clonidine has been researched along with Bradycardia in 96 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Paediatric clonidine poisoning commonly results in bradycardia, hypotension and decreased GCS, but rarely severe or requiring major interventions." | 8.31 | Reality of clonidine poisoning in children and adolescents. ( Downes, MA; Duong, C; Isbister, GK; Lovett, C, 2023) |
| "A 37-year-old man suffered irreversible profound symptomatic bradycardia requiring a pacemaker 3 days after beginning tizanidine/loxoprofen combination therapy for neck pain." | 7.88 | Irreversible profound symptomatic bradycardia requiring pacemaker after tizanidine/loxoprofen combination therapy: a case report. ( Jin, Y; Li, X, 2018) |
| "We report a case of profound symptomatic bradycardia after a single dose of tizanidine." | 7.81 | Profound symptomatic bradycardia requiring transvenous pacing after a single dose of tizanidine. ( Cortes, J; Hall, B; Redden, D, 2015) |
| "The incidence of bradycardia following oral or intravenous premedication with clonidine in a pediatric population scheduled for anesthesia is low." | 7.81 | Incidence of bradycardia at arrival to the operating room after oral or intravenous premedication with clonidine in children. ( Eksborg, S; Larsson, PG; Lönnqvist, PA, 2015) |
| "The addition of tizanidine in a patient receiving long-term treatment with lisinopril was associated with severe hypotension and bradycardia." | 7.76 | Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy. ( Branam, DL; Publow, SW, 2010) |
| " During the 33 days before admission, she received oral tizanidine hydrochloride at 3 mg/day for leg cramps." | 7.73 | Symptomatic bradycardia probably due to tizanidine hydrochloride in a chronic hemodialysis patient. ( Abe, T; Akizawa, T; Kamimura, M; Kitabata, Y; Kobata, H; Narukawa, N; Orita, H; Shiizaki, K, 2005) |
| "The case of a 59-year-old healthy woman is described, who developed an extreme sinus bradycardia (30/min) with chest pain and acute right heart failure associated with gastrointestinal symptoms and elevation of the liver enzymes while simultaneously taking tizanidine (Sirdalud), diclofenac (Voltaren), and rofecoxib (Vioxx)." | 7.73 | [Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)]. ( Bertoli, R; Caduff Janosa, P; Cerny, A; Kick, A; Moschovitis, G, 2005) |
| "To identify cases of clonidine poisoning presenting to a tertiary paediatric hospital and to investigate trends in presentation, outcome and prevention." | 7.72 | Clonidine poisoning in children: a recent experience. ( Cranswick, NE; Sinha, Y, 2004) |
| "Clonidine is an alpha-adrenergic agent that is used in the treatment of hypertension." | 7.69 | Clonidine-induced bradycardia. ( Blount, BW; Golusinski, LL, 1995) |
| "We identified eight hypertensive patients who developed severe bradycardia during oral clonidine hydrochloride therapy." | 7.67 | Risk factors for severe bradycardia during oral clonidine therapy for hypertension. ( Byrd, BF; Collins, HW; Primm, RK, 1988) |
| " Clonidine can be compounded as a liquid formula for patients who are unable to take pills, however, this can add to the risk of dosing errors." | 5.56 | Clonidine Compounding Error: Bradycardia and Sedation in a Pediatric Patient. ( Barbuto, AF; Burns, MM, 2020) |
| "Naloxone was not associated with improved outcomes." | 5.46 | Adult clonidine overdose: prolonged bradycardia and central nervous system depression, but not severe toxicity. ( Heppell, SP; Isbister, GK; Page, CB; Ryan, NM, 2017) |
| "Once clonidine was discontinued, the resting heart rate returned to normal." | 5.29 | Clonidine-induced bradycardia in patients with spinal cord injury. ( Rosenblum, D, 1993) |
| " Both the groups receiving dexmedetomidine had higher number of patients developing bradycardia as compared to patients receiving clonidine." | 5.22 | Comparision of clonidine and dexmedetomidine for attenuation of laryngoscopy and intubation response - A randomized controlled trial. ( Kakkar, A; Nabi, N; Sethi, AK; Tyagi, A; Verma, UC, 2016) |
| "There were more incidents of bradycardia in subjects treated with clonidine compared with those not treated with clonidine (17." | 5.13 | Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis. ( Bukstein, OG; Daviss, WB; Harris, P; McDERMOTT, MP; Palumbo, D; Patel, NC; Pelham, WE; Robb, AS; Sallee, FR, 2008) |
| " Our review, based on moderate-quality evidence, revealed that hypotension occurred frequently during the preoperative and postoperative periods, for both clonidine and dexmedetomidine." | 5.01 | Perioperative adverse events attributed to α2-adrenoceptor agonists in patients not at risk of cardiovascular events: systematic review and meta-analysis. ( Antunes, T; Demiri, M; Fletcher, D; Martinez, V, 2019) |
