clonidine has been researched along with Anxiety Neuroses in 46 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonidine hydrochloride, an alpha 2-adrenergic receptor agonist that decreases noradrenergic function, was administered to 21 healthy subjects and 26 drug-free patients with agoraphobia and panic attacks." | 9.06 | Abnormal regulation of noradrenergic function in panic disorders. Effects of clonidine in healthy subjects and patients with agoraphobia and panic disorder. ( Charney, DS; Heninger, GR, 1986) |
| "To examine the role of the noradrenergic system in anxiety disorders, 23 patients (nine with generalized anxiety disorders and 14 with panic disorders) were studied for four weeks with clonidine hydrochloride, a predominantly presynaptic noradrenergic agonist, and with placebo." | 9.05 | Effects of clonidine on anxiety disorders. ( Hoehn-Saric, R; Keyser, ML; Merchant, AF; Smith, VK, 1981) |
| "Clonidine hydrochloride, an alpha 2-adrenergic receptor agonist that decreases noradrenergic function, was administered to 21 healthy subjects and 26 drug-free patients with agoraphobia and panic attacks." | 5.06 | Abnormal regulation of noradrenergic function in panic disorders. Effects of clonidine in healthy subjects and patients with agoraphobia and panic disorder. ( Charney, DS; Heninger, GR, 1986) |
| "Six subjects with the phobic-anxiety syndrome were treated in a controlled, crossover trial of clonidine hydrochloride v imipramine hydrochloride for periods of four weeks each." | 5.05 | Panic-induced elevation of plasma MHPG levels in phobic-anxious patients. Effects of clonidine and imipramine. ( Elsworth, JD; Ko, GN; Leigh, H; Redmond, DE; Rifkin, BG; Roth, RH, 1983) |
| "To examine the role of the noradrenergic system in anxiety disorders, 23 patients (nine with generalized anxiety disorders and 14 with panic disorders) were studied for four weeks with clonidine hydrochloride, a predominantly presynaptic noradrenergic agonist, and with placebo." | 5.05 | Effects of clonidine on anxiety disorders. ( Hoehn-Saric, R; Keyser, ML; Merchant, AF; Smith, VK, 1981) |
| " Among the more important recent discoveries are the efficacy of the tricyclic antidepressants for panic disorder and agoraphobia with panic attacks; the use of the monoamine oxidase inhibitors for the above disorders and for atypical depression and hysteroid dysphoria; the use of propranolol for anxiety disorders and for uncontrollable violent outbursts; the antianxiety and antipanic effects of clonidine; and the usefulness of lithium in treating schizophrenia and schizoaffective disorder and for emotionally unstable character disorders." | 4.76 | Newer uses for older psychotropic medications. ( Liebowitz, MR, 1982) |
| " These two studies indicate that while clonidine has short-term anxiolytic effects in patients with panic disorder, these effects do not persist with long-term administration in most patients." | 2.66 | Behavioral and physiologic effects of short-term and long-term administration of clonidine in panic disorder. ( Boulenger, JP; Klein, E; Mellman, TA; Siever, LJ; Stein, MB; Uhde, TW; Vittone, BJ, 1989) |
| "Clonidine was associated with different changes in cerebral perfusion in each group." | 1.38 | Central noradrenergic responsiveness to a clonidine challenge in Generalized Anxiety Disorder: a Single Photon Emission Computed Tomography study. ( Daglish, MR; Edwards, T; Holmes, RB; Hood, S; Kalk, NJ; Lennox-Smith, A; Lingford-Hughes, AR; Melichar, J; Nutt, DJ; Taylor, LG, 2012) |
| "Treatment with imipramine hydrochloride decreased the number of sites, as measured with either ligand, in both patient groups and increased catecholamine levels in patients with panic attacks." | 1.27 | Platelet alpha 2-adrenergic receptor binding and plasma catecholamines. Before and during imipramine treatment in patients with panic anxiety. ( Cameron, OG; Curtis, GC; Hollingsworth, PJ; Nesse, RM; Smith, CB, 1984) |
| "Six patients with akathisia were treated with clonidine in an open, on-drug/off-drug trial." | 1.27 | Use of clonidine in treating neuroleptic-induced akathisia. ( Cohen, BM; Jonas, JM; Lipinski, JF; Zubenko, GS, 1984) |
| "Pretreatment with clonidine hydrochloride and propranolol hydrochloride, both of which have been reported to have anxiolytic actions in man, attenuated only selective aspects of the response to beta-CCE." | 1.27 | A benzodiazepine receptor-mediated model of anxiety. Studies in nonhuman primates and clinical implications. ( Aloi, J; Insel, TR; Jimerson, DC; Ninan, PT; Paul, SM; Skolnick, P, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (54.35) | 18.7374 |
| 1990's | 14 (30.43) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (15.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Efron, D | 1 |
| Lycett, K | 1 |
| Sciberras, E | 1 |
| Mattingly, GW | 1 |
| Anderson, RH | 1 |
| Hood, SD | 2 |
| Melichar, JK | 1 |
| Taylor, LG | 2 |
| Kalk, N | 1 |
| Edwards, TR | 1 |
| Hince, DA | 1 |
| Lenox-Smith, A | 1 |
| Lingford-Hughes, AR | 2 |
| Nutt, DJ | 4 |
| Mansur, SS | 1 |
| Terenzi, MG | 1 |
| Neto, JM | 1 |
| Faria, MS | 1 |
| Paschoalini, MA | 1 |
| Garcia de Miguel, B | 1 |
| Davies, SJ | 1 |
| Kalk, NJ | 1 |
| Melichar, J | 1 |
| Holmes, RB | 1 |
| Daglish, MR | 1 |
| Hood, S | 1 |
| Edwards, T | 1 |
| Lennox-Smith, A | 1 |
| Heussler, H | 1 |
| Chan, P | 1 |
| Price, AM | 1 |
| Waters, K | 1 |
| Davey, MJ | 1 |
| Hiscock, H | 1 |
| Cameron, OG | 3 |
| Smith, CB | 3 |
| Hollingsworth, PJ | 3 |
| Nesse, RM | 1 |
| Curtis, GC | 3 |
| Garver, DL | 1 |
| Strain, JJ | 1 |
| Liebowitz, MR | 3 |
| Klein, DF | 1 |
| Altesman, RI | 1 |
| Cole, JO | 1 |
| Rickels, K | 1 |
| Skolnick, P | 2 |
| Ninan, P | 1 |
| Insel, T | 1 |
| Crawley, J | 1 |
| Paul, S | 1 |
| Zubenko, GS | 1 |
| Cohen, BM | 1 |
| Lipinski, JF | 1 |
| Jonas, JM | 1 |
| Insel, TR | 1 |
| Ninan, PT | 1 |
| Aloi, J | 1 |
| Jimerson, DC | 1 |
| Paul, SM | 2 |
| Sternberg, DE | 1 |
| Fyer, AJ | 1 |
| Gorman, JM | 1 |
| Dillon, D | 1 |
| Appleby, IL | 1 |
| Levy, G | 1 |
| Anderson, S | 1 |
| Levitt, M | 1 |
| Palij, M | 1 |
| Davies, SO | 1 |
| Ko, GN | 1 |
| Elsworth, JD | 1 |
| Roth, RH | 1 |
| Rifkin, BG | 1 |
| Leigh, H | 1 |
| Redmond, DE | 1 |
| Fielding, S | 1 |
| Lal, H | 1 |
| Hoehn-Saric, R | 1 |
| Merchant, AF | 1 |
| Keyser, ML | 1 |
| Smith, VK | 1 |
| Sovner, R | 1 |
| Pitchot, W | 1 |
| Hansenne, M | 1 |
| Moreno, AG | 1 |
| Ansseau, M | 1 |
| Schittecatte, M | 3 |
| Garcia-Valentin, J | 2 |
| Charles, G | 3 |
| Machowski, R | 2 |
| Pena-Othaitz, MJ | 1 |
| Mendlewicz, J | 2 |
| Wilmotte, J | 3 |
| Wilens, TE | 1 |
| Spencer, T | 1 |
| Biederman, J | 1 |
| Wozniak, J | 1 |
| Connor, D | 1 |
