clonidine has been researched along with Alloxan Diabetes in 46 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypertension is often present in the diabetic individual and it is known to aggravate the vascular complications associated with diabetes." | 5.29 | Opposite influences of hypertension and diabetes mellitus on pressor responses induced by different alpha-adrenoceptor agonists and angiotensin II in pithed rats. ( Beenen, OH; Mathy, MJ; Pfaffendorf, M; van Zwieten, PA, 1996) |
| "Leptin treatment decreased NE release modestly but produced a robust reduction in corticosterone (CS) levels." | 1.51 | Leptin and HPA axis activity in diabetic rats: Effects of adrenergic agonists. ( Clark, KA; Jacob, EB; MohanKumar, PS; MohanKumar, SMJ, 2019) |
| "This study aimed to develop a novel type 2 diabetes model designated the HND (Horio-Niki diabetic) mouse, by transferring diabetogenic genes from wild castaneus mice (Mus musculus castaneus) captured in the Philippines into laboratory mice (C57BL/6J:B6)." | 1.33 | The HND mouse, a nonobese model of type 2 diabetes mellitus with impaired insulin secretion. ( Anunciado, RV; Horio, F; Imamura, T; Kobayashi, M; Namikawa, T; Niki, I; Teradaira, S, 2005) |
| "Systemic hypertension is common in individuals with non-insulin-dependent diabetes (NIDD) and, in this population, markedly increases the risk for cardiovascular complications." | 1.31 | NaCl-induced hypertensive rat model of non-insulin-dependent diabetes: role of sympathetic modulation. ( Mozaffari, MS; Patel, C; Schaffer, SW; Warren, BK, 2000) |
| "Hypertension is often present in the diabetic individual and it is known to aggravate the vascular complications associated with diabetes." | 1.29 | Opposite influences of hypertension and diabetes mellitus on pressor responses induced by different alpha-adrenoceptor agonists and angiotensin II in pithed rats. ( Beenen, OH; Mathy, MJ; Pfaffendorf, M; van Zwieten, PA, 1996) |
| "Hypertension was associated with enhanced pressor response, whereas the diabetic state counteracted this effect." | 1.29 | Influence of nifedipine on pressor responses induced by different alpha-adrenoceptor agonists and angiotensin II in pithed diabetic hypertensive rats. ( Beenen, OH; Mathy, MJ; Pfaffendorf, M; van Zwieten, PA, 1996) |
| "Clonidine treatment significantly increased the weight gain, but did not affect plasma glucose, insulin, glucagon and norepinephrine in the diabetic animals." | 1.28 | Central adrenergic suppression augments the insulin and glucagon secretory, and the glycogenolytic responses in streptozotocin-diabetic rats. ( Colemen, ER; Dunbar, JC; Marzouq, L; Shaffer, LR, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (23.91) | 18.7374 |
| 1990's | 15 (32.61) | 18.2507 |
| 2000's | 14 (30.43) | 29.6817 |
| 2010's | 6 (13.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Taguchi, K | 6 |
| Bessho, N | 1 |
| Hasegawa, M | 1 |
| Narimatsu, H | 1 |
| Matsumoto, T | 7 |
| Kobayashi, T | 7 |
| Clark, KA | 1 |
| Jacob, EB | 1 |
| MohanKumar, PS | 1 |
| MohanKumar, SMJ | 1 |
| Hida, M | 1 |
| Lazahari, MI | 1 |
| Sattar, MA | 3 |
| Abdullah, NA | 4 |
| Khan, MA | 3 |
| Johns, EJ | 4 |
| Takenouchi, Y | 2 |
| Kamata, K | 6 |
| Armenia, A | 2 |
| Munavvar, AS | 1 |
| Helmi, A | 1 |
| Yasuhiro, T | 1 |
| Koga, K | 1 |
| Honda, K | 1 |
| Ando, S | 1 |
| Harasawa, I | 1 |
| Kamiya, HO | 1 |
| Takano, Y | 1 |
| Hwang, SL | 1 |
| Liu, IM | 1 |
| Tzeng, TF | 1 |
| Cheng, JT | 1 |
| Horio, F | 1 |
| Teradaira, S | 1 |
| Imamura, T | 1 |
| Anunciado, RV | 1 |
| Kobayashi, M | 1 |
| Namikawa, T | 1 |
| Niki, I | 1 |
| Scarborough, NL | 2 |
| Carrier, GO | 3 |
| Nakadate, T | 1 |
| Nakaki, T | 1 |
| Yamamoto, S | 1 |
| Kato, R | 1 |
| DiTullio, NW | 1 |
| Cieslinski, L | 1 |
| Matthews, WD | 1 |
| Storer, B | 1 |
| Nechifor, M | 1 |
| Filip, C | 1 |
| Teslariu, E | 1 |
| Neughebauer, BI | 1 |
| Costuleanu, M | 1 |
| Negru, A | 1 |
| Courteix, C | 1 |
| Bardin, M | 1 |
| Chantelauze, C | 1 |
| Lavarenne, J | