clonidine has been researched along with Anxiety in 113 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings indicate that children receiving clonidine or DEX preoperatively have similar levels of anxiety and sedation postoperatively as those receiving midazolam." | 9.12 | Effects of preanesthetic administration of midazolam, clonidine, or dexmedetomidine on postoperative pain and anxiety in children. ( Auler, JO; Bandeira, D; Bertacchi, MF; Schmidt, AP; Simões, CM; Valinetti, EA, 2007) |
| "To test the hypothesis that clonidine premedication could prevent an increase of plasma epinephrine occurring as a result of anxiety, and a decrease of the serum potassium (K+) levels before the induction of anesthesia." | 9.10 | Clonidine premedication prevents preoperative hypokalemia. ( Cho, HS; Chung, IS; Hahm, TS; Kim, JA; Kim, MH; Lee, KH, 2002) |
| "To evaluate noradrenergic (NE) function in obsessive-compulsive disorder (OCD), behavioral, physiological, and neuroendocrine responses to the alpha 2-adrenergic agonist clonidine were examined in 18 patients with OCD and 10 healthy subjects." | 9.07 | Noradrenergic function in obsessive-compulsive disorder: behavioral and neuroendocrine responses to clonidine and comparison to healthy controls. ( Cooper, T; DeCaria, C; Gully, R; Hollander, E; Klein, DF; Liebowitz, MR; Nitescu, A; Stover, B, 1991) |
| "To assess the influence of adrenergic modulation on preoperative anxiety, we used a randomized, double-blind, placebo-controlled trial to compare temazepam, clonidine, and timolol as preanesthetic medications in patients undergoing minor orthopedic surgery." | 9.07 | Adrenergic modulation of preoperative anxiety: a comparison of temazepam, clonidine, and timolol. ( Carabine, UA; Milligan, KR; Moore, JA, 1991) |
| "Clonidine may be useful in controlling tobacco withdrawal and in facilitating smoking cessation." | 9.07 | Transdermal clonidine reduced some withdrawal symptoms but did not increase smoking cessation. ( Daughton, DM; Grimm, RH; Heim, C; Nett, L; Petty, TL; Prochazka, AV; Rennard, SI; Sachs, DP; Silvers, GW, 1992) |
| "We included 27 randomized controlled trials (RCTs), involving 2319 participants, that assessed melatonin for treating preoperative anxiety, postoperative anxiety, or both." | 9.05 | Melatonin for preoperative and postoperative anxiety in adults. ( Madsen, BK; Møller, AM; Rosenberg, J; Zetner, D, 2020) |
| "To assess the effect of melatonin on pre- and postoperative anxiety in adults when comparing melatonin with placebo or when comparing melatonin with benzodiazepines." | 8.91 | Melatonin for pre- and postoperative anxiety in adults. ( Gögenur, I; Halladin, NL; Hansen, MV; Møller, AM; Rosenberg, J, 2015) |
| "Present study investigated the role of agmatine in ethanol-induced anxiolysis and withdrawal anxiety using elevated plus maze (EPM) test in rats." | 7.76 | Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats. ( Chopde, CT; Kotagale, NR; Patel, MR; Shelkar, GP; Taksande, BG; Ugale, RR, 2010) |
| "In order to investigate possible neurobiologic mechanisms underlying carbon dioxide-induced anxiety, the effects of oral alprazolam 0." | 7.67 | Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects. ( Charney, DS; Heninger, GR; Krystal, JH; Woods, SW, 1989) |
| "Yohimbine (30 mg) produced significant increases in subjective anxiety, autonomic symptoms, blood pressure, and plasma 3-methoxy-4-hydroxy-phenylethyleneglycol (MHPG) in ten healthy subjects." | 7.66 | Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine. ( Charney, DS; Heninger, GR; Redmond, DE, 1983) |
| "Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment." | 6.67 | Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992) |
| "Current pharmacotherapies for PTSD manage only a subset of these symptoms and typically have adverse side effects which limit their overall effectiveness." | 5.39 | Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. ( Diamond, DM; Fleshner, M; Zoladz, PR, 2013) |
| "In 139 patients anxiety, sedation and adverse effects were measured at 6 consecutive perioperative time points after administration of midazolam, clonidine or a placebo." | 5.14 | [Quality of premedication and patient satisfaction after premedication with midazolam, clonidine or placebo : Randomized double-blind study with age-adjusted dosage]. ( Ivleva-Sauerborn, A; Seifert, B; Spahn, DR; Zalunardo, MP, 2010) |
| "These findings indicate that children receiving clonidine or DEX preoperatively have similar levels of anxiety and sedation postoperatively as those receiving midazolam." | 5.12 | Effects of preanesthetic administration of midazolam, clonidine, or dexmedetomidine on postoperative pain and anxiety in children. ( Auler, JO; Bandeira, D; Bertacchi, MF; Schmidt, AP; Simões, CM; Valinetti, EA, 2007) |
| "Both clonidine as well as midazolam showed a significant reduction of the state-anxiety over time (p < 0,001)." | 5.10 | [Clonidine vs. Midazolam for premedication - comparison of the anxiolytic effect by using the STAI-test]. ( Frank, T; Heinke, W; Schmädicke, I; Wehner, M, 2002) |
| "To test the hypothesis that clonidine premedication could prevent an increase of plasma epinephrine occurring as a result of anxiety, and a decrease of the serum potassium (K+) levels before the induction of anesthesia." | 5.10 | Clonidine premedication prevents preoperative hypokalemia. ( Cho, HS; Chung, IS; Hahm, TS; Kim, JA; Kim, MH; Lee, KH, 2002) |