| Uhde, TW | 3 |
| Malloy, LC | 1 |
| Benson, BB | 1 |
| Sallee, FR | 1 |
| Richman, H | 1 |
| Sethuraman, G | 1 |
| Dougherty, D | 1 |
| Sine, L | 1 |
| Altman-Hamamdzic, S | 1 |
| Newcorn, JH | 1 |
| Schulz, K | 1 |
| Harrison, M | 1 |
| DeBellis, MD | 1 |
| Udarbe, JK | 1 |
| Halperin, JM | 1 |
| Abelson, JL | 1 |
| Glitz, D | 1 |
| Lee, MA | 2 |
| Bronzo, M | 1 |
| Iruela, LM | 1 |
| Gilaberte, I | 1 |
| Oliveros, SC | 1 |
| Rojo, VI | 1 |
| Bihari, K | 1 |
| Pato, MT | 1 |
| Hill, JL | 1 |
| Murphy, DL | 1 |
| Grunhaus, LJ | 1 |
| Cameron, O | 1 |
| Pande, AC | 1 |
| Haskett, RF | 1 |
| Hill, EM | 1 |
| Toutoungi, M | 1 |
| Stein, MB | 1 |
| Vittone, BJ | 2 |
| Siever, LJ | 2 |
| Boulenger, JP | 1 |
| Klein, E | 1 |
| Mellman, TA | 1 |
| Wolkowitz, OM | 1 |
| Breier, A | 1 |
| Charney, DS | 3 |
| Heninger, GR | 3 |
| Goodman, WK | 1 |
| Price, LH | 1 |
| Woods, SW | 1 |
| Svensson, TH | 1 |
| Depauw, Y | 1 |
| Mesters, P | 1 |
| Wålinder, J | 1 |
| Kaye, WH | 1 |
| Post, RM | 1 |
| Frewin, DB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Follow-up Studies of PS and OSAHS in Chinese Children[NCT02447614] | 500 participants (Actual) | Observational [Patient Registry] | 2014-11-30 | Completed | |||
| Transcranial Direct Current Stimulation (tDCS) as a Treatment for Acute Fear[NCT02410954] | 14 participants (Actual) | Interventional | 2015-12-31 | Terminated | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for clonidine and Anxiety Neuroses
| Article | Year |
|---|---|
Optimizing outcomes in ADHD treatment: from clinical targets to novel delivery systems.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Anxiety Disorders; Atomoxetine H | 2016 |
Elucidation of neurobiology of anxiety disorders in children through pharmacological challenge tests and cortisol measurements: a systematic review.
Topics: Anxiety Disorders; Brain; Carbon Dioxide; Child; Clonidine; Fenfluramine; Human Growth Hormone; Huma | 2012 |
Anxiety and panic attacks in the medically ill.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Antidepressive Agents, Tricyclic; Anxiety Disorders; | 1981 |
Newer uses for older psychotropic medications.
Topics: Adrenergic beta-Antagonists; Agoraphobia; Anxiety Disorders; Bipolar Disorder; Clonidine; Depressive | 1982 |
A novel chemically induced animal model of human anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Behavior, Animal; Blood Pressure; Carbolines; Cloni | 1984 |
Biologic tests in psychiatry.
Topics: Anxiety Disorders; Apomorphine; Clonidine; Dexamethasone; Dextroamphetamine; Growth Hormone; Humans; | 1984 |
Clonidine: new research in psychotropic drug pharmacology.
Topics: Aggression; Analgesics; Animals; Anxiety Disorders; Arousal; Avoidance Learning; Behavior, Animal; B | 1981 |
Alpha 2 adrenergic agonists. Neurochemistry, efficacy, and clinical guidelines for use in children.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Anxiety Disorders; Attention Defici | 1998 |
Neural and molecular mechanisms in anxiety.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Binding, Competitive; C | 1985 |
The diagnostic validity of anxiety disorders and their relationship to depressive illness.
Topics: Anti-Anxiety Agents; Antidepressive Agents; Anxiety Disorders; Benzodiazepines; Caffeine; Clonidine; | 1985 |
Clonidine in abstinence reactions: basic mechanisms.
