clonidine has been researched along with Body Weight in 111 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonidine did not improve stuttering." | 9.08 | Lack of effect of clonidine on stuttering in children. ( Althaus, M; Goorhuis-Brouwer, SM; Minderaa, RB; Oosterhoff, MD; Vink, HJ, 1995) |
| "1 A double-blind cross over trial between clonidine, propranolol and a placebo in patients with moderate hypertension has been performed." | 9.04 | A comparative trial of clonidine, propranolol and placebo in the treatment of moderate hypertension. ( Raftery, EB; Wilkinson, PR, 1977) |
| "To assess growth hormone (GH) levels in response to acute clonidine stimulation in nonobese patients with polycystic ovary syndrome (PCOS) in comparison to patients with idiopathic hirsutism (IH) and normal women without hirsutism." | 7.72 | Increased growth hormone response to clonidine in nonobese normoinsulinemic patients with polycystic ovary syndrome. ( Comim, FV; Spritzer, PM, 2004) |
| "The role that the central sympathetic nervous system plays in the development of obesity hypertension and insulin was evaluated by feeding dogs a high fat diet with or without clonidine treatment." | 7.70 | Clonidine prevents insulin resistance and hypertension in obese dogs. ( Babu, K; Mao, HZ; Marker, P; Rocchini, AJ; Rocchini, AP, 1999) |
| "Clonidine's action on naloxone (Nx)-induced suppression of fixed-ratio (FR15) responding and body weight loss was studied in morphine (M)-dependent rats." | 7.66 | Clonidine antagonizes naloxone-induced suppression of conditioned behavior and body weight loss in morphine-dependent rats. ( Meyer, DR; Sparber, SB, 1978) |
| "5 mg clonidine (clonidine-TTS) was investigated in 21 patients with essential hypertension over a period of 10 weeks." | 7.66 | [Clonidine transdermal therapeutic system in essential hypertension: effect and tolerance]. ( Baumgart, P; Boerlin, HJ; Groth, H; Knüsel, J; Siegenthaler, W; Vetter, H; Vetter, W; Walger, P; Wehling, M, 1983) |
| " Contrary to beta-adrenoceptor blocking agents, we found no inhibition of the beneficial effect on SBP of training in combination with CL or R." | 5.28 | Effects of swim training alone and in combination with clonidine and rilmenidine on blood pressure, plasma electrolytes, vasopressin, and renin activity in spontaneously hypertensive rats. ( Frutoso, J; Geelen, G; Ghaemmaghami, F; Gharib, C; Ibanez, J; Vincent, M, 1990) |
| "Clonidine did not improve stuttering." | 5.08 | Lack of effect of clonidine on stuttering in children. ( Althaus, M; Goorhuis-Brouwer, SM; Minderaa, RB; Oosterhoff, MD; Vink, HJ, 1995) |
| "The effectiveness of transdermally administered clonidine hydrochloride was evaluated in a multicenter study in 85 patients with mild essential hypertension." | 5.05 | Transdermal administration of clonidine for treatment of high BP. ( Drayer, JI; Hamburger, R; Kirk, LN; McMahon, FG; Shah, AR; Weber, MA, 1984) |
| " Sixteen patients with essential hypertension were treated with guanfacine and with clonidine for 5 weeks each in a double-blind, placebo-controlled, cross-over trial." | 5.05 | Antihypertensive effect of guanfacine: a double-blind cross-over trial compared with clonidine. ( Distler, A; Kirch, W; Lüth, B, 1980) |
| "1 A double-blind cross over trial between clonidine, propranolol and a placebo in patients with moderate hypertension has been performed." | 5.04 | A comparative trial of clonidine, propranolol and placebo in the treatment of moderate hypertension. ( Raftery, EB; Wilkinson, PR, 1977) |
| "Sixteen patients with essential hypertension were treated with N-Amidino-2-(2,6-dichlorophenyl) acetamide hydrochloride (BS 100--141) and clonidine for five weeks each in a double-blind cross-over trial." | 5.04 | Antihypertensive effect of N-amidino-2-(2,6-dichlorophenyl) acetamide hydrochloride. A double-blind cross-over trial versus clonidine. ( Distler, A; Kirch, W, 1978) |
| "To assess growth hormone (GH) levels in response to acute clonidine stimulation in nonobese patients with polycystic ovary syndrome (PCOS) in comparison to patients with idiopathic hirsutism (IH) and normal women without hirsutism." | 3.72 | Increased growth hormone response to clonidine in nonobese normoinsulinemic patients with polycystic ovary syndrome. ( Comim, FV; Spritzer, PM, 2004) |
| "The role that the central sympathetic nervous system plays in the development of obesity hypertension and insulin was evaluated by feeding dogs a high fat diet with or without clonidine treatment." | 3.70 | Clonidine prevents insulin resistance and hypertension in obese dogs. ( Babu, K; Mao, HZ; Marker, P; Rocchini, AJ; Rocchini, AP, 1999) |
| " Bradycardia was induced in rats by administering the bradycardic drug alinidine (3 mg/kg body weight) twice daily." | 3.70 | Bradycardia-induced coronary angiogenesis is dependent on vascular endothelial growth factor. ( Bjercke, RJ; Brock, TA; Brown, MD; Tomanek, RJ; Zheng, W, 1999) |
| "Apraclonidine and brimonidine administered topically to one eye of ketamine-anesthetized normal cynomolgus monkeys each produced a dose-related bilateral reduction in intraocular pressure which was not dependent on intact sympathetic innervation." | 3.69 | Apraclonidine and brimonidine effects on anterior ocular and cardiovascular physiology in normal and sympathectomized monkeys. ( Debink, N; Gabelt, BT; Hubbard, WC; Kaufman, PL; Peterson, CM; Robinson, JC; Wadhwa, A, 1994) |
