clonidine has been researched along with Arrhythmias, Cardiac in 46 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of the 50 patients with hypertension (American Society of Anesthesiologists class II), 25 received 2 mL of 2% lidocaine with clonidine (15 μg/mL) and 25 received lidocaine with epinephrine (12." | 9.16 | Is clonidine an adequate alternative to epinephrine as a vasoconstrictor in patients with hypertension? ( Patil, PM; Patil, SP, 2012) |
| "The effects of the opioid agonist dextromethorphan and the alpha 2-adrenoceptor agonist tizanidine on ouabain-induced cardiac arrhythmias were investigated in rats." | 7.71 | Protective effects of dextromethorphan and tizanidine on ouabain-induced arrhythmias. ( Ozek, M; Sevgi, S; Uresin, Y, 2002) |
| "11 coronary patients, 8 with mild hypertension, were treated with clonidine, at a dose of 75 micrograms b." | 7.66 | The therapeutic value of clonidine in patients with coronary heart disease. ( Amrein, R; Chu, D; Cocco, G; Haeusler, G; Padovan, GC; Strozzi, C, 1979) |
| "Myocardial infarction was produced in 27 anesthetized dogs by ligating the left anterior descending (LAD) coronary artery proximal to the septal branch." | 5.29 | Electropharmacology of the bradycardic agents alinidine and zatebradine (UL-FS 49) in a conscious canine ventricular arrhythmia model of permanent coronary artery occlusion. ( Aidonidis, I; Brachmann, J; Kübler, W; Rizos, I; Stavridis, I; Toutouzas, P; Zacharoulis, A, 1995) |
| "A second spell of arrhythmia of similar intensity and pattern, which had the same latency to onset, was reproduced 60 min after the first spell of arrhythmia." | 5.28 | Isolated paced guinea pig left atrium: a new ouabain-induced arrhythmia model. ( Thomas, GP; Varma, RK, 1991) |
| "Serious ventricular arrhythmias, including brief ventricular tachycardia, developed in two patients who had greater increases in mean systolic blood pressure (28 +/- 3 vs 10 +/- 8 mm Hg) and double product (552 +/- 681 vs 333 +/- 195) than the others." | 5.27 | Cardiac arrhythmias after abrupt clonidine withdrawal. ( Hamilton, BP; Hamilton, J; Kuzbida, G; Pavlis, R; Peters, RW, 1983) |
| "Clonidine was administered as a bolus injection of 1-2 micrograms/kg body weight and repeated every 1-3 h." | 5.27 | Intravenous clonidine treatment in acute myocardial infarction (with comparison to a nitroglycerin-treated and control group). ( Lada, W; Zochowski, RJ, 1986) |
| "Of the 50 patients with hypertension (American Society of Anesthesiologists class II), 25 received 2 mL of 2% lidocaine with clonidine (15 μg/mL) and 25 received lidocaine with epinephrine (12." | 5.16 | Is clonidine an adequate alternative to epinephrine as a vasoconstrictor in patients with hypertension? ( Patil, PM; Patil, SP, 2012) |
| "The incidence of perioperative myocardial ischemia was significantly reduced with clonidine (intraoperative and postoperative, 18 of 125, 14% vs." | 5.11 | Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery. ( Boisvert, DM; Galindez, D; Haratonik, KA; Kardatzke, D; Layug, EL; Lazo, EA; Salahieh, A; Wallace, AW, 2004) |
| "In a double-blind study, we examined the effects of early intravenous and continued oral administration of a beta-blocker (atenolol), a specific bradycardiac agent (alinidine) or placebo on left ventricular function, late coronary artery patency, infarct size, exercise capacity and incidence of arrhythmias." | 5.07 | Short-term effects of early intravenous treatment with a beta-adrenergic blocking agent or a specific bradycardiac agent in patients with acute myocardial infarction receiving thrombolytic therapy. ( Brzostek, T; Collen, D; Heidbüchel, H; Janssens, L; Lesaffre, E; Mortelmans, L; Scheys, I; Van de Werf, F; Wackers, FJ; Willems, GM, 1993) |