| "To investigate the effects of preanesthetic oral clonidine on total propofol requirement for uniform minor surgery (breast conservative surgery: breast cancer removal with axillary lymph node dissection), and to compare the action of clonidine with that of preanesthetic oral diazepam, a commonly used benzodiazepine." | 5.08 | The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia. ( Imai, Y; Kagawa, K; Kirita, T; Kishi, Y; Kita, T; Mammoto, T; Murakami, K; Sakai, T; Sugimura, M, 1998) |
| "To evaluate noradrenergic (NE) function in obsessive-compulsive disorder (OCD), behavioral, physiological, and neuroendocrine responses to the alpha 2-adrenergic agonist clonidine were examined in 18 patients with OCD and 10 healthy subjects." | 5.07 | Noradrenergic function in obsessive-compulsive disorder: behavioral and neuroendocrine responses to clonidine and comparison to healthy controls. ( Cooper, T; DeCaria, C; Gully, R; Hollander, E; Klein, DF; Liebowitz, MR; Nitescu, A; Stover, B, 1991) |
| "Clonidine may be useful in controlling tobacco withdrawal and in facilitating smoking cessation." | 5.07 | Transdermal clonidine reduced some withdrawal symptoms but did not increase smoking cessation. ( Daughton, DM; Grimm, RH; Heim, C; Nett, L; Petty, TL; Prochazka, AV; Rennard, SI; Sachs, DP; Silvers, GW, 1992) |
| "Clonidine's actions and efficacy in mental disorders are reviewed and examined." | 5.06 | Psychiatric indications for clonidine: the neuropharmacologic and clinical basis. ( Bond, WS, 1986) |
| "We included 27 randomized controlled trials (RCTs), involving 2319 participants, that assessed melatonin for treating preoperative anxiety, postoperative anxiety, or both." | 5.05 | Melatonin for preoperative and postoperative anxiety in adults. ( Madsen, BK; Møller, AM; Rosenberg, J; Zetner, D, 2020) |
| "To assess the effect of melatonin on pre- and postoperative anxiety in adults when comparing melatonin with placebo or when comparing melatonin with benzodiazepines." | 4.91 | Melatonin for pre- and postoperative anxiety in adults. ( Gögenur, I; Halladin, NL; Hansen, MV; Møller, AM; Rosenberg, J, 2015) |
| "Based on the findings from this cohort, high preinduction anxiety does not appear to be associated with NBCs postoperatively in children premedicated with clonidine or midazolam." | 4.31 | Preoperative anxiety level is not associated with postoperative negative behavioral changes in premedicated children. ( Brorsson, C; Haney, M; Hultin, M; Johansson, G; Winsö, O; Zickerman, C, 2023) |
| "Present study investigated the role of agmatine in ethanol-induced anxiolysis and withdrawal anxiety using elevated plus maze (EPM) test in rats." | 3.76 | Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats. ( Chopde, CT; Kotagale, NR; Patel, MR; Shelkar, GP; Taksande, BG; Ugale, RR, 2010) |
| " This sleep deprivation-induced anxiety-like behavior was unaffected by treatment with chlordiazepoxide (5." | 3.72 | Anxiogenic effect of sleep deprivation in the elevated plus-maze test in mice. ( Abílio, VC; Carvalho, RC; Frussa-Filho, R; Kameda, SR; Niigaki, ST; Silva, RH; Takatsu-Coleman, AL; Tufik, S, 2004) |
| "In the present study, the effect of alpha-adrenoceptor agents on response to nicotine in an anxiety model (elevated plus-maze) in mice was investigated." | 3.70 | Involvement of adrenergic and cholinergic systems in nicotine-induced anxiogenesis in mice. ( Babaie, A; Etminani, A; Gharib, B; Homayoun, H; Zarrindast, MR, 2000) |
| "The alpha 2 agonist clonidine has been shown to be anxiolytic in a number of preclinical anxiety models." | 3.69 | The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration. ( Dunn, RW; La Marca, S, 1994) |
| "The purpose of this study was to determine the mechanism by which caffeine increases anxiety." | 3.67 | Caffeine-induced anxiogenesis: the role of adenosine, benzodiazepine and noradrenergic receptors. ( Baldwin, HA; File, SE, 1989) |
| "The effect of the alpha-2-adrenoceptor agonist clonidine on anxiety-related behavior was investigated using two different rat anxiety models: a modified Vogel's drinking conflict model and Montgomery's elevated plus-maze." | 3.67 | Biphasic effects of clonidine on conflict behavior: involvement of different alpha-adrenoceptors. ( Engel, JA; Söderpalm, B, 1988) |
| "Yohimbine (30 mg) produced significant increases in subjective anxiety, autonomic symptoms, blood pressure, and plasma 3-methoxy-4-hydroxy-phenylethyleneglycol (MHPG) in ten healthy subjects." | 3.66 | Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine. ( Charney, DS; Heninger, GR; Redmond, DE, 1983) |
| " The population pharmacokinetic modeling was done with NONMEM." | 2.80 | Melatonin and clonidine premedication has similar impact on the pharmacokinetics and pharmacodynamics of propofol target controlled-infusions. ( Bienert, A; Grześkowiak, E; Józefowicz, M; Kokot, ZJ; Kusza, K; Matysiak, J; Pachutko, A; Przybyłowski, K; Wawrzyniak, K; Wiczling, P, 2015) |
| "Clonidine is a preferential alpha-2 agonist drug that has been used for over 35 years to treat hypertension." | 2.72 | Oral clonidine pretreatment prior to venous cannulation. ( Hall, DL; Rezvan, E; Tatakis, DN; Walters, JD, 2006) |
| "Withdrawal symptoms were the highest during the first assessment of the day, at the time of BUP administration." | 2.68 | A protocol to switch high-dose, methadone-maintained subjects to buprenorphine. ( Connerney, I; Fischman, MW; Foltin, RW; Levin, FR, 1997) |
| "Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment." | 2.67 | Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992) |
| "While having significant withdrawal symptoms, 50 hospitalized men were randomly assigned to receive either transdermal clonidine or chlordiazepoxide over a 4-day study period." | 2.67 | Transdermal clonidine versus chlordiazepoxide in alcohol withdrawal: a randomized, controlled clinical trial. ( Baumgartner, GR; Rowen, RC, 1991) |