Topics: Adrenergic alpha-Agonists; Animals; Anxiety Disorders; Autonomic Nervous System; Central Nervous Sys | 1986 |
8 trials available for clonidine and Anxiety Neuroses
| Article | Year |
|---|---|
Use of sleep medication in children with ADHD.
Topics: Adolescent; Anxiety Disorders; Attention Deficit and Disruptive Behavior Disorders; Attention Defici | 2014 |
Nonbenzodiazepine anxiolytics: clinical usefulness.
Topics: Adrenergic beta-Antagonists; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Antipsychotic Ag | 1983 |
Panic-induced elevation of plasma MHPG levels in phobic-anxious patients. Effects of clonidine and imipramine.
Topics: Adult; Anxiety Disorders; Clonidine; Double-Blind Method; Fear; Female; Glycols; Humans; Imipramine; | 1983 |
Effects of clonidine on anxiety disorders.
Topics: Adult; Anxiety Disorders; Clonidine; Female; Humans; Male; Middle Aged; Norepinephrine; Panic; Psych | 1981 |
Clonidine challenge in childhood anxiety disorder.
Topics: Adolescent; Adrenergic alpha-Agonists; Age of Onset; Analysis of Variance; Anxiety Disorders; Biomar | 1998 |
Behavioral and physiologic effects of short-term and long-term administration of clonidine in panic disorder.
Topics: Administration, Oral; Adult; Anxiety Disorders; Blood Pressure; Clinical Trials as Topic; Clonidine; | 1989 |
Ineffectiveness of clonidine in the treatment of the benzodiazepine withdrawal syndrome: report of three cases.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Blood Pressure; Clinical | 1986 |
Abnormal regulation of noradrenergic function in panic disorders. Effects of clonidine in healthy subjects and patients with agoraphobia and panic disorder.
Topics: Adult; Agoraphobia; Anxiety Disorders; Blood Pressure; Clonidine; Fear; Female; Growth Hormone; Huma | 1986 |
27 other studies available for clonidine and Anxiety Neuroses
| Article | Year |
|---|---|
Noradrenergic function in generalized anxiety disorder: impact of treatment with venlafaxine on the physiological and psychological responses to clonidine challenge.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Anxiety Disorders; Blood Pressure; Clonidine; Cyclohexa | 2011 |
Changes in food intake and anxiety-like behaviors after clonidine injected into the median raphe nucleus.
Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Anxiety Disorders; Behavior, Animal; Cloni | 2010 |
Central noradrenergic responsiveness to a clonidine challenge in Generalized Anxiety Disorder: a Single Photon Emission Computed Tomography study.
Topics: Adult; Aged; Anxiety Disorders; Brain; Cerebrovascular Circulation; Clonidine; Humans; Memory, Short | 2012 |
Pharmacological and non-pharmacological management of sleep disturbance in children: an Australian Paediatric Research Network survey.
Topics: Adult; Aged; Anxiety Disorders; Australia; Behavior Therapy; Child; Clonidine; Comorbidity; Dose-Res | 2013 |
Platelet alpha 2-adrenergic receptor binding and plasma catecholamines. Before and during imipramine treatment in patients with panic anxiety.
Topics: Adolescent; Adult; Anxiety Disorders; Blood Platelets; Catecholamines; Clonidine; Dopamine; Epinephr | 1984 |
A psychobiologic perspective in treating psychiatric disorders.
Topics: Anxiety Disorders; Clonidine; Humans; Lithium; Mental Disorders; Mood Disorders; Psychotic Disorders | 1984 |
Psychopharmacologic treatment of anxiety.
Topics: Adrenergic beta-Antagonists; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety Disorders; Benzodiaz | 1983 |
Use of clonidine in treating neuroleptic-induced akathisia.
Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Anxiety Disorders; Bipolar D | 1984 |
A benzodiazepine receptor-mediated model of anxiety. Studies in nonhuman primates and clinical implications.
Topics: Animals; Anxiety Disorders; Behavior, Animal; Blood Pressure; Carbolines; Clonidine; Diazepam; Dose- | 1984 |
Lactate provocation of panic attacks. I. Clinical and behavioral findings.