| " Fifteen minutes later, each group was randomly subdivided into two equal groups and an infusion of bupivacaine or ropivacaine, 3 mg kg(-1) min(-1), was given until cardiac arrest (asystole) occurred." | 3.72 | Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats. ( Aydin, Y; Gulec, S; Senturk, Y; Uzuner, K; Yelken, B, 2004) |
| "The effects of the opioid agonist dextromethorphan and the alpha 2-adrenoceptor agonist tizanidine on ouabain-induced cardiac arrhythmias were investigated in rats." | 3.71 | Protective effects of dextromethorphan and tizanidine on ouabain-induced arrhythmias. ( Ozek, M; Sevgi, S; Uresin, Y, 2002) |
| "In this model, clonidine given prophylactically delays the toxic manifestations of bupivacaine overdose and does not accentuate the subsequent hypotension." | 3.68 | Clonidine pretreatment reduces the systemic toxicity of intravenous bupivacaine in rats. ( De Kock, M; Henin, D; Le Polain, B; Scholtes, JL; Vandewalle, F, 1993) |
| "Automatic arrhythmias induced by alpha 1-adrenergic stimulation during simulated ischemia may be attributed to a specific alpha 1-adrenergic receptor subtype that is blocked by WB 4101." | 3.68 | Abnormal automatic rhythms in ischemic Purkinje fibers are modulated by a specific alpha 1-adrenergic receptor subtype. ( Anyukhovsky, EP; Rosen, MR, 1991) |
| "0 micrograms kg-1) was studied for its effect on the cardiac arrhythmias and lethality induced by slow intravenous infusion of ouabain in guinea-pigs." | 3.68 | Protective action of clonidine against the arrhythmogenic and lethal effects of ouabain in guinea-pigs. ( Stephen, PM; Thomas, GP, 1991) |
| "Cardiac arrhythmias and cardiac arrest were induced in pentobarbitone anaesthetised cats by slow intravenous infusion of ouabain." | 3.68 | Protective effect of clonidine against the cardiotoxic effects of ouabain in cat. ( Stephen, PM; Thomas, GP, 1990) |
| "15 mg clonidine (Catapresan) in 11 patients (averaged age 60 years) with symptomatic bradycardia (dizzy spells, syncope, palpitations)." | 3.66 | [Clinidine-induced bradycardia: studies of the effect on the human sinus node (author's transl)]. ( Horn, H; Neuss, H; Schlepper, M; Thormann, J, 1981) |
| "11 coronary patients, 8 with mild hypertension, were treated with clonidine, at a dose of 75 micrograms b." | 3.66 | The therapeutic value of clonidine in patients with coronary heart disease. ( Amrein, R; Chu, D; Cocco, G; Haeusler, G; Padovan, GC; Strozzi, C, 1979) |
| "Ventricular arrhythmias were more frequent in patients who were not premedicated with clonidine." | 2.69 | The effect of clonidine premedication on hemodynamic responses to microlaryngoscopy and rigid bronchoscopy. ( Gozal, Y; Matot, I; Sichel, JY; Yofe, V, 2000) |
| "We investigated prospectively the arrhythmia incidence in 244 patients with AMI receiving alteplase and a double-blind randomized adjunctive therapy with intravenous atenolol, alinidine, or placebo." | 2.67 | Significance of arrhythmias during the first 24 hours of acute myocardial infarction treated with alteplase and effect of early administration of a beta-blocker or a bradycardiac agent on their incidence. ( Ballet, A; Ector, H; Heidbüchel, H; Tack, J; Van de Werf, F; Vanneste, L, 1994) |