| "2) treatment on the withdrawal symptoms associated with smoking cessation." | 2.66 | Effects of transdermal clonidine treatment on withdrawal symptoms associated with smoking cessation. A randomized, controlled trial. ( McAdams, LA; Ornish, SA; Zisook, S, 1988) |
| "Clonidine and alprazolam diminished withdrawal symptoms." | 2.65 | Cigarette craving, smoking withdrawal, and clonidine. ( Glassman, AH; Jackson, WK; Roose, SP; Rosenfeld, B; Walsh, BT, 1984) |
| " Other reported effects are toxic confusional states and psychotic reactions." | 2.36 | Psychiatric side effects of antihypertensive drugs other than reserpine. ( Fleminger, R; Paykel, ES; Watson, JP, 1982) |
| "As an addictive drug, alcohol produces withdrawal symptoms if discontinued abruptly after chronic use." | 1.43 | Comparative Evaluation of Partial α2 -Adrenoceptor Agonist and Pure α2 -Adrenoceptor Antagonist on the Behavioural Symptoms of Withdrawal after Chronic Alcohol Administration in Mice. ( Arora, S; Vohora, D, 2016) |
| "Whether the additional PTSD and functional neurologic deficits were due to a direct effect of the lightning strike on the central nervous system or a secondary response is open to speculation." | 1.39 | Central hyperadrenergic state after lightning strike. ( Ahlskog, JE; Craft, JM; Gelfman, R; Kantor, B; Low, PA; Parsaik, AK; Seime, RJ; Sheldon, SH; Singer, W; Staab, JP, 2013) |
| "Current pharmacotherapies for PTSD manage only a subset of these symptoms and typically have adverse side effects which limit their overall effectiveness." | 1.39 | Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. ( Diamond, DM; Fleshner, M; Zoladz, PR, 2013) |
| " Dose-response studies using two classes of anxiolytics (chlordiazepoxide: 2." | 1.35 | Modelling the anxiety-depression continuum in chicks. ( Acevedo, EO; Huang, CJ; Sufka, KJ; Warnick, JE, 2009) |
| "When clonidine was administered, locomotion reduction was not observed on any post-stress day." | 1.31 | Clonidine immediately after immobilization stress prevents long-lasting locomotion reduction in the rat. ( Mugishima, G; Shinba, T; Shinozaki, T, 2001) |
| "Two cases of tardive akathisia, which were misdiagnosed as anxiety originating from a schizophrenic disorder, had been treated with anxiolytics in addition to neuroleptics and anticholinergics." | 1.28 | Treatment of tardive akathisia with clonidine. ( Koga, I; Nishikawa, T; Tanaka, M; Uchida, Y, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (35.40) | 18.7374 |
| 1990's | 25 (22.12) | 18.2507 |
| 2000's | 23 (20.35) | 29.6817 |
| 2010's | 22 (19.47) | 24.3611 |
| 2020's | 3 (2.65) | 2.80 |
| Authors | Studies |
|---|---|
| Zickerman, C | 1 |
| Brorsson, C | 1 |
| Hultin, M | 2 |
| Johansson, G | 1 |
| Winsö, O | 1 |
| Haney, M | 1 |
| Madsen, BK | 1 |
| Zetner, D | 1 |
| Møller, AM | 2 |
| Rosenberg, J | 2 |
| Bromfalk, Å | 1 |
| Myrberg, T | 1 |
| Walldén, J | 1 |
| Engström, Å | 1 |
| Hayden, JC | 1 |
| Dawkins, I | 1 |
| Breatnach, C | 1 |
| Leacy, FP | 1 |
| Foxton, J | 1 |
| Healy, M | 1 |
| Cousins, G | 1 |
| Gallagher, PJ | 1 |
| Doherty, DR | 1 |
| Spalink, CL | 1 |
| Barnes, E | 1 |
| Palma, JA | 1 |
| Norcliffe-Kaufmann, L | 1 |
| Kaufmann, H | 1 |
| Ye, L | 1 |
| Lippmann, S | 1 |
| Rorabaugh, BR | 1 |
| Bui, AD | 1 |
| Seeley, SL | 1 |
| Eisenmann, ED | 1 |
| Rose, RM | 1 |
| Johnson, BL | 1 |
| Huntley, MR | 1 |
| Heikkila, ME | 1 |
| Zoladz, PR | 2 |
| Parsaik, AK | 1 |
| Ahlskog, JE | 1 |
| Singer, W | 1 |
| Gelfman, R | 1 |
| Sheldon, SH | 1 |
| Seime, RJ | 1 |
| Craft, JM | 1 |
| Staab, JP | 1 |
| Kantor, B | 1 |
| Low, PA | 1 |
| Smith, CD | 1 |
| Piasecki, CC | 1 |
| Weera, M | 1 |
| Olszewicz, J | 1 |
| Lonstein, JS | 1 |
| Mitra, S | 1 |
| Kazal, S | 1 |
| Anand, LK | 1 |
| Bortone, L | 1 |
| Bertolizio, G | 1 |
| Engelhardt, T | 1 |
| Frawley, G | 1 |
| Somaini, M | 1 |
| Ingelmo, PM | 1 |
| Bienert, A | 1 |
| Wawrzyniak, K | 1 |
| Wiczling, P | 1 |
| Przybyłowski, K | 1 |
| Kokot, ZJ | 1 |
| Matysiak, J | 1 |
| Pachutko, A | 1 |
| Józefowicz, M | 1 |
| Kusza, K | 1 |
| Grześkowiak, E | 1 |
| Hansen, MV | 1 |
| Halladin, NL | 1 |
| Gögenur, I | 1 |
| Arora, S | 1 |
| Vohora, D | 1 |
| Bashiri, H | 1 |
| Rezayof, A | 1 |
| Sahebgharani, M | 1 |
| Tavangar, SM | 1 |
| Zarrindast, MR | 2 |
| Warnick, JE | 1 |
| Huang, CJ | 1 |
| Acevedo, EO | 1 |
| Sufka, KJ | 2 |
| Katayama, K | 1 |
| Yamada, K | 1 |
| Ornthanalai, VG | 1 |
| Inoue, T | 1 |
| Ota, M | 1 |
| Murphy, NP | 1 |
| Aruga, J | 1 |
| Ziedonis, DM | 1 |
| Amass, L | 1 |
| Steinberg, M | 1 |
| Woody, G | 1 |
| Krejci, J | 1 |
| Annon, JJ | 1 |
| Cohen, AJ | 1 |
| Waite-O'Brien, N | 1 |
| Stine, SM | 1 |
| McCarty, D | 1 |
| Reid, MS | 1 |
| Brown, LS | 1 |
| Maslansky, R | 1 |
| Winhusen, T | 1 |
| Babcock, D | 1 |
| Brigham, G | 1 |
| Muir, J | 1 |
| Orr, D | 1 |
| Buchan, BJ | 1 |
| Horton, T | 1 |
| Ling, W | 1 |
| Caumo, W | 2 |
| Levandovski, R | 1 |
| Hidalgo, MP | 1 |
| Inagaki, H | 1 |
| Kiyokawa, Y | 1 |
| Takeuchi, Y | 1 |
| Mori, Y | 1 |
| Cao, J | 1 |
| Shi, X | 1 |
| Miao, X | 1 |
| Xu, J | 1 |
| Zalunardo, MP | 1 |
| Ivleva-Sauerborn, A | 1 |
| Seifert, B | 1 |
| Spahn, DR | 1 |
| Taksande, BG | 1 |
| Kotagale, NR | 1 |
| Patel, MR | 1 |
| Shelkar, GP | 1 |
| Ugale, RR | 1 |
| Chopde, CT | 1 |
| Attigah, N | 1 |
| Kutter, J | 1 |
| Demirel, S | 1 |
| Hakimi, M | 1 |
| Hinz, U | 1 |
| Motsch, J | 1 |
| Böckler, D | 1 |
| Iezhitsa, IN | 1 |
| Spasov, AA | 1 |
| Kharitonova, MV | 1 |
| Kravchenko, MS | 1 |
| Hymel, KA | 1 |
| Kochenborger, L | 1 |
| Zanatta, D | 1 |
| Berretta, LM | 1 |
| Lopes, AP | 1 |
| Wunderlich, BL | 1 |
