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clonidine and Apnea

clonidine has been researched along with Apnea in 16 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Apnea: A transient absence of spontaneous respiration.

Research Excerpts

ExcerptRelevanceReference
" It is concluded that fetal hypoxic apnea may be mediated by inhibitory alpha 2-adrenergic receptors which can be blocked by the antagonist L-657,743."7.68Central effects of an alpha 2-adrenergic antagonist on fetal lambs: a possible mechanism for hypoxic apnea. ( Bamford, O; Hawkins, RL, 1990)
" There was no tonic activation of TS or Abd EMG during apneas; however, TA activity became tonic throughout the apnea."3.70Differential respiratory muscle recruitment induced by clonidine in awake goats. ( Bisgard, GE; Dwinell, MR; Hedrick, MS; Janssen, PL; Pizarro, J, 1998)
" Periods of apnea were commonly observed."3.70Differential effects of clonidine on upper airway abductor and adductor muscle activity in awake goats. ( Bisgard, GE; Herman, JK; O'Halloran, KD, 1999)
" Clonidine-induced central apneas were always associated with continuous tonic activation of the MPC."3.70Clonidine induces upper airway closure in awake goats. ( Bisgard, GE; Herman, JK; O'Halloran, KD, 2000)
"The purpose of this study was to test the hypothesis that respiratory and apneas induced by alpha 2 agonists in anesthetized goats are associated with an increase of upper airway expiratory-related activity, rather than a general depression of breathing."3.69Recurrent laryngeal nerve activation by alpha 2 adrenergic agonists in goats. ( Bisgard, GE; Hedrick, MS; Ryan, ML, 1995)
" It is concluded that fetal hypoxic apnea may be mediated by inhibitory alpha 2-adrenergic receptors which can be blocked by the antagonist L-657,743."3.68Central effects of an alpha 2-adrenergic antagonist on fetal lambs: a possible mechanism for hypoxic apnea. ( Bamford, O; Hawkins, RL, 1990)
" Ventilatory support must be available if apnea occurs."3.66Clonidine poisoning. A complex problem. ( Artman, M; Boerth, RC, 1983)
"Awake regional anaesthesia for inguinal hernia repair in former preterm infants is suggested to avoid life-threatening respiratory complications known to occur after general anaesthesia."1.31Apnoea in a former preterm infant after caudal bupivacaine with clonidine for inguinal herniorrhaphy. ( Fellmann, C; Gerber, AC; Weiss, M, 2002)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19904 (25.00)18.7374
1990's7 (43.75)18.2507
2000's5 (31.25)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fellmann, C1
Gerber, AC1
Weiss, M1
Hussain, AS1
Siddiqui, MS1
Hamdard, F1
Mayhew, JF1
Silvani, P1
Camporesi, A1
Zoia, E1
Leoncino, S1
Salvo, I1
Galante, D1
Artman, M1
Boerth, RC1
Yagupsky, P1
Gorodischer, R1
Kulig, K1
Duffy, J1
Rumack, BH1
Mauro, R1
Gaylord, M1
Hedrick, MS2
Ryan, ML1
Bisgard, GE4
Dwinell, MR1
Janssen, PL1
Pizarro, J1
Kraft, ME1
O'Halloran, KD2
Herman, JK2
Breschan, C1
Krumpholz, R1
Likar, R1
Kraschl, R1
Schalk, HV1
Narchi, P1
Benhamou, D1
Hamza, J1
Bouaziz, H1
Bamford, O1
Hawkins, RL1
Deutsch, J1
Grubbauer, HM1
Beitzke, A1

Trials

1 trial available for clonidine and Apnea

ArticleYear
Ventilatory effects of epidural clonidine during the first 3 hours after caesarean section.
    Acta anaesthesiologica Scandinavica, 1992, Volume: 36, Issue:8

    Topics: Analgesia, Epidural; Analgesia, Obstetrical; Apnea; Cesarean Section; Clonidine; Double-Blind Method