| "Whether the additional PTSD and functional neurologic deficits were due to a direct effect of the lightning strike on the central nervous system or a secondary response is open to speculation." | 1.39 | Central hyperadrenergic state after lightning strike. ( Ahlskog, JE; Craft, JM; Gelfman, R; Kantor, B; Low, PA; Parsaik, AK; Seime, RJ; Sheldon, SH; Singer, W; Staab, JP, 2013) |
| "It is concluded that automatic arrhythmias induced by alpha 1-adrenergic stimulation during simulated ischemia may be attributed to a specific alpha 1-adrenergic receptor subtype that is blocked by WB-4101." | 1.29 | [The modulation of anomalous automatism in ischemic Purkinje fibers by a specific subclass of alpha 1-adrenoblockers]. ( Aniukhovskiĭ, EP; Rosen, MR, 1993) |
| "Myocardial infarction was produced in 27 anesthetized dogs by ligating the left anterior descending (LAD) coronary artery proximal to the septal branch." | 1.29 | Electropharmacology of the bradycardic agents alinidine and zatebradine (UL-FS 49) in a conscious canine ventricular arrhythmia model of permanent coronary artery occlusion. ( Aidonidis, I; Brachmann, J; Kübler, W; Rizos, I; Stavridis, I; Toutouzas, P; Zacharoulis, A, 1995) |
| "A second spell of arrhythmia of similar intensity and pattern, which had the same latency to onset, was reproduced 60 min after the first spell of arrhythmia." | 1.28 | Isolated paced guinea pig left atrium: a new ouabain-induced arrhythmia model. ( Thomas, GP; Varma, RK, 1991) |
| "Clonidine has been used in the management of hypertension in adults with few cases of cardiac dysrhythmia reported." | 1.28 | Cardiac dysrhythmia with the use of clonidine in explosive disorder. ( Dawson, PM; Tyma, TA; Vander Zanden, JA; Washington, RL; Werkman, SL, 1989) |
| "Serious ventricular arrhythmias, including brief ventricular tachycardia, developed in two patients who had greater increases in mean systolic blood pressure (28 +/- 3 vs 10 +/- 8 mm Hg) and double product (552 +/- 681 vs 333 +/- 195) than the others." | 1.27 | Cardiac arrhythmias after abrupt clonidine withdrawal. ( Hamilton, BP; Hamilton, J; Kuzbida, G; Pavlis, R; Peters, RW, 1983) |
| "Clonidine was administered as a bolus injection of 1-2 micrograms/kg body weight and repeated every 1-3 h." | 1.27 | Intravenous clonidine treatment in acute myocardial infarction (with comparison to a nitroglycerin-treated and control group). ( Lada, W; Zochowski, RJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (45.65) | 18.7374 |
| 1990's | 16 (34.78) | 18.2507 |
| 2000's | 6 (13.04) | 29.6817 |
| 2010's | 2 (4.35) | 24.3611 |
| 2020's | 1 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Patel, SA | 1 |
| Bg, R | 1 |
| Parsaik, AK | 1 |
| Ahlskog, JE | 1 |
| Singer, W | 1 |
| Gelfman, R | 1 |
| Sheldon, SH | 1 |
| Seime, RJ | 1 |
| Craft, JM | 1 |
| Staab, JP | 1 |
| Kantor, B | 1 |
| Low, PA | 1 |
| Patil, PM | 1 |
| Patil, SP | 1 |
| Uresin, Y | 1 |
| Ozek, M | 1 |
| Sevgi, S | 1 |
| Wijeysundera, DN | 1 |
| Naik, JS | 1 |
| Beattie, WS | 1 |
| Gulec, S | 1 |
| Aydin, Y | 1 |
| Uzuner, K | 1 |
| Yelken, B | 1 |
| Senturk, Y | 1 |
| Wallace, AW | 1 |
| Galindez, D | 1 |
| Salahieh, A | 1 |
| Layug, EL | 1 |
| Lazo, EA | 1 |
| Haratonik, KA | 1 |
| Boisvert, DM | 1 |
| Kardatzke, D | 1 |
| Schipke, JD | 1 |
| Büter, I | 1 |
| Hohlfeld, T | 1 |
| Schmitz-Spanke, S | 1 |
| Gams, E | 1 |
| Millar, JS | 1 |
| Williams, EM | 1 |
| Houston, MC | 1 |
| Brest, AN | 1 |
| Borokhova, IA | 1 |
| Peters, RW | 1 |
| Hamilton, BP | 1 |
| Hamilton, J | 1 |