| Januário, AC | 1 |
| Neto, JM | 1 |
| Terenzi, MG | 1 |
| Paschoalini, MA | 1 |
| Faria, MS | 1 |
| Rickards, H | 1 |
| Cavanna, AE | 1 |
| Worrall, R | 1 |
| Fleshner, M | 1 |
| Diamond, DM | 1 |
| Hackmann, T | 1 |
| Friesen, M | 1 |
| Allen, S | 1 |
| Precious, DS | 1 |
| Talalaenko, AN | 1 |
| Pankrat'ev, DV | 1 |
| Goncharenko, NV | 1 |
| Coleman, K | 1 |
| Dahl, RE | 1 |
| Ryan, ND | 1 |
| Cameron, JL | 1 |
| Silva, RH | 1 |
| Kameda, SR | 1 |
| Carvalho, RC | 1 |
| Takatsu-Coleman, AL | 1 |
| Niigaki, ST | 1 |
| Abílio, VC | 1 |
| Tufik, S | 1 |
| Frussa-Filho, R | 1 |
| Cameron, OG | 1 |
| Abelson, JL | 1 |
| Young, EA | 1 |
| Schweimer, J | 1 |
| Fendt, M | 1 |
| Schnitzler, HU | 1 |
| Hidalgo, MPL | 1 |
| Auzani, JAS | 1 |
| Rumpel, LC | 1 |
| Moreira, NL | 1 |
| Cursino, AWC | 1 |
| Massé, F | 1 |
| Hascoët, M | 1 |
| Bourin, M | 1 |
| Hall, DL | 1 |
| Rezvan, E | 1 |
| Tatakis, DN | 1 |
| Walters, JD | 1 |
| Schmidt, AP | 1 |
| Valinetti, EA | 1 |
| Bandeira, D | 1 |
| Bertacchi, MF | 1 |
| Simões, CM | 1 |
| Auler, JO | 1 |
| Coffey, B | 1 |
| Wieland, N | 1 |
| Almenrader, N | 1 |
| Passariello, M | 1 |
| Coccetti, B | 1 |
| Haiberger, R | 1 |
| Pietropaoli, P | 1 |
| Paykel, ES | 1 |
| Fleminger, R | 1 |
| Watson, JP | 1 |
| Boulenger, JP | 2 |
| Uhde, TW | 3 |
| Sonnendecker, EW | 1 |
| Polakow, ES | 1 |
| Gerdes, L | 1 |
| Redmond, DE | 3 |
| Charney, DS | 3 |
| Heninger, GR | 3 |
| Sternberg, DE | 1 |
| Siever, LJ | 2 |
| Thiébot, MH | 1 |
| Soubrié, P | 1 |
| Doaré, L | 1 |
| Simon, P | 1 |
| Glassman, AH | 1 |
| Jackson, WK | 1 |
| Walsh, BT | 1 |
| Roose, SP | 1 |
| Rosenfeld, B | 1 |
| Wilkins, AJ | 1 |
| Jenkins, WJ | 1 |
| Steiner, JA | 1 |
| Post, RM | 1 |
| Vittone, BJ | 1 |
| Jimerson, DC | 1 |
| Roy-Byrne, PP | 1 |
| Svensson, A | 1 |
| Camí, J | 2 |
| de Torres, S | 2 |
| Solé, A | 2 |
| Guerra, D | 2 |
| Rodríguez, H | 1 |
| Ugena, B | 2 |
| Keup, W | 1 |
| Stiff, JL | 1 |
| Harris, DB | 1 |
| Gold, MS | 2 |
| Pottash, AL | 2 |
| Sweeney, DR | 2 |
| Davies, RK | 1 |
| Kleber, HD | 2 |
| Cole, JC | 1 |
| Burroughs, GJ | 1 |
| Laverty, CR | 1 |
| Sheriff, NC | 1 |
| Sparham, EA | 1 |
| Rodgers, RJ | 1 |
| Verbanac, JS | 1 |
| Commissaris, RL | 1 |
| Altman, HJ | 1 |
| Pitts, DK | 1 |
| Tornatzky, W | 1 |
| Miczek, KA | 1 |
| La Marca, S | 1 |
| Dunn, RW | 1 |
| Venault, P | 1 |
| Jacquot, F | 1 |
| Save, E | 1 |
| Sara, S | 1 |
| Chapouthier, G | 1 |
| Zhang, HT | 1 |
| Luo, ZP | 2 |
| de Angelis, L | 1 |
| Mizuki, Y | 1 |
| Suetsugi, M | 1 |
| Ushijima, I | 1 |
| Yamada, M | 1 |
| Levin, FR | 1 |
| Fischman, MW | 1 |
| Connerney, I | 1 |
| Foltin, RW | 1 |
| Coplan, JD | 1 |
| Pine, DS | 1 |
| Papp, LA | 1 |
| Gorman, JM | 1 |
| Bharucha, AE | 1 |
| Camilleri, M | 1 |
| Zinsmeister, AR | 1 |
| Hanson, RB | 1 |
| Broderick, PA | 1 |
| Bitsios, P | 1 |
| Szabadi, E | 1 |
| Bradshaw, CM | 1 |
| Imai, Y | 1 |
| Mammoto, T | 1 |
| Murakami, K | 1 |
| Kita, T | 1 |
| Sakai, T | 1 |
| Kagawa, K | 1 |
| Kirita, T | 1 |
| Sugimura, M | 1 |
| Kishi, Y | 1 |
| Homayoun, H | 1 |
| Babaie, A | 1 |
| Etminani, A | 1 |
| Gharib, B | 1 |
| Fahlke, C | 1 |
| Berggren, U | 1 |
| Balldin, J | 1 |
| Shishkina, GT | 2 |
| Kalinina, TS | 2 |
| Sournina, NY | 2 |
| Dygalo, NN | 2 |
| Shinba, T | 1 |
| Shinozaki, T | 1 |
| Mugishima, G | 1 |
| Frank, T | 1 |
| Wehner, M | 1 |
| Heinke, W | 1 |
| Schmädicke, I | 1 |
| Hahm, TS | 1 |
| Cho, HS | 1 |
| Lee, KH | 1 |
| Chung, IS | 1 |
| Kim, JA | 1 |
| Kim, MH | 1 |
| Saharov, DG | 1 |
| Kobzev, VF | 1 |
| Swift, RM | 1 |
| Stout, RL | 1 |
| Coupland, N | 1 |
| Glue, P | 1 |
| Nutt, DJ | 1 |
| Prochazka, AV | 1 |
| Petty, TL | 1 |
| Nett, L | 1 |
| Silvers, GW | 1 |
| Sachs, DP | 1 |
| Rennard, SI | 1 |
| Daughton, DM | 1 |
| Grimm, RH | 1 |
| Heim, C | 1 |
| Hewlett, WA | 1 |
| Vinogradov, S | 1 |
| Agras, WS | 1 |
| Carabine, UA | 3 |
| Milligan, KR | 1 |
| Moore, JA | 1 |
| Steketee, JD | 1 |
| Silverman, PB | 1 |
| Swann, AC | 1 |
| Wright, PM | 2 |
| Moore, J | 2 |
| Hollander, E | 1 |
| DeCaria, C | 1 |
| Nitescu, A | 1 |
| Cooper, T | 1 |
| Stover, B | 1 |
| Gully, R | 1 |
| Klein, DF | 1 |
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| Koga, I | 1 |
| Uchida, Y | 1 |
| Tanaka, M | 1 |
| Baumgartner, GR | 1 |
| Rowen, RC | 1 |
| McClune, S | 1 |
| Orr, DA | 1 |
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| Krystal, JH | 1 |
| Baldwin, HA | 2 |
| File, SE | 4 |
| Johnston, AL | 1 |
| Söderpalm, B | 2 |
| Ferrari, F | 1 |
| Tartoni, PG | 1 |
| Monti, A | 1 |
| Mangiafico, V | 1 |
| Hitchcott, PK | 1 |
| Pellow, S | 1 |
| Engel, JA | 1 |
| Koella, WP | 1 |
| Peachey, JE | 1 |
| Adler, LA | 1 |
| Angrist, B | 2 |
| Peselow, E | 2 |
| Reitano, J | 2 |
| Rotrosen, J | 2 |
| Costall, B | 1 |
| Kelly, ME | 1 |
| Naylor, RJ | 1 |
| Crawley, JN | 1 |
| Ninan, PT | 1 |
| Pickar, D | 1 |
| Chrousos, GP | 1 |
| Linnoila, M | 1 |
| Skolnick, P | 1 |
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| Simson, PG | 1 |
| Ornish, SA | 1 |
| Zisook, S | 1 |
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| Mattila, M | 1 |
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| Mattila, MJ | 1 |
| Yang, XM | 1 |
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| Scheinin, B | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Premedication With Melatonin vs. Placebo in Patients Undergoing Interventional Pain Procedure[NCT02415309] | Phase 3 | 25 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| SurgerySMART: Studying Melatonin and Recovery in Teens[NCT06093477] | 40 participants (Anticipated) | Interventional | 2024-07-31 | Not yet recruiting | |||