| "The authors report a clinical case of clonidine poisoning in a 20-month-old child." | 4.79 | [Coma with miosis and bradycardia]. ( Matos, LD; Porfírio, H, 1994) |
| "Clonidine poisoning usually causes depressed sensorium, hypotension, and bradycardia." | 4.76 | Clonidine overdose: report of six cases and review of the literature. ( Anderson, RJ; Crumpler, CP; Hart, GR; Lerman, MJ, 1981) |
| "Paediatric clonidine poisoning commonly results in bradycardia, hypotension and decreased GCS, but rarely severe or requiring major interventions." | 4.31 | Reality of clonidine poisoning in children and adolescents. ( Downes, MA; Duong, C; Isbister, GK; Lovett, C, 2023) |
| "A 37-year-old man suffered irreversible profound symptomatic bradycardia requiring a pacemaker 3 days after beginning tizanidine/loxoprofen combination therapy for neck pain." | 3.88 | Irreversible profound symptomatic bradycardia requiring pacemaker after tizanidine/loxoprofen combination therapy: a case report. ( Jin, Y; Li, X, 2018) |
| "Although administration of clonidine is often associated with bradycardia and hypotension, these complications do not seem clinically significant in a mixed PICU population with a high degree of disease severity." | 3.88 | Hemodynamic Tolerance to IV Clonidine Infusion in the PICU. ( de Wildt, SN; Kleiber, N; Tibboel, D; van Rosmalen, J, 2018) |
| "We report a case of profound symptomatic bradycardia after a single dose of tizanidine." | 3.81 | Profound symptomatic bradycardia requiring transvenous pacing after a single dose of tizanidine. ( Cortes, J; Hall, B; Redden, D, 2015) |
| "The incidence of bradycardia following oral or intravenous premedication with clonidine in a pediatric population scheduled for anesthesia is low." | 3.81 | Incidence of bradycardia at arrival to the operating room after oral or intravenous premedication with clonidine in children. ( Eksborg, S; Larsson, PG; Lönnqvist, PA, 2015) |
| "The addition of tizanidine in a patient receiving long-term treatment with lisinopril was associated with severe hypotension and bradycardia." | 3.76 | Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy. ( Branam, DL; Publow, SW, 2010) |
| "The case of a 59-year-old healthy woman is described, who developed an extreme sinus bradycardia (30/min) with chest pain and acute right heart failure associated with gastrointestinal symptoms and elevation of the liver enzymes while simultaneously taking tizanidine (Sirdalud), diclofenac (Voltaren), and rofecoxib (Vioxx)." | 3.73 | [Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)]. ( Bertoli, R; Caduff Janosa, P; Cerny, A; Kick, A; Moschovitis, G, 2005) |
| " During the 33 days before admission, she received oral tizanidine hydrochloride at 3 mg/day for leg cramps." | 3.73 | Symptomatic bradycardia probably due to tizanidine hydrochloride in a chronic hemodialysis patient. ( Abe, T; Akizawa, T; Kamimura, M; Kitabata, Y; Kobata, H; Narukawa, N; Orita, H; Shiizaki, K, 2005) |
| "To identify cases of clonidine poisoning presenting to a tertiary paediatric hospital and to investigate trends in presentation, outcome and prevention." | 3.72 | Clonidine poisoning in children: a recent experience. ( Cranswick, NE; Sinha, Y, 2004) |
| "Bradycardia was induced in rats by administering alinidine via osmotic pumps beginning 1 day after coronary artery ligation." | 3.72 | Bradycardia induces angiogenesis, increases coronary reserve, and preserves function of the postinfarcted heart. ( Christensen, LP; Lei, L; Tomanek, RJ; Weiss, RM; Zheng, W; Zhou, R, 2004) |
| " Intrathecal tizanidine at the dose that reversed hyperalgesia would be preferable for neuropathic pain management because of absence of hypotension and bradycardia and lower incidence of sedation." | 3.72 | Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain. ( Kawamata, T; Namiki, A; Omote, K; Toriyabe, M; Wada, K; Yamamoto, H, 2003) |
| " Bradycardia was induced in rats by administering the bradycardic drug alinidine (3 mg/kg body weight) twice daily." | 3.70 | Bradycardia-induced coronary angiogenesis is dependent on vascular endothelial growth factor. ( Bjercke, RJ; Brock, TA; Brown, MD; Tomanek, RJ; Zheng, W, 1999) |
| "Clonidine is an alpha-adrenergic agent that is used in the treatment of hypertension." | 3.69 | Clonidine-induced bradycardia. ( Blount, BW; Golusinski, LL, 1995) |
