clonidine and Asthma
clonidine has been researched along with Asthma in 18 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen patients with asthma were randomized into a double-blind, placebo controlled, crossover trial evaluating whether clonidine increased airway resistance." | 9.08 | Oral clonidine in patients with asthma: no significant effect on airway reactivity. ( Foxworth, JW; Knudson, SM; Pyszczynski, DR; Reisz, GR, 1995) |
| " The effects of pretreatment with clonidine and rilmenidine, a new alpha 2-adrenoceptor agonist, on the bronchial responses to inhaled histamine were studied on 3 different days in a controlled, double-blind, randomized study in 12 asymptomatic asthmatic subjects." | 9.06 | Comparative effects of rilmenidine and clonidine on bronchial responses to histamine in asthmatic subjects. ( Advenier, C; Dinh Xuan, AT; Lockhart, A; Matran, R; Regnard, J; Vitou, P, 1988) |
| "We investigated the possibility that clonidine, an alpha 2-adrenoceptor agonist, can reduce the wheal-and-flare reactions induced by intradermal injections of allergen in patients with extrinsic asthma." | 9.06 | Inhibitory effects of clonidine on the allergen-induced wheal-and-flare reactions in patients with extrinsic asthma. ( Andersson, RG; Brundin, A; Lindgren, BR, 1987) |
| " Results obtained in the present study showed that EZJF and JB significantly inhibited clonidine-induced catalepsy, milk-induced leucocytosis and eosinophilia, clonidine-induced mast cell degranulation, and passive paw anaphylaxis." | 7.91 | Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B. - Possible role in the treatment of asthma. ( Ninave, PB; Patil, SD, 2019) |
| "To study the effect of inhaled clonidine on broncho-obstruction in asthmatics, 10 patients with extrinsic asthma were broncho-provoked twice with an allergen that had been shown to give positive skin prick test results." | 7.67 | The effect of inhaled clonidine in patients with asthma. ( Andersson, RG; Ekström, T; Lindgren, BR, 1986) |
| " The dose-response curves were compared by an analysis of variance." | 6.66 | Effects of clonidine on bronchial responses to histamine in normal and asthmatic subjects. ( Advenier, C; Dinh Xuan, AT; Lockhart, A; Mantrand, P; Matran, R; Regnard, J, 1988) |
| "Alinidine is a new bradycardic agent which has been shown to be beneficial in the treatment of coronary heart disease." | 6.66 | Safety and efficacy of alinidine in symptom-free asthmatics. ( Friedrich, T; Hoffmann, M; Huckauf, H; Kammradt, G; Lichey, J, 1986) |
| "Fifteen patients with asthma were randomized into a double-blind, placebo controlled, crossover trial evaluating whether clonidine increased airway resistance." | 5.08 | Oral clonidine in patients with asthma: no significant effect on airway reactivity. ( Foxworth, JW; Knudson, SM; Pyszczynski, DR; Reisz, GR, 1995) |
| " The effects of pretreatment with clonidine and rilmenidine, a new alpha 2-adrenoceptor agonist, on the bronchial responses to inhaled histamine were studied on 3 different days in a controlled, double-blind, randomized study in 12 asymptomatic asthmatic subjects." | 5.06 | Comparative effects of rilmenidine and clonidine on bronchial responses to histamine in asthmatic subjects. ( Advenier, C; Dinh Xuan, AT; Lockhart, A; Matran, R; Regnard, J; Vitou, P, 1988) |
| "We investigated the possibility that clonidine, an alpha 2-adrenoceptor agonist, can reduce the wheal-and-flare reactions induced by intradermal injections of allergen in patients with extrinsic asthma." | 5.06 | Inhibitory effects of clonidine on the allergen-induced wheal-and-flare reactions in patients with extrinsic asthma. ( Andersson, RG; Brundin, A; Lindgren, BR, 1987) |