| " The circadian rhythm of beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH), and their responses to the administration of corticotropin releasing hormone (CRH, 1 micrograms/kg body weight, i." | 3.68 | Peripheral opioid secretory pattern in anorexia nervosa. ( Brambilla, F; Catalano, M; Facchinetti, F; Ferrari, E; Genazzani, AR; Petraglia, F, 1991) |
| "Phenelzine (PLZ), a nonselective monoamine oxidase inhibitor, is widely used in psychiatry for the treatment of panic disorder and depression." | 3.68 | Chronic administration of the antidepressant-antipanic drug phenelzine and its N-acetylated analogue: effects on monoamine oxidase, biogenic amines, and alpha 2-adrenoreceptor function. ( Baker, GB; Coutts, RT; Greenshaw, AJ; McKenna, KF, 1992) |
| " This study evaluates whether early reduction of CNH by the alpha-2 presynaptic adrenoreceptor agonist clonidine, prevents long-term morphofunctional deficits induced by protein-energy malnutrition in the rat." | 3.67 | Effect of clonidine early in life on brain morphofunctional deficits induced by neonatal malnutrition in the rat. ( Belmar, J; Galleguillos, X; Hernandez, A; Perez, H; Ruiz, S; Soto-Moyano, R, 1989) |
| "The effect of short-term diuretic treatment on the action of clonidine was evaluated in eight subjects with mild, uncomplicated hypertension." | 3.67 | Diuretic treatment alters clonidine suppression of plasma norepinephrine. ( Felton, K; Hui, TP; Krakoff, LR; Yeager, K, 1986) |
| " The plasma level of growth hormone (GH) over 24 hours was elevated during fasting and administration of the alpha 2-adrenergic receptor agonist clonidine resulted in a subnormal GH response after restoration of original body weight." | 3.67 | Weight loss causes neuroendocrine disturbances: experimental study in healthy starving subjects. ( Fichter, MM; Holsboer, F; Pirke, KM, 1986) |
| "5 mg clonidine (clonidine-TTS) was investigated in 21 patients with essential hypertension over a period of 10 weeks." | 3.66 | [Clonidine transdermal therapeutic system in essential hypertension: effect and tolerance]. ( Baumgart, P; Boerlin, HJ; Groth, H; Knüsel, J; Siegenthaler, W; Vetter, H; Vetter, W; Walger, P; Wehling, M, 1983) |
| "The systemic, cardiovascular hemodynamic and biochemical interactions between clonidine and minoxidil were studied in ten patients with refractory and/or accelerated hypertension." | 3.66 | Cardiovascular hemodynamic interactions between clonidine and minoxidil in hypertensive patients. ( Angeli-Greaves, M; Hernandez-Pieretti, O; Morillo, J; Silva, H; Urbina-Quintana, A; Velasco, M, 1983) |
| "We examined the hemodynamic interaction between clonidine, a centrally acting antiadrenergic drug, and minoxidil, a potent antihypertensive vasodilator in 10 inpatients with refractory or accelerated hypertension or both." | 3.66 | Systemic and cardiac hemodynamic interactions between clonidine and minoxidil. ( Aliendres, R; Andrews-Figueroa, P; Hernańdez-Pieretti, O; Morillo, J; Ramiŕez, A; Urbina-Quintana, A; Velasco, M, 1981) |
| "Clonidine's action on naloxone (Nx)-induced suppression of fixed-ratio (FR15) responding and body weight loss was studied in morphine (M)-dependent rats." | 3.66 | Clonidine antagonizes naloxone-induced suppression of conditioned behavior and body weight loss in morphine-dependent rats. ( Meyer, DR; Sparber, SB, 1978) |
| " Clonidine (6 mg of base/l of water) was given as drinking fluid to normotensive rats or rats with established or early hypertension." | 3.66 | Effect of chronic clonidine treatment and its abrupt cessation on mean blood pressure of rats with a normal or an elevated blood pressure. ( Atkinson, J; Boillat, N; Kirchertz, EJ; Pera-Bally, R; Peters-Haefeli, L, 1979) |
| "Among nonsmokers, the peak concentration (C(max)) and area under concentration-time curve from 0 to infinity [AUC(0-infinity)] of tizanidine did not differ significantly between females and males." | 2.73 | Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine. ( Backman, JT; Neuvonen, PJ; Schröder, MT, 2008) |
| "Hypocalcemia was detected in five of the 30 thalassemic patients: hypoparathyroidism was diagnosed in two of the five and rickets in the other three." | 2.69 | Bone mineral density in prepubertal children with beta-thalassemia: correlation with growth and hormonal data. ( Abdel Fattah, M; Ansari, BM; El Banna, N; ElZalabani, MM; Soliman, AT, 1998) |
| "1 Tiamenidine (Hoe 440) is an imidazoline with blood pressure lowering properties." | 2.65 | Changes in blood pressure, plasma catecholamines and plasma renin activity during and after treatment with tiamenidine and clonidine. ( Hansson, BG; Hökfelt, B, 1981) |
| "Morphine-treated rats (10 mg/kg/12 h) received naloxone (3." | 1.36 | Precipitated and conditioned withdrawal in morphine-treated rats. ( Becker, GL; France, CP; Gerak, LR; Koek, W; Li, JX, 2010) |
| "Rehabilitation of COPD-patients is an important part of the therapeutic management." | 1.33 | [COPD-rehabilitation]. ( Lichtenschopf, A; Zwick, H, 2005) |
| "Clonidine is an effective spinal analgesic, but it is dose-limited by cardiovascular side effects." | 1.32 | Continuous intrathecal clonidine and tizanidine in conscious dogs: analgesic and hemodynamic effects. ( Ivankovich, AD; Kroin, JS; Lubenow, TJ; McCarthy, RJ; Penn, RD, 2003) |
| " Contrary to beta-adrenoceptor blocking agents, we found no inhibition of the beneficial effect on SBP of training in combination with CL or R." | 1.28 | Effects of swim training alone and in combination with clonidine and rilmenidine on blood pressure, plasma electrolytes, vasopressin, and renin activity in spontaneously hypertensive rats. ( Frutoso, J; Geelen, G; Ghaemmaghami, F; Gharib, C; Ibanez, J; Vincent, M, 1990) |