| " Reflex bradycardia was produced by a bolus injection of phenylephrine at a dose which produces about a 25-mmHg increase in mean blood pressure." | 3.68 | Influence of transient global cerebral ischemia on the facilitatory modulation of the vagal baroreflex in dogs. ( Kato, H; Kurihara, J; Tamaoki, S, 1993) |
| " The presence of alpha 1-adrenergic receptors at this site was confirmed by microinjections of phenylephrine (a specific agonist for these receptors); phenylephrine elicited tachycardia." | 3.68 | Cardiac effects of injections of epinephrine into the spinal intermediolateral column. ( Kachroo, A; Malhotra, VK; Sapru, HN, 1993) |
| "We identified eight hypertensive patients who developed severe bradycardia during oral clonidine hydrochloride therapy." | 3.67 | Risk factors for severe bradycardia during oral clonidine therapy for hypertension. ( Byrd, BF; Collins, HW; Primm, RK, 1988) |
| " Ventilatory support must be available if apnea occurs." | 3.66 | Clonidine poisoning. A complex problem. ( Artman, M; Boerth, RC, 1983) |
| "15 mg clonidine (Catapresan) in 11 patients (averaged age 60 years) with symptomatic bradycardia (dizzy spells, syncope, palpitations)." | 3.66 | [Clinidine-induced bradycardia: studies of the effect on the human sinus node (author's transl)]. ( Horn, H; Neuss, H; Schlepper, M; Thormann, J, 1981) |
| "Clonidine is a sedative-sparing agent and this can help reduce complications associated with prolonged use of opioids and benzodiazepines." | 1.72 | Use of continuous infusion of clonidine for sedation in critically ill infants and children. ( Bourdon, O; Dauger, S; Deho, A; Prot-Labarthe, S; Sadozai, L, 2022) |
| " Clonidine can be compounded as a liquid formula for patients who are unable to take pills, however, this can add to the risk of dosing errors." | 1.56 | Clonidine Compounding Error: Bradycardia and Sedation in a Pediatric Patient. ( Barbuto, AF; Burns, MM, 2020) |
| "Naloxone was not associated with improved outcomes." | 1.46 | Adult clonidine overdose: prolonged bradycardia and central nervous system depression, but not severe toxicity. ( Heppell, SP; Isbister, GK; Page, CB; Ryan, NM, 2017) |
| "He was found to have a subarachnoid hemorrhage and was treated for hypertensive emergency." | 1.40 | Dermal exposure to a compounded pain cream resulting in severely elevated clonidine concentration. ( Fantz, CR; Gooden, CE; Morgan, BW; Pomerleau, AC, 2014) |
| "Clonidine exposures were the most commonly reported, more symptomatic, and associated with 3 deaths." | 1.40 | Unintentional pediatric exposures to central alpha-2 agonists reported to the National Poison Data System. ( Heard, K; Le Lait, MC; Wang, GS, 2014) |
| "(3,4) We report adverse effects of topical apraclonidine when used in the diagnosis of Horner syndrome in infants." | 1.34 | Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants. ( Lim, MK; Satterfield, D; Watts, P, 2007) |
| "We performed a prospective case series to seek dosage or clinical parameters to better identify patients who need direct medical evaluation." | 1.33 | Toxic clonidine ingestion in children. ( Anderson, DL; Colvin, JM; Johnson, PB; Klein-Schwartz, W; Spiller, HA; Villalobos, D, 2005) |
| "To analyze the trends, demographics, and toxic effects associated with pediatric clonidine hydrochloride exposures reported to poison centers." | 1.31 | Trends and toxic effects from pediatric clonidine exposures. ( Klein-Schwartz, W, 2002) |
| "Clonidine overdose is a potentially serious condition, often requiring intensive care management." | 1.30 | Clonidine overdose in childhood: implications of increased prescribing. ( Hanson, RM; Hutchins, P; Kappagoda, C; Schell, DN, 1998) |
| "Once clonidine was discontinued, the resting heart rate returned to normal." | 1.29 | Clonidine-induced bradycardia in patients with spinal cord injury. ( Rosenblum, D, 1993) |
| "The tizanidine effect was inhibited by yohimbine and the alpha(2)/imidazoline antagonist idazoxan, as well as the parasympathetic blocker glycopyrrolate." | 1.29 | Intrathecal clonidine and tizanidine in conscious dogs: comparison of analgesic and hemodynamic effects. ( Ivankovich, AD; Kroin, JS; Lubenow, TR; McCarthy, RJ; Penn, RD, 1996) |
| "Clonidine has some central component for induction of postural hypotension in addition to the frequency-related peripheral component." | 1.28 | Evaluation of the central and peripheral components for induction of postural hypotension by guanethidine, clonidine, dopamine2 receptor agonists and 5-hydroxytryptamine1A receptor agonists. ( Cannon, JG; Long, JP; Park, KH, 1991) |
