic responses to different levels of alpha-adrenergic interruption in congestive heart failure.
    Cardiovascular drugs and therapy, 1988, Volume: 1, Issue:5

    Topics: Adrenergic alpha-Antagonists; Clonidine; Extremities; Female; Heart Failure; Hemodynamics; Humans; I

1988
Acute and short-term effects of clonidine in heart failure.
    Angiology, 1987, Volume: 38, Issue:7

    Topics: Administration, Oral; Adult; Aged; Blood Pressure; Chronic Disease; Clinical Trials as Topic; Clonid

1987

Other Studies

40 other studies available for clonidine and Cardiac Failure

ArticleYear
Plasma catecholamines and chronic congestive heart failure.
    Circulation, 2002, Dec-17, Volume: 106, Issue:25

    Topics: Adrenal Glands; Catecholamines; Chronic Disease; Clonidine; Diagnostic Techniques, Cardiovascular; D

2002
Successful resuscitation of serious bupivacaine intoxication in a patient with pre-existing heart failure.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Anesthetics, Local; Bupivacaine; Clonidine; Dob

2003
Left ventricular isovolumic relaxation is a predictor of left ventricular end-diastolic pressure.
    The Canadian journal of cardiology, 2003, Mar-31, Volume: 19, Issue:4

    Topics: Cardiac Catheterization; Clonidine; Diastole; Female; Heart Failure; Hemodynamics; Humans; Male; Mid

2003
[Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)].
    Medizinische Klinik (Munich, Germany : 1983), 2005, Apr-15, Volume: 100, Issue:4

    Topics: Acute Disease; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bradycardia; Clonidine; Cyclooxy

2005
Intrathecal clonidine reduces the incidence of ischemia-provoked ventricular arrhythmias in a canine postinfarction heart failure model.
    Heart rhythm, 2005, Volume: 2, Issue:10

    Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Disease Models, Animal; Dogs; Electro

2005
[The use of vasodilator agents in the therapy of chronic cardiac insufficiency].
    Wiener medizinische Wochenschrift (1946), 1982, Oct-15, Volume: 132, Issue:19

    Topics: Adrenergic alpha-Antagonists; Calcium Channel Blockers; Captopril; Clonidine; Diuretics; Heart Failu

1982
Principles of therapy for congestive heart failure.
    European heart journal, 1983, Volume: 4 Suppl A

    Topics: Calcium; Calcium Channel Blockers; Calmodulin; Cardiotonic Agents; Clonidine; Cyclic AMP; Cytosol; D

1983
Platelet alpha 2 adrenoreceptors in chronic congestive heart failure.
    The American journal of cardiology, 1983, Volume: 52, Issue:1

    Topics: Adult; Aged; Blood Platelets; Clonidine; Dopamine; Epinephrine; Female; Heart Failure; Humans; In Vi

1983
[Clonidine: new aspects of a known principle].
    MMW, Munchener medizinische Wochenschrift, 1983, May-20, Volume: 125, Issue:20

    Topics: Cardiovascular Diseases; Clonidine; Heart Failure; Humans; Hypertension

1983
[The hypertensive crisis].
    Wiener medizinische Wochenschrift (1946), 1984, Jul-31, Volume: 134, Issue:13-14

    Topics: Acute Disease; Calcium Channel Blockers; Clonidine; Coronary Disease; Diazoxide; Dihydralazine; Dilt

1984
[Effect of clophelin on the hemodynamics of patients with circulatory insufficiency].
    Sovetskaia meditsina, 1984, Issue:11

    Topics: Adult; Aged; Blood Pressure; Cardiac Output; Clonidine; Heart Failure; Hemodynamics; Humans; Middle

1984
The effect of intravenous clonidine hydrochloride on the isolated forearm venous segment in heart failure.
    Chest, 1983, Volume: 83, Issue:2 Suppl