| " Chronic administration of spironolactone prevented the development of hypertension but failed to prevent other adaptive physiological changes characteristically occurring during exposure to cold and seen in the cold-treated control rats." | 1.28 | Effect of chronic treatment with clonidine and spironolactone on cold-induced elevation of blood pressure. ( Baron, A; Fregly, MJ; Riesselmann, A, 1991) |
| "Clonidine treatment significantly increased the weight gain, but did not affect plasma glucose, insulin, glucagon and norepinephrine in the diabetic animals." | 1.28 | Central adrenergic suppression augments the insulin and glucagon secretory, and the glycogenolytic responses in streptozotocin-diabetic rats. ( Colemen, ER; Dunbar, JC; Marzouq, L; Shaffer, LR, 1991) |
| "The nicotine intake was then maintained at a level of 6." | 1.27 | Prenatal nicotine exposure increases adrenergic receptor binding in the rat cerebral cortex. ( Peters, DA, 1984) |
| "Clonidine was delivered via osmotic minipumps." | 1.27 | Chronic clonidine treatment and its withdrawal: effects on blood pressure and catecholamine synthesizing enzymes in brain-stem nuclei. ( Atkinson, J; Boillat, N; Lambas-Senas, L; Luthi, P; Parker, M; Renaud, B; Seccia, M; Sonnay, M, 1986) |
| "Prazosin, which was without effect in nonandrogenized animals, also attenuated the inhibitory effect of TP on differentiation of lordosis behavior." | 1.27 | Postnatal treatment of rats with adrenergic receptor agonists or antagonists influences differentiation of sexual behavior. ( Döhler, KD; Geerlings, H; Jarzab, B; Sickmöller, PM, 1987) |
| "Maternal body weight was reduced in a dose dependent manner." | 1.27 | Neurochemical evaluation of rats prenatally exposed to the adrenergic agonists clonidine and lofexidine. ( Ali, SF; Holson, RR; Newport, GD; Pizzi, WJ; Slikker, W, 1988) |
| " These data argue against desensitisation of peripheral presynaptic alpha 2-adrenoceptors by chronic administration of alpha 2-adrenoceptor agonist." | 1.27 | Chronic clonidine treatment produces desensitisation of post- but not presynaptic alpha 2-adrenoceptors. ( Finberg, JP; Kopin, IJ, 1987) |
| "Clonidine (CLON), is a widely used antihypertensive agent with a potential for expanded therapeutic application in combating drug withdrawal symptoms in opiate and alcohol addiction." | 1.27 | Behavioral evaluation of rats prenatally exposed to the adrenergic agonists clonidine and lofexidine. ( Ali, SF; Holson, RR; Pizzi, WJ, 1988) |
| "Treatment with clonidine (100 micrograms/kg s." | 1.27 | Changes in locomotor-activity patterns as a measure of spontaneous morphine withdrawal: no effect of clonidine. ( de Groot, G; van der Laan, JW, 1988) |
| "Clonidine-treated animals showed significant weight loss and decrease in temperature, and those treated with high doses showed marked hypothermia and hind-limb flaccidity." | 1.27 | Intrathecal clonidine: analgesia and effect on opiate withdrawal in the rat. ( Cervenko, FW; Jhamandas, K; Milne, B; Sutak, M, 1985) |
| " Independent groups of pups from dams given either 6% or 25% casein diets received one of five doses of clonidine at 5, 10, 15, 20 or 25 days of age and dose-response relationships for motor activity were determined." | 1.27 | Altered development of responsiveness to clonidine in severely malnourished rats. ( Goodlett, CR; Morgane, PJ; Resnick, O; Valentino, ML, 1985) |
| "Clonidine was given in doses of 0." | 1.26 | Clonidine and prazosin effects in hypernoradrenergic vasodilator-treated and beta-blocker-treated patients. ( Mitchell, HC; Pettinger, WA, 1981) |
| "The present experiments were undertaken to elucidate the effect of long-term administration of clonidine and its cessation on blood pressure, heart rate and sympathetic nerve activity in spontaneously hypertensive rats (SHR)." | 1.26 | [Effects of long-term administration and cessation of clonidine on blood pressure in spontaneously hypertensive rats (author's transl)]. ( Yomaida, I, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 64 (57.66) | 18.7374 |
| 1990's | 30 (27.03) | 18.2507 |
| 2000's | 12 (10.81) | 29.6817 |
| 2010's | 5 (4.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trifa, M | 1 |
| Tumin, D | 1 |
| Whitaker, EE | 1 |
| Bhalla, T | 1 |
| Jayanthi, VR | 1 |
| Tobias, JD | 1 |
| Zhou, G | 1 |
| Du, R | 1 |
| Lee, J | 1 |
| Yoon, J | 1 |
| Kang, MJ | 1 |
| Lee, YA | 1 |
| Lee, SY | 1 |
| Shin, CH | 1 |
| Yang, SW | 1 |
| Kazi, RN | 1 |
| Munavvar, AS | 1 |
| Abdullah, NA | 1 |
| Khan, AH | 1 |
| Johns, EJ | 1 |
| Becker, GL | 1 |
| Gerak, LR | 1 |
| Li, JX | 1 |
| Koek, W | 1 |
| France, CP | 1 |
| af Klint, R | 1 |
| Mazzaro, N | 1 |
| Nielsen, JB | 1 |
| Sinkjaer, T | 1 |
| Grey, MJ | 1 |
| Kroin, JS | 1 |
| McCarthy, RJ | 1 |
| Penn, RD | 1 |
| Lubenow, TJ | 1 |
| Ivankovich, AD | 1 |
| Comim, FV | 1 |
| Spritzer, PM | 1 |
| Nwosu, BU | 1 |
| Coco, M | 1 |
| Jones, J | 1 |
| Barnes, KM | 1 |
| Yanovski, JA | 1 |
| Baron, J | 1 |
| Zwick, H | 1 |
| Lichtenschopf, A | 1 |
| Akbas, M | 1 |
| Akbas, H | 1 |
| Yegin, A | 1 |
| Sahin, N | 1 |
| Titiz, TA | 1 |
| Kurcer, Z | 1 |
| Sahna, E | 1 |
| Olmez, E | 1 |
| Backman, JT | 1 |
| Schröder, MT | 1 |
| Neuvonen, PJ | 1 |
| Takenouchi, Y | 1 |
| Kobayashi, T | 1 |
| Matsumoto, T | 1 |
| Kamata, K | 1 |
| Mitchell, HC | 1 |
| Pettinger, WA | 1 |
| Schlemmer, RF | 3 |
| Casper, RC | 3 |
| Elder, JK | 1 |
