clonidine has been researched along with Ascites in 9 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Ascites: Accumulation or retention of free fluid within the peritoneal cavity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty cirrhotic patients with refractory or recurrent ascites were prospectively studied after long-term administration of clonidine (n=15) or midodrine (n=15), or both (n=15) plus standard medical therapy (SMT), or SMT alone (n=15), in a randomized controlled trial at a tertiary center." | 9.17 | Midodrine and clonidine in patients with cirrhosis and refractory or recurrent ascites: a randomized pilot study. ( Bhalla, A; Ghai, A; Sharma, N; Singh, A; Singh, B; Singh, V; Vijayvergiya, R, 2013) |
| "To study the usefulness of the combination of clonidine--spironolactone in refractory ascites." | 9.11 | Comparative pilot study of repeated large volume paracentesis vs the combination on clonidine-spironolactone in the treatment of cirrhosis-associated refractory ascites. ( Codden, T; Henry, JP; Legros, F; Lenaerts, A; Ligny, G, 2005) |
| "The aim of the present study was to examine the short- and long-term effects of the alpha 2-agonist clonidine on sympathetic overactivity, systemic, splanchnic, and renal circulation changes, and abnormal renal sodium excretion in cirrhotic patients with ascites." | 9.07 | Long-term sympathetic and hemodynamic responses to clonidine in patients with cirrhosis and ascites. ( Bacq, Y; Braillon, A; Frohly, P; Gaudin, C; Hadengue, A; Lebrec, D; Moreau, R; Roulot, D, 1992) |
| "In human cirrhosis, adrenergic hyperfunction causes proximal tubular fluid retention and contributes to diuretic-resistant ascites, and clonidine, a sympatholytic drug, improves natriuresis in difficult-to-treat ascites." | 7.83 | Alpha-2A Adrenoceptor Agonist Guanfacine Restores Diuretic Efficiency in Experimental Cirrhotic Ascites: Comparison with Clonidine. ( Aragno, M; Mastrocola, R; Mengozzi, G; Parola, M; Sansoè, G, 2016) |
| "Sixty cirrhotic patients with refractory or recurrent ascites were prospectively studied after long-term administration of clonidine (n=15) or midodrine (n=15), or both (n=15) plus standard medical therapy (SMT), or SMT alone (n=15), in a randomized controlled trial at a tertiary center." | 5.17 | Midodrine and clonidine in patients with cirrhosis and refractory or recurrent ascites: a randomized pilot study. ( Bhalla, A; Ghai, A; Sharma, N; Singh, A; Singh, B; Singh, V; Vijayvergiya, R, 2013) |
| "The effects of the addition of clonidine to diuretics on the mobilization of ascites in the short term (diuretic response and requirement of diuretics) and the long term (readmissions for tense ascites and requirement of diuretics) were examined in patients with cirrhosis and with increased sympathetic nervous system (SNS) activity." | 5.12 | Effects of clonidine on diuretic response in ascitic patients with cirrhosis and activation of sympathetic nervous system. ( Codden, T; Henry, JP; Lenaerts, A; Ligny, G; Meunier, JC, 2006) |
| "To study the usefulness of the combination of clonidine--spironolactone in refractory ascites." | 5.11 | Comparative pilot study of repeated large volume paracentesis vs the combination on clonidine-spironolactone in the treatment of cirrhosis-associated refractory ascites. ( Codden, T; Henry, JP; Legros, F; Lenaerts, A; Ligny, G, 2005) |
| "The aim of the present study was to examine the short- and long-term effects of the alpha 2-agonist clonidine on sympathetic overactivity, systemic, splanchnic, and renal circulation changes, and abnormal renal sodium excretion in cirrhotic patients with ascites." | 5.07 | Long-term sympathetic and hemodynamic responses to clonidine in patients with cirrhosis and ascites. ( Bacq, Y; Braillon, A; Frohly, P; Gaudin, C; Hadengue, A; Lebrec, D; Moreau, R; Roulot, D, 1992) |
| "In human cirrhosis, adrenergic hyperfunction causes proximal tubular fluid retention and contributes to diuretic-resistant ascites, and clonidine, a sympatholytic drug, improves natriuresis in difficult-to-treat ascites." | 3.83 | Alpha-2A Adrenoceptor Agonist Guanfacine Restores Diuretic Efficiency in Experimental Cirrhotic Ascites: Comparison with Clonidine. ( Aragno, M; Mastrocola, R; Mengozzi, G; Parola, M; Sansoè, G, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, V | 1 |
| Singh, A | 1 |
| Singh, B | 1 |
| Vijayvergiya, R | 1 |
| Sharma, N | 1 |
| Ghai, A | 1 |
| Bhalla, A | 1 |
| Sansoè, G | 2 |
| Aragno, M | 2 |
| Mastrocola, R | 2 |
| Parola, M | 2 |
| Mengozzi, G | 1 |
| Singhal, S | 1 |
| Baikati, KK | 1 |
| Jabbour, II | 1 |
| Anand, S | 1 |
| Lenaerts, A | 3 |
| Codden, T | 2 |
| Henry, JP | 2 |
| Legros, F | 1 |
| Ligny, G | 3 |
| Meunier, JC | 2 |
| Rai, RR | 1 |
| Jain, P | 1 |
| Van Cauter, J | 1 |
| Moukaiber, H | 1 |
| Roulot, D | 1 |
| Moreau, R | 1 |
| Gaudin, C | 1 |
| Bacq, Y | 1 |
| Braillon, A | 1 |
| Hadengue, A | 1 |
| Frohly, P | 1 |
| Lebrec, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Peritoneal Dialysis Catheters for the Treatment of Refractory Ascites Management: A Randomized Un-Blinded Pilot Study[NCT02975726] | 2 participants (Actual) | Interventional | 2017-01-31 | Completed | |||
| The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients With Ascites and Activation of Sympathetic Nervous System: a Randomized Double-Blind Placebo Controlled Study.[NCT00356226] | 64 participants | Interventional | 2000-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for clonidine and Ascites
| Article | Year |
|---|---|
Management of refractory ascites.
Topics: Albumins; Ascites; Clonidine; Diuretics; Humans; Liver Cirrhosis; Liver Transplantation; Paracentesi | 2012 |
4 trials available for clonidine and Ascites
| Article | Year |
|---|---|
Midodrine and clonidine in patients with cirrhosis and refractory or recurrent ascites: a randomized pilot study.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Ascites; Cl | 2013 |
Comparative pilot study of repeated large volume paracentesis vs the combination on clonidine-spironolactone in the treatment of cirrhosis-associated refractory ascites.
Topics: Adrenergic alpha-Agonists; Ascites; Clonidine; Diuretics; Drug Resistance; Drug Therapy, Combination | 2005 |
Effects of clonidine on diuretic response in ascitic patients with cirrhosis and activation of sympathetic nervous system.
Topics: Angiotensins; Ascites; Clonidine; Diuretics; Drug Therapy, Combination; Female; Furosemide; Heart Ra | 2006 |
Long-term sympathetic and hemodynamic responses to clonidine in patients with cirrhosis and ascites.
Topics: Ascites; Clonidine; Female; Hemodynamics; Humans; Liver Cirrhosis; Male; Middle Aged; Norepinephrine | 1992 |
4 other studies available for clonidine and Ascites
| Article | Year |
|---|---|
Dose-dependency of clonidine's effects in ascitic cirrhotic rats: comparison with α1-adrenergic agonist midodrine.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Animals; Ascites; Blood | 2016 |
Alpha-2A Adrenoceptor Agonist Guanfacine Restores Diuretic Efficiency in Experimental Cirrhotic Ascites: Comparison with Clonidine.
Topics: Adrenergic Agonists; Animals; Ascites; Canrenoic Acid; Clonidine; Diuretics; Drug Synergism; Fibrosi | 2016 |
Combination of clonidine and diuretic in cirrhotic ascites with activated sympathetic nervous system: Would it be a magical bullet?
Topics: Ascites; Clonidine; Diuretics; Humans; Liver Cirrhosis; Spironolactone; Sympathetic Nervous System; | 2008 |
[Treatment of refractory ascites with clonidine and spironolactone].
Topics: Adrenergic alpha-Agonists; Adult; Aged; Ascites; Clonidine; Drug Therapy, Combination; Female; Human | 1997 |