Topics: Adult; Agoraphobia; Anxiety Disorders; Clonidine; Desipramine; Fear; Female; Humans; Imipramine; Lac | 1984 |
Thioridazine withdrawal-induced behavioral deterioration treated with clonidine: two case reports.
Topics: Administration, Cutaneous; Anxiety Disorders; Bipolar Disorder; Clonidine; Dose-Response Relationshi | 1995 |
Growth hormone response to clonidine in nondepressed patients with a history of suicide attempts.
Topics: Adjustment Disorders; Adult; Anxiety Disorders; Clonidine; Depressive Disorder; Growth Hormone; Huma | 1995 |
Efficacy of the 'clonidine REM suppression test (CREST)' to separate patients with major depression from controls; a comparison with three currently proposed biological markers of depression.
Topics: Adult; Anxiety Disorders; Arousal; Biomarkers; Bipolar Disorder; Clonidine; Depressive Disorder; Ele | 1995 |
Combined pharmacotherapy: an emerging trend in pediatric psychopharmacology.
Topics: Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Benzodiazepines; Child Psychiatry; | 1995 |
Growth hormone response to clonidine in the nervous pointer dog model of anxiety.
Topics: Adrenergic alpha-Agonists; Animals; Anxiety Disorders; Clonidine; Disease Models, Animal; Dog Diseas | 1994 |
Reduced clonidine rapid eye movement sleep suppression in patients with primary major affective illness.
Topics: Adult; Anxiety Disorders; Biomarkers; Clonidine; Depressive Disorder; Diagnosis, Differential; Dose- | 1992 |
Blunted growth hormone response to clonidine in patients with generalized anxiety disorder.
Topics: Adult; Anxiety Disorders; Biomarkers; Blood Pressure; Clonidine; Depressive Disorder; Female; Growth | 1991 |
Clonidine-imipramine therapy.
Topics: Adult; Anxiety Disorders; Clonidine; Drug Administration Schedule; Drug Therapy, Combination; Female | 1991 |
Neurologic soft signs in obsessive-compulsive disorder.
Topics: Adult; Anxiety Disorders; Central Nervous System Diseases; Clomipramine; Clonidine; Depressive Disor | 1991 |
Comorbidity of panic disorder and major depressive disorder: effects on platelet alpha 2 adrenergic receptors.
Topics: Adult; Anxiety Disorders; Binding, Competitive; Blood Platelets; Clonidine; Depressive Disorder; Fea | 1990 |
Adrenergic status in anxiety disorders: platelet alpha 2-adrenergic receptor binding, blood pressure, pulse, and plasma catecholamines in panic and generalized anxiety disorder patients and in normal subjects.
Topics: Adult; Agoraphobia; Anxiety Disorders; Arousal; Blood Platelets; Blood Pressure; Clonidine; Epinephr | 1990 |
Clonidine, cortisol, panic disorder, and depression.
Topics: Anxiety Disorders; Arousal; Circadian Rhythm; Clonidine; Depressive Disorder; Fear; Humans; Hydrocor | 1990 |
Altered central alpha 2-adrenoceptor sensitivity in panic disorder.
Topics: Adult; Age Factors; Anxiety Disorders; Blood Pressure; Clonidine; Fear; Female; Growth Hormone; Hear | 1989 |
Growth hormone response to clonidine in panic disorder patients.
Topics: Adolescent; Adult; Anxiety Disorders; Clonidine; Depressive Disorder; Fear; Female; Growth Hormone; | 1988 |
The use of clonidine in psychiatric disorders. Preliminary clinical observations.
Topics: Anxiety Disorders; Bipolar Disorder; Clonidine; Humans; Mental Disorders; Panic; Psychophysiologic D | 1986 |
Blunted growth hormone response to clonidine in panic disorder patients.
Topics: Adrenergic Fibers; Adult; Agoraphobia; Antidepressive Agents, Tricyclic; Anxiety Disorders; Brain; C | 1986 |
Clonidine. Quo vadis?
Topics: Adrenal Gland Neoplasms; Anxiety Disorders; Climacteric; Clonidine; Female; Humans; Hypertension; Mi | 1985 |