| Kuzbida, G | 1 |
| Pavlis, R | 1 |
| Onida, L | 1 |
| Bonazzi, M | 1 |
| Dell'Aquila, F | 1 |
| Della Pietra, A | 1 |
| Thormann, J | 1 |
| Neuss, H | 1 |
| Horn, H | 1 |
| Schlepper, M | 2 |
| Aniukhovskiĭ, EP | 2 |
| Rosen, MR | 5 |
| Lee, JH | 1 |
| Heidbüchel, H | 2 |
| Tack, J | 1 |
| Vanneste, L | 1 |
| Ballet, A | 1 |
| Ector, H | 1 |
| Van de Werf, F | 2 |
| Janssens, L | 1 |
| Brzostek, T | 1 |
| Mortelmans, L | 1 |
| Wackers, FJ | 1 |
| Willems, GM | 1 |
| Lesaffre, E | 1 |
| Scheys, I | 1 |
| Collen, D | 1 |
| De Kock, M | 1 |
| Le Polain, B | 1 |
| Henin, D | 1 |
| Vandewalle, F | 1 |
| Scholtes, JL | 1 |
| Aidonidis, I | 1 |
| Brachmann, J | 1 |
| Rizos, I | 1 |
| Zacharoulis, A | 1 |
| Stavridis, I | 1 |
| Toutouzas, P | 1 |
| Kübler, W | 1 |
| Geller, JC | 1 |
| Cua, M | 1 |
| Prieto, L | 1 |
| Guo, SD | 1 |
| Danilo, P | 1 |
| Challinor-Rogers, JL | 1 |
| Rosenfeldt, FL | 1 |
| Du, XJ | 1 |
| McPherson, GA | 1 |
| Matot, I | 1 |
| Sichel, JY | 1 |
| Yofe, V | 1 |
| Gozal, Y | 1 |
| Cocco, G | 1 |
| Strozzi, C | 1 |
| Haeusler, G | 1 |
| Chu, D | 1 |
| Amrein, R | 1 |
| Padovan, GC | 1 |
| Piancone, RM | 1 |
| Mucedola, LB | 1 |
| Antonucci, G | 1 |
| Lipartiti, P | 1 |
| Marangi, M | 1 |
| Rispoli, M | 1 |
| Tilser, I | 1 |
| Segre, G | 1 |
| Rozen, MP | 1 |
| Staĭnberg, SF | 1 |
| Anyukhovsky, EP | 2 |
| Molina-Viamonte, V | 1 |
| Thomas, GP | 3 |
| Stephen, PM | 2 |
| Varma, RK | 1 |
| Ditter, H | 1 |
| Müller, KD | 1 |
| Bahavar, H | 1 |
| Gombotz, H | 1 |
| Clementy, J | 1 |
| Castagné, D | 1 |
| Wicker, P | 1 |
| Dallocchio, M | 1 |
| Bricaud, H | 1 |
| Zochowski, RJ | 1 |
| Lada, W | 1 |
| Dawson, PM | 1 |
| Vander Zanden, JA | 1 |
| Werkman, SL | 1 |
| Washington, RL | 1 |
| Tyma, TA | 1 |
| Meinertz, T | 1 |
| Kasper, W | 1 |
| Jähnchen, E | 1 |
| Vaughan Williams, EM | 1 |
| Krumpl, G | 1 |
| Schneider, W | 1 |
| Raberger, G | 1 |
| Deutsch, J | 1 |
| Grubbauer, HM | 1 |
| Beitzke, A | 1 |
| Harron, DW | 1 |
| Brezina, M | 1 |
| Lillie, C | 1 |
| Kobinger, W | 1 |
| Plastina, F | 1 |
| De Rosa, F | 1 |
| Del Tacca, M | 1 |
| Duchêne-Marullaz, P | 1 |
| Lavarenne, J | 1 |
| Lapalus, P | 1 |
| Boucher, M | 1 |
| Chassaing, C | 1 |
| Gillis, RA | 1 |
| Dionne, RA | 1 |
| Standaert, FG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| Effect of Ivabradine on Heart Rate and Hemodynamics in Patients With Stage D Heart Failure (HF)/Cardiogenic Shock on Dobutamine Treatment[NCT03387605] | Phase 4 | 40 participants (Anticipated) | Interventional | 2018-03-15 | Recruiting | ||
| Effects of Clonidine and Midazolam Premedication on Bispectral Index and Recovery After Elective Surgery[NCT00638729] | 60 participants (Actual) | Interventional | 2005-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
6 reviews available for clonidine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: a meta-analysis.
Topics: Adrenergic alpha-Agonists; Arrhythmias, Cardiac; Cardiac Surgical Procedures; Clonidine; Dexmedetomi | 2003 |
[Selective I(f) channel inhibition: an alternative for treating coronary artery disease?].
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzazepines; Cardiotonic Agents; Cardiovascular Agent | 2006 |
Abrupt cessation of treatment in hypertension: consideration of clinical features, mechanisms, prevention and management of the discontinuation syndrome.
Topics: Acute Disease; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Bethanidine; Blood Pressure; Cloni | 1981 |
Hemodynamic and cardiac effects of clonidine.
