Page last updated: 2024-10-25

clonidine and Blood Poisoning

clonidine has been researched along with Blood Poisoning in 6 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

ExcerptRelevanceReference
"Administration of clonidine during hypotensive sepsis reduced renal sympathetic nerve activity, restored vascular sensitivity to both phenylephrine and angiotensin II, and resulted in better preservation of arterial pressure."7.81Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis. ( Bellomo, R; Booth, LC; Evans, RG; Kosaka, J; Lankadeva, YR; May, CN; Quintin, L, 2015)
" Presently, the most robust clinical evidence involves the use of the cardioselective β-blocker esmolol in patients with septic shock with persistent tachycardia secondary to catecholamine use."4.98Misdirected Sympathy: The Role of Sympatholysis in Sepsis and Septic Shock. ( Bissell, BD; Ferreira, JA, 2018)
"Administration of clonidine during hypotensive sepsis reduced renal sympathetic nerve activity, restored vascular sensitivity to both phenylephrine and angiotensin II, and resulted in better preservation of arterial pressure."3.81Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis. ( Bellomo, R; Booth, LC; Evans, RG; Kosaka, J; Lankadeva, YR; May, CN; Quintin, L, 2015)
"With early trauma, beta-adrenergic responsiveness and receptor number were significantly decreased."1.27Adrenergic control of adipocyte lipolysis in trauma and sepsis. ( Askanazi, J; Forse, RA; Hirsch, J; Kinney, JM; Leibel, R, 1987)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Lankadeva, YR2
Shehabi, Y1
Deane, AM1
Plummer, MP1
Bellomo, R2
May, CN2
Booth, LC1
Kosaka, J1
Evans, RG1
Quintin, L2
Gradwohl-Matis, I1
Dünser, MW1
Geloën, A1
Ferreira, JA1
Bissell, BD1
Forse, RA1
Leibel, R1
Askanazi, J1
Hirsch, J1
Kinney, JM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Study to Quantify the Autonomic Nervous System Balance in Healthy, Able-Bodied Individuals[NCT04100486]48 participants (Anticipated)Observational2019-08-29Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for clonidine and Blood Poisoning

ArticleYear
Emerging benefits and drawbacks of α
    British journal of pharmacology, 2021, Volume: 178, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Clonidine; Critical Illness; Dexmed

2021
Misdirected Sympathy: The Role of Sympatholysis in Sepsis and Septic Shock.
    Journal of intensive care medicine, 2018, Volume: 33, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Animals; Catecholamine

2018

Other Studies

4 other studies available for clonidine and Blood Poisoning

ArticleYear
Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis.
    Critical care medicine, 2015, Volume: 43, Issue:7

    Topics: Adrenergic alpha-2 Receptor Agonists; Angiotensin II; Animals; Blood Pressure; Clonidine; Female; Hy

2015
Reverse Physiology: Applying an Antihypertensive Drug to Increase Arterial Blood Pressure in Septic Shock.
    Critical care medicine, 2015, Volume: 43, Issue:7

    Topics: Adrenergic alpha-2 Receptor Agonists; Angiotensin II; Animals; Blood Pressure; Clonidine; Female; Hy

2015
Reverse Physiology, i.e., Cellular Versus Integrative Versus Comparative Physiology? α-2 Agonists and Septic Shock.
    Critical care medicine, 2016, Volume: 44, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Angiotensin II; Animals; Blood Pressure; Clonidine; Female; Hy

2016
Adrenergic control of adipocyte lipolysis in trauma and sepsis.
    Annals of surgery, 1987, Volume: 206, Issue:6

    Topics: Adipose Tissue; Adult; Aged; Clonidine; Energy Metabolism; Female; Humans; Isoproterenol; Lipolysis;

1987