| Davis, JM | 2 |
| Estes, KS | 1 |
| Simpkins, JW | 1 |
| Brenner, E | 1 |
| Mirmiran, M | 1 |
| Uylings, HB | 1 |
| Van der Gugten, J | 1 |
| Velasco, M | 2 |
| Silva, H | 1 |
| Morillo, J | 2 |
| Urbina-Quintana, A | 2 |
| Hernandez-Pieretti, O | 2 |
| Angeli-Greaves, M | 1 |
| Weber, MA | 1 |
| Drayer, JI | 1 |
| McMahon, FG | 1 |
| Hamburger, R | 1 |
| Shah, AR | 1 |
| Kirk, LN | 1 |
| Eigenmann, JE | 1 |
| Patterson, DF | 1 |
| Froesch, ER | 1 |
| Kemnitz, JW | 1 |
| Ishise, S | 1 |
| Pegram, BL | 1 |
| Frohlich, ED | 1 |
| Plänitz, V | 1 |
| Peters, DA | 1 |
| Lichtenstein, SS | 1 |
| Marinescu, C | 1 |
| Leibowitz, SF | 2 |
| Groth, H | 1 |
| Vetter, H | 1 |
| Knüsel, J | 1 |
| Boerlin, HJ | 1 |
| Walger, P | 1 |
| Baumgart, P | 1 |
| Wehling, M | 1 |
| Siegenthaler, W | 1 |
| Vetter, W | 1 |
| Jerie, P | 1 |
| Distler, A | 2 |
| Kirch, W | 2 |
| Lüth, B | 1 |
| Hansson, BG | 1 |
| Hökfelt, B | 1 |
| Walker, BR | 1 |
| Hare, LE | 1 |
| Deitch, MW | 1 |
| Yomaida, I | 2 |
| Andrews-Figueroa, P | 1 |
| Ramiŕez, A | 1 |
| Aliendres, R | 1 |
| Gabelt, BT | 1 |
| Robinson, JC | 1 |
| Hubbard, WC | 1 |
| Peterson, CM | 1 |
| Debink, N | 1 |
| Wadhwa, A | 1 |
| Kaufman, PL | 1 |
| Althaus, M | 1 |
| Vink, HJ | 1 |
| Minderaa, RB | 1 |
| Goorhuis-Brouwer, SM | 1 |
| Oosterhoff, MD | 1 |
| Yaksh, TL | 1 |
| Rathbun, M | 1 |
| Jage, J | 1 |
| Mirzai, T | 1 |
| Grafe, M | 1 |
| Hiles, RA | 1 |
| Baranowska, B | 1 |
| Wasilewska-Dziubińska, E | 1 |
| Radzikowska, M | 1 |
| Płonowski, A | 1 |
| Roguski, K | 1 |
| Tsuchida, A | 1 |
| Liu, Y | 1 |
| Liu, GS | 1 |
| Cohen, MV | 1 |
| Downey, JM | 1 |
| Fletcher, PJ | 1 |
| Currie, PJ | 2 |
| Chambers, JW | 1 |
| Coscina, DV | 1 |
| Soltis, EE | 1 |
| Newman, PS | 1 |
| Trowbridge, JL | 1 |
| Matthews, K | 1 |
| Hall, FS | 1 |
| Wilkinson, LS | 1 |
| Robbins, TW | 1 |
| Bitar, MS | 2 |
| Pilcher, CW | 2 |
| Gilson, TL | 1 |
| Kennedy, AD | 1 |
| Rampersand, T | 1 |
| Etchegoyen, GS | 1 |
| Del Zotto, H | 1 |
| Gagliardino, JJ | 1 |
| Conway, S | 1 |
| Ling, SY | 1 |
| Leidy, JW | 1 |
| Blaine, K | 1 |
| Holtzman, T | 1 |
| Soliman, AT | 1 |
| El Banna, N | 1 |
| Abdel Fattah, M | 1 |
| ElZalabani, MM | 1 |
| Ansari, BM | 1 |
| Crow, S | 1 |
| Meller, W | 1 |
| Praus, B | 1 |
| Raatz, S | 1 |
| Mitchell, J | 1 |
| Rocchini, AP | 1 |
| Mao, HZ | 1 |
| Babu, K | 1 |
| Marker, P | 1 |
| Rocchini, AJ | 1 |
| Zheng, W | 1 |
| Brown, MD | 2 |
| Brock, TA | 1 |
| Bjercke, RJ | 1 |
| Tomanek, RJ | 1 |
| West, JP | 1 |
| Dykstra, LA | 1 |
| Lysle, DT | 1 |
| Highfield, D | 1 |
| Yap, J | 1 |
| Grimm, JW | 1 |
| Shalev, U | 1 |
| Shaham, Y | 1 |
| Auman, JT | 1 |
| Seidler, FJ | 1 |
| Tate, CA | 1 |
| Slotkin, TA | 1 |
| Narasimhachari, N | 1 |
| Atkinson, J | 3 |
| Boillat, N | 3 |
| Pera-Bally, R | 1 |
| Peters-Haefeli, L | 1 |
| Kirchertz, EJ | 1 |
| Wilkinson, PR | 1 |
| Raftery, EB | 1 |
| Saito, H | 1 |
| Koike, Y | 1 |
| Otani, T | 1 |
| Togashi, H | 1 |
| Sparber, SB | 1 |
| Meyer, DR | 1 |
| Sweet, RM | 1 |
| Danielson, BD | 1 |
| Wathen, RL | 1 |
| Sugimoto, S | 1 |
| Hashida, M | 1 |
| Kasahara, K | 1 |
| Nygren, LG | 1 |
| Olson, L | 1 |
| Harris, R | 1 |
| Snell, D | 1 |
| Loh, HH | 1 |
| Way, EL | 1 |
| Rieg, TS | 1 |
| Aravich, PF | 1 |
| McFarland, JW | 1 |
| Ricketts, AP | 1 |
| Newcomb, DM | 1 |
| Shively, JE | 1 |
| Glazer, EA | 1 |
| Hudlicka, O | 1 |
| McKenna, KF | 1 |
| Baker, GB | 1 |
| Coutts, RT | 1 |
| Greenshaw, AJ | 1 |
| Brambilla, F | 1 |
| Ferrari, E | 1 |
| Petraglia, F | 1 |
| Facchinetti, F | 1 |
| Catalano, M | 1 |
| Genazzani, AR | 1 |
| Ghaemmaghami, F | 1 |
| Ibanez, J | 1 |
| Geelen, G | 1 |
| Vincent, M | 1 |
| Frutoso, J | 1 |
| Gharib, C | 1 |
| Baron, A | 1 |
| Riesselmann, A | 1 |
| Fregly, MJ | 1 |
| Dunbar, JC | 1 |
| Colemen, ER | 1 |
| Shaffer, LR | 1 |
| Marzouq, L | 1 |
| Jin, HK | 2 |
| Yang, RH | 2 |
| Wyss, JM | 2 |
| Chen, YF | 2 |
| Oparil, S | 2 |
| Leenen, FH | 1 |
| Klement, G | 1 |
| Mathias, CJ | 1 |
| Wilson, LM | 1 |
| Coiro, V | 1 |
| Capretti, L | 1 |
| Volpi, R | 1 |
| d'Amato, L | 1 |
| Marchesi, C | 1 |
| De Ferri, A | 1 |
| Rossi, G | 1 |
| Bianconi, L | 1 |
| Marcato, A | 1 |
| Chiodera, P | 1 |
| Soto-Moyano, R | 1 |
| Hernandez, A | 1 |
| Perez, H | 1 |
| Ruiz, S | 1 |
| Galleguillos, X | 1 |
| Belmar, J | 1 |
| Szemeredi, K | 1 |
| Zukowska-Grojec, Z | 1 |
| Bagdy, G | 1 |
| Fekete, MI | 1 |
| Kopin, IJ | 2 |
| Lewis, SJ | 1 |
| Dunlop, M | 1 |
| Jarrott, B | 1 |
| Krishnan, KR | 1 |
| Manepalli, AN | 1 |
| Ritchie, JC | 1 |
| Rayasam, K | 1 |
| Melville, ML | 1 |
| Daughtry, G | 1 |
| Thorner, MO | 1 |
| Rivier, JE | 1 |
| Vale, WW | 1 |
| Nemeroff, CB | 1 |
| Lambas-Senas, L | 1 |
| Parker, M | 1 |
| Luthi, P | 1 |
| Sonnay, M | 1 |
| Seccia, M | 1 |
| Renaud, B | 1 |
| Jarzab, B | 1 |
| Sickmöller, PM | 1 |
| Geerlings, H | 1 |
| Döhler, KD | 1 |
| Costall, B | 1 |
| Kelly, ME | 1 |
| Naylor, RJ | 1 |
| Ali, SF | 2 |
| Holson, RR | 2 |
| Pizzi, WJ | 2 |
| Newport, GD | 1 |
| Slikker, W | 1 |
| Michel, JB | 1 |
| Dussaule, JC | 1 |
| Choudat, L | 1 |
| Auzan, C | 1 |
| Nochy, D | 1 |
| Corvol, P | 1 |
| Menard, J | 1 |
| Hamilton, CA | 1 |
| Barr, SM | 1 |
| Reid, JL | 1 |
| Finberg, JP | 1 |
| Fichter, MM | 2 |
| Pirke, KM | 2 |
| Holsboer, F | 1 |
| Taylor, JR | 1 |
| Elsworth, JD | 1 |
| Garcia, EJ | 1 |
| Grant, SJ | 1 |
| Roth, RH | 1 |
| Redmond, DE | 1 |
| van der Laan, JW | 1 |
| de Groot, G | 1 |
| Słowińska-Srzednicka, J | 1 |
| Zgliczyński, S | 1 |
| Wierzbicki, M | 1 |
| Soszyński, P | 1 |
| Jeske, W | 1 |