| " In toddlers poisoning is seen after ingestion of a single tablet of 150 micrograms clonidine, whilst in adults poisoning may occur already at a dosage just exceeding the therapeutic limit, which is subject to wide individual variation (1 to 3 tablets)." | 1.27 | [Poisoning with clonidin hydrochloride in children and adults]. ( Gössinger, H; Haubenstock, A; Hruby, K; Jung, M; Pfister, R, 1983) |
| "dose, a tachycardia was observed in all rats following initial transient bradycardia." | 1.27 | Tachycardic and hypertensive effects of centrally administered clonidine in conscious rats. ( Imai, Y; Johnston, CI; Nolan, PL, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (35.42) | 18.7374 |
| 1990's | 25 (26.04) | 18.2507 |
| 2000's | 19 (19.79) | 29.6817 |
| 2010's | 14 (14.58) | 24.3611 |
| 2020's | 4 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Knaus, A | 1 |
| Zong, X | 1 |
| Beetz, N | 1 |
| Jahns, R | 1 |
| Lohse, MJ | 1 |
| Biel, M | 1 |
| Hein, L | 1 |
| Sadozai, L | 1 |
| Prot-Labarthe, S | 1 |
| Bourdon, O | 1 |
| Dauger, S | 1 |
| Deho, A | 1 |
| Duong, C | 1 |
| Lovett, C | 1 |
| Downes, MA | 1 |
| Isbister, GK | 2 |
| Demiri, M | 1 |
| Antunes, T | 1 |
| Fletcher, D | 1 |
| Martinez, V | 1 |
| Nadeau, N | 1 |
| Samuels-Kalow, M | 1 |
| Wittels, K | 1 |
| Wilcox, SR | 1 |
| Barbuto, AF | 1 |
| Burns, MM | 1 |
| Adams, A | 1 |
| Copley, C | 1 |
| El-Boghdadly, K | 1 |
| Brull, R | 1 |
| Sehmbi, H | 1 |
| Abdallah, FW | 1 |
| Li, X | 1 |
| Jin, Y | 1 |
| Kleiber, N | 1 |
| van Rosmalen, J | 1 |
| Tibboel, D | 1 |
| de Wildt, SN | 1 |
| Wang, GS | 1 |
| Le Lait, MC | 1 |
| Heard, K | 1 |
| Pomerleau, AC | 1 |
| Gooden, CE | 1 |
| Fantz, CR | 1 |
| Morgan, BW | 1 |
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Cortes, J | 1 |
| Hall, B | 1 |
| Redden, D | 1 |
| Chen, K | 1 |
| Lu, Z | 1 |
| Xin, YC | 1 |
| Cai, Y | 1 |
| Chen, Y | 1 |
| Pan, SM | 1 |
| Larsson, PG | 1 |
| Eksborg, S | 1 |
| Lönnqvist, PA | 1 |
| Kakkar, A | 1 |
| Tyagi, A | 1 |
| Nabi, N | 1 |
| Sethi, AK | 1 |
| Verma, UC | 1 |
| Heppell, SP | 1 |
| Page, CB | 1 |
| Ryan, NM | 1 |
| Publow, SW | 1 |
| Branam, DL | 1 |
| Kawamata, T | 1 |
| Omote, K | 1 |
| Yamamoto, H | 1 |
| Toriyabe, M | 1 |
| Wada, K | 1 |
| Namiki, A | 1 |
| Tank, J | 1 |
| Diedrich, A | 1 |
| Szczech, E | 1 |
| Luft, FC | 1 |
| Jordan, J | 1 |
| Shen, KP | 1 |
| Chiu, CC | 1 |
| Chen, SJ | 1 |
| Chen, IJ | 1 |
| Wu, BN | 1 |
| Lei, L | 1 |
| Zhou, R | 1 |
| Zheng, W | 2 |
| Christensen, LP | 1 |
| Weiss, RM | 1 |
| Tomanek, RJ | 2 |
| El-Mas, MM | 3 |
| Abdel-Rahman, AA | 1 |
| Sinha, Y | 1 |
| Cranswick, NE | 1 |
| Spiller, HA | 1 |
| Klein-Schwartz, W | 2 |
| Colvin, JM | 1 |
| Villalobos, D | 1 |
| Johnson, PB | 1 |
| Anderson, DL | 1 |
| Kitabata, Y | 1 |
| Orita, H | 1 |
| Kamimura, M | 1 |
| Shiizaki, K | 1 |
| Narukawa, N | 1 |
| Abe, T | 1 |
| Kobata, H | 1 |
| Akizawa, T | 1 |
| Kick, A | 1 |
| Bertoli, R | 1 |
| Moschovitis, G | 1 |
| Caduff Janosa, P | 1 |
| Cerny, A | 1 |
| Chan, CK | 1 |
| Burke, SL | 1 |
| Zhu, H | 1 |
| Piletz, JE | 1 |
| Head, GA | 1 |
| Galante, D | 1 |
| Tobias, JD | 1 |
| Tavakoli, S | 1 |
| Hajrasouliha, AR | 1 |
| Jabehdar-Maralani, P | 1 |
| Ebrahimi, F | 1 |
| Sadeghipour, H | 1 |
| Dehghani, M | 1 |
| Shafaroodi, H | 1 |
| Dehpour, AR | 1 |
| Watts, P | 1 |
| Satterfield, D | 1 |
| Lim, MK | 1 |
| Hajduk, A | 1 |
| Sein Anand, J | 1 |
| Chodorowski, Z | 1 |
| Daviss, WB | 1 |
| Patel, NC | 1 |
| Robb, AS | 1 |
| McDERMOTT, MP | 1 |
| Bukstein, OG | 1 |
| Pelham, WE | 1 |
| Palumbo, D | 1 |
| Harris, P | 1 |
| Sallee, FR | 1 |
| de Jonge, A | 1 |
| Timmermans, PB | 1 |
| van Zwieten, PA | 1 |
| Selmi, W | 1 |
| Matricardi, L | 1 |
| Roquebert, J | 1 |
| Demichel, P | 1 |
| Malek, A | 1 |
| Banner, W | 1 |
| Lund, ME | 1 |
| Clawson, L | 1 |
| Marruecos, L | 1 |
| Roglan, A | 1 |
| Frati, ME | 1 |
| Artigas, A | 1 |
| Anagnos, DJ | 1 |
| Mazyck, EM | 1 |
| Artman, M | 1 |
| Boerth, RC | 1 |
| Gössinger, H | 1 |
| Hruby, K | 1 |
| Haubenstock, A | 1 |
| Jung, M | 1 |
| Pfister, R | 1 |
| Anderson, RJ | 1 |
| Hart, GR | 1 |
| Crumpler, CP | 1 |
| Lerman, MJ | 1 |
| Thormann, J | 2 |
| Neuss, H | 2 |
| Schlepper, M | 2 |
| Mitrovic, V | 1 |
| Tritthart, HA | 1 |
| Windisch, H | 1 |
| Heuberger, S | 1 |
| Williford, DJ | 1 |
| Hamilton, BL | 1 |
| Souza, JD | 1 |
| Williams, TP | 1 |
| DiMicco, JA | 1 |
| Gillis, RA | 1 |
| Horn, H | 1 |
| Golusinski, LL | 1 |
| Blount, BW | 1 |
| Johnson, MA | 1 |
| Blackwell, CP | 1 |
| Smith, J | 1 |
| Ricci, D | 1 |
| Taira, CA | 1 |
| Porfírio, H | 1 |
| Matos, LD | 1 |
| Rosenblum, D | 1 |
| Kurihara, J | 1 |
| Tamaoki, S | 1 |
| Kato, H | 1 |
| Malhotra, VK | 1 |
| Kachroo, A | 1 |
| Sapru, HN | 1 |
| Flacke, JW | 1 |
| Flacke, WE | 1 |
| Kroin, JS | 1 |
| McCarthy, RJ | 1 |
| Penn, RD | 1 |
| Lubenow, TR | 1 |