    Topics: Adult; Aged; Clonidine; Forearm; Heart Failure; Humans; Middle Aged; Pulse; Vascular Resistance; Ven

1983
Clonidine in congestive heart failure: a vasodilator with negative inotropic effects.
    The American journal of cardiology, 1983, Mar-01, Volume: 51, Issue:5

    Topics: Adult; Aged; Blood Pressure; Cardiac Output; Clonidine; Depression, Chemical; Heart Failure; Heart R

1983
Short-term effects of intravenous clonidine in congestive heart failure.
    Clinical pharmacology and therapeutics, 1981, Volume: 30, Issue:6

    Topics: Adult; Aged; Blood Pressure; Cardiac Output; Clonidine; Female; Heart Failure; Heart Rate; Humans; I

1981
ED management of acute congestive heart failure in renal dialysis patients.
    The American journal of emergency medicine, 1993, Volume: 11, Issue:6

    Topics: Acute Disease; Administration, Cutaneous; Administration, Oral; Administration, Sublingual; Captopri

1993
A method of dynamic analysis of iodine-123-metaiodobenzylguanidine scintigrams in cardiac mechanical overload hypertrophy and failure.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1993, Volume: 34, Issue:4

    Topics: 3-Iodobenzylguanidine; Clonidine; Female; Heart; Heart Failure; Heart Transplantation; Humans; Hyper

1993
Clonidine and heart failure.
    Hypertension (Dallas, Tex. : 1979), 1996, Volume: 27, Issue:5

    Topics: Clonidine; Heart Failure; Humans; Sympatholytics

1996
Vascular alpha-2 adrenoceptor function is decreased in rats with congestive heart failure.
    Cardiovascular research, 1996, Volume: 31, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Clonidine; Dose-Response

1996
Sympathoinhibitory response to clonidine is blunted in patients with heart failure.
    Hypertension (Dallas, Tex. : 1979), 1997, Volume: 30, Issue:3 Pt 1

    Topics: Adrenergic alpha-Agonists; Aged; Clonidine; Heart Failure; Hemodynamics; Humans; Kinetics; Neural In

1997
Chloroethylclonidine and alpha-adrenoceptor agonist interaction in blood vessels following heart failure.
    European journal of pharmacology, 1997, Oct-08, Volume: 336, Issue:2-3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Dogs; Dose-Re

1997
Effect of clonidine on heart rate variability in congestive heart failure.
    The American journal of cardiology, 1998, Aug-01, Volume: 82, Issue:3

    Topics: Adrenergic alpha-Agonists; Blood Pressure; Chronic Disease; Clonidine; Death, Sudden, Cardiac; Elect

1998
Chronic sympathetic suppression in the treatment of chronic congestive heart failure.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 1998, Volume: 20, Issue:7

    Topics: Administration, Oral; Catecholamines; Chronic Disease; Clonidine; Echocardiography; Electrocardiogra

1998
Cardiac and systemic sympathetic activity in response to clonidine in human heart failure.
    Journal of the American College of Cardiology, 1999, Volume: 33, Issue:1

    Topics: Adrenergic alpha-Agonists; Cardiomyopathy, Dilated; Clonidine; Coronary Circulation; Dose-Response R

1999
Decreased responsiveness of vascular postjunctional alpha1-, alpha2-adrenoceptors and neuropeptide Y1 receptors in rats with heart failure.
    Acta physiologica Scandinavica, 1999, Volume: 166, Issue:4

    Topics: Adrenergic alpha-Agonists; Animals; Atrial Natriuretic Factor; Autonomic Fibers, Preganglionic; Azep

1999
Beta-blockers - again, a lesson to us all, especially the research funding community.
    International journal of cardiology, 2000, Apr-28, Volume: 73, Issue:2

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Clinical Trials as T

2000
Sympathetic inhibition with clonidine prolongs survival in experimental chronic heart failure.
    International journal of cardiology, 2000, Apr-28, Volume: 73, Issue:2