| Anxiolytic and Analgesic Effects of Melatonin: A Randomized, Double-blinded, Placebo-controlled Clinical Study[NCT02386319] | Phase 3 | 36 participants (Actual) | Interventional | 2016-08-31 | Completed | ||
| Perioperative Analgesic and Anxiolytic Effect of Melatonin in Patients Undergoing Lumbar Laminectomy[NCT01126294] | 84 participants (Anticipated) | Interventional | 2010-04-30 | Recruiting | |||
| Use of Melatonin for Prevention of POCD After TURP Surgery Under Spinal Anesthesia for Elderly Patients[NCT03966950] | 104 participants (Anticipated) | Interventional | 2017-06-26 | Recruiting | |||
| The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome[NCT02451293] | Phase 2/Phase 3 | 252 participants (Actual) | Interventional | 2016-01-18 | Completed | ||
| Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery[NCT01505465] | 50 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| Effects of Premedication by Midazolam on Preoperative Anxiety for Emergency Surgery[NCT02213302] | Phase 4 | 59 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Investigation of the DNA Methylation Profile in Children Who Presented Emergence Delirium[NCT03787849] | 175 participants (Actual) | Interventional | 2018-09-24 | Completed | |||
| Effects of Clonidine and Midazolam Premedication on Bispectral Index and Recovery After Elective Surgery[NCT00638729] | 60 participants (Actual) | Interventional | 2005-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The State scale of the State-Trait Anxiety Inventory (STAI). Construct: Current level of anxiety. Scale range: 20-40 (higher scores indicate higher level of current anxiety) Scores are calculated according to the STAI scoring manual by adding point from each item (possible point for each item is 1-4)." (NCT02386319)
Timeframe: 60 minutes preoperative
| Intervention | score on a scale (Median) |
|---|---|
| Melatonin | 27 |
| Placebo | 28 |
Sleep time change from 96 hours before surgery to 72 hours after surgery (NCT01505465)
Timeframe: 96 hours before surgery to 72 hours after surgery
| Intervention | minutes (Mean) |
|---|---|
| Study: Melatonin | 20 |
| Control: Placebo | -55 |
7 reviews available for clonidine and Anxiety
| Article | Year |
|---|---|
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for preoperative and postoperative anxiety in adults.
Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Anxiety; Bias; Clonidine; Drug Admi | 2020 |
Melatonin for pre- and postoperative anxiety in adults.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Clonidine; Drug Administration Schedule; Humans; Melatonin; Mid | 2015 |
Psychiatric side effects of antihypertensive drugs other than reserpine.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Anxiety; Bethanidine; Clonidine; Debrisoquin; | 1982 |
[Biochemical aspects of anxiety].
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Catecholamines; Central Nervous S | 1982 |
A view on noradrenergic, hypothalamic-pituitary-adrenal axis and extrahypothalamic corticotrophin-releasing factor function in anxiety and affective disorders: the reduced growth hormone response to clonidine.
Topics: Animals; Anxiety; Clonidine; Corticotropin-Releasing Hormone; Depressive Disorder; Growth Hormone; H | 1997 |
Challenge tests: assessment of the noradrenergic and GABA systems in depression and anxiety disorders.
Topics: Anxiety; Clonidine; Depression; gamma-Aminobutyric Acid; Growth Hormone; Humans; Hydrocortisone; Nor | 1992 |
CNS-related (side-)effects of beta-blockers with special reference to mechanisms of action.
Topics: Adrenergic beta-Antagonists; Amphetamine; Animals; Anxiety; Blood-Brain Barrier; Central Nervous Sys | 1985 |
35 trials available for clonidine and Anxiety
| Article | Year |
|---|---|
Preoperative anxiety in preschool children: A randomized clinical trial comparing midazolam, clonidine, and dexmedetomidine.
Topics: Anxiety; Child; Child, Preschool; Clonidine; Dexmedetomidine; Double-Blind Method; Humans; Hypnotics | 2021 |
Intranasal clonidine vs. midazolam as premedication in children: a randomized controlled trial.
Topics: Administration, Intranasal; Anesthesia; Anti-Anxiety Agents; Anxiety; Child; Child, Preschool; Cloni | 2014 |
The effect of fentanyl and clonidine on early postoperative negative behavior in children: a double-blind placebo controlled trial.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Anxiety; Child; Child Behavior; Child, Preschool; Clo | 2014 |
Melatonin and clonidine premedication has similar impact on the pharmacokinetics and pharmacodynamics of propofol target controlled-infusions.
Topics: Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Anesthetics, Intravenous; A | 2015 |
Predictors of outcome for short-term medically supervised opioid withdrawal during a randomized, multicenter trial of buprenorphine-naloxone and clonidine in the NIDA clinical trials network drug and alcohol dependence.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Anxiety; Buprenorphine; Clonidine; Data Interpretation, Stat | 2009 |
Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study.
Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anxiety; Central | 2009 |
Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study.
Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anxiety; Central | 2009 |
Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study.
Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anxiety; Central | 2009 |
Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study.
Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anxiety; Central | 2009 |
Effects of premedication of midazolam or clonidine on perioperative anxiety and pain in children.
