Page last updated: 2024-10-25

clonidine and Bernard Syndrome

clonidine has been researched along with Bernard Syndrome in 48 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

ExcerptRelevanceReference
"A 40-year-old man developed a Horner syndrome as part of a dorsolateral medullary brainstem infarction."6.46Positive apraclonidine test 36 hours after acute onset of horner syndrome in dorsolateral pontomedullary stroke. ( Debroucker, T; Lebas, M; Seror, J, 2010)
"Apraclonidine (0."5.33The sensitivity and specificity of 0.5% apraclonidine in the diagnosis of oculosympathetic paresis. ( Acaroglu, G; Firat, E; Kansu, T; Kavuncu, S; Koc, F, 2005)
" Two children with anisocoria, one of whom had Horner Syndrome confirmed with apraclonidine 1% and the other, in whom an apraclonidine test ruled out this syndrome but in whom pilocarpine 0."3.75[Usefulness of apraclonidine in the diagnosis of Horner syndrome]. ( Alias, E; Díaz, S; Fernández, FJ; Ferrer, C; González, I; Honrubia, FM; Pérez-Iñigo, MA, 2009)
"To determine the location of action of apraclonidine, an alpha-adrenergic receptor agonist that reduces aqueous production and lowers intraocular pressure (IOP)."3.70Ocular effects of apraclonidine in Horner syndrome. ( Abdul-Rahim, AS; Brown, SM; Crosson, CE; Morales, J, 2000)
"The diagnosis of Horner's syndrome (HS) can be difficult, as patients rarely present with the classic triad of ptosis, miosis, and anhydrosis."2.49Adult Horner's syndrome: a combined clinical, pharmacological, and imaging algorithm. ( Daniel, CS; Davagnanam, I; Fraser, CL; Miszkiel, K; Plant, GT, 2013)
"Apraclonidine seems to be a good alternative to cocaine to confirm Horner's syndrome."2.47[Acquired Horner's syndrome]. ( Alstadhaug, KB, 2011)
"A 40-year-old man developed a Horner syndrome as part of a dorsolateral medullary brainstem infarction."2.46Positive apraclonidine test 36 hours after acute onset of horner syndrome in dorsolateral pontomedullary stroke. ( Debroucker, T; Lebas, M; Seror, J, 2010)
"First described in 1727, Horner syndrome occurs from injury to one of the three neurons in the oculosympathetic pathway."2.45Current pharmacologic testing for Horner syndrome. ( Longmuir, R; Mughal, M, 2009)
"Apraclonidine 0."1.72The evaluation of patient demographics, etiologies and apraclonidine test results in adult Horner's syndrome. ( Celebisoy, N; Gokcay, F; Karti, O; Saruhan Durmaz, G; Top Karti, D, 2022)
"The utility of apraclonidine in acute Horner syndrome remains controversial as the exact timing for denervation sensitivity to develop remains unknown."1.56Apraclonidine for the pharmacologic confirmation of acute Horner syndrome. ( Farahvash, A; Micieli, JA; Nguyen, MTB; Zhang, A, 2020)
"Apraclonidine hydrochloride is a topical ophthalmic solution with selective alpha-2 and weak alpha-1 receptor agonist activity that has the ability to elevate the eye lid."1.46Apraclonidine in the treatment of ptosis. ( Jankovic, J; Vijayakumar, D; Wijemanne, S, 2017)
"Nineteen patients with unilateral Horner syndrome (Horner group) and age-matched controls of 30 healthy individuals with normal vision and neither optic nerve dysfunction nor pupillary abnormalities were included."1.46Efficacy of digital pupillometry for diagnosis of Horner syndrome. ( Hwang, JM; Yang, HK; Yoo, YJ, 2017)
"The diagnosis of Horner syndrome (HS) using apraclonidine eye drops is an alternative to the use of topical cocaine drops."1.37Early diagnosis of Horner syndrome using topical apraclonidine. ( Cooper-Knock, J; Hodgson, T; Pepper, I; Sharrack, B, 2011)
"Apraclonidine 0."1.35Topical apraclonidine to diagnose Bernard-Horner syndrome. ( Gocmez, E; Kocabora, M; Taskapili, M, 2009)
"(3,4) We report adverse effects of topical apraclonidine when used in the diagnosis of Horner syndrome in infants."1.34Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants. ( Lim, MK; Satterfield, D; Watts, P, 2007)
"Apraclonidine (0."1.33The sensitivity and specificity of 0.5% apraclonidine in the diagnosis of oculosympathetic paresis. ( Acaroglu, G; Firat, E; Kansu, T; Kavuncu, S; Koc, F, 2005)
"A diagnosis of Horner's syndrome (HS) was presumed and was confirmed by instillation of apraclonidine eye drops."1.33Congenital Horner's syndrome and the usefulness of the apraclonidine test in its diagnosis. ( Baser, EF; Mirzai, H, 2006)
"Three patients with Horner syndrome showed positive values (reversal of anisocoria) only under high ambient illumination, but not under low illumination."1.33Efficacy of apraclonidine 0.5% in the diagnosis of Horner syndrome in pediatric patients under low or high illumination. ( Chen, JT; Chen, PL; Chen, WY; Hsiao, CH; Lu, DW, 2006)