| Javaid, JI | 1 |
| Kather, H | 1 |
| Wieland, E | 1 |
| Scheurer, A | 1 |
| Vogel, G | 1 |
| Wildenberg, U | 1 |
| Joost, C | 1 |
| Hui, TP | 1 |
| Krakoff, LR | 1 |
| Felton, K | 1 |
| Yeager, K | 1 |
| Baeyens, JM | 1 |
| Esposito, E | 1 |
| Ossowska, G | 1 |
| Samanin, R | 1 |
| Dennis, T | 1 |
| Langer, SZ | 1 |
| Scatton, B | 1 |
| Goodwin, GM | 1 |
| Fairburn, CG | 1 |
| Cowen, PJ | 1 |
| Zimlichman, R | 1 |
| Goldstein, DS | 1 |
| Stull, R | 1 |
| Folio, CJ | 1 |
| Keiser, HR | 1 |
| Milne, B | 1 |
| Cervenko, FW | 1 |
| Jhamandas, K | 1 |
| Sutak, M | 1 |
| Holtzman, SG | 1 |
| Weiss, GF | 1 |
| Goodlett, CR | 1 |
| Valentino, ML | 1 |
| Resnick, O | 1 |
| Morgane, PJ | 1 |
| Niggeschulze, A | 1 |
| Frölke, W | 1 |
| Stötzer, H | 1 |
| Salvetti, A | 1 |
| Arzilli, F | 1 |
| Zucchelli, GC | 1 |
| Safar, M | 2 |
| Baglin, A | 1 |
| Sobel, A | 2 |
| Merceron, R | 1 |
| Milliez, P | 2 |
| Matts, SG | 1 |
| Hashida, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| Denosumab Versus Zoledronic Acid for Patients With Beta-Thalassemia Major-Induced Osteoporosis[NCT03040765] | Phase 3 | 17 participants (Actual) | Interventional | 2018-05-14 | Terminated (stopped due to failed to recruit eligible subjects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
2 reviews available for clonidine and Body Weight
| Article | Year |
|---|---|
Obesity in macaques: spontaneous and induced.
Topics: Age Factors; Animals; Animals, Laboratory; Body Weight; Clonidine; Enteral Nutrition; Female; Humans | 1984 |
Management of hypertension by reduction in sympathetic activity.
Topics: Behavior Therapy; Blood Pressure; Body Weight; Clonidine; Humans; Hypertension; Methyldopa; Sympathe | 1991 |
15 trials available for clonidine and Body Weight
| Article | Year |
|---|---|
Comparison of the effects of clonidine and ketamine added to ropivacaine on stress hormone levels and the duration of caudal analgesia.
Topics: Adjuvants, Anesthesia; Aging; Amides; Anesthesia, Caudal; Anesthetics, Dissociative; Anesthetics, Lo | 2005 |
Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine.
Topics: Adrenergic alpha-Agonists; Adult; Area Under Curve; Blood Pressure; Body Weight; Caffeine; Clonidine | 2008 |
Transdermal administration of clonidine for treatment of high BP.
Topics: Age Factors; Black People; Blood Pressure; Body Weight; Clinical Trials as Topic; Clonidine; Female; | 1984 |
Crossover comparison of moxonidine and clonidine in mild to moderate hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Body Weight; Clonidine; Creatine; Double-Blind Metho | 1984 |
Antihypertensive effect of guanfacine: a double-blind cross-over trial compared with clonidine.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as To | 1980 |
Changes in blood pressure, plasma catecholamines and plasma renin activity during and after treatment with tiamenidine and clonidine.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Body Weight; Catecholamines; Clonidine; Epinephrine; | 1981 |
Comparative antihypertensive effects of guanabenz and clonidine.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Clonidi | 1982 |
Lack of effect of clonidine on stuttering in children.
Topics: Adolescent; Body Weight; Child; Clonidine; Cross-Over Studies; Double-Blind Method; Drug Administrat | 1995 |
Bone mineral density in prepubertal children with beta-thalassemia: correlation with growth and hormonal data.
Topics: Absorptiometry, Photon; Adolescent; Adrenocorticotropic Hormone; Age Factors; Alkaline Phosphatase; | 1998 |
Failure of clonidine to stimulate feeding in healthy humans.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Body Weight; Clonidine; Double-Blind Method; | 1998 |
A comparative trial of clonidine, propranolol and placebo in the treatment of moderate hypertension.
Topics: Adult; Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Clonidine; Double-Blind Method; | 1977 |
Antihypertensive effect of N-amidino-2-(2,6-dichlorophenyl) acetamide hydrochloride. A double-blind cross-over trial versus clonidine.
Topics: Adolescent; Adult; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; C | 1978 |
Growth hormone responses to growth hormone-releasing hormone, clonidine and insulin-induced hypoglycemia in normal weight bulimic women.
Topics: Adult; Blood Glucose; Body Weight; Bulimia; Clonidine; Female; Growth Hormone; Growth Hormone-Releas | 1990 |
Growth hormone (GH) secretion during nocturnal sleep and after clonidine in patients with essential hypertension.
Topics: Adolescent; Adult; Blood Pressure; Body Weight; Clonidine; Female; Growth Hormone; Humans; Hypertens | 1988 |
A placebo-controlled crossover study of oral clonidine in acute anorexia nervosa.
Topics: Adult; Anorexia Nervosa; Blood Pressure; Body Weight; Clinical Trials as Topic; Clonidine; Emotions; | 1987 |
94 other studies available for clonidine and Body Weight
| Article | Year |
|---|---|
Spinal anesthesia for surgery longer than 60 min in infants: experience from the first 2 years of a spinal anesthesia program.
Topics: Anesthesia, General; Anesthesia, Spinal; Body Weight; Bupivacaine; Clonidine; Dexmedetomidine; Fenta | 2018 |
Dynamic Ghrelin and GH serum levels during combined simultaneous arginine clonidine stimulation test in children with dwarfism.
Topics: Adrenergic alpha-2 Receptor Agonists; Arginine; Body Height; Body Weight; Child; Clonidine; Dwarfism | 2019 |
Influence of body mass index on the growth hormone response to provocative testing in short children without growth hormone deficiency.