Topics: Administration, Oral; Analgesics; Anti-Anxiety Agents; Anxiety; Child; Child, Preschool; Clonidine; | 2009 |
[Quality of premedication and patient satisfaction after premedication with midazolam, clonidine or placebo : Randomized double-blind study with age-adjusted dosage].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aging; Anesthesia; Anxiety; Blood Gas Analysis; | 2010 |
Clonidine facilitates controlled hypotension in adolescent children.
Topics: Adolescent; Adrenergic alpha-Agonists; Anesthesia, Inhalation; Anxiety; Blood Pressure; Clonidine; C | 2003 |
Anxious and depressive disorders and their comorbidity: effect on central nervous system noradrenergic function.
Topics: Adrenergic alpha-Agonists; Adult; Analysis of Variance; Anxiety; Case-Control Studies; Central Nervo | 2004 |
The clinical effect of small oral clonidine doses on perioperative outcomes in patients undergoing abdominal hysterectomy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics; Anti-Anxiety Agents; Anxiety; Blood Press | 2005 |
Oral clonidine pretreatment prior to venous cannulation.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Anxiety; Awareness; Blinking; Catheterizatio | 2006 |
Effects of preanesthetic administration of midazolam, clonidine, or dexmedetomidine on postoperative pain and anxiety in children.
Topics: Adrenergic alpha-Agonists; Anesthetics, Intravenous; Anxiety; Blood Pressure; Carbon Dioxide; Child, | 2007 |
Premedication in children: a comparison of oral midazolam and oral clonidine.
Topics: Administration, Oral; Analgesics; Anxiety; Child; Child, Preschool; Clonidine; Conscious Sedation; F | 2007 |
Psycho-endocrine differences and correlations in symptomatic and asymptomatic climacteric women - the possible role of prolactin.
Topics: Adult; Anxiety; Climacteric; Clonidine; Depression; Estradiol; Estrogens, Conjugated (USP); Female; | 1981 |
Cigarette craving, smoking withdrawal, and clonidine.
Topics: Adult; Alprazolam; Anxiety; Benzodiazepines; Clinical Trials as Topic; Clonidine; Double-Blind Metho | 1984 |
Efficacy of clonidine in treatment of alcohol withdrawal state.
Topics: Adult; Aged; Alcoholism; Anxiety; Blood Pressure; Body Temperature; Clonidine; Female; Humans; Male; | 1983 |
Differential effects of noradrenergic drugs on anxiety and arousal in healthy volunteers with high and low anxiety.
Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Anxiety; Arousal; | 1996 |
A protocol to switch high-dose, methadone-maintained subjects to buprenorphine.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Buprenorphine; Clonidine; Cocaine; Drug Administration Schedule | 1997 |
Adrenergic modulation of human colonic motor and sensory function.
Topics: Adrenergic Agents; Adult; Anxiety; Blood Pressure; Clonidine; Colon; Depression; Female; Gastrointes | 1997 |
The effects of clonidine on the fear-inhibited light reflex.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Arousal; Clonidine; Diazepam; Double-Blind Method; Electroshock | 1998 |
The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia.
Topics: Administration, Oral; Adult; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; | 1998 |
[Clonidine vs. Midazolam for premedication - comparison of the anxiolytic effect by using the STAI-test].
Topics: Adrenergic alpha-Agonists; Adult; Anti-Anxiety Agents; Anxiety; Clonidine; Female; Humans; Male; Mid | 2002 |
Clonidine premedication prevents preoperative hypokalemia.
Topics: Adrenergic alpha-Agonists; Adult; Anesthesia, General; Anxiety; Clonidine; Double-Blind Method; Epin | 2002 |
Transdermal clonidine reduced some withdrawal symptoms but did not increase smoking cessation.
Topics: Administration, Cutaneous; Adult; Anxiety; Behavior Therapy; Clonidine; Double-Blind Method; Female; | 1992 |
Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder.
Topics: Adult; Analysis of Variance; Anxiety; Clomipramine; Clonazepam; Clonidine; Depression; Double-Blind | 1992 |
Adrenergic modulation of preoperative anxiety: a comparison of temazepam, clonidine, and timolol.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Clonidine; Female; Humans; Hypnotics and Sedatives; Male; Prean | 1991 |
Preanaesthetic medication with clonidine: a dose-response study.
Topics: Adolescent; Adult; Aged; Anxiety; Blood Pressure; Clonidine; Conscious Sedation; Dose-Response Relat | 1991 |
Noradrenergic function in obsessive-compulsive disorder: behavioral and neuroendocrine responses to clonidine and comparison to healthy controls.
Topics: Adolescent; Adult; Affect; Anxiety; Behavior; Clonidine; Growth Hormone; Humans; Hydrocortisone; Met | 1991 |
Transdermal clonidine versus chlordiazepoxide in alcohol withdrawal: a randomized, controlled clinical trial.
Topics: Administration, Cutaneous; Adult; Anxiety; Chlordiazepoxide; Clonidine; Double-Blind Method; Ethanol | 1991 |
Preanaesthetic medication with clonidine.
Topics: Administration, Oral; Adult; Anxiety; Clonidine; Double-Blind Method; Female; Heart Rate; Humans; Hy | 1990 |
Effects of transdermal clonidine treatment on withdrawal symptoms associated with smoking cessation. A randomized, controlled trial.
Topics: Acute Disease; Administration, Cutaneous; Adult; Akathisia, Drug-Induced; Analysis of Variance; Anxi | 1988 |
Anxiogenic effect of yohimbine in healthy subjects: comparison with caffeine and antagonism by clonidine and diazepam.
Topics: Adult; Anxiety; Arousal; Caffeine; Clonidine; Diazepam; Dose-Response Relationship, Drug; Double-Bli | 1988 |
Oral premedication with clonidine: effects on stress responses during general anaesthesia.
Topics: Administration, Oral; Adult; Aged; Anesthesia, Endotracheal; Anesthesia, General; Anxiety; Catechola | 1987 |
Psychiatric indications for clonidine: the neuropharmacologic and clinical basis.
Topics: Animals; Anxiety; Bipolar Disorder; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug T | 1986 |
71 other studies available for clonidine and Anxiety
| Article | Year |
|---|---|
Preoperative anxiety level is not associated with postoperative negative behavioral changes in premedicated children.
Topics: Anesthesia; Anxiety; Child; Clonidine; Humans; Midazolam; Postoperative Period | 2023 |
Effectiveness of α
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anxiety; Child; Child, Prescho | 2017 |
Intranasal dexmedetomidine for adrenergic crisis in familial dysautonomia.
Topics: Administration, Intranasal; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; | 2017 |
Reduction of anxiety after treatment with transdermal clonidine.
Topics: Administration, Cutaneous; Adolescent; Adrenergic alpha-Agonists; Aggression; Antipsychotic Agents; | 2018 |
Myocardial hypersensitivity to ischemic injury is not reversed by clonidine or propranolol in a predator-based rat model of posttraumatic stress disorder.