| " It has also been used intravenously in phaeochromocytoma, tetanus, clonidine withdrawal, and as an adjunct to halothane to produce hypotensive anaesthesia." | 4.76 | Combined alpha- and beta-receptor inhibition in the treatment of hypertension. ( Prichard, BN, 1984) |
| " Results obtained in the present study showed that EZJF and JB significantly inhibited clonidine-induced catalepsy, milk-induced leucocytosis and eosinophilia, clonidine-induced mast cell degranulation, and passive paw anaphylaxis." | 3.91 | Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B. - Possible role in the treatment of asthma. ( Ninave, PB; Patil, SD, 2019) |
| " effect on clonidine and haloperidol induced catalepsy, milk-induced leucocytosis and eosinophilia, mast cell stabilizing activity in mice and studies on smooth muscle preparation of guinea pig ileum (in vitro)." | 3.78 | Antihistaminic and antiallergic actions of extracts of Solanum nigrum berries: possible role in the treatment of asthma. ( Bhawar, SB; Nirmal, SA; Patel, AP; Pattan, SR, 2012) |
| "To study the effect of inhaled clonidine on broncho-obstruction in asthmatics, 10 patients with extrinsic asthma were broncho-provoked twice with an allergen that had been shown to give positive skin prick test results." | 3.67 | The effect of inhaled clonidine in patients with asthma. ( Andersson, RG; Ekström, T; Lindgren, BR, 1986) |
| " The dose-response curves were compared by an analysis of variance." | 2.66 | Effects of clonidine on bronchial responses to histamine in normal and asthmatic subjects. ( Advenier, C; Dinh Xuan, AT; Lockhart, A; Mantrand, P; Matran, R; Regnard, J, 1988) |
| "Alinidine is a new bradycardic agent which has been shown to be beneficial in the treatment of coronary heart disease." | 2.66 | Safety and efficacy of alinidine in symptom-free asthmatics. ( Friedrich, T; Hoffmann, M; Huckauf, H; Kammradt, G; Lichey, J, 1986) |
Research
Studies (18)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (55.56) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ninave, PB | 1 |
| Patil, SD | 1 |
| Nirmal, SA | 1 |
| Patel, AP | 1 |
| Bhawar, SB | 1 |
| Pattan, SR | 1 |
| Hauache, AG | 1 |
| Spinola-Castro, A | 1 |
| Lourenzi, V | 1 |
| Tufik, S | 1 |
| Naspitz, CK | 1 |
| Solé, D | 1 |
| Stella, MJ | 1 |
| Bailey, AG | 1 |
| Prichard, BN | 1 |
| Kallenbach, JM | 1 |
| Joffe, BI | 1 |
| Seftel, HC | 1 |
| Zwi, S | 1 |
| Ashkenazi, S | 1 |
| Mimouni, M | 1 |
| Laron, Z | 1 |
| Varsano, I | 1 |
| Foxworth, JW | 1 |
| Reisz, GR | 1 |
| Pyszczynski, DR | 1 |
| Knudson, SM | 1 |
| Reynisdottir, S | 1 |
| Wahrenberg, H | 1 |
| Bylin, G | 1 |
| Arner, P | 1 |
| Dinh Xuan, AT | 4 |
| Lockhart, A | 4 |
| Matran, R | 3 |
| Regnard, J | 3 |
| Advenier, C | 3 |
| Scott, GC | 1 |
| Chu, CS | 1 |
| Braun, SR | 1 |
| Lindgren, BR | 3 |
| Vitou, P | 1 |
| Mantrand, P | 1 |
| Brundin, A | 1 |
| Andersson, RG | 2 |
| Ekström, T | 1 |
| Lichey, J | 1 |
| Hoffmann, M | 1 |
| Huckauf, H | 1 |
| Kammradt, G | 1 |
| Friedrich, T | 1 |
Reviews
3 reviews available for clonidine and Asthma
| Article | Year |
|---|---|
Combined alpha- and beta-receptor inhibition in the treatment of hypertension.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia; Antihyp | 1984 |
Bronchial effects of alpha 2-adrenoceptor agonists and of other antihypertensive agents in asthma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; An | 1989 |
New aspects on the treatment of inflammatory reactions and broncho-obstruction in bronchial asthma.