    Topics: Animals; Blood Pressure; Chronic Disease; Clonidine; Disease Models, Animal; Heart Failure; Heart Ra

2000
Evidence for functional presynaptic alpha-2 adrenoceptors and their down-regulation in human heart failure.
    Journal of the American College of Cardiology, 2001, Volume: 37, Issue:5

    Topics: Aged; Clonidine; Down-Regulation; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; No

2001
Difficult airway management in a patient with severe aortic stenosis, coronary artery disease, and heart failure.
    Journal of clinical anesthesia, 2002, Volume: 14, Issue:2

    Topics: Aortic Valve Stenosis; Clonidine; Conscious Sedation; Coronary Disease; Heart Failure; Hemodynamics;

2002
Plasma norepinephrine and dopamine-beta-hydroxylase activity in chronic renal failure.
    Japanese circulation journal, 1979, Volume: 43, Issue:7

    Topics: Adolescent; Adult; Aged; Blood Pressure; Clonidine; Dopamine beta-Hydroxylase; Epinephrine; Heart Fa

1979
Effects of clonidine on renal sympathetic nerve activity, natriuresis and diuresis in chronic congestive heart failure rats.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:3

    Topics: Animals; Atrial Natriuretic Factor; Chronic Disease; Clonidine; Diuresis; Epinephrine; Heart Failure

1992
Blunted renal response to atrial natriuretic peptide in congestive heart failure rats is reversed by the alpha 2-adrenergic agonist clonidine.
    Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:5

    Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Clonidine; Heart Failure; Heart Rate; Kidney; Ma

1990
Clonidine influences renal sympathetic nerve activity and renal function in experimental heart failure.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1991, Volume: 9, Issue:6

    Topics: Animals; Blood Pressure; Clonidine; Epinephrine; Heart Failure; Kidney; Norepinephrine; Rats; Rats,

1991
Hemodynamic effects of alinidine (ST 567) at rest and during exercise in patients with chronic congestive heart failure.
    American heart journal, 1990, Volume: 119, Issue:6

    Topics: Aged; Anti-Arrhythmia Agents; Blood Pressure; Chronic Disease; Clonidine; Exercise; Female; Heart Fa

1990
[What is safe in the therapy of hypertensive heart disease?].
    Der Internist, 1985, Volume: 26, Issue:12

    Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Animal

1985
[Therapy of chronic heart failure with vasodilators].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1986, Feb-01, Volume: 41, Issue:3

    Topics: Adrenergic beta-Agonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Captop

1986
[Progression and regression of heart hypertrophy in arterial hypertension: pathophysiology and clinical aspects].
    Zeitschrift fur Kardiologie, 1985, Volume: 74 Suppl 7

    Topics: Blood Pressure; Cardiac Volume; Cardiomegaly; Cardiomyopathy, Hypertrophic; Clonidine; Coronary Circ

1985
[Use of klofenil in heart failure].
    Sovetskaia meditsina, 1988, Issue:6

    Topics: Clonidine; Drug Evaluation; Heart Failure; Heart Function Tests; Hemodynamics; Humans; Injections, I

1988
[Hemodynamic effects of clonidine in patients with heart failure during exercise].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1988, Volume: 9, Issue:3

    Topics: Adult; Aged; Clonidine; Exercise; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged

1988
Postural influences on the hemodynamic responses to vasodilating drugs in congestive heart failure.
    Archives of internal medicine, 1985, Volume: 145, Issue:4

    Topics: Adult; Aged; Blood Pressure; Cardiac Output; Clonidine; Female; Heart Failure; Heart Rate; Hemodynam

1985
Clonidine withdrawal syndrome in a patient with heart failure.
    Critical care medicine, 1985, Volume: 13, Issue:5

    Topics: Aged; Blood Pressure; Clonidine; Female; Heart Failure; Heart Rate; Humans; Nitroprusside; Pulmonary

1985