Topics: Adolescent; Body Height; Body Mass Index; Body Weight; Child; Child, Preschool; Clonidine; Dopamine; | 2013 |
Influence of high dietary sodium intake on the functional subtypes of alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Body | 2009 |
Precipitated and conditioned withdrawal in morphine-treated rats.
Topics: Animals; Body Weight; Clonidine; Conditioning, Classical; Male; Morphine; Morphine Dependence; Nalox | 2010 |
Load rather than length sensitive feedback contributes to soleus muscle activity during human treadmill walking.
Topics: Adult; Afferent Pathways; Ankle Joint; Biomechanical Phenomena; Body Weight; Clonidine; Electromyogr | 2010 |
Continuous intrathecal clonidine and tizanidine in conscious dogs: analgesic and hemodynamic effects.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Body Temperature; Body Weight; Clonidine; Dogs; Dose | 2003 |
Increased growth hormone response to clonidine in nonobese normoinsulinemic patients with polycystic ovary syndrome.
Topics: Adolescent; Adult; Body Weight; Case-Control Studies; Clonidine; Cross-Sectional Studies; Female; Hi | 2004 |
Short stature with normal growth hormone stimulation testing: lack of evidence for partial growth hormone deficiency or insensitivity.
Topics: Adolescent; Adrenergic alpha-Agonists; Arginine; Body Weight; Child; Clonidine; Dwarfism, Pituitary; | 2004 |
[COPD-rehabilitation].
Topics: Acupuncture Therapy; Adrenergic alpha-Agonists; Antidepressive Agents, Second-Generation; Antidepres | 2005 |
Vascular reactivity to various vasoconstrictor agents and endothelium-dependent relaxations of rat thoracic aorta in the long-term period of pinealectomy.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta, Thoracic; Body Weight; Clonidine; Dose-Response Relat | 2006 |
Possible involvement of Akt activity in endothelial dysfunction in type 2 diabetic mice.
Topics: Adrenomedullin; Animals; Aorta; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Clonidine; | 2008 |
Clonidine and prazosin effects in hypernoradrenergic vasodilator-treated and beta-blocker-treated patients.
Topics: Adrenergic beta-Antagonists; Blood Pressure; Body Weight; Clonidine; Diastole; Diuretics; Female; Hu | 1981 |
Hyperphagia and weight gain in monkeys treated with clonidine.
Topics: Animals; Body Weight; Clonidine; Dose-Response Relationship, Drug; Drinking; Eating; Female; Macaca; | 1981 |
Resumption of pulsatile luteinizing hormone release after alpha-adrenergic stimulation in aging constant estrous rat.
Topics: Aging; Animals; Body Weight; Castration; Clonidine; Estrus; Female; Luteinizing Hormone; Organ Size; | 1982 |
Impaired growth of the cerebral cortex of rats treated neonatally with 6-hydroxydopamine under different environmental conditions.
Topics: Animals; Animals, Newborn; Body Weight; Cerebral Cortex; Clonidine; Environment; Hydroxydopamines; N | 1983 |
Cardiovascular hemodynamic interactions between clonidine and minoxidil in hypertensive patients.
Topics: Adult; Blood Pressure; Body Weight; Clonidine; Dopamine beta-Hydroxylase; Drug Interactions; Heart R | 1983 |
Body size parallels insulin-like growth factor I levels but not growth hormone secretory capacity.
Topics: Animals; Biometry; Body Weight; Clonidine; Dogs; Growth Hormone; Insulin; Peptides; Secretory Rate; | 1984 |
Disparate effects of methyldopa and clonidine on cardiac mass and haemodynamics in rats.
Topics: Animals; Body Weight; Cardiomegaly; Clonidine; Hemodynamics; Hypertension; Methyldopa; Myocardium; O | 1980 |
Prenatal nicotine exposure increases adrenergic receptor binding in the rat cerebral cortex.
Topics: Animals; Body Weight; Cerebral Cortex; Clonidine; Dihydroalprenolol; Dioxanes; Female; Neurons; Nico | 1984 |
Chronic infusion of norepinephrine and clonidine into the hypothalamic paraventricular nucleus.
Topics: Animals; Body Weight; Clonidine; Drinking; Eating; Hypothalamus; Male; Norepinephrine; Rats; Rats, I | 1984 |
[Clonidine transdermal therapeutic system in essential hypertension: effect and tolerance].
Topics: Adult; Body Weight; Clonidine; Dermatitis, Contact; Drug Tolerance; Female; Heart Rate; Humans; Hydr | 1983 |
Clinical experience with guanfacine in long-term treatment of hypertension. Part II: adverse reactions to guanfacine.
Topics: Antihypertensive Agents; Body Weight; Clonidine; Dose-Response Relationship, Drug; Drug Administrati | 1980 |
[Effects of long-term administration and cessation of clonidine on blood pressure in spontaneously hypertensive rats (author's transl)].
Topics: Action Potentials; Animals; Blood Pressure; Body Weight; Catecholamines; Clonidine; Eating; Heart Ra | 1980 |
Systemic and cardiac hemodynamic interactions between clonidine and minoxidil.
Topics: Adult; Blood Pressure; Body Weight; Clonidine; Female; Heart; Heart Rate; Hemodynamics; Humans; Hype | 1981 |
Apraclonidine and brimonidine effects on anterior ocular and cardiovascular physiology in normal and sympathectomized monkeys.
Topics: Adrenergic alpha-Agonists; Animals; Aqueous Humor; Blood Pressure; Body Weight; Brimonidine Tartrate | 1994 |
Pharmacology and toxicology of chronically infused epidural clonidine.HCl in dogs.
Topics: Analgesia; Animals; Blood Pressure; Body Weight; Clonidine; Dogs; Epidural Space; Heart Rate; Male; | 1994 |
Impaired response of atrial natriuretic peptide to acute water load in obesity and in anorexia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Atrial Natriuretic Factor; Body Weight; Clonidine; Female; Huma | 1995 |
alpha 1-adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals | 1994 |
Radiofrequency lesions of the PVN fail to modify the effects of serotonergic drugs on food intake.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Clonidine; Feeding Behavior; Fenfluram | 1993 |
Differential cerebrovascular responsiveness in spontaneously hypertensive rats following antihypertensive treatment with clonidine and verapamil.
Topics: Animals; Blood Pressure; Body Weight; Cerebrovascular Circulation; Clonidine; Heart Rate; Hypertensi | 1993 |
Retarded acquisition and reduced expression of conditioned locomotor activity in adult rats following repeated early maternal separation: effects of prefeeding, d-amphetamine, dopamine antagonists and clonidine.
Topics: Adrenergic alpha-Agonists; Amphetamine; Analysis of Variance; Animals; Anxiety, Separation; Behavior | 1996 |
Insulin-dependent attenuation in alpha 2-adrenoreceptor-mediated nociception in experimental diabetes.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 1997 |
Effects of breed and adipose depot location on responsiveness and sensitivity to adrenergic stimulation in ovine adipose tissue.
