clonidine has been researched along with Breakthrough Pain in 2 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Breakthrough Pain: Acute pain that comes on rapidly despite the use of pain medication.
| Excerpt | Relevance | Reference |
|---|---|---|
| "0625% with fentanyl 2 μg/mL at 12 mL/h, a patient-administered bolus of 5 mL at lockout 6-10 min and a maximum of four boluses per hour, and experiencing breakthrough pain ≥5/10, were randomized to receive a 10 mL bolus containing 12." | 9.34 | Comparative efficacy of epidural clonidine versus epidural fentanyl for treating breakthrough pain during labor: a randomized double-blind clinical trial. ( Goodman, S; Landau, R; Lavin, T; Lee, A; Menon, P; Smiley, R, 2020) |
| "0625% with fentanyl 2 μg/mL at 12 mL/h, a patient-administered bolus of 5 mL at lockout 6-10 min and a maximum of four boluses per hour, and experiencing breakthrough pain ≥5/10, were randomized to receive a 10 mL bolus containing 12." | 5.34 | Comparative efficacy of epidural clonidine versus epidural fentanyl for treating breakthrough pain during labor: a randomized double-blind clinical trial. ( Goodman, S; Landau, R; Lavin, T; Lee, A; Menon, P; Smiley, R, 2020) |
| "To evaluate the quality of analgesia with epidural neostigmine and clonidine, added to initial spinal analgesia, and to test the hypothesis that the incidence of breakthrough pain could be reduced and patient satisfaction improved." | 5.19 | Epidural neostigmine and clonidine improves the quality of combined spinal epidural analgesia in labour: a randomised, double-blind controlled trial. ( Boogmans, T; Devroe, S; Roofthooft, E; Valkenborgh, T; Van de Velde, M; Vertommen, J, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, A | 1 |
| Landau, R | 1 |
| Lavin, T | 1 |
| Goodman, S | 1 |
| Menon, P | 1 |
| Smiley, R | 1 |
| Boogmans, T | 1 |
| Vertommen, J | 1 |
| Valkenborgh, T | 1 |
| Devroe, S | 1 |
| Roofthooft, E | 1 |
| Van de Velde, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Double Blind Clinical Trial Comparing Programed Intermittent Epidural Boluses (PIEB) Versus Patient Controlled Epidural Analgesia (PCEA) With Epidural or Combined Spinal-epidural (CSE) Technique[NCT02768272] | Phase 4 | 240 participants (Actual) | Interventional | 2016-03-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for clonidine and Breakthrough Pain
| Article | Year |
|---|---|
Comparative efficacy of epidural clonidine versus epidural fentanyl for treating breakthrough pain during labor: a randomized double-blind clinical trial.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics; Analgesics, Opioid; Breakthrough Pai | 2020 |
Epidural neostigmine and clonidine improves the quality of combined spinal epidural analgesia in labour: a randomised, double-blind controlled trial.
Topics: Adult; Amides; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Anesthesi | 2014 |