clonidine has been researched along with Brain Injuries in 13 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tizanidine is an imidazoline central alpha(2)-adrenoceptor agonist widely used to manage spasticity secondary to conditions such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI)." | 8.84 | A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. ( Henney, HR; Kamen, L; Runyan, JD, 2008) |
| "Tizanidine is an imidazoline central alpha(2)-adrenoceptor agonist widely used to manage spasticity secondary to conditions such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI)." | 4.84 | A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. ( Henney, HR; Kamen, L; Runyan, JD, 2008) |
| " The experience with six patients, aged 17-73 years, treated with clonidine for spasticity due to brain injuries of various causes is presented." | 3.69 | Use of clonidine for treatment of spasticity arising from various forms of brain injury: a case series. ( Dall, JT; Harmon, RL; Quinn, CM, 1996) |
| " The average dosage at 4 weeks was 25." | 2.70 | Prospective assessment of tizanidine for spasticity due to acquired brain injury. ( Brunner, RM; Guin-Renfroe, S; Johnson, A; Meythaler, JM, 2001) |
| "Akathisia is also a rare cause of psychomotor agitation in patients with traumatic brain injury (TBI)." | 2.48 | Akathisia--rare cause of psychomotor agitation in patients with traumatic brain injury: case report and review of literature. ( Ribbers, GM; Wielenga-Boiten, JE, 2012) |
| " Planned subgroup analyses include specific alpha-2 agonist agent, study design, clinical diagnosis, dosing regimen, and use of adjunctive agents." | 1.43 | Alpha-2 agonists for sedation in mechanically ventilated neurocritical care patients: a systematic review protocol. ( Blinder, H; English, S; Hutton, B; Tran, A, 2016) |
| "To describe the successful treatment of PTSD associated nightmares in two patients with PTSD." | 1.38 | The use of clonidine in the treatment of nightmares among patients with co-morbid PTSD and traumatic brain injury. ( Alao, A; Razi, S; Selvarajah, J, 2012) |
| " Secondary objectives included determining correlations between dosage and age, injury type, location of spasticity, comorbid seizures, or concomitant antispasticity medications." | 1.33 | Oral baclofen and clonidine for treatment of spasticity in children. ( Haase, M; Habersang, R; Lubsch, L; Luedtke, S, 2006) |
| "Treatment with clonidine significantly slowed the rate of recovery (Kruskal-Wallis H = 8." | 1.28 | Clonidine impairs recovery of beam-walking after a sensorimotor cortex lesion in the rat. ( Davis, JN; Goldstein, LB, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, YY | 1 |
| Gao, YX | 1 |
| Gao, W | 1 |
| Xu, Y | 1 |
| Xu, YZ | 1 |
| Wang, YJ | 1 |
| Chang, S | 1 |
| Yu, LG | 1 |
| Zhang, LY | 1 |
| Liao, H | 1 |
| Yang, LF | 1 |
| Pang, T | 1 |
| Qiu, WW | 1 |
| Wielenga-Boiten, JE | 1 |
| Ribbers, GM | 1 |
| Alao, A | 1 |
| Selvarajah, J | 1 |
| Razi, S | 1 |
| Tran, A | 1 |
| Blinder, H | 1 |
| Hutton, B | 1 |
| English, S | 1 |
| Patel, MB | 1 |
| McKenna, JW | 1 |
| Alvarez, JM | 1 |
| Sugiura, A | 1 |
| Jenkins, JM | 1 |
| Guillamondegui, OD | 1 |
| Pandharipande, PP | 1 |
| Lubsch, L | 1 |
| Habersang, R | 1 |
| Haase, M | 1 |
| Luedtke, S | 1 |
| Kamen, L | 1 |
| Henney, HR | 1 |
| Runyan, JD | 1 |
| Dall, JT | 1 |
| Harmon, RL | 1 |
| Quinn, CM | 1 |
| ter Minassian, A | 1 |
| Beydon, L | 1 |
| Decq, P | 1 |
| Bonnet, F | 1 |
| Meythaler, JM | 1 |
| Guin-Renfroe, S | 1 |
| Johnson, A | 1 |
| Brunner, RM | 1 |
| Elovic, E | 1 |
| Payen, D | 1 |
| Quintin, L | 1 |
