clonidine has been researched along with Altered Level of Consciousness in 7 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Apraclonidine eye drop is an alpha adrenergic agonist derived topical clonidine, used for the treatment of intraocular pressure elevation." | 1.33 | More than just an ocular solution. ( Karakus, G; Pekdemir, M; Yanturali, S, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nadeau, N | 1 |
| Samuels-Kalow, M | 1 |
| Wittels, K | 1 |
| Wilcox, SR | 1 |
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Sevrez, C | 1 |
| Lavocat, MP | 1 |
| Mounier, G | 1 |
| Elefant, E | 1 |
| Magnin, S | 1 |
| Teyssier, G | 1 |
| Patural, H | 1 |
| Pekdemir, M | 1 |
| Yanturali, S | 1 |
| Karakus, G | 1 |
| Lehmann, A | 1 |
| Arakawa, S | 1 |
| Nakamura, S | 1 |
| Kawashima, N | 1 |
| Nishiike, S | 1 |
| Okuyama, S | 1 |
| Bhatara, VS | 1 |
| Kallepalli, BR | 1 |
| Misra, LK | 1 |
| Awadallah, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
7 other studies available for clonidine and Altered Level of Consciousness
| Article | Year |
|---|---|
A Common Antidote for an Uncommon Indication.
Topics: Antidotes; Bradycardia; Child, Preschool; Clonidine; Consciousness Disorders; Eating; Emergency Serv | 2019 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
[Transplacental or breast milk intoxication to clonidine: a case of neonatal hypotonia and drowsiness].
Topics: Clonidine; Consciousness Disorders; Diagnosis, Differential; Female; Humans; Hypertension, Pregnancy | 2014 |
More than just an ocular solution.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Clonidine; Consciousness Disorders; Female; Huma | 2005 |
[Clonidine poisoning (author's transl)].
Topics: Clonidine; Consciousness Disorders; Dose-Response Relationship, Drug; Hemodynamics; Humans | 1981 |
Antagonizing effects of VA-045 on reduced activity of rat locus coeruleus neurons following head injury or intravenous injection of clonidine.
Topics: Animals; Clonidine; Consciousness Disorders; Craniocerebral Trauma; Drug Interactions; Electrophysio | 1995 |
A possible clonidine-trazodone-dextroamphetamine interaction in a 12-year-old boy.
Topics: Antihypertensive Agents; Bradycardia; Central Nervous System Stimulants; Child; Clonidine; Conscious | 1996 |