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.08)18.7374
1990's0 (0.00)18.2507
2000's21 (43.75)29.6817
2010's20 (41.67)24.3611
2020's6 (12.50)2.80

Authors

AuthorsStudies
Top Karti, D1
Karti, O1
Saruhan Durmaz, G1
Gokcay, F1
Celebisoy, N1
Eldib, AA1
Patil, P1
Nischal, KK1
Mitchell, ER1
Hiasat, JG1
Pihlblad, MS1
Bellégo, C1
Borruat, FX2
Kawasaki, A2
Kraker, JA1
Tajfirouz, DA1
Bhatti, MT1
Chen, JJ1
Margolin, E1
Jeeva-Patel, T1
Hainc, N1
Nguyen, MTB1
Farahvash, A1
Zhang, A1
Micieli, JA1
Wijemanne, S1
Vijayakumar, D1
Jankovic, J1
Yoo, YJ1
Yang, HK1
Hwang, JM1
Sahin, CB1
Chaudhary, N1
Trobe, JD1
Escrivá, E1
Martínez-Costa, L1
Kauh, CY1
Bursztyn, LL1
Chen, Y1
Morgan, ML1
Barros Palau, AE1
Yalamanchili, S1
Lee, AG1
McInnis, CP1
Haynor, DR1
Francis, CE1
Malem, A1
Bohnsack, BL1
Parker, JW1
Pishdad, GR2
Pishdad, P2
Pishdad, R2
Dewan, MA1
Harrison, AR1
Lee, MS1
Pérez-Iñigo, MA1
González, I1
Fernández, FJ1
Díaz, S1
Ferrer, C1
Alias, E1
Honrubia, FM1
Martín-Moro, JG1
Botín, DM1
Muñoz-Negrete, FJ1
Mughal, M1
Longmuir, R1
Kocabora, M1
Gocmez, E1
Taskapili, M1
Lebas, M1
Seror, J1
Debroucker, T1
Sueke, H1
Chandna, A1
O'Connor, J1
Rochford, M1
O'Connor, G1
Fanning, N1
Chu, CJ1
Ferris, JD1
Pradhan, S1
Goyal, G1
Cooper-Knock, J1
Pepper, I1
Hodgson, T1
Sharrack, B1
Shin, RK1
Cheek, AG1
Alstadhaug, KB1
Ramos, R1
Ureña, A1
Rivas, F1
Macia, I1
Rosado, G1
Pequeño, S1
Masuet, C1
Badia, M1
Miguel, M1
Delgado, MA1
Escobar, I1
Moya, J1
Yokoyama, T1
Toga, A1
Hashida, Y1
Wakabayashi, Y1
Hayashi, K1
Kato, E1
Davagnanam, I1
Fraser, CL1
Miszkiel, K1
Daniel, CS1
Plant, GT1
Brown, SM4
Aouchiche, R1
Freedman, KA2
Bacal, DA1
Levy, SR1
Kardon, R1
Koc, F1
Kavuncu, S1
Kansu, T1
Acaroglu, G1
Firat, E1
Chen, PL2
Chen, JT2
Lu, DW2
Chen, YC1
Hsiao, CH2
Mirzai, H1
Baser, EF1
Chen, WY1
Watts, P1
Satterfield, D1
Lim, MK1
Chu, EA1
Byrne, PJ1
Moodley, AA1
Spooner, RB1
Morales, J1
Abdul-Rahim, AS1
Crosson, CE1
Gmünder, HP1
Girke, W1