Topics: Adrenergic Agents; Animals; Anxiety; Cardiovascular Agents; Clonidine; Disease Models, Animal; Disea | 2019 |
Central hyperadrenergic state after lightning strike.
Topics: Activities of Daily Living; Adrenergic alpha-Agonists; Anxiety; Arrhythmias, Cardiac; Autonomic Nerv | 2013 |
Noradrenergic alpha-2 receptor modulators in the ventral bed nucleus of the stria terminalis: effects on anxiety behavior in postpartum and virgin female rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Anxiety; Clo | 2013 |
Comparative Evaluation of Partial α2 -Adrenoceptor Agonist and Pure α2 -Adrenoceptor Antagonist on the Behavioural Symptoms of Withdrawal after Chronic Alcohol Administration in Mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Alcoholism; Animals; Anxiety; Be | 2016 |
Modulatory effects of the basolateral amygdala α2-adrenoceptors on nicotine-induced anxiogenic-like behaviours of rats in the elevated plus maze.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Anxiety; Bas | 2016 |
Modelling the anxiety-depression continuum in chicks.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Chickens; Chlordiaze | 2009 |
Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities.
Topics: Adrenergic alpha-Agonists; Animals; Anxiety; Behavior, Animal; Brain; Chromatography, High Pressure | 2010 |
The alarm pheromone in male rats as a unique anxiety model: psychopharmacological evidence using anxiolytics.
Topics: Administration, Inhalation; Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Clonidine; Disease Mod | 2010 |
Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats.
Topics: Agmatine; Animals; Anti-Anxiety Agents; Anxiety; Arginine; Biguanides; Brain; Clonidine; Dose-Respon | 2010 |
Assessment of patients' satisfaction in carotid surgery under local anaesthesia by psychometrical testing--a prospective cohort study.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anxiety; Cervical Plexus; Clonidine; Endarterecto | 2011 |
Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine, d-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anxiety; Apomorphine; Arecoline; Clonidine; Depression; D | 2011 |
Pharmacological reversal of cognitive bias in the chick anxiety-depression model.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antidepressive Agents; Anxiety; Bias; Chickens; Clo | 2012 |
Modulation of fear/anxiety responses, but not food intake, following α-adrenoceptor agonist microinjections in the nucleus accumbens shell of free-feeding rats.
Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Anxiety; Clonidine; Disease Models, Animal | 2012 |
Treatment practices in Tourette syndrome: the European perspective.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety; Aripiprazole; Atomoxetine Hydrochloride | 2012 |
Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD.
Topics: Adrenocorticotropic Hormone; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antihypertens | 2013 |
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti- | 2003 |
Growth hormone response to growth hormone-releasing hormone and clonidine in young monkeys: correlation with behavioral characteristics.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Anxiety; Area Under Curve; Behavior, Animal; Clonidine; F | 2003 |
Anxiogenic effect of sleep deprivation in the elevated plus-maze test in mice.
Topics: Animals; Anxiety; Chlordiazepoxide; Clonidine; Dose-Response Relationship, Drug; Male; Maze Learning | 2004 |
Effects of clonidine injections into the bed nucleus of the stria terminalis on fear and anxiety behavior in rats.
Topics: Animals; Anxiety; Clonidine; Darkness; Fear; Injections, Intraventricular; Lighting; Male; Motor Act | 2005 |
alpha2-Adrenergic agonists antagonise the anxiolytic-like effect of antidepressants in the four-plate test in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Anti-Anxiety Agents; Antidepressiv | 2005 |
Tics, anxiety, and possible PANDAS in an adolescent.
Topics: Adolescent; Adrenergic alpha-Agonists; Antidepressive Agents, Second-Generation; Anxiety; Autoimmune | 2007 |
Clonidine and the primate locus coeruleus: evidence suggesting anxiolytic and anti-withdrawal effects.
Topics: Animals; Anxiety; Clonidine; Electric Stimulation; Emotions; Fear; Haplorhini; Humans; Locus Coerule | 1981 |
Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of oral yohimbine.
Topics: Adult; Analysis of Variance; Antidepressive Agents; Anxiety; Blood Pressure; Clonidine; Depression; | 1982 |
New studies and perspectives on the noradrenergic receptor system in depression: effects of the alpha 2-adrenergic agonist clonidine.
Topics: Adult; Anxiety; Blood Pressure; Clonidine; Depressive Disorder; Female; Growth Hormone; Heart Rate; | 1984 |
Evidence against the involvement of a noradrenergic mechanism in the release by diazepam of novelty-induced hypophagia in rats.
Topics: Animals; Anxiety; Clonidine; Diazepam; Drug Interactions; Eating; Guanfacine; Guanidines; Humans; Ma | 1984 |
Fear and anxiety: relationship to noradrenergic function.
Topics: Animals; Anxiety; Caffeine; Clonidine; Dose-Response Relationship, Drug; Fear; Humans; Locus Coerule | 1984 |
[Interruption of Catapresan therapy as a cause of severe crisis in a patient].
Topics: Anxiety; Clonidine; Humans; Male; Middle Aged; Motor Activity; Psychoses, Substance-Induced; Substan | 1983 |
[Cardiovascular and neuropsychologic changes during detoxification of heroin addicts with clonidine].
Topics: Anxiety; Blood Pressure; Clonidine; Depression; Heart Rate; Heroin Dependence; Humans; Inactivation, | 1984 |
[Clonidine in opiate withdrawal. II. Potential side-effects].
Topics: Aggression; Anxiety; Clonidine; Depression; Humans; Narcotics; Opioid-Related Disorders; Psychoses, | 1982 |
Clonidine withdrawal complicated by amitriptyline therapy.
Topics: Aged; Amitriptyline; Anxiety; Clonidine; Female; Humans; Hypertension; Intraoperative Care; Methyldo | 1983 |
Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine.
Topics: Adult; Anxiety; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Diazepam; Drug Interac | 1983 |
Clonidine decreases opiate withdrawal-related anxiety: possible opiate noradrenergic interaction in anxiety and panic.
Topics: Adult; Anxiety; Clonidine; Double-Blind Method; Fear; Humans; Male; Norepinephrine; Opioid-Related D | 1980 |
Anxiolytic-like effects of yohimbine in the murine plus-maze: strain independence and evidence against alpha 2-adrenoceptor mediation.
Topics: Animals; Anxiety; Behavior, Animal; Clonidine; Dioxanes; Genotype; Idazoxan; Imidazoles; Mice; Mice, | 1995 |
Electrophysiological characteristics of locus coeruleus neurons in the Maudsley reactive (MR) and non-reactive (MNRA) rat strains.
Topics: Action Potentials; Animals; Anxiety; Clonidine; Dose-Response Relationship, Drug; Electrophysiology; | 1994 |
Behavioral and autonomic responses to intermittent social stress: differential protection by clonidine and metoprolol.
