clonidine and Brain Vascular Disorders studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

Excerpt	Relevance	Reference
"Thirty patients with old post-stroke spastic hemiparesis took part in the investigation."	1.29	Mechanisms of tizanidine action on spasticity. ( Georgiev, D; Milanov, I, 1994)
"On the spastic side a reflex with prolonged latencies and durations, as well as with decreased amplitudes and thresholds of both reflex responses was found."	1.28	Flexor reflex for assessment of common interneurone activity in spasticity. ( Milanov, IG, 1992)
"Treatment with clonidine significantly slowed the rate of recovery (Kruskal-Wallis H = 8."	1.28	Clonidine impairs recovery of beam-walking after a sensorimotor cortex lesion in the rat. ( Davis, JN; Goldstein, LB, 1990)
"It is hypothesized that enlargement of berry aneurysms, the progression of cerebral atherosclerosis, and embolism from carotid lesions might all be decreased by the selection of antihypertensive agents which decrease blood velocity."	1.26	Effects of antihypertensive drugs on blood velocity: implications for prevention of cerebral vascular disease. ( Spence, JD, 1977)

Research

Studies (21)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Amount of Morphine Given

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (52.38)	18.7374
1990's	9 (42.86)	18.2507
2000's	1 (4.76)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Zhang, Y	1
Yamada, S	1
Ishima, T	1
Hayashi, M	1
Tomita, T	1
Hayashi, E	1
Ram, CV	2
Eninia, GI	1
Smeltere, ES	1
Godlevska, MA	1
Uzulinia, IP	1
Zamotaev, IP	1
Abramova, VG	1
Stankovskaia, IM	1
Sattar, MA	1
Johns, EJ	1
Prattichizzo, FA	1
Galetta, F	1
Bonechi, I	1
Giusti, C	1
Milanov, I	1
Georgiev, D	1
Goldberg-Stern, H	1
Atlas, D	1
Schwartz, L	1
Achiron, A	1
Ziv, I	1
Djaldetti, R	1
Zoldan, Y	1
Melamed, E	1
Lockette, W	1
Kirkland, K	1
Farrow, S	1
Medvedev, OS	2
Kunduzova, OR	2
Murashev, AN	2
Medvedeva, NA	2
Spence, JD	1
Zweifler, AJ	1
Esler, M	1
Milanov, IG	1
Goldstein, LB	1
Davis, JN	1
Medici, M	1
Pebet, M	1
Ciblis, D	1
Meese, RB	1
Regli, F	1
Bauer, GE	2
Raftos, J	1
Lewis, RG	1
Stokes, GS	1
Mitchell, AS	1
Young, AA	1
Maclachlan, I	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Phase I-II Clinical Trial to Determine the Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia[NCT01862250]	Phase 1/Phase 2	13 participants (Actual)	Interventional	2013-10-03	Completed
Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment: Double Blinded Comparison Between Botulinum Toxin and Baclofen.[NCT02462317]	Phase 4	184 participants (Actual)	Interventional	2015-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intravenous morphine (mg/kg) was given. The standard dose is 0.05 mg/kg per dose (NCT01862250)
Timeframe: Up to 2 days

Presence of Shivering After Clonidine

Intervention	mg/kg (Median)
Clonidine Infants With HIE	0.02

Babies were assessed after administration of clonidine for the presence or absence of shivering. (NCT01862250)
Timeframe: 48hrs

Steady State Clonidine Blood Levels During Hypothermia

Intervention	Participants (Count of Participants)
Clonidine Infants With HIE	0

"Trough clonidine blood levels were measured after 4-7 doses of clonidine were given intravenously with a dosing interval of every 8 hrs. Mean and standard deviation (SD) of the number of doses given prior to levels being drawn was 5.3 (mean) and 0.37 (SD).~Time after last dose before measurement was 9hrs (mean) and 2.7hrs (SD)." (NCT01862250)
Timeframe: 3 days

Time to Passive Rewarming

Intervention	ng/ml (Median)
Clonidine Infants With HIE	0.6

Following 2 hours of therapeutic hypothermia, the temperature of the thermo-blanket is adjusted up half degree per hour allowing passive rewarming until 36.5 degrees is reached (NCT01862250)
Timeframe: Beginning at 72 hours up to 12 hours

Article	Year
Hypertensive crisis. Cardiology clinics, 1984, Volume: 2, Issue:2 Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia	1984
Hypertensive cardiovascular emergencies. Comprehensive therapy, 1985, Volume: 11, Issue:10 Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia	1985

Article	Year
A double-blind, long-term study of tizanidine ('Sirdalud') in spasticity due to cerebrovascular lesions. Current medical research and opinion, 1989, Volume: 11, Issue:6 Topics: Adult; Aged; Baclofen; Cerebrovascular Disorders; Clinical Trials as Topic; Clonidine; Double-Blind	1989
[Treatment of vascular headaches]. Deutsche medizinische Wochenschrift (1946), 1973, Aug-31, Volume: 98, Issue:35 Topics: Adrenergic beta-Antagonists; Carbamazepine; Cerebrovascular Disorders; Clonidine; Ergotamine; Female	1973

