clonidine has been researched along with Benign Neoplasms in 19 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite weak evidence, clonidine may be a useful adjunct in epidural or spinal morphine therapy of cancer pain." | 8.84 | [Clonidine in the treatment of cancer pain]. ( Nielsen, JB; Sjøgren, P, 2008) |
| "To assess the benefit of ketamine addition to a morphine-clonidine-lidocaine mixture administered continuously by the intrathecal route for the treatment of cancer pain." | 7.69 | [Cancer pain: beneficial effect of ketamine addition to spinal administration of morphine-clonidine-lidocaine mixture]. ( Lemos, D; Muller, A, 1996) |
| "Despite weak evidence, clonidine may be a useful adjunct in epidural or spinal morphine therapy of cancer pain." | 4.84 | [Clonidine in the treatment of cancer pain]. ( Nielsen, JB; Sjøgren, P, 2008) |
| "This review has covered the five potential causes for opioid poorly responsive pain, namely (a) a loss of opioid receptors on the spinal terminals of C-fibres as a result of peripheral nerve damage, (b) an accumulation of morphine-3-glucuronide, (c) changes in the non-opioid peptides, F8Fa or CCK, either spinally or supraspinally, (d) actions of the opioid peptide dynorphin and (e) spinally generated hypersensitive states via activation of the NMDA receptor." | 4.79 | Neurophysiology of opioid poorly responsive pain. ( Dickenson, AH, 1994) |
| "To assess the benefit of ketamine addition to a morphine-clonidine-lidocaine mixture administered continuously by the intrathecal route for the treatment of cancer pain." | 3.69 | [Cancer pain: beneficial effect of ketamine addition to spinal administration of morphine-clonidine-lidocaine mixture]. ( Lemos, D; Muller, A, 1996) |
| "Eighty-five patients with severe cancer pain despite large doses of opioids or with therapy-limiting side effects from opioids were randomized to receive, in a double-blind manner, 30 micrograms/h epidural clonidine or placebo for 14 days, together with rescue epidural morphine." | 2.68 | Epidural clonidine analgesia for intractable cancer pain. The Epidural Clonidine Study Group. ( Allin, D; Dubois, M; DuPen, S; Eisenach, JC; Miguel, R, 1995) |
| "A third of female patients with cancer report dissatisfaction with the quality and length of physician-patient discussions about reproductive health, including menopause." | 2.58 | Managing menopausal symptoms after cancer: an evidence-based approach for primary care. ( Hickey, M; Marino, JL; McNamara, HC, 2018) |
| "Additionally, a pronounced effect on cancer pain was seen." | 1.28 | Effect of epidural clonidine on somatosensory evoked potentials to dermatomal stimulation. ( Hansen, OB; Kehlet, H; Lund, C, 1989) |
| "Clonidine was absorbed in a dose-dependent manner into the systemic circulation, although absorption and elimination kinetics were highly variable." | 1.28 | Epidural clonidine analgesia for intractable cancer pain: phase I. ( Buzzanell, C; Eisenach, JC; Lysak, SZ; Rauck, RL, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Maharani, ND | 1 |
| Fuadi, A | 1 |
| Halimi, RA | 1 |
| Marino, JL | 1 |
| McNamara, HC | 1 |
| Hickey, M | 1 |
| De Andres, J | 1 |
| Asensio-Samper, JM | 1 |
| Fabregat-Cid, G | 1 |
| Taira, T | 1 |
| Nielsen, JB | 1 |
| Sjøgren, P | 1 |
| Fitzgerald, PJ | 1 |
| Friedman, GD | 1 |
| Udaltsova, N | 1 |
| Habel, LA | 1 |
| Walker, SM | 1 |
| Goudas, LC | 1 |
| Cousins, MJ | 1 |
| Carr, DB | 1 |
| Vranken, JH | 1 |
| van Kan, HJ | 1 |
| van der Vegt, MH | 1 |
| Christensen, NJ | 1 |
| Eisenach, JC | 2 |
| DuPen, S | 1 |
| Dubois, M | 1 |
| Miguel, R | 1 |
| Allin, D | 1 |
| Dickenson, AH | 1 |
| Ricci, V | 1 |
| Dalpane, A | 1 |
| Lolli, E | 1 |
| Muller, A | 2 |
| Lemos, D | 1 |
| Roman, J | 1 |
| Villaizán, CJ | 1 |
| García-Foncillas, J | 1 |
| Salvador, J | 1 |
| Sierrasesúmaga, L | 1 |
| Lechin, F | 1 |
| van der Dijs, B | 1 |
| Vitelli-Florez, G | 1 |
| Lechin-Baez, S | 1 |
| Azocar, J | 1 |
| Cabrera, A | 1 |
| Lechin, A | 1 |
| Jara, H | 1 |
| Lechin, M | 1 |
| Gomez, F | 1 |
| Lund, C | 1 |
| Hansen, OB | 1 |
| Kehlet, H | 1 |
| Rauck, RL | 1 |
| Buzzanell, C | 1 |
| Lysak, SZ | 1 |
| Laugner, B | 1 |
| Thiébaut, JB | 1 |
| Farcot, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325] | Phase 3 | 24 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
8 reviews available for clonidine and Benign Neoplasms
| Article | Year |
|---|---|
Managing menopausal symptoms after cancer: an evidence-based approach for primary care.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Amenorrhea; Anti-Anxiety Agents; Breast Neoplasms; Canc | 2018 |
Intrathecal delivery of analgesics.