1992

Other Studies

15 other studies available for clonidine and Apnea

ArticleYear
Apnoea in a former preterm infant after caudal bupivacaine with clonidine for inguinal herniorrhaphy.
    Paediatric anaesthesia, 2002, Volume: 12, Issue:7

    Topics: Anesthesia, Caudal; Anesthetics, Combined; Apnea; Bupivacaine; Clonidine; Hernia, Inguinal; Humans;

2002
Postoperative apnoea in an ex-premature infant: is it only related to clonidine?
    Paediatric anaesthesia, 2003, Volume: 13, Issue:8

    Topics: Analgesics; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; Apnea; Bupivacaine; Clonidi

2003
Anesthetic management in a child with Coffin-Siris syndrome.
    Paediatric anaesthesia, 2004, Volume: 14, Issue:8

    Topics: Abnormalities, Multiple; Amides; Analgesia, Epidural; Analgesics; Anesthetics, Inhalation; Anestheti

2004
Preoperative apnea in a preterm infant after caudal block with ropivacaine and clonidine.
    Paediatric anaesthesia, 2005, Volume: 15, Issue:8

    Topics: Amides; Analgesics; Anesthesia, Caudal; Anesthetics, Local; Apnea; Bradycardia; Clonidine; Hernia, I

2005
Clonidine poisoning. A complex problem.
    American journal of diseases of children (1960), 1983, Volume: 137, Issue:2

    Topics: Apnea; Bradycardia; Child, Preschool; Clonidine; Dopamine; Female; Fluid Therapy; Gastric Lavage; Hu

1983
Massive clonidine ingestion with hypertension in a 9-month-old infant.
    Pediatrics, 1983, Volume: 72, Issue:4

    Topics: Accidents, Home; Age Factors; Apnea; Blood Pressure; Clonidine; Female; Heart Rate; Humans; Hyperten

1983
Naloxone for treatment of clonidine overdose.
    JAMA, 1982, Mar-26, Volume: 247, Issue:12

    Topics: Apnea; Clonidine; Coma; Female; Humans; Infant; Naloxone

1982
Recurrent laryngeal nerve activation by alpha 2 adrenergic agonists in goats.
    Respiration physiology, 1995, Volume: 101, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apnea; Benzazepines; Carbon Dioxid

1995
Differential respiratory muscle recruitment induced by clonidine in awake goats.
    Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 84, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Apnea; Clonidine; Dopamine

1998
A 9-month-old with bradycardia and periodic apnea.
    Journal of emergency nursing, 1998, Volume: 24, Issue:5

    Topics: Antihypertensive Agents; Apnea; Bradycardia; Clonidine; Drug Overdose; Emergency Nursing; Female; Hu

1998
Differential effects of clonidine on upper airway abductor and adductor muscle activity in awake goats.
    Journal of applied physiology (Bethesda, Md. : 1985), 1999, Volume: 87, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anima

1999
Can a dose of 2microg.kg(-1) caudal clonidine cause respiratory depression in neonates?
    Paediatric anaesthesia, 1999, Volume: 9, Issue:1

    Topics: Adrenergic alpha-Agonists; Amides; Anesthesia, Caudal; Anesthesia, Inhalation; Anesthetics, Local; A

1999
Clonidine induces upper airway closure in awake goats.
    Respiration physiology, 2000, Volume: 123, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apnea; Benzazepines; Clonidine; Co

2000
Central effects of an alpha 2-adrenergic antagonist on fetal lambs: a possible mechanism for hypoxic apnea.
    Journal of developmental physiology, 1990, Volume: 13, Issue:6

    Topics: Adrenergic alpha-Antagonists; Animals; Apnea; Clonidine; Female; Fetal Diseases; Fetal Hypoxia; Preg

1990
[Clonidine poisoning].
    Padiatrie und Padologie, 1985, Volume: 20, Issue:1

    Topics: Apnea; Arrhythmias, Cardiac; Child, Preschool; Clonidine; Female; Humans; Hypotension; Infant; Male

1985