| Plaisance, P | 1 |
| Chiron, B | 1 |
| Lhoste, F | 1 |
| Goldstein, LB | 1 |
| Davis, JN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Severe Traumatic Brain Injury, A Pilot Randomized Clinical Trial Using Propranolol and Clonidine[NCT01322048] | Phase 2 | 48 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment: Double Blinded Comparison Between Botulinum Toxin and Baclofen.[NCT02462317] | Phase 4 | 184 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01322048)
Timeframe: Post-treatment (t=Day 8)
| Intervention | pg/mL (Median) |
|---|---|
| Adrenergic Blockade | 962 |
| Placebo | 714 |
(NCT01322048)
Timeframe: Baseline to day 28
| Intervention | days (Median) |
|---|---|
| Adrenergic Blockade | 16.2 |
| Placebo | 18.05 |
3 reviews available for clonidine and Brain Injuries
| Article | Year |
|---|---|
Akathisia--rare cause of psychomotor agitation in patients with traumatic brain injury: case report and review of literature.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Brain Injuries; Clonidine; Female; Humans; Psychomotor | 2012 |
A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury.
Topics: Brain Injuries; Clonidine; Disease Progression; Drug Interactions; Female; Humans; Middle Aged; Mult | 2008 |
Principles of pharmaceutical management of spastic hypertonia.
Topics: Anti-Dyskinesia Agents; Baclofen; Benzodiazepines; Botulinum Toxins; Brain Injuries; Clonidine; Dant | 2001 |
2 trials available for clonidine and Brain Injuries
| Article | Year |
|---|---|
Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Adrenergic Fibers; Biomarkers; Br | 2012 |
Prospective assessment of tizanidine for spasticity due to acquired brain injury.
Topics: Administration, Oral; Adult; Aged; Brain Injuries; Clonidine; Cross-Over Studies; Dose-Response Rela | 2001 |
8 other studies available for clonidine and Brain Injuries
| Article | Year |
|---|---|
Design, synthesis and biological evaluation of tricyclic diterpene derivatives as novel neuroprotective agents against ischemic brain injury.
Topics: Animals; Brain Injuries; Cell Survival; Diterpenes; Dose-Response Relationship, Drug; Drug Design; G | 2015 |
The use of clonidine in the treatment of nightmares among patients with co-morbid PTSD and traumatic brain injury.
Topics: Adult; Brain Injuries; Clonidine; Combat Disorders; Dreams; Humans; Male; Middle Aged; Stress Disord | 2012 |
Alpha-2 agonists for sedation in mechanically ventilated neurocritical care patients: a systematic review protocol.
Topics: Adrenergic alpha-2 Receptor Agonists; Brain Injuries; Clonidine; Conscious Sedation; Critical Care; | 2016 |
Oral baclofen and clonidine for treatment of spasticity in children.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Agonists; Adult; Age Factors; Baclofen; Brain Inj | 2006 |
Use of clonidine for treatment of spasticity arising from various forms of brain injury: a case series.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Brain Injuries; Clonidine; Female; Humans; Male; | 1996 |
Changes in cerebral hemodynamics after a single dose of clonidine in severely head-injured patients.
Topics: Adrenergic alpha-Agonists; Adult; Blood Flow Velocity; Blood Pressure; Brain Injuries; Carbon Dioxid | 1997 |
Head injury: clonidine decreases plasma catecholamines.
Topics: Acute Disease; Adult; Blood Flow Velocity; Brain Injuries; Carotid Arteries; Cerebrovascular Circula | 1990 |
Clonidine impairs recovery of beam-walking after a sensorimotor cortex lesion in the rat.
Topics: Animals; Brain Injuries; Cerebral Cortex; Cerebrovascular Disorders; Clonidine; Disease Models, Anim | 1990 |