Topics: Animals; Arrhythmias, Cardiac; Clonidine; Coronary Circulation; Drug Interactions; Heart; Hemodynami | 1980 |
[Significance of free fatty acid levels in evaluating the severity of myocardial infarction and the efficacy of drug therapy].
Topics: Acute Disease; Arrhythmias, Cardiac; Catecholamines; Clonidine; Fatty Acids, Nonesterified; Follow-U | 1984 |
[Acute clinidine intoxication. Critical review].
Topics: Adult; Arrhythmias, Cardiac; Clonidine; Female; Heroin Dependence; Humans; Hypertension; Male; Self | 1981 |
6 trials available for clonidine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Is clonidine an adequate alternative to epinephrine as a vasoconstrictor in patients with hypertension?
Topics: Adult; Analgesics, Non-Narcotic; Anesthetics, Local; Antihypertensive Agents; Arrhythmias, Cardiac; | 2012 |
Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery.
Topics: Adrenergic alpha-Agonists; Aged; Anesthesia; Arrhythmias, Cardiac; Cardiovascular Diseases; Catechol | 2004 |
Significance of arrhythmias during the first 24 hours of acute myocardial infarction treated with alteplase and effect of early administration of a beta-blocker or a bradycardiac agent on their incidence.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atenolol; Clonidine; Double-Blind Method; Electrocardi | 1994 |
Short-term effects of early intravenous treatment with a beta-adrenergic blocking agent or a specific bradycardiac agent in patients with acute myocardial infarction receiving thrombolytic therapy.
Topics: Adult; Aged; Arrhythmias, Cardiac; Atenolol; Cardiovascular Agents; Clonidine; Double-Blind Method; | 1993 |
The effect of clonidine premedication on hemodynamic responses to microlaryngoscopy and rigid bronchoscopy.
Topics: Adrenergic alpha-Agonists; Aged; Arrhythmias, Cardiac; Blood Pressure; Bronchoscopy; Chi-Square Dist | 2000 |
Alinidine in heart patients: electrophysiologic and antianginal actions.
Topics: Adult; Angina Pectoris; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Cl | 1987 |
34 other studies available for clonidine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Clonidine and Life Threatening Arrythmias.
Topics: Arrhythmias, Cardiac; Blood Pressure; Clonidine; Humans | 2020 |
Central hyperadrenergic state after lightning strike.
Topics: Activities of Daily Living; Adrenergic alpha-Agonists; Anxiety; Arrhythmias, Cardiac; Autonomic Nerv | 2013 |
Protective effects of dextromethorphan and tizanidine on ouabain-induced arrhythmias.
Topics: Adrenergic alpha-Agonists; Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Clonidine; Dextrometho | 2002 |
Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats.
Topics: Adrenergic alpha-Agonists; Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure | 2004 |
Anion antagonism--a fifth class of antiarrhythmic action?
Topics: Anions; Arrhythmias, Cardiac; Cations; Clonidine; Humans; Ion Channels; Myocardial Contraction | 1981 |
Cardiac arrhythmias after abrupt clonidine withdrawal.
Topics: Adult; Arrhythmias, Cardiac; Blood Pressure; Clonidine; Electrocardiography; Heart Rate; Humans; Mal | 1983 |
[Clinidine-induced bradycardia: studies of the effect on the human sinus node (author's transl)].
Topics: Aged; Arrhythmias, Cardiac; Bradycardia; Carotid Sinus; Clonidine; Female; Heart Rate; Humans; Male; | 1981 |
[The modulation of anomalous automatism in ischemic Purkinje fibers by a specific subclass of alpha 1-adrenoblockers].
Topics: Action Potentials; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Arrhythmias, Cardiac | 1993 |
Modulation of delayed afterdepolarisations by alpha 1 adrenergic receptor subtypes.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Calcium; Clonidine; | 1993 |
Clonidine pretreatment reduces the systemic toxicity of intravenous bupivacaine in rats.
Topics: Anesthesia, Epidural; Animals; Arrhythmias, Cardiac; Bupivacaine; Clonidine; Electroencephalography; | 1993 |
Electropharmacology of the bradycardic agents alinidine and zatebradine (UL-FS 49) in a conscious canine ventricular arrhythmia model of permanent coronary artery occlusion.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzazepines; Blood Pressure; Cardiotonic Age | 1995 |
Chloroethylclonidine increases the incidence of lethal arrhythmias during coronary occlusion in anesthetized dogs.