| Ivankovich, AD | 1 |
| Singelyn, FJ | 1 |
| Gouverneur, JM | 1 |
| Robert, A | 1 |
| Challinor-Rogers, JL | 1 |
| Rosenfeldt, FL | 1 |
| Du, XJ | 1 |
| McPherson, GA | 1 |
| Bhatara, VS | 1 |
| Kallepalli, BR | 1 |
| Misra, LK | 1 |
| Awadallah, S | 1 |
| Kraft, ME | 1 |
| Kappagoda, C | 1 |
| Schell, DN | 1 |
| Hanson, RM | 1 |
| Hutchins, P | 1 |
| Brown, MD | 1 |
| Brock, TA | 1 |
| Bjercke, RJ | 1 |
| Breschan, C | 1 |
| Krumpholz, R | 1 |
| Likar, R | 1 |
| Kraschl, R | 1 |
| Schalk, HV | 1 |
| Blumberg, MS | 1 |
| Sokoloff, G | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| The Use of Transcranial Focused Ultrasound for the Treatment of Neurodegenerative Dementias[NCT04250376] | 100 participants (Anticipated) | Interventional | 2017-11-27 | Enrolling by invitation | |||
| Lymphatic System Health in Alzheimer's Disease[NCT04205539] | Phase 1 | 0 participants (Actual) | Interventional | 2021-12-10 | Withdrawn (stopped due to Pending COVID-19 pandemic) | ||
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
8 reviews available for clonidine and Bradycardia
| Article | Year |
|---|---|
Perioperative adverse events attributed to α2-adrenoceptor agonists in patients not at risk of cardiovascular events: systematic review and meta-analysis.
Topics: Adrenergic alpha-2 Receptor Agonists; Bradycardia; Clonidine; Dexmedetomidine; Humans; Hypotension; | 2019 |
Perineural Dexmedetomidine Is More Effective Than Clonidine When Added to Local Anesthetic for Supraclavicular Brachial Plexus Block: A Systematic Review and Meta-analysis.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics, Local; Brachial Plexus Block; Bradycardia; Chi-Sq | 2017 |
Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Bradycardia; Clonidine; Conscious Sedation; Critical Il | 2015 |
Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Bradycardia; Clonidine; Conscious Sedation; Critical Il | 2015 |
Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Bradycardia; Clonidine; Conscious Sedation; Critical Il | 2015 |
Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Bradycardia; Clonidine; Conscious Sedation; Critical Il | 2015 |
[Side effects of hypotensive agents].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Benzothiadiazines; Bradycardia; Clonidine; Deh | 1982 |
Clonidine overdose: report of six cases and review of the literature.
Topics: Adolescent; Adult; Atropine; Bradycardia; Child, Preschool; Clonidine; Dopamine; Female; Humans; Hyp | 1981 |
[Coma with miosis and bradycardia].
Topics: Bradycardia; Clonidine; Coma; Diagnosis, Differential; Emergencies; Female; Humans; Infant; Miosis; | 1994 |
Diagnosis and management of baroreflex failure.
Topics: Antihypertensive Agents; Autonomic Nervous System Diseases; Baroreflex; Bradycardia; Carotid Sinus; | 1995 |
On the function of central catecholamine neurons--their role in cardiovascular and arousal mechanisms.
Topics: Adrenergic alpha-Antagonists; Animals; Bradycardia; Brain; Cardiovascular Physiological Phenomena; C | 1972 |
5 trials available for clonidine and Bradycardia
| Article | Year |
|---|---|
Comparision of clonidine and dexmedetomidine for attenuation of laryngoscopy and intubation response - A randomized controlled trial.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Anesthesia, General; Blood Pressure; Bradyc | 2016 |
Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis.
Topics: Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Bradycardia; Central Nervo | 2008 |
Effects of clonidine on sinus node function in man.
Topics: Aged; Bradycardia; Clinical Trials as Topic; Clonidine; Coronary Disease; Diabetes Complications; El | 1981 |
Antagonism of the effects of clonidine by the alpha 2-adrenoceptor antagonist, fluparoxan.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Antidepressive Agents; Blood Pressure; Br | 1995 |
A minimum dose of clonidine added to mepivacaine prolongs the duration of anesthesia and analgesia after axillary brachial plexus block.
Topics: Adrenergic alpha-Agonists; Adult; Ambulatory Surgical Procedures; Analgesia; Analgesics; Anesthetics | 1996 |
83 other studies available for clonidine and Bradycardia
| Article | Year |
|---|---|
Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine.
Topics: Animals; Bradycardia; Cardiovascular Agents; Cell Line; Clonidine; Cyclic Nucleotide-Gated Cation Ch | 2007 |
Use of continuous infusion of clonidine for sedation in critically ill infants and children.
Topics: Bradycardia; Child, Preschool; Clonidine; Critical Care; Critical Illness; Female; Humans; Hypnotics | 2022 |
Reality of clonidine poisoning in children and adolescents.