Topics: Agonistic Behavior; Animals; Anxiety; Autonomic Nervous System; Body Temperature; Clonidine; Dose-Re | 1994 |
The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anti-Anxiety Agents; Anxiety; Beha | 1994 |
Anxiogenic-like effects of yohimbine and idazoxan in two behavioral situations in mice.
Topics: Adrenergic alpha-Antagonists; Animals; Anxiety; Behavior, Animal; Choice Behavior; Clonidine; Condit | 1993 |
[Potentiating effect of clonidine on anxiolytic action of buspirone in rats].
Topics: Animals; Anxiety; Buspirone; Clonidine; Drug Synergism; Male; Rats; Rats, Wistar | 1993 |
Effects of valproate and lorazepam on experimental anxiety: tolerance, withdrawal, and role of clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Clonidine; Dru | 1995 |
Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia.
Topics: Adrenergic alpha-Antagonists; Alprazolam; Anesthetics, Intravenous; Animals; Anti-Anxiety Agents; An | 1997 |
Involvement of adrenergic and cholinergic systems in nicotine-induced anxiogenesis in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anxiety; Atropine; Clonidine; Hexa | 2000 |
Cardiovascular responses to clonidine in alcohol withdrawal: are they related to psychopathology and mental well-being?
Topics: Adrenergic alpha-Agonists; Adult; Affect; Alcoholism; Anxiety; Blood Pressure; Central Nervous Syste | 2000 |
Effects of antisense to the (alpha)2A-adrenoceptors administered into the region of the locus ceruleus on behaviors in plus-maze and sexual behavior tests in sham-operated and castrated male rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Anxiety; Binding Sites; | 2001 |
Clonidine immediately after immobilization stress prevents long-lasting locomotion reduction in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Anxiety; Clonidine; Disease Models, Animal; Locomotion; Male; Ra | 2001 |
Effects of antisense oligodeoxynucleotide to the alpha2A-adrenoceptors on the plasma corticosterone level and on elevated plus-maze behavior in rats.
Topics: Adrenergic alpha-Agonists; Animals; Anxiety; Behavior, Animal; Cerebral Cortex; Clonidine; Corticost | 2002 |
Rapid opiate detoxification: clinical evidence of antidepressant and antipanic effects of opiates.
Topics: Adult; Anxiety; Clonidine; Depression; Drug Therapy, Combination; Fear; Humans; Imipramine; Male; Me | 1979 |
The relationship between craving, anxiety, and other symptoms in opioid withdrawal.
Topics: Anxiety; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Motivati | 1992 |
Noradrenergic receptor mechanisms in neophobia.
Topics: Adenylyl Cyclases; Animals; Anxiety; Behavior, Animal; Clonidine; Colforsin; Dopamine beta-Hydroxyla | 1992 |
Treatment of tardive akathisia with clonidine.
Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Anxiety; Clonidine; Diagnosis, Differential; H | 1990 |
Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects.
Topics: Adult; Alprazolam; Anxiety; Carbon Dioxide; Clonidine; Female; Humans; Male; Pulse; Reference Values | 1989 |
Caffeine-induced anxiogenesis: the role of adenosine, benzodiazepine and noradrenergic receptors.
Topics: 2-Chloroadenosine; Adenosine; Alprazolam; Anxiety; Caffeine; Chlordiazepoxide; Clonidine; Flumazenil | 1989 |
Yohimbine's anxiogenic action: evidence for noradrenergic and dopaminergic sites.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic alpha-Agonists; Animals; Anxi | 1989 |
The SHR exhibits less "anxiety" but increased sensitivity to the anticonflict effect of clonidine compared to normotensive controls.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Clonidine; Conflict, Psychological; Drinking Behavior; Electr | 1989 |
Does anxiety underly imidazole-induced behavioural effects in the rat?
Topics: Animals; Anxiety; Arousal; Behavior, Animal; Blood Pressure; Clonidine; Diazepam; Emotions; Hemodyna | 1989 |
Evidence that the increased anxiety detected in the elevated plus-maze during chlordiazepoxide withdrawal is not due to enhanced noradrenergic activity.
Topics: Animals; Anxiety; Chlordiazepoxide; Clonidine; Learning; Male; Norepinephrine; Propranolol; Rats; Ra | 1989 |
Can anti-panic drugs antagonise the anxiety produced in the rat by drugs acting at the GABA-benzodiazepine receptor complex?
Topics: Animals; Anxiety; Carbolines; Clonidine; Fear; Imipramine; Male; Panic; Pentylenetetrazole; Rats; Ra | 1987 |
Biphasic effects of clonidine on conflict behavior: involvement of different alpha-adrenoceptors.
Topics: Animals; Anxiety; Clonidine; Conflict, Psychological; Male; Rats; Rats, Inbred Strains; Receptors, A | 1988 |
The role of drugs in the treatment of opioid addicts.
Topics: Alcoholism; Anxiety; Clonidine; Dextropropoxyphene; Heroin; Humans; Inactivation, Metabolic; Kinetic | 1986 |
Clonidine in neuroleptic-induced akathisia.
Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Anxiety; Clonidine; Hospitalization; Humans; M | 1987 |
The anxiolytic and anxiogenic actions of ethanol in a mouse model.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Body Weight; Clonidine; Diazepam; Drinking; | 1988 |
Neuropharmacological antagonism of the beta-carboline-induced "anxiety" response in rhesus monkeys.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Blood Pressure; Carbolines; Clonidi | 1985 |
Depression in an animal model: focus on the locus ceruleus.
Topics: Action Potentials; Animals; Anxiety; Behavior, Animal; Clonidine; Depression; Electroshock; Locus Co | 1986 |
[Potentiating effect of clonidine on the anxiolytic action of diazepam in a rat social interaction model of anxiety].
Topics: Animals; Anxiety; Behavior, Animal; Clonidine; Diazepam; Drug Synergism; Male; Rats | 1988 |
Preliminary studies of clonidine in psychotic patients.
Topics: Adult; Anxiety; Clonidine; Female; Humans; Male; Middle Aged; Psychotic Disorders | 1988 |
Efficacy of clonidine and of methadone in the rapid detoxification of patients dependent on heroin.
Topics: Adolescent; Adult; Analysis of Variance; Anxiety; Blood Pressure; Clonidine; Double-Blind Method; Dr | 1985 |
Trazodone and m-chlorophenylpiperazine. Concentration in brain and receptor activity in regions in the brain associated with anxiety.
Topics: Animals; Anxiety; Brain; Clonidine; Flunitrazepam; In Vitro Techniques; Isomerism; Male; Membranes; | 1985 |
Atypical migraine.
Topics: Aneurysm; Anxiety; Blood Pressure; Clonidine; Diagnosis, Differential; Ergotamine; Headache; Humans; | 1973 |