Topics: Adrenergic alpha-Agonists; Animals; Asthma; Cattle; Clonidine; Guinea Pigs; Humans; In Vitro Techniq | 1987 |
Trials
6 trials available for clonidine and Asthma
| Article | Year |
|---|---|
Oral clonidine in patients with asthma: no significant effect on airway reactivity.
Topics: Adult; Airway Resistance; Asthma; Blood Pressure; Bronchial Hyperreactivity; Clonidine; Cross-Over S | 1995 |
Transdermal delivery of the alpha 2-agonist clonidine does not alter airways responses to inhaled histamine or methacholine.
Topics: Administration, Cutaneous; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Br | 1991 |
Comparative effects of rilmenidine and clonidine on bronchial responses to histamine in asthmatic subjects.
Topics: Adrenergic alpha-Agonists; Adult; Asthma; Bronchi; Clonidine; Female; Forced Expiratory Volume; Hist | 1988 |
Effects of clonidine on bronchial responses to histamine in normal and asthmatic subjects.
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Bronchial Spasm; Clonidine; Dose-Response Relationship | 1988 |
Inhibitory effects of clonidine on the allergen-induced wheal-and-flare reactions in patients with extrinsic asthma.
Topics: Allergens; Asthma; Clonidine; Histamine; Humans; Hydrocortisone; Hypersensitivity, Delayed; Hypersen | 1987 |
Safety and efficacy of alinidine in symptom-free asthmatics.
Topics: Adult; Asthma; Blood Pressure; Cardiovascular Agents; Clonidine; Double-Blind Method; Heart Rate; Hu | 1986 |
Other Studies
9 other studies available for clonidine and Asthma
| Article | Year |
|---|---|
Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B. - Possible role in the treatment of asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Catalepsy; Clonidine; Cytokines; Disease Models, Animal; Eos | 2019 |
Antihistaminic and antiallergic actions of extracts of Solanum nigrum berries: possible role in the treatment of asthma.
Topics: Animals; Anti-Allergic Agents; Asthma; Catalepsy; Clonidine; Eosinophilia; Fruit; Guinea Pigs; Halop | 2012 |
IGF-I, IGF-BP3, and GH serum levels after stimulation tests in prepubertal allergic boys.
Topics: Adolescent; Asthma; Body Height; Child; Clonidine; Exercise; Growth Hormone; Humans; Insulin-Like Gr | 2003 |
Intranasal clonidine as a premedicant: three cases with unique indications.
Topics: Administration, Intranasal; Adrenergic alpha-Agonists; Asthma; Attention Deficit Disorder with Hyper | 2008 |
Comparison of the metabolic responses to alpha-adrenergic stimulation in asthmatics and non-asthmatics after clonidine.
Topics: Adult; Asthma; Blood Glucose; Blood Pressure; Clonidine; Female; Growth Hormone; Humans; Insulin; Ma | 1984 |
Asthmatic attack associated with oral clonidine test.
Topics: Asthma; Child; Clonidine; Humans; Male | 1984 |
Effect of glucocorticosteroid treatment on beta-adrenoceptor subtype function in adipocytes from patients with asthma.
Topics: Administration, Oral; Adult; Asthma; Cells, Cultured; Clonidine; Dobutamine; Dose-Response Relations | 1993 |
Bronchial effects of alpha 2-adrenoceptor antagonists in asthma.
Topics: Adrenergic alpha-Antagonists; Animals; Asthma; Clonidine; Dogs; Humans; Imidazoles; Yohimbine | 1991 |
The effect of inhaled clonidine in patients with asthma.
Topics: Administration, Intranasal; Adolescent; Adult; Asthma; Clonidine; Eosinophils; Female; Forced Expira | 1986 |