Topics: Adolescent; Atropine; Bradycardia; Child; Child, Preschool; Clonidine; Female; Humans; Hypotension; | 2023 |
A Common Antidote for an Uncommon Indication.
Topics: Antidotes; Bradycardia; Child, Preschool; Clonidine; Consciousness Disorders; Eating; Emergency Serv | 2019 |
Clonidine Compounding Error: Bradycardia and Sedation in a Pediatric Patient.
Topics: Adrenergic alpha-2 Receptor Agonists; Bradycardia; Child; Clonidine; Drug Compounding; Humans; Male; | 2020 |
High dose naloxone for acute tizanidine overdose in the emergency department: a case report.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Bradycardia; Clonidine; Drug Overdose; Emergency Servic | 2021 |
Irreversible profound symptomatic bradycardia requiring pacemaker after tizanidine/loxoprofen combination therapy: a case report.
Topics: Adult; Analgesics; Atrioventricular Block; Bradycardia; Cardiac Pacing, Artificial; Clonidine; Drug | 2018 |
Hemodynamic Tolerance to IV Clonidine Infusion in the PICU.
Topics: Administration, Intravenous; Blood Pressure; Body Temperature; Bradycardia; Child, Preschool; Clonid | 2018 |
Unintentional pediatric exposures to central alpha-2 agonists reported to the National Poison Data System.
Topics: Adrenergic alpha-2 Receptor Agonists; Bradycardia; Child; Child, Preschool; Clonidine; Female; Guanf | 2014 |
Dermal exposure to a compounded pain cream resulting in severely elevated clonidine concentration.
Topics: Administration, Cutaneous; Adrenergic alpha-2 Receptor Agonists; Adult; Analgesics; Bradycardia; Clo | 2014 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
Profound symptomatic bradycardia requiring transvenous pacing after a single dose of tizanidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged, 80 and over; Bradycardia; Cardiac Pacing, Artificial; Cl | 2015 |
Incidence of bradycardia at arrival to the operating room after oral or intravenous premedication with clonidine in children.
Topics: Administration, Oral; Adolescent; Analgesics; Bradycardia; Child; Child, Preschool; Clonidine; Elect | 2015 |
Adult clonidine overdose: prolonged bradycardia and central nervous system depression, but not severe toxicity.
Topics: Adolescent; Adult; Aged; Antidotes; Antihypertensive Agents; Atropine; Bradycardia; Central Nervous | 2017 |
Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; B | 2010 |
Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Behavior, Animal; Blood Pressure; Bradycardia; Cloni | 2003 |
Alpha-2 adrenergic transmission and human baroreflex regulation.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic beta- | 2004 |
Hypotensive effects of eugenosedin-A with serotonin, alpha- and beta-adrenoceptor antagonistic activities in spontaneously hypertensive and normotensive rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Binding, Compet | 2004 |
Bradycardia induces angiogenesis, increases coronary reserve, and preserves function of the postinfarcted heart.
Topics: Angiopoietin-1; Angiopoietin-2; Animals; Bradycardia; Cardiovascular Agents; Clonidine; Coronary Ves | 2004 |
Chronic ethanol-clonidine hemodynamic interaction in telemetered spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Bradycardia; Clonidine; Delayed-Action Preparations; Drug Administrat | 2004 |
Clonidine poisoning in children: a recent experience.
Topics: Adolescent; Analgesics; Australia; Bradycardia; Child; Child, Preschool; Clonidine; Coma; Dose-Respo | 2004 |
Toxic clonidine ingestion in children.
Topics: Analgesics; Bradycardia; Child; Child, Preschool; Clonidine; Coma; Dose-Response Relationship, Drug; | 2005 |
Symptomatic bradycardia probably due to tizanidine hydrochloride in a chronic hemodialysis patient.
Topics: Aged; Bradycardia; Clonidine; Female; Humans; Kidney Failure, Chronic; Muscle Cramp; Muscle Relaxant | 2005 |
[Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)].
Topics: Acute Disease; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bradycardia; Clonidine; Cyclooxy | 2005 |
Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine.
Topics: 5,6-Dihydroxytryptamine; Adrenergic Agents; Animals; Antihypertensive Agents; Blotting, Western; Bra | 2005 |
Preoperative apnea in a preterm infant after caudal block with ropivacaine and clonidine.
Topics: Amides; Analgesics; Anesthesia, Caudal; Anesthetics, Local; Apnea; Bradycardia; Clonidine; Hernia, I | 2005 |
Dexmedetomidine in the treatment of cyclic vomiting syndrome.
Topics: Adrenergic alpha-Agonists; Bradycardia; Child; Clonidine; Dexmedetomidine; Humans; Hypnotics and Sed | 2005 |
Modulated hemodynamic response to clonidine in bile duct-ligated rats: the role of nitric oxide.
Topics: Animals; Antihypertensive Agents; Bile Ducts; Blood Pressure; Bradycardia; Cholestasis; Clonidine; D | 2006 |
Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants.
Topics: Adrenergic alpha-Agonists; Bradycardia; Clonidine; Emergency Treatment; Female; Horner Syndrome; Hum | 2007 |
[Acute intoxication with clonidine--a case report].
Topics: Acute Disease; Adult; Antidotes; Bradycardia; Clonidine; Female; Gastric Lavage; Humans; Hypertensio | 2007 |
Quantitative aspects of alpha adrenergic effects induced by clonidine-like imidazolidines. II. Central and peripheral bradycardic activities.
Topics: Adrenergic alpha-Agonists; Animals; Bradycardia; Central Nervous System; Clonidine; Dose-Response Re | 1982 |
Effects of thymoxamine and its metabolites on clonidine-induced hypotension and bradycardia in rats.
Topics: Anesthesia; Animals; Blood Pressure; Bradycardia; Clonidine; Heart Rate; Hypotension; Male; Moxisyly | 1982 |
Failure of naloxone to reverse clonidine toxic effect.
Topics: Bradycardia; Child, Preschool; Clonidine; Female; Humans; Hypotension; Infant; Male; Monitoring, Phy | 1983 |
Clonidine overdose.
Topics: Bradycardia; Brain; Clonidine; Female; Humans; Hypotension; Hypothermia; Middle Aged | 1983 |
Clonidine overdose from minimal ingestion.
Topics: Adolescent; Bradycardia; Clonidine; Female; Humans; Syncope | 1984 |
Clonidine poisoning. A complex problem.
Topics: Apnea; Bradycardia; Child, Preschool; Clonidine; Dopamine; Female; Fluid Therapy; Gastric Lavage; Hu | 1983 |
[Poisoning with clonidin hydrochloride in children and adults].
Topics: Adolescent; Adult; Bradycardia; Bundle-Branch Block; Child; Child, Preschool; Clonidine; Female; Gas | 1983 |
The effects of the bradycardia-producing compound alinidine on action potentials and tension development in cardiac fibres.
Topics: Action Potentials; Animals; Barium; Bradycardia; Calcium; Cardiovascular Agents; Chick Embryo; Cloni | 1981 |
Central nervous system mechanisms involving GABA influence arterial pressure and heart rate in the cat.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Bradycardia; Cats; Central Nervous System; Clonid | 1980 |
[Clinidine-induced bradycardia: studies of the effect on the human sinus node (author's transl)].
Topics: Aged; Arrhythmias, Cardiac; Bradycardia; Carotid Sinus; Clonidine; Female; Heart Rate; Humans; Male; | 1981 |
Clonidine-induced bradycardia.
Topics: Antihypertensive Agents; Bradycardia; Clonidine; Humans; Hypertension; Male; Middle Aged | 1995 |
Imidazoline and adrenoceptor involvement in cardiovascular responses to clonidine in sham and sinoaortic denervated rats.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Bradycardia; Clonidine; Denervation; Imidazol | 1995 |
Clonidine-induced bradycardia in patients with spinal cord injury.
Topics: Adult; Bradycardia; Clonidine; Humans; Male; Muscle Spasticity; Spinal Cord Injuries | 1993 |
Influence of transient global cerebral ischemia on the facilitatory modulation of the vagal baroreflex in dogs.
Topics: Animals; Baroreflex; Bradycardia; Clonidine; Dogs; Electric Stimulation; Female; Ischemic Attack, Tr | 1993 |
Cardiac effects of injections of epinephrine into the spinal intermediolateral column.
Topics: Animals; Bradycardia; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Heart; Heart Rate; I | 1993 |
Clonidine prevention of myocardial ischemia during cardiac surgery: will this change outcome?
Topics: Bradycardia; Cardiac Output; Cardiac Pacing, Artificial; Clonidine; Coronary Artery Bypass; Heart; H | 1993 |
Intrathecal clonidine and tizanidine in conscious dogs: comparison of analgesic and hemodynamic effects.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Blood Pressure; Bradyc | 1996 |
Antiischemic and antiarrhythmic activities of some novel alinidine analogs in the rat heart.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Cardiac Pacing, Artificial; Card | 1997 |
A possible clonidine-trazodone-dextroamphetamine interaction in a 12-year-old boy.
Topics: Antihypertensive Agents; Bradycardia; Central Nervous System Stimulants; Child; Clonidine; Conscious | 1996 |
Facilitation of reflex bradycardia does not contribute to the enhanced hypotensive effect of clonidine in aortic barodenervated rats.
Topics: Animals; Antihypertensive Agents; Aorta; Baroreflex; Blood Pressure; Bradycardia; Clonidine; Denerva | 1998 |
A 9-month-old with bradycardia and periodic apnea.
Topics: Antihypertensive Agents; Apnea; Bradycardia; Clonidine; Drug Overdose; Emergency Nursing; Female; Hu | 1998 |
Clonidine overdose in childhood: implications of increased prescribing.
Topics: Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Bradycardia; Child; Child, | 1998 |
Ethanol abolishes clonidine-induced impairment of baroreflex control of heart rate in conscious rats.
Topics: Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Bradycardia; Clonidine; Denervation; D | 1999 |
Bradycardia-induced coronary angiogenesis is dependent on vascular endothelial growth factor.
Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; Antibodies; Blotting, Northern; Blotting, Western; B | 1999 |
Can a dose of 2microg.kg(-1) caudal clonidine cause respiratory depression in neonates?
Topics: Adrenergic alpha-Agonists; Amides; Anesthesia, Caudal; Anesthesia, Inhalation; Anesthetics, Local; A | 1999 |
A developmental analysis of clonidine's effects on cardiac rate and ultrasound production in infant rats.
Topics: Animals; Autonomic Nervous System; Behavior, Animal; Bradycardia; Clonidine; Female; Heart Rate; Mal | 2000 |
Trends and toxic effects from pediatric clonidine exposures.
Topics: Adolescent; Adrenergic alpha-Agonists; Age Distribution; Attention Deficit Disorder with Hyperactivi | 2002 |
Clonidine poisoning in children.
Topics: Age Factors; Bradycardia; Child, Preschool; Clonidine; Female; Humans; Male | 1977 |
Antihypertensive action of clonidine (Catapresan).
Topics: Animals; Blood Pressure; Bradycardia; Brain Stem; Cats; Clonidine; Depression, Chemical; Drug Evalua | 1977 |
Clonidine poisoning: is there a single antidote?
Topics: Antidotes; Bradycardia; Child, Preschool; Clonidine; Dopamine; Gastric Lavage; Humans; Hypotension; | 1979 |
Severe poisoning in a child caused by a small dose of clonidine.
Topics: Bradycardia; Clonidine; Female; Humans; Hypotension; Infant; Unconsciousness | 1979 |
Adverse effects of sympatholytic agents in patients with hypertension and sinus node dysfunction.
Topics: Aged; Arrhythmia, Sinus; Bradycardia; Clonidine; Electrocardiography; Female; Guanethidine; Heart Ra | 1978 |
Severe bradycardia with clonidine.
Topics: Bradycardia; Clonidine; Humans; Male; Middle Aged | 1978 |
Clonidine poisoning.
Topics: Atropine; Blood Pressure; Bradycardia; Child, Preschool; Clonidine; Coma; Heart Rate; Humans; Hypoth | 1976 |
Management in cases of clonidine overdosage.
Topics: Adolescent; Atropine; Blood Pressure; Bradycardia; Clonidine; Diuresis; Female; Humans; Hypotension; | 1976 |
[Letter: Bradycardia induced by clonidine].
Topics: Aged; Blood Pressure; Bradycardia; Clonidine; Electrocardiography; Female; Humans | 1976 |
Evidence for antagonistic activity of endothelin for clonidine induced hypotension and bradycardia.
Topics: Animals; Blood Pressure; Bradycardia; Clonidine; Depression, Chemical; Endothelins; Heart Rate; Hypo | 1992 |
Esmolol and clonidine--a possible interaction.
Topics: Adrenergic beta-Antagonists; Bradycardia; Clonidine; Drug Interactions; Humans; Male; Propanolamines | 1992 |
Evaluation of the central and peripheral components for induction of postural hypotension by guanethidine, clonidine, dopamine2 receptor agonists and 5-hydroxytryptamine1A receptor agonists.
Topics: Animals; Blood Pressure; Bradycardia; Cats; Central Nervous System; Clonidine; Female; Guanethidine; | 1991 |
Clonidine poisoning in young children.
Topics: Atropine; Bradycardia; Charcoal; Child; Child, Preschool; Clonidine; Female; Gastric Lavage; Heart R | 1990 |
[Acute klofelin poisoning].
Topics: Acute Disease; Adolescent; Adult; Antidotes; Atropine; Benzilates; Bradycardia; Child, Preschool; Ch | 1990 |
[Clinical aspects and diagnosis of klofelin poisoning].
Topics: Adolescent; Adult; Bradycardia; Clonidine; Combined Modality Therapy; Electrocardiography; Female; H | 1990 |
Are opioid receptors involved in the bradycardiac and hypotensive action of clonidine?
Topics: Animals; Blood Pressure; Bradycardia; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Hyper | 1988 |
Circadian rhythm of heart rate in the rabbit: prolongation of action potential duration by sustained beta adrenoceptor blockade is not due to associated bradycardia.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Bradycardia; Circadian Rhythm; Clonidine; H | 1986 |
Risk factors for severe bradycardia during oral clonidine therapy for hypertension.
Topics: Administration, Oral; Aged; Bradycardia; Clonidine; Electrocardiography; Female; Humans; Hypertensio | 1988 |
Tachycardic and hypertensive effects of centrally administered clonidine in conscious rats.
Topics: Animals; Atropine; Blood Pressure; Bradycardia; Clonidine; Heart Rate; Hypertension; Hypotension; In | 1986 |
Anion-channel blockade with alinidine: a specific bradycardic drug for coronary heart disease without negative inotropic activity?
Topics: Adult; Aged; Bradycardia; Cardiac Pacing, Artificial; Cardiotonic Agents; Clonidine; Coronary Diseas | 1985 |
[Lifting with clonidine of atropinic inhibition of heart-moderation tonus].
Topics: Animals; Antihypertensive Agents; Atropine; Bradycardia; Clonidine; Dogs; Drug Antagonism; Electroca | 1971 |
Involvement of adrenergic receptors in central vagus activity.
Topics: Angiotensin II; Animals; Blood Pressure; Bradycardia; Clonidine; Dogs; Heart Rate; Phentolamine; Rec | 1971 |
Evidence for a central activation of a vagal cardiodepressor reflex by clonidine.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Atropine; Blood Pressure; Bradycardia; Central Nervous | 1972 |
Facilitation of vagal reflex bradycardia by an action of clonidine on central -receptors.
Topics: Acetylcholine; Adrenergic beta-Antagonists; Animals; Blood Pressure; Bradycardia; Cerebellum; Chlorp | 1972 |
[Does vagal hypertonia induced by clonidine modify the atrial refractory period in chloralose-treated dogs?].
Topics: Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Bradycardia; Chloralose; Clonidine; Dogs; Electr | 1972 |
[Effects of clonidine treatment in advanced forms of essential arterial hypertension].
Topics: Aged; Aortic Arch Syndromes; Bradycardia; Cerebral Hemorrhage; Chemical Phenomena; Chemistry; Chlort | 1973 |