clonidine has been researched along with Brain Edema in 6 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We hypothesized that early and unselective beta-blockade with propranolol alone or in combination with the alfa2-agonist clonidine would decrease brain edema, blood-brain barrier permeability, and glycocalyx disruption at 24 hours after trauma." | 7.88 | Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat. ( Bentzer, P; Genét, GF; Hansen, MB; Johansson, PI; Ostrowski, SR, 2018) |
| " We hypothesized that early and unselective beta-blockade with propranolol alone or in combination with the alfa2-agonist clonidine would decrease brain edema, blood-brain barrier permeability, and glycocalyx disruption at 24 hours after trauma." | 3.88 | Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat. ( Bentzer, P; Genét, GF; Hansen, MB; Johansson, PI; Ostrowski, SR, 2018) |
| "Clonidine and yohimbine were intraperitoneally given to the rats each day for a week before ischemia." | 1.43 | Clonidine preconditioning alleviated focal cerebral ischemic insult in rats via up-regulating p-NMDAR1 and down-regulating NMDAR2A / p-NMDAR2B. ( Bo, Z; Lingling, Y; Min, Z; Xizhou, Z; Yan, W; Yanli, L; Yunhong, Z; Zhangao, C; Zhi, H; Zicheng, L, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Genét, GF | 1 |
| Bentzer, P | 1 |
| Hansen, MB | 1 |
| Ostrowski, SR | 1 |
| Johansson, PI | 1 |
| Yanli, L | 1 |
| Xizhou, Z | 1 |
| Yan, W | 1 |
| Bo, Z | 1 |
| Yunhong, Z | 1 |
| Zicheng, L | 1 |
| Lingling, Y | 2 |
| Zhangao, C | 1 |
| Min, Z | 1 |
| Zhi, H | 1 |
| Sansing, LH | 1 |
| Messe, SR | 1 |
| Cucchiara, BL | 1 |
| Lyden, PD | 1 |
| Kasner, SE | 1 |
| Jugé, M | 2 |
| Grimaud, N | 2 |
| Petit, JY | 2 |
| Robert, B | 1 |
| Welin, L | 1 |
| Philipp, T | 1 |
| Nast, HP | 1 |
1 trial available for clonidine and Brain Edema
| Article | Year |
|---|---|
Anti-adrenergic medications and edema development after intracerebral hemorrhage.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; An | 2011 |
5 other studies available for clonidine and Brain Edema
| Article | Year |
|---|---|
Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Blood-Brain Barrier; Bra | 2018 |
Clonidine preconditioning alleviated focal cerebral ischemic insult in rats via up-regulating p-NMDAR1 and down-regulating NMDAR2A / p-NMDAR2B.
Topics: Animals; Brain Edema; Clonidine; Down-Regulation; Infarction, Middle Cerebral Artery; Ischemic Preco | 2016 |
Involvement of alpha2-adrenergic mechanisms in experimental analgesic and anti-inflammatory activities of a benzamide derivative.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Blood Press | 1997 |
Effect of clonidine on experimental brain edema in the rat.
Topics: Animals; Blood Pressure; Brain; Brain Edema; Clonidine; Copper; Dexamethasone; Indomethacin; Male; P | 1992 |
[Hypertensive emergencies].
Topics: Brain Edema; Clonidine; Diazoxide; Digitalis Glycosides; Diuretics; Drug Combinations; Emergencies; | 1974 |