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clonidine and Amnesia

clonidine has been researched along with Amnesia in 10 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Amnesia: Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)

Research Excerpts

ExcerptRelevanceReference
"The effect of the Ca2+ blocker verapamil on amnesia induced by electroconvulsive shock (ECS) or by the alpha-adrenoceptor agonist clonidine was studied in male Wistar rats trained in passive avoidance task ("step down")."7.69Effects of verapamil on electroconvulsive shock- and clonidine-induced amnesia. ( Bojanova, E; Genkova-Papazova, M; Lazarova-Bakarova, M; Petkova, B, 1997)
"The role of noradrenergic (NE) mechanisms in amnesia induced by the dopamine-beta-hydroxylase (DBH) inhibitor, diethyldithiocarbamate (DEDTC) was examined by studying the antiamnestic characteristics of the alpha-NE receptor stimulator clonidine."7.66Clonidine reverses the amnesia induced by dopamine beta hydroxylase inhibition. ( Backman, MZ; Freedman, LS; Quartermain, D, 1979)
"Amnesia for a multiple trial appetitive spatial dicrimination habit induced by the protein synthesis inhibitor cycloheximide (CXM) was reversed by peripheral injections of both alpha (clonidine) and beta (isoproterenol) norepinephrine receptor stimulators."7.65Reversal of cycloheximide-induced amnesia by adrenergic receptor stimulation. ( Botwinick, CY; Freedman, LS; Gutwein, BM; Quartermain, D, 1977)
" Since many studies have demonstrated the impairment effect of morphine on memory through mPFC, we aimed to investigate the possible interaction between α2-ARs of the mPFC and morphine induced amnesia in passive avoidance learning in rats."3.81Influence of morphine on medial prefrontal cortex alpha2 adrenergic system in passive avoidance learning in rats. ( Hashemi-Hezaveh, SM; Sheidadoust, H; Torkaman-Boutorabi, A; Zarrindast, MR, 2015)
"The effect of the Ca2+ blocker verapamil on amnesia induced by electroconvulsive shock (ECS) or by the alpha-adrenoceptor agonist clonidine was studied in male Wistar rats trained in passive avoidance task ("step down")."3.69Effects of verapamil on electroconvulsive shock- and clonidine-induced amnesia. ( Bojanova, E; Genkova-Papazova, M; Lazarova-Bakarova, M; Petkova, B, 1997)
"The role of noradrenergic (NE) mechanisms in amnesia induced by the dopamine-beta-hydroxylase (DBH) inhibitor, diethyldithiocarbamate (DEDTC) was examined by studying the antiamnestic characteristics of the alpha-NE receptor stimulator clonidine."3.66Clonidine reverses the amnesia induced by dopamine beta hydroxylase inhibition. ( Backman, MZ; Freedman, LS; Quartermain, D, 1979)
"Amnesia for a multiple trial appetitive spatial dicrimination habit induced by the protein synthesis inhibitor cycloheximide (CXM) was reversed by peripheral injections of both alpha (clonidine) and beta (isoproterenol) norepinephrine receptor stimulators."3.65Reversal of cycloheximide-induced amnesia by adrenergic receptor stimulation. ( Botwinick, CY; Freedman, LS; Gutwein, BM; Quartermain, D, 1977)
"Yohimbine pre-treatment decreased the amnestic effects of dexamethasone or dexamethasone plus clonidine."1.31The role of alpha-adrenoceptors in the amnestic effect of intracerebroventricular dexamethasone. ( Hadi, M; Homayoun, H; Khavandgar, S; Postami, P; Shafaghi, B; Zarrindast, MR, 2002)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19902 (20.00)18.7374
1990's2 (20.00)18.2507
2000's3 (30.00)29.6817
2010's3 (30.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Torkaman-Boutorabi, A1
Sheidadoust, H1
Hashemi-Hezaveh, SM1
Zarrindast, MR4
Beiranvand, A1
Nasehi, M1
Moghaddasi, M1
Piri, M1
Hadi, M1
Homayoun, H1
Postami, P1
Shafaghi, B1
Khavandgar, S1
Galeotti, N2
Bartolini, A2
Ghelardini, C2
Genkova-Papazova, M2
Lazarova-Bakarova, M2
Petkov, VD1
Bojanova, E1
Petkova, B1
Manetti, D1
Bellucci, C1
Dei, S1
Gualtieri, F1
Romanelli, MN1
Scapecchi, S1
Teodori, E1
Freedman, LS2
Backman, MZ1
Quartermain, D2
Botwinick, CY1
Gutwein, BM1

Other Studies

10 other studies available for clonidine and Amnesia

ArticleYear
Influence of morphine on medial prefrontal cortex alpha2 adrenergic system in passive avoidance learning in rats.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 133

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Amnesia; Animals; Avo

2015
Involvement of medial prefrontal cortex alpha-2 adrenoceptors on memory acquisition deficit induced by arachidonylcyclopropylamide, a cannabinoid CB1 receptor agonist, in rats; possible involvement of Ca2+ channels.
    Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:9

    Topics: Amnesia; Animals; Arachidonic Acids; Calcium Channels; Clonidine; Dose-Response Relationship, Drug;

2016
Modulation of WIN55,212-2 state-dependent memory by α2-adrenergic receptors of the dorsal hippocampus.
    Archives of Iranian medicine, 2011, Volume: 14, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Amnesia; Analysis of

2011
The role of alpha-adrenoceptors in the amnestic effect of intracerebroventricular dexamethasone.
    Pharmacological research, 2002, Volume: 46, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amnesia; Animals; Avoidance Learning; Cloni

2002
Alpha-2 agonists induce amnesia through activation of the Gi-protein signalling pathway.
    Neuroscience, 2004, Volume: 126, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Amnesia; Animals; Avoidance Learnin

2004
The 5-HT2 receptor antagonist ketanserine prevents electroconvulsive shock- and clonidine-induced amnesia.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:4

    Topics: Amnesia; Animals; Avoidance Learning; Clonidine; Electroshock; Injections, Intraperitoneal; Ketanser

1994
Effects of verapamil on electroconvulsive shock- and clonidine-induced amnesia.
    Methods and findings in experimental and clinical pharmacology, 1997, Volume: 19, Issue:2

    Topics: Adrenergic alpha-Agonists; Amnesia; Animals; Avoidance Learning; Calcium Channel Blockers; Clonidine

1997
Design, synthesis, and preliminary pharmacological evaluation of 1, 4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic agents.
    Journal of medicinal chemistry, 2000, May-18, Volume: 43, Issue:10

    Topics: Adrenergic alpha-Agonists; Amnesia; Animals; Avoidance Learning; Baclofen; Clonidine; Dose-Response

2000
Clonidine reverses the amnesia induced by dopamine beta hydroxylase inhibition.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 11, Issue:3

    Topics: Amnesia; Animals; Behavior, Animal; Clonidine; Dextroamphetamine; Ditiocarb; Dopamine beta-Hydroxyla

1979
Reversal of cycloheximide-induced amnesia by adrenergic receptor stimulation.
    Pharmacology, biochemistry, and behavior, 1977, Volume: 7, Issue:3

    Topics: Amnesia; Animals; Brain Chemistry; Catecholamines; Clonidine; Cycloheximide; Drug Interactions; Huma

1977