Topics: Adipocytes; Adipose Tissue; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Analysis of Varia | 1996 |
Effect of prolonged feeding of a sucrose-rich diet to normal rats on their hypothalamic alpha-2 adrenergic receptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Binding, Competitive; Body | 1997 |
Effect of fetal ethanol exposure on the in vitro release of growth hormone, somatostatin and growth hormone-releasing factor induced by clonidine and growth hormone feedback in male and female rats.
Topics: Adrenergic alpha-Agonists; Animals; Body Weight; Clonidine; Culture Techniques; Feedback; Female; Fe | 1997 |
Clonidine prevents insulin resistance and hypertension in obese dogs.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Cardiac Output; Clonid | 1999 |
Bradycardia-induced coronary angiogenesis is dependent on vascular endothelial growth factor.
Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; Antibodies; Blotting, Northern; Blotting, Western; B | 1999 |
Immunomodulatory effects of morphine withdrawal in the rat are time dependent and reversible by clonidine.
Topics: Animals; Body Weight; Clonidine; Hypothalamo-Hypophyseal System; Immune System; Interferon-gamma; Ki | 1999 |
Diabetes attenuates the response of the lumbospinal noradrenergic system to idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Body Weight; Clonidine; Diabetes Mellit | 2000 |
Repeated lofexidine treatment attenuates stress-induced, but not drug cues-induced reinstatement of a heroin-cocaine mixture (speedball) seeking in rats.
Topics: Adrenergic alpha-Agonists; Animals; Body Weight; Clonidine; Cocaine-Related Disorders; Conditioning, | 2001 |
Beta-adrenoceptor-mediated cell signaling in the neonatal heart and liver: responses to terbutaline.
Topics: Animals; Animals, Newborn; Body Weight; Clonidine; Colforsin; Down-Regulation; Female; GTP-Binding P | 2001 |
Clonidine induced hyperphagia and weight gain in monkeys.
Topics: Animals; Body Weight; Clonidine; Feeding Behavior; Female; Haplorhini; Macaca; Male; Stimulation, Ch | 1979 |
Effect of chronic clonidine treatment and its abrupt cessation on mean blood pressure of rats with a normal or an elevated blood pressure.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Clonidine; Female; Hypertension; Kidney; Organ S | 1979 |
[Effect of chronic oral administration of clonidine on the endogenous catecholamine metabolism in spontaneously hypertensive rats (author's transl)].
Topics: Administration, Oral; Adrenal Glands; Animals; Blood Pressure; Body Weight; Brain Stem; Catecholamin | 1977 |
Clonidine antagonizes naloxone-induced suppression of conditioned behavior and body weight loss in morphine-dependent rats.
Topics: Animals; Body Weight; Clonidine; Conditioning, Operant; Dose-Response Relationship, Drug; Humans; Ma | 1978 |
Refractory hypertension. Treatment with clonidine hydrochloride.
Topics: Adult; Blood Pressure; Body Weight; Clonidine; Female; Humans; Hypertension; Male; Middle Aged; Reni | 1978 |
Effect of prolonged administration of clonidine to spontaneously hypertensive rats on blood pressure, cerebral norpinephrine content and angiographic finding in the kidney.
Topics: Animals; Blood Pressure; Body Weight; Brain; Clonidine; Female; Hypertension; Kidney; Norepinephrine | 1976 |
On spinal noradrenaline receptor supersensitivity: correlation between nerve terminal densities and flexor reflexes various times after intracisternal 6-hydroxydopamine.
Topics: Animals; Apomorphine; Body Weight; Cell Count; Clonidine; Dose-Response Relationship, Drug; Hindlimb | 1976 |
Behavioral interactions of apomorphine, clonidine and naloxone: possible presynatpic involvement.
Topics: Animals; Apomorphine; Behavior, Animal; Body Weight; Clonidine; Drug Interactions; Male; Naloxone; R | 1976 |
Paraventricular hypothalamic clonidine increases rather than decreases susceptibility to activity-based anorexia in the rat.
Topics: Animals; Appetite; Body Weight; Clonidine; Dose-Response Relationship, Drug; Hunger; Male; Motor Act | 1992 |
Anticoccidial activities of 7-bromo-N-(2-imidazolidinylidene)-1H-indazol-6-amine and other alpha 2 adrenergic agonists.
Topics: Adrenergic alpha-Agonists; Animals; Body Weight; Chickens; Clonidine; Coccidiosis; Coccidiostats; Ei | 1992 |
Capillary growth in the heart.
Topics: Animals; Anti-Arrhythmia Agents; Body Weight; Capillaries; Clonidine; Coronary Circulation; Dobutami | 1992 |
Chronic administration of the antidepressant-antipanic drug phenelzine and its N-acetylated analogue: effects on monoamine oxidase, biogenic amines, and alpha 2-adrenoreceptor function.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents; Biogenic Amines; Body Weight; Brain; | 1992 |
Peripheral opioid secretory pattern in anorexia nervosa.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Anorexia Nervosa; beta-Endorphin; beta-Lipotropin; Body Weig | 1991 |
Effects of swim training alone and in combination with clonidine and rilmenidine on blood pressure, plasma electrolytes, vasopressin, and renin activity in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Body Weight; Clonidine; Electrolytes; Heart; Mal | 1990 |
Effect of chronic treatment with clonidine and spironolactone on cold-induced elevation of blood pressure.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Body Weight; Clonidine; Cold Temperature; Drin | 1991 |
Central adrenergic suppression augments the insulin and glucagon secretory, and the glycogenolytic responses in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Clonidine; Diabetes Mellitus, Experimental; Glucagon; Glycogen; | 1991 |
Intrahypothalamic clonidine infusion prevents NaCl-sensitive hypertension.
Topics: Analysis of Variance; Animals; Blood Pressure; Body Weight; Clonidine; Heart Rate; Heart Ventricles; | 1991 |
Dietary sodium restriction and blood pressure response to sympathetic blockade in young versus adolescent spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Body Weight; Clonidine; Diet, Sodium-Restrict | 1990 |
Bidirectional effects of clonidine on carbohydrate intake in genetically obese (ob/ob) mice.
Topics: Animals; Body Weight; Clonidine; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Energy | 1991 |
Dietary Ca2+ supplementation prevents the exaggerated responsiveness of anterior hypothalamic alpha 2-adrenoceptors in NaCl-loaded spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Body Weight; Calcium, Dietary; Clonidine; Diet; Heart Rate; Hypertension; H | 1989 |
Effect of clonidine early in life on brain morphofunctional deficits induced by neonatal malnutrition in the rat.
Topics: Animals; Animals, Newborn; Body Weight; Brain; Brain Chemistry; Clonidine; Evoked Potentials, Visual | 1989 |
Opposite effects of chronic cortisol treatment on pre- and postsynaptic actions of clonidine in pithed rats.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Blood Pressure; Body Weight; Clonidine; Decerebrate St | 1989 |
Serum glucose and insulin levels in normotensive (WKY) and spontaneously hypertensive (SH) rats during and after the cessation of continuous (10 day) clonidine infusion.
