clonidine has been researched along with Asialia in 13 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind crossover trial was undertaken to compare the efficacy of sustained-release clonidine and long-acting propranolol in the treatment of 20 patients (8 males and 12 females) with sustained hypertension." | 9.05 | Comparison of sustained-release clonidine and long-acting propranolol in the treatment of hypertension. ( Lawson, AA; Rodrigues, E, 1982) |
| "A double-blind crossover trial was undertaken to compare the efficacy of sustained-release clonidine and long-acting propranolol in the treatment of 20 patients (8 males and 12 females) with sustained hypertension." | 5.05 | Comparison of sustained-release clonidine and long-acting propranolol in the treatment of hypertension. ( Lawson, AA; Rodrigues, E, 1982) |
| "5 ng x h/mL), and the half-life (1." | 2.75 | Effects of mexiletine, a CYP1A2 inhibitor, on tizanidine pharmacokinetics and pharmacodynamics. ( Homma, M; Inomata, S; Kohda, Y; Momo, K; Osaka, Y; Tanaka, M, 2010) |
| " The bioavailability of oral clonidine in the tablets tested averaged 75." | 1.26 | Pharmacokinetics and concentration-effect relationships of intervenous and oral clonidine. ( Davies, DS; Dollery, CT; Neill, DM; Reid, JL; Tippett, P; Wing, AM, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Momo, K | 1 |
| Homma, M | 1 |
| Osaka, Y | 1 |
| Inomata, S | 1 |
| Tanaka, M | 1 |
| Kohda, Y | 1 |
| Bunevicius, R | 1 |
| Hinderliter, AL | 1 |
| Light, KC | 1 |
| Pedersen, CA | 1 |
| Girdler, SS | 1 |
| Sills, M | 1 |
| Congdon, P | 1 |
| Forsythe, I | 1 |
| Dollery, CT | 2 |
| Davies, DS | 2 |
| Rodrigues, E | 1 |
| Lawson, AA | 1 |
| Jerie, P | 1 |
| Jäättelä, A | 1 |
| Johnson, MA | 1 |
| Blackwell, CP | 1 |
| Smith, J | 1 |
| Chilla, R | 1 |
| Arglebe, C | 1 |
| Ringwald, E | 1 |
| Campean, SJ | 1 |
| Gerstenbrand, F | 1 |
| Lorincz, A | 1 |
| Lörincz, P | 1 |
| Ludin, HP | 1 |
| Conrads, H | 1 |
| Wing, AM | 1 |
| Reid, JL | 1 |
| Neill, DM | 1 |
| Tippett, P | 1 |
| Abrams, DA | 1 |
| Robin, AL | 1 |
| Pollack, IP | 1 |
| deFaller, JM | 1 |
| DeSantis, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
9 trials available for clonidine and Asialia
| Article | Year |
|---|---|
Effects of mexiletine, a CYP1A2 inhibitor, on tizanidine pharmacokinetics and pharmacodynamics.
Topics: Adult; Anti-Arrhythmia Agents; Antihypertensive Agents; Area Under Curve; Blood Pressure; Chromatogr | 2010 |
Lack of beneficial effects of clonidine in the treatment of premenstrual dysphoric disorder: results of a double-blind, randomized study.
Topics: Administration, Oral; Adult; Clonidine; Cross-Over Studies; Dizziness; Double-Blind Method; Drug Adm | 2005 |
Clonidine and childhood migraine: a pilot and double-blind study.
Topics: Child; Child, Preschool; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Eruptions; F | 1982 |
Centrally acting drugs in antihypertensive therapy.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Brain; Clonidine; Dose-Response Relationship, Drug; | 1980 |
Comparison of sustained-release clonidine and long-acting propranolol in the treatment of hypertension.
Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Delayed-Action Preparations; Double-Blind Method; | 1982 |
Comparison of guanfacine and clonidine as antihypertensive agents.
Topics: Antihypertensive Agents; Blood Pressure; Clonidine; Female; Guanfacine; Guanidines; Humans; Hyperten | 1980 |
Antagonism of the effects of clonidine by the alpha 2-adrenoceptor antagonist, fluparoxan.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Antidepressive Agents; Blood Pressure; Br | 1995 |
[Clinical experiences with a new muscle relaxant (DS 103-282 Sandoz) (author's transl)].
Topics: Adult; Clinical Trials as Topic; Clonidine; Drug Evaluation; Drug Tolerance; Female; Humans; Male; M | 1977 |
[Observations on the treatment of glaucoma with clonidin (author's transl)].
Topics: Adult; Clinical Trials as Topic; Clonidine; Drug Evaluation; Fatigue; Glaucoma; Humans; Intraocular | 1976 |
4 other studies available for clonidine and Asialia
| Article | Year |
|---|---|
Clinical experience with guanfacine in long-term treatment of hypertension. Part II: adverse reactions to guanfacine.
Topics: Antihypertensive Agents; Body Weight; Clonidine; Dose-Response Relationship, Drug; Drug Administrati | 1980 |
[Pharmacotherapy of hypertension and its significance for the function of the salivary glands (author's transl)].
Topics: Animals; Antihypertensive Agents; Autonomic Nervous System; Clonidine; Guanidines; Hypertension; Mas | 1975 |
Pharmacokinetics and concentration-effect relationships of intervenous and oral clonidine.
Topics: Administration, Oral; Adult; Biological Availability; Blood Pressure; Clonidine; Computers; Half-Lif | 1977 |
The safety and efficacy of topical 1% ALO 2145 (p-aminoclonidine hydrochloride) in normal volunteers.
Topics: Adult; Blood Pressure; Body Water; Clonidine; Female; Humans; Intraocular Pressure; Male; Middle Age | 1987 |