clonidine has been researched along with Anterior Circulation Transient Ischemic Attack in 7 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Reflex bradycardia was produced by a bolus injection of phenylephrine at a dose which produces about a 25-mmHg increase in mean blood pressure." | 3.68 | Influence of transient global cerebral ischemia on the facilitatory modulation of the vagal baroreflex in dogs. ( Kato, H; Kurihara, J; Tamaoki, S, 1993) |
| "Tizanidine was given to each group of rats intraperitoneally before the ischemic insult, 2 hours after ischemia, right after the reperfusion, 2 h after reperfusion, and 4 hours after reperfusion; the animals survived for 24 hours after the reperfusion." | 1.30 | Tizanidine is an effective agent in the prevention of focal cerebral ischemia in rats: an experimental study. ( Berkman, K; Berkman, MZ; Pamir, MN; Zirh, TA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Y | 1 |
| McNicholas, F | 1 |
| Motala, F | 1 |
| Pich, EM | 1 |
| Grimaldi, R | 2 |
| Zini, I | 2 |
| Frasoldati, A | 1 |
| Marrama, P | 1 |
| Agnati, LF | 2 |
| Kurihara, J | 1 |
| Tamaoki, S | 1 |
| Kato, H | 1 |
| Berkman, MZ | 1 |
| Zirh, TA | 1 |
| Berkman, K | 1 |
| Pamir, MN | 1 |
| Biagini, G | 1 |
| Toffano, G | 1 |
| Miyazaki, M | 1 |
| Nazarali, AJ | 1 |
| Boisvert, DP | 1 |
| Bayens-Simmonds, J | 1 |
| Baker, GB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I-II Clinical Trial to Determine the Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia[NCT01862250] | Phase 1/Phase 2 | 13 participants (Actual) | Interventional | 2013-10-03 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Intravenous morphine (mg/kg) was given. The standard dose is 0.05 mg/kg per dose (NCT01862250)
Timeframe: Up to 2 days
| Intervention | mg/kg (Median) |
|---|---|
| Clonidine Infants With HIE | 0.02 |
Babies were assessed after administration of clonidine for the presence or absence of shivering. (NCT01862250)
Timeframe: 48hrs
| Intervention | Participants (Count of Participants) |
|---|---|
| Clonidine Infants With HIE | 0 |
"Trough clonidine blood levels were measured after 4-7 doses of clonidine were given intravenously with a dosing interval of every 8 hrs. Mean and standard deviation (SD) of the number of doses given prior to levels being drawn was 5.3 (mean) and 0.37 (SD).~Time after last dose before measurement was 9hrs (mean) and 2.7hrs (SD)." (NCT01862250)
Timeframe: 3 days
| Intervention | ng/ml (Median) |
|---|---|
| Clonidine Infants With HIE | 0.6 |
Following 2 hours of therapeutic hypothermia, the temperature of the thermo-blanket is adjusted up half degree per hour allowing passive rewarming until 36.5 degrees is reached (NCT01862250)
Timeframe: Beginning at 72 hours up to 12 hours
| Intervention | Hours (Median) |
|---|---|
| Clonidine Infants With HIE | 8.7 |
7 other studies available for clonidine and Anterior Circulation Transient Ischemic Attack
| Article | Year |
|---|---|
Clonidine preconditioning decreases infarct size and improves neurological outcome from transient forebrain ischemia in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2004 |
Transient ischemic attack with risperidone and clonidine.
Topics: Adrenergic alpha-Agonists; Antipsychotic Agents; Child; Clonidine; Diagnosis, Differential; Drug Adm | 2007 |
Involvement of alpha 2-receptors in the analgesia induced by transient forebrain ischemia in rats.
Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Brain; Carotid Artery, Common; Clonidine; Dioxanes | 1993 |
Influence of transient global cerebral ischemia on the facilitatory modulation of the vagal baroreflex in dogs.
Topics: Animals; Baroreflex; Bradycardia; Clonidine; Dogs; Electric Stimulation; Female; Ischemic Attack, Tr | 1993 |
Tizanidine is an effective agent in the prevention of focal cerebral ischemia in rats: an experimental study.
Topics: Adrenergic alpha-Agonists; Animals; Blood Glucose; Blood Pressure; Body Temperature; Carbon Dioxide; | 1998 |
Effects of centrally administered clonidine and neuropeptide Y on arterial blood pressure in the rat after transient forebrain ischemia.
Topics: Animals; Blood Pressure; Cerebral Ventricles; Clonidine; Injections, Intraventricular; Ischemic Atta | 1990 |
Inhibition of ischemia-induced brain catecholamine alterations by clonidine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catecholamines; Clonidine; Gerbillinae; Homovanillic Acid; | 1989 |