Topics: Analgesics, Opioid; Baclofen; Bupivacaine; Catheters, Indwelling; Chronic Pain; Clonidine; Drug Deli | 2014 |
[Chronic intrathecal drug administration for the control of intractable pain].
Topics: Amines; Analgesics, Opioid; Anesthetics, Local; Baclofen; Calcium Channel Blockers; Clonidine; Cyclo | 2008 |
[Clonidine in the treatment of cancer pain].
Topics: Adrenergic alpha-Agonists; Analgesics; Clonidine; Humans; Injections, Epidural; Injections, Spinal; | 2008 |
Is norepinephrine an etiological factor in some types of cancer?
Topics: Animals; Anticarcinogenic Agents; Clonidine; Humans; Models, Biological; Neoplasms; Norepinephrine; | 2009 |
Combination spinal analgesic chemotherapy: a systematic review.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthetics, Local; Antineoplastic Agents; Cholineste | 2002 |
Neurophysiology of opioid poorly responsive pain.
Topics: Analgesics, Opioid; Animals; Central Nervous System; Clonidine; Dextromethorphan; Dextrorphan; Dynor | 1994 |
[Continuous spinal analgesia in home care of oncologic pain].
Topics: Analgesics, Opioid; Bupivacaine; Clonidine; Home Infusion Therapy; Humans; Infusion Pumps, Implantab | 1995 |
2 trials available for clonidine and Benign Neoplasms
| Article | Year |
|---|---|
Comparison of the effect of scalp block analgesia bupivacaine 0.25% and clonidine 2 μg/kg with bupivacaine 0.25% and dexamethasone 8 mg on cortisol levels and Numeric Rating Scale in craniotomy tumour.
Topics: Analgesia; Anesthetics, Local; Bupivacaine; Clonidine; Craniotomy; Dexamethasone; Humans; Hydrocorti | 2023 |
Epidural clonidine analgesia for intractable cancer pain. The Epidural Clonidine Study Group.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics, Opioid; Analysis of Variance; Cloni | 1995 |
9 other studies available for clonidine and Benign Neoplasms
| Article | Year |
|---|---|
Norepinephrine antagonists and cancer risk.
Topics: Atenolol; Breast Neoplasms; Clonidine; Colonic Neoplasms; Female; Humans; Lung Neoplasms; Male; Meto | 2011 |
Stability and compatibility of a meperidine-clonidine mixture in portable pump reservoirs for the management of cancer pain syndromes.
Topics: Analgesics; Analgesics, Opioid; Clonidine; Complex Mixtures; Drug Combinations; Drug Stability; Huma | 2006 |
Adrenergic mechanisms in selected diseases: arterial hypertension, duodenal ulcer, primary depressive illness, malignant tumors, and ketotic hypoglycemia.
Topics: Adult; Blood Pressure; Child; Clonidine; Depression; Duodenal Ulcer; Epinephrine; Female; Gastrins; | 1980 |
[Cancer pain: beneficial effect of ketamine addition to spinal administration of morphine-clonidine-lidocaine mixture].
Topics: Aged; Analgesics; Catheters, Indwelling; Clonidine; Drug Combinations; Drug Synergism; Female; Human | 1996 |
Growth and growth hormone secretion in children with cancer treated with chemotherapy.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Age Factors; Antibiotics, Antineoplastic; Antineoplast | 1997 |
Psychoneuroendocrinological and immunological parameters in cancer patients: involvement of stress and depression.
Topics: Adult; Aged; Antibodies, Monoclonal; Catecholamines; Clonidine; Depression; Female; Hormones; Humans | 1990 |
Effect of epidural clonidine on somatosensory evoked potentials to dermatomal stimulation.
Topics: Aged; Clonidine; Electric Stimulation; Evoked Potentials, Somatosensory; Female; Humans; Injections, | 1989 |
Epidural clonidine analgesia for intractable cancer pain: phase I.
Topics: Analgesia, Epidural; Blood Pressure; Clonidine; Female; Heart Rate; Humans; Male; Middle Aged; Morph | 1989 |
[Analgesia with an implanted device for repetitive intrathecal injections of morphine].
Topics: Adolescent; Adult; Aged; Aspirin; Chronic Disease; Clonidine; Drug Tolerance; Humans; Injections, Sp | 1985 |