Page last updated: 2024-10-25

clonidine and Carcinoma

clonidine has been researched along with Carcinoma in 4 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.

Research Excerpts

ExcerptRelevanceReference
"The present study was aimed to prepare nanoparticles of tizanidine hydrochloride using biodegradable polymers and loading them on orodispersible films to obtain a sustained release dissolution profile with improved permeability and further study the cytotoxicity on A549 lung carcinoma cells, MCF7 breast cancer cells, and HOP 92 non-small lung adenocarcinoma cells."4.12Development of Biocompatible Nanoparticles of Tizanidine Hydrochloride in Orodispersible Films: ( Dutt, R; Kaushik, D; Mittal, V; Pandey, P; Rahman, MH; Singh, S; Sinha, S; Thapa, S; Verma, R, 2022)
"alpha 2-adrenergic receptor-mediated signal transduction in rat adrenocortical carcinoma cells occurs through the opposing regulation of two second messengers, cyclic GMP and cyclic AMP, in which guanylate cyclase is coupled positively and adenylate cyclase negatively to the receptor signal."3.67Inhibition of alpha 2-adrenergic receptor-mediated cyclic GMP formation by a phorbol ester, a protein kinase C activator. ( Jaiswal, RK; Sharma, RK, 1988)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19903 (75.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Sinha, S1
Thapa, S1
Singh, S1
Dutt, R1
Verma, R1
Pandey, P1
Mittal, V1
Rahman, MH1
Kaushik, D1
Coombs, DW1
Saunders, RL1
Fratkin, JD1
Jensen, LE1
Murphy, CA1
Jaiswal, RK1
Sharma, RK1
Krames, ES1
Wilkie, DJ1
Gershow, J1

Other Studies

4 other studies available for clonidine and Carcinoma

ArticleYear
Development of Biocompatible Nanoparticles of Tizanidine Hydrochloride in Orodispersible Films:
    Current drug delivery, 2022, Volume: 19, Issue:10

    Topics: Animals; Biological Availability; Carcinoma; Clonidine; Drug Delivery Systems; Nanoparticles; Polyme

2022
Continuous intrathecal hydromorphone and clonidine for intractable cancer pain.
    Journal of neurosurgery, 1986, Volume: 64, Issue:6

    Topics: Carcinoma; Clonidine; Female; Humans; Hydromorphone; Injections, Spinal; Middle Aged; Pain, Intracta

1986
Inhibition of alpha 2-adrenergic receptor-mediated cyclic GMP formation by a phorbol ester, a protein kinase C activator.
    Biochemical and biophysical research communications, 1988, Oct-31, Volume: 156, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex Neoplasms; Animals; Carcinoma; Clonidi

1988
Intrathecal D-Ala2-D-Leu5-enkephalin (DADL) restores analgesia in a patient analgetically tolerant to intrathecal morphine sulfate.
    Pain, 1986, Volume: 24, Issue:2

    Topics: Aged; Carcinoma; Clonidine; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Huma

1986