Article	Year
Clonidine preconditioning decreases infarct size and improves neurological outcome from transient forebrain ischemia in the rat. Neuroscience, 2004, Volume: 125, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon	2004
Reduced alpha 2-adrenoceptor binding in lower brainstem of stroke-prone spontaneously hypertensive rats. Japanese journal of pharmacology, 1984, Volume: 35, Issue:4 Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Brain Stem; Cerebrovascular Disorders; Clonidine	1984
[Characteristics of the action of gemiton, adelfan and dopegit on cerebral circulation in arterial hypertension]. Klinicheskaia meditsina, 1984, Volume: 62, Issue:3 Topics: Aged; Antihypertensive Agents; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disea	1984
[Withdrawal syndrome in the treatment of arterial hypertension with clofelin]. Klinicheskaia meditsina, 1983, Volume: 61, Issue:3 Topics: Adult; Aged; Cerebrovascular Disorders; Clonidine; Humans; Hypertension; Male; Middle Aged; Substanc	1983
Evidence for an alpha 1-adrenoceptor subtype mediating adrenergic vasoconstriction in Wistar normotensive and stroke-prone spontaneously hypertensive rat kidney. Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:2 Topics: Adrenergic alpha-Antagonists; Amlodipine; Animals; Cerebrovascular Disorders; Clonidine; Dose-Respon	1994
[Therapy of arterial hypertension associated with acute stroke. Current trends and problems]. La Clinica terapeutica, 1994, Volume: 145, Issue:11 Topics: Acute Disease; Aged; Antihypertensive Agents; Blood Pressure Monitors; Cerebral Hemorrhage; Cerebrov	1994
Mechanisms of tizanidine action on spasticity. Acta neurologica Scandinavica, 1994, Volume: 89, Issue:4 Topics: Adult; Aged; Cerebrovascular Disorders; Clonidine; Electromyography; Female; H-Reflex; Hemiplegia; H	1994
Detection and measurement of an endogenous clonidine-displacing substance in human cerebrospinal fluid. Brain research, 1993, Jan-22, Volume: 601, Issue:1-2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Binding, Competitive; Cerebrospinal Fluid Proteins; Cere	1993
Alpha 2-adrenergic agonists increase cellular lactate efflux. Hypertension (Dallas, Tex. : 1979), 1996, Volume: 27, Issue:5 Topics: Adrenergic alpha-Agonists; Animals; Body Temperature Regulation; Cells, Cultured; Cerebrovascular Di	1996
Chronopharmacological dependence of antihypertensive effects of the imidazoline-like drugs in stroke-prone spontaneously hypertensive rats. Journal of the autonomic nervous system, 1998, Oct-15, Volume: 72, Issue:2-3 Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Circadian Rhythm; Cloni	1998
Influence of sinoaortic barodenervation on the hypotensive effects of imidazoline-like drugs in stroke-prone spontaneously hypertensive rats. Annals of the New York Academy of Sciences, 1999, Jun-21, Volume: 881 Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Circadian Rhythm; Cloni	1999
Effects of antihypertensive drugs on blood velocity: implications for prevention of cerebral vascular disease. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1977, Volume: 4, Issue:2 Topics: Animals; Antihypertensive Agents; Blood Circulation; Blood Flow Velocity; Cerebrovascular Disorders;	1977
Factors influencing the choice of antihypertensive agents. Postgraduate medicine, 1976, Volume: 60, Issue:7 Topics: Age Factors; Aldosterone; Cerebrovascular Disorders; Clonidine; Depression; Diabetes Complications;	1976
Flexor reflex for assessment of common interneurone activity in spasticity. Electromyography and clinical neurophysiology, 1992, Volume: 32, Issue:12 Topics: Adult; Aged; Anti-Anxiety Agents; Baclofen; Benzodiazepines; Benzodiazepinones; Cerebrovascular Diso	1992
Clonidine impairs recovery of beam-walking after a sensorimotor cortex lesion in the rat. Brain research, 1990, Feb-05, Volume: 508, Issue:2 Topics: Animals; Brain Injuries; Cerebral Cortex; Cerebrovascular Disorders; Clonidine; Disease Models, Anim	1990
Treatment of hypertension in the elderly. Drugs, 1974, Volume: 7, Issue:3 Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Cerebrovascular Disorders; Clonidine; Di	1974
Clonidine in the treatment of severe hypertension. The Medical journal of Australia, 1973, Apr-21, Volume: 1, Issue:16 Topics: Adult; Anesthesia, General; Cerebrovascular Disorders; Clonidine; Coronary Disease; Depression; Huma	1973

clonidine and Brain Vascular Disorders