Topics: Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Clonidine; Dioxanes; Dogs; Female; Male | 1995 |
Antiischemic and antiarrhythmic activities of some novel alinidine analogs in the rat heart.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Cardiac Pacing, Artificial; Card | 1997 |
The therapeutic value of clonidine in patients with coronary heart disease.
Topics: Angina Pectoris; Arrhythmias, Cardiac; Clonidine; Coronary Disease; Drug Tolerance; Female; Humans; | 1979 |
["Torsades de pointe". Observations on 8 cases].
Topics: Aged; Antihypertensive Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Clonidine; Coronary | 1979 |
The effect of clonidine, triamterene, and amiloride on pharmacokinetics and cardiotoxicity of ouabain in rabbits.
Topics: Amiloride; Animals; Arrhythmias, Cardiac; Clonidine; Electrocardiography; Heart Rate; Kinetics; Male | 1978 |
[Modulation of heart rhythm by alpha-1 adrenoreceptors].
Topics: Animals; Arrhythmias, Cardiac; Clonidine; Dioxanes; Dogs; Electrocardiography; Heart Rate; Myocardia | 1992 |
Abnormal automatic rhythms in ischemic Purkinje fibers are modulated by a specific alpha 1-adrenergic receptor subtype.
Topics: Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Calcium; Clonidine; Coronary Disease; D | 1991 |
An alpha-1-adrenergic receptor subtype is responsible for delayed afterdepolarizations and triggered activity during simulated ischemia and reperfusion of isolated canine Purkinje fibers.
Topics: Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Clonidine; Dioxanes; Dogs; Myocardial R | 1991 |
Protective action of clonidine against the arrhythmogenic and lethal effects of ouabain in guinea-pigs.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atropine; Blood | 1991 |
Isolated paced guinea pig left atrium: a new ouabain-induced arrhythmia model.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Function, Left; Clonidine; Disease Mod | 1991 |
[Alinidine in multi-vessel coronary disease: reduction of stress-induced ischemic reaction].
Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clonidine; Coronary Disease; Electrocardiograph | 1991 |
[Sinus node inhibitors in coronary surgery].
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clonidine; Coronary Artery Bypass; Female; Heart | 1990 |
Protective effect of clonidine against the cardiotoxic effects of ouabain in cat.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Clonidine; Female; Heart Arrest; Heart Diseases | 1990 |
Study of the electrophysiologic properties of clonidine administered intravenously.
Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Atrioventricular Node; Blood Pressure; Bundle | 1986 |
Intravenous clonidine treatment in acute myocardial infarction (with comparison to a nitroglycerin-treated and control group).
Topics: Adult; Aged; Arrhythmias, Cardiac; Catecholamines; Clonidine; Female; Humans; Male; Middle Aged; Myo | 1986 |
Cardiac dysrhythmia with the use of clonidine in explosive disorder.
Topics: Arrhythmias, Cardiac; Child; Clonidine; Electrocardiography; Humans; Male; Mood Disorders | 1989 |
Antiarrhythmic action of specific bradycardic agents.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clonidine; Heart Rate; Humans | 1987 |
Can exercise-induced regional contractile dysfunction be prevented by selective bradycardic agents?
Topics: Animals; Arrhythmias, Cardiac; Benzazepines; Cardiovascular Agents; Clonidine; Dogs; Hemodynamics; M | 1986 |
[Clonidine poisoning].
Topics: Apnea; Arrhythmias, Cardiac; Child, Preschool; Clonidine; Female; Humans; Hypotension; Infant; Male | 1985 |
Antifibrillatory properties of alinidine after coronary artery occlusion in rats.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiovascular Agents; Clonidine; Coronary Di | 1985 |
[A case of acute clonidine poisoning].
Topics: Adult; Arrhythmias, Cardiac; Clonidine; Electrocardiography; Female; Humans | 1985 |
[Does vagal hypertonia induced by clonidine modify the atrial refractory period in chloralose-treated dogs?].
Topics: Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Bradycardia; Chloralose; Clonidine; Dogs; Electr | 1972 |
Suppression by clonidine (St-155) of cardiac arrhythmias induced by digitalis.
Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Cats; Clonidine; Depression, | 1972 |