Reviews

4 reviews available for clonidine and Bernard Syndrome

ArticleYear
Current pharmacologic testing for Horner syndrome.
    Current neurology and neuroscience reports, 2009, Volume: 9, Issue:5

    Topics: Clonidine; Cocaine; False Negative Reactions; Horner Syndrome; Humans; p-Hydroxyamphetamine; Sympath

2009
Positive apraclonidine test 36 hours after acute onset of horner syndrome in dorsolateral pontomedullary stroke.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2010, Volume: 30, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Horner Syndrome; Humans; Magnetic Resonance Angiography

2010
[Acquired Horner's syndrome].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2011, May-20, Volume: 131, Issue:9-10

    Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Clonidine; Cocaine; Diagnosis, Differential; Fema

2011
Adult Horner's syndrome: a combined clinical, pharmacological, and imaging algorithm.
    Eye (London, England), 2013, Volume: 27, Issue:3

    Topics: Adult; Algorithms; Angiography, Digital Subtraction; Clonidine; Cocaine; Diagnostic Imaging; Horner

2013

Trials

1 trial available for clonidine and Bernard Syndrome

ArticleYear
Comparing efficacies of 0.5% apraclonidine with 4% cocaine in the diagnosis of horner syndrome in pediatric patients.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2006, Volume: 22, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Clonidine; Cocaine; Cross-Over Studies; Female; Horner Syndrome

2006

Other Studies

43 other studies available for clonidine and Bernard Syndrome

ArticleYear
The evaluation of patient demographics, etiologies and apraclonidine test results in adult Horner's syndrome.
    International ophthalmology, 2022, Volume: 42, Issue:4

    Topics: Adult; Clonidine; Demography; Female; Horner Syndrome; Humans; Male; Middle Aged; Retrospective Stud

2022
Safety of apraclonidine eye drops in diagnosis of Horner syndrome in an outpatient pediatric ophthalmology clinic.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2021, Volume: 25, Issue:6

    Topics: Adult; Child; Child, Preschool; Clonidine; Horner Syndrome; Humans; Infant; Ophthalmic Solutions; Op

2021
Long-term prognosis of patients with idiopathic Horner syndrome.
    Journal of neurology, 2022, Volume: 269, Issue:5

    Topics: Clonidine; Horner Syndrome; Humans; Prognosis; Pupil

2022
Tachyphylaxis With Sustained Apraclonidine Use in the Treatment of Ptosis Associated With Horner Syndrome.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2023, Dec-01, Volume: 43, Issue:4

    Topics: Blepharoptosis; Clonidine; Horner Syndrome; Humans; Tachyphylaxis

2023
Horner's syndrome and apraclonidine eye drops.
    Practical neurology, 2020, Volume: 20, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Cervical Vertebrae; Clonidine; Female; Horner Syndrome; Humans

2020
Apraclonidine for the pharmacologic confirmation of acute Horner syndrome.
    Journal of the neurological sciences, 2020, Dec-15, Volume: 419

    Topics: Adrenergic alpha-Agonists; Clonidine; Horner Syndrome; Humans; Motivation

2020
Apraclonidine in the treatment of ptosis.
    Journal of the neurological sciences, 2017, May-15, Volume: 376

    Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Blepharoptosis; Botulinum Toxins; Clo

2017
Efficacy of digital pupillometry for diagnosis of Horner syndrome.
    PloS one, 2017, Volume: 12, Issue:6

    Topics: Case-Control Studies; Clonidine; Female; Horner Syndrome; Humans; Light; Male; Pupil; Reflex, Pupill

2017
Horner Syndrome as the Only Focal Neurologic Manifestation of Hypothalamic Hemorrhage.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2018, Volume: 38, Issue:2

    Topics: Administration, Ophthalmic; Adrenergic alpha-2 Receptor Agonists; Aged; Anisocoria; Clonidine; Femal

2018
[Incomplete Horner's syndrome as a presenting sign of fourth ventricle ependymoma].
    Archivos de la Sociedad Espanola de Oftalmologia, 2013, Volume: 88, Issue:9

    Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Blepharoptosis; Cerebral Ventricle Neoplasms; Clonidine

2013
Positive Apraclonidine Test in Horner Syndrome Caused by Thalamic Hemorrhage.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2015, Volume: 35, Issue:3