Topics: Animals; Blood Glucose; Body Temperature; Body Weight; Clonidine; Female; Infusions, Intravenous; In | 1989 |
Growth hormone-releasing factor stimulation test in depression.
Topics: Adult; Age Factors; Body Weight; Clonidine; Depressive Disorder; Dextroamphetamine; Female; Growth H | 1988 |
Chronic clonidine treatment and its withdrawal: effects on blood pressure and catecholamine synthesizing enzymes in brain-stem nuclei.
Topics: Adrenal Medulla; Animals; Blood Pressure; Body Weight; Brain Stem; Catecholamines; Clonidine; Dopami | 1986 |
Postnatal treatment of rats with adrenergic receptor agonists or antagonists influences differentiation of sexual behavior.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Body Weight; Clo | 1987 |
The anxiolytic and anxiogenic actions of ethanol in a mouse model.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Body Weight; Clonidine; Diazepam; Drinking; | 1988 |
Neurochemical evaluation of rats prenatally exposed to the adrenergic agonists clonidine and lofexidine.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Body Weight; Brain; Brain Chemistry; Cl | 1988 |
Effects of antihypertensive treatment in one-clip, two kidney hypertension in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Clonidine; Dihydrala | 1986 |
Long-term amitriptyline treatment alters the affinity state of alpha 2 adrenoceptors in rabbit hindbrain.
Topics: Amitriptyline; Animals; Blood Pressure; Body Weight; Brain Stem; Cerebellum; Clonidine; Dioxanes; Ep | 1986 |
Chronic clonidine treatment produces desensitisation of post- but not presynaptic alpha 2-adrenoceptors.
Topics: Animals; Blood Pressure; Body Weight; Catecholamines; Clonidine; Decerebrate State; Dose-Response Re | 1987 |
Weight loss causes neuroendocrine disturbances: experimental study in healthy starving subjects.
Topics: Adult; Affective Symptoms; Body Weight; Clonidine; Dexamethasone; Fasting; Female; Growth Hormone; H | 1986 |
Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal.
Topics: Animals; Behavior, Animal; Body Weight; Brain Chemistry; Clonidine; Hippocampus; Injections; Locus C | 1988 |
Behavioral evaluation of rats prenatally exposed to the adrenergic agonists clonidine and lofexidine.
Topics: Animals; Antihypertensive Agents; Behavior, Animal; Body Weight; Clonidine; Drug Evaluation, Preclin | 1988 |
Changes in locomotor-activity patterns as a measure of spontaneous morphine withdrawal: no effect of clonidine.
Topics: Animals; Body Weight; Clonidine; Eating; Male; Morphine; Morphine Dependence; Motor Activity; Rats; | 1988 |
Influences of variation in total energy intake and dietary composition on regulation of fat cell lipolysis in ideal-weight subjects.
Topics: Adenosine; Adipose Tissue; Body Weight; Catecholamines; Clonidine; Diet; Dinoprostone; Energy Metabo | 1987 |
Diuretic treatment alters clonidine suppression of plasma norepinephrine.
Topics: Administration, Oral; Amiloride; Blood Glucose; Blood Pressure; Body Weight; Clonidine; Drug Interac | 1986 |
Effects of peripheral and central administration of calcium channel blockers in the naloxone-precipitated abstinence syndrome in morphine-dependent rats.
Topics: Animals; Body Weight; Brain; Calcium Channel Blockers; Clonidine; Diarrhea; Flunarizine; Injections, | 1987 |
Effect of prolonged clonidine treatment and its withdrawal on noradrenaline turnover in the cerebral cortex and medulla oblongata of the spontaneously hypertensive rat.
Topics: Animals; Body Weight; Cerebral Cortex; Clonidine; Hypertension; Male; Medulla Oblongata; Methoxyhydr | 1987 |
The effects of dieting and weight loss on neuroendocrine responses to tryptophan, clonidine, and apomorphine in volunteers. Important implications for neuroendocrine investigations in depression.
Topics: Adult; Apomorphine; Body Weight; Clonidine; Diet; Female; Growth Hormone; Humans; Male; Neurosecreto | 1987 |
Dietary salt intake and the clonidine suppression test.
Topics: Adult; Aging; Body Weight; Cardiography, Impedance; Catecholamines; Clonidine; Humans; Hypertension; | 1987 |
Effect of experimental and pathological weight loss upon the hypothalamo-pituitary-adrenal axis.
Topics: Adult; Anorexia Nervosa; Body Weight; Clonidine; Depressive Disorder; Dexamethasone; Female; Growth | 1986 |
Intrathecal clonidine: analgesia and effect on opiate withdrawal in the rat.
Topics: Analgesics; Anesthesia, Spinal; Animals; Blood Pressure; Body Temperature; Body Weight; Clonidine; H | 1985 |
Discriminative stimulus effects of morphine withdrawal in the dependent rat: suppression by opiate and nonopiate drugs.
Topics: Animals; Body Weight; Clonidine; Haloperidol; Humans; Male; Morphine Dependence; Naloxone; Naltrexon | 1985 |
Efferent projections from the paraventricular nucleus mediating alpha 2-noradrenergic feeding.
Topics: Animals; Body Weight; Brain Chemistry; Brain Stem; Clonidine; Efferent Pathways; Feeding Behavior; F | 1985 |
Altered development of responsiveness to clonidine in severely malnourished rats.
Topics: Aging; Animals; Body Weight; Clonidine; Female; Motor Activity; Nutrition Disorders; Rats; Rats, Inb | 1985 |
[Blood glucose studies in rats under treatment with clonidine].
Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Clonidine; Female; Fetus; Gestational Age | 1974 |
The effect of clonidine on plasma renin activity in human hypertension.
Topics: Adult; Body Weight; Clonidine; Female; Humans; Hypertension; Male; Middle Aged; Oxprenolol; Phentola | 1973 |
[Treatment of arterial hypertension with new drugs. 1. Severe arterial hypertension].
Topics: Antihypertensive Agents; Body Weight; Clonidine; Diuresis; Furosemide; Hemodynamics; Humans; Hyperte | 1972 |
Hypertension.
Topics: Antihypertensive Agents; Body Weight; Clonidine; Humans; Hypertension; Methyldopa; Propranolol; Smok | 1973 |
[Hypertension: 3 H-catecholamine metabolism in the adrenal glands and brain and tissue metabolism of 3 3 H-DOPA during reserpine, alpha-methyl DOPA and ST-155 administration in spontaneously hypertensive rats].
Topics: Adrenal Glands; Animals; Blood Pressure; Body Weight; Brain; Catecholamines; Clonidine; Dihydroxyphe | 1973 |
[Water-sodium depletion and clonidine in severe arterial hypertension].
Topics: Adult; Antihypertensive Agents; Body Weight; Clonidine; Creatinine; Drug Synergism; Electrocardiogra | 1972 |