    Topics: Aged; Clonidine; Diagnostic Techniques, Ophthalmological; Hemorrhage; Horner Syndrome; Humans; Magne

2015
Evaluation and neuroimaging of the Horner syndrome.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2015, Volume: 50, Issue:2

    Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Aged, 80 and over; Child; Child, Pres

2015
Horner syndrome in fibromuscular dysplasia without carotid dissection.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2016, Volume: 51, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Blepharoptosis; Carotid Artery, Internal, Dissection; Clonidin

2016
Unequal pupils and ptosis.
    BMJ (Clinical research ed.), 2017, 02-23, Volume: 356

    Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Anisocoria; Blepharoptosis; Carotid Arteries; Clonidine;

2017
Positive apraclonidine test within two weeks of onset of Horner syndrome caused by carotid artery dissection.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2008, Volume: 28, Issue:3

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Carotid Artery, Internal; Ca

2008
Pupillary autonomic neuropathy simulating partial Horner syndrome in diabetes mellitus and its reversal with control of blood glucose.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2008, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Agonists; Anisocoria; Blood Glucose; Clonidine; Diabetic Neuropathies; Female; Horn

2008
False-negative apraclonidine testing in acute Horner syndrome.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2009, Volume: 44, Issue:1

    Topics: Acute Disease; Adrenergic alpha-Agonists; Anisocoria; Carotid Artery, Internal, Dissection; Clonidin

2009
[Usefulness of apraclonidine in the diagnosis of Horner syndrome].
    Archivos de la Sociedad Espanola de Oftalmologia, 2009, Volume: 84, Issue:2

    Topics: Adrenergic alpha-Agonists; Adult; Anisocoria; Birth Injuries; Brachial Plexus; Clonidine; Cocaine; D

2009
Possible effect of systemic sympathicolytic drugs on apraclonidine test.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2009, Volume: 44, Issue:4

    Topics: Acute Disease; Adrenergic alpha-Agonists; Anisocoria; Carotid Artery, Internal, Dissection; Clonidin

2009
Topical apraclonidine to diagnose Bernard-Horner syndrome.
    Bulletin de la Societe belge d'ophtalmologie, 2009, Issue:312

    Topics: Administration, Topical; Adult; Child; Clonidine; Female; Horner Syndrome; Humans; Male; Pupil

2009
Using apraclonidine in diagnosing Horner syndrome in children.
    American journal of ophthalmology, 2010, Volume: 149, Issue:5

    Topics: Adrenergic alpha-Agonists; Clonidine; Dark Adaptation; Horner Syndrome; Humans; Light; Photography;

2010
Pharmacological diagnosis of Horner's syndrome in the emergency department.
    Emergency medicine journal : EMJ, 2011, Volume: 28, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Anticoagulants; Clonidine; Female; Horner Syndrome; Humans; Ma

2011
Horner's syndrome as a complication of percutaneous ethanol treatment of thyroid nodule.
    Thyroid : official journal of the American Thyroid Association, 2011, Volume: 21, Issue:3

    Topics: Clonidine; Ethanol; Female; Horner Syndrome; Humans; Middle Aged; Thyroid Nodule

2011
Confirmation of Horner's syndrome using apraclonidine eye drops.
    Postgraduate medical journal, 2011, Volume: 87, Issue:1028

    Topics: Adrenergic alpha-2 Receptor Agonists; Clonidine; Horner Syndrome; Humans; Male; Middle Aged; Ophthal

2011
Teaching NeuroImages: honeycomb appearance of the brain in a patient with Canavan disease.
    Neurology, 2011, Mar-29, Volume: 76, Issue:13

    Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Clonidine; Female; Horner Syndrome; Humans

2011
Early diagnosis of Horner syndrome using topical apraclonidine.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2011, Volume: 31, Issue:3

    Topics: Administration, Topical; Adrenergic alpha-2 Receptor Agonists; Adult; Anisocoria; Carotid Artery, In

2011
Teaching NeuroImages: Positive apraclonidine test in Horner syndrome.
    Neurology, 2011, May-17, Volume: 76, Issue:20

    Topics: Adrenergic alpha-Agonists; Adult; Blepharoptosis; Clonidine; Diskectomy; Female; Horner Syndrome; Hu

2011
Impact of T3 thoracoscopic sympathectomy on pupillary function: a cause of partial Horner's syndrome?
    Surgical endoscopy, 2012, Volume: 26, Issue:4

    Topics: Adolescent; Adult; Clonidine; Equipment Design; Horner Syndrome; Humans; Hyperhidrosis; Intraoperati

2012
Hemifacial flushing after bathing and crying.
    The Journal of pediatrics, 2012, Volume: 160, Issue:6

    Topics: Administration, Topical; Adrenergic alpha-2 Receptor Agonists; Baths; Clonidine; Crying; Diagnosis,

2012
The utility of 0.5% apraclonidine in the diagnosis of horner syndrome.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2003, Volume: 121, Issue:8

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Anisocoria; Clonidine; Drug Evaluation; Female; Horner Syndr

2003
The use of apraclonidine in the diagnosis of horner syndrome in pediatric patients.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2004, Volume: 122, Issue:2

    Topics: Adolescent; Adrenergic alpha-Agonists; Anisocoria; Child; Clonidine; Female; Horner Syndrome; Humans

2004
The utility of 0.5% apraclonidine in the diagnosis of horner syndrome.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2005, Volume: 123, Issue:4

    Topics: Adrenergic alpha-Agonists; Anisocoria; Clonidine; Horner Syndrome; Humans; Ophthalmic Solutions

2005
Are we ready to replace cocaine with apraclonidine in the pharmacologic diagnosis of Horner syndrome?
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2005, Volume: 25, Issue:2

    Topics: Adrenergic alpha-Agonists; Clonidine; Cocaine; Dopamine Uptake Inhibitors; Horner Syndrome; Humans

2005
Topical apraclonidine in the diagnosis of suspected Horner syndrome.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2005, Volume: 25, Issue:2

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Adult; Child, Preschool; Clonidine; Cocaine; Dop

2005
The sensitivity and specificity of 0.5% apraclonidine in the diagnosis of oculosympathetic paresis.
    The British journal of ophthalmology, 2005, Volume: 89, Issue:11

    Topics: Adrenergic alpha-Agonists; Adult; Anisocoria; Blepharoptosis; Clonidine; Diabetic Neuropathies; Fema

2005
Congenital Horner's syndrome and the usefulness of the apraclonidine test in its diagnosis.
    Indian journal of ophthalmology, 2006, Volume: 54, Issue:3

    Topics: Adrenergic alpha-Agonists; Clonidine; Diagnosis, Differential; Female; Horner Syndrome; Humans; Infa

2006
Efficacy of apraclonidine 0.5% in the diagnosis of Horner syndrome in pediatric patients under low or high illumination.
    American journal of ophthalmology, 2006, Volume: 142, Issue:3

    Topics: Adolescent; Adrenergic alpha-Agonists; Child; Child, Preschool; Clonidine; Dark Adaptation; Female;

2006
Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2007, Volume: 11, Issue:3

    Topics: Adrenergic alpha-Agonists; Bradycardia; Clonidine; Emergency Treatment; Female; Horner Syndrome; Hum

2007
Pharmacologic reversal of Horner's syndrome-related ptosis with apraclonidine.
    Ear, nose, & throat journal, 2007, Volume: 86, Issue:5

    Topics: Adrenergic alpha-Agonists; Adult; Blepharoptosis; Clonidine; Female; Horner Syndrome; Humans; Treatm

2007
Apraclonidine in the diagnosis of Horner's syndrome.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2007, Volume: 97, Issue:7

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Aged; Clonidine; Horner Syndrome; Humans; Male

2007
False negative apraclonidine test in two patients with Horner syndrome.
    Klinische Monatsblatter fur Augenheilkunde, 2008, Volume: 225, Issue:5

    Topics: Adrenergic alpha-Agonists; Adult; Clonidine; False Negative Reactions; Female; Horner Syndrome; Huma

2008
Ocular effects of apraclonidine in Horner syndrome.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2000, Volume: 118, Issue:7

    Topics: Adrenergic alpha-Agonists; Aqueous Humor; Ciliary Body; Clonidine; Cohort Studies; Horner Syndrome;

2000
[Clonidine in the diagnosis of Horner syndrome].
    Der Nervenarzt, 1989, Volume: 60, Issue:5

    Topics: Adult; Aged; Blood Pressure; Clonidine; Diagnosis, Differential; Female; Heart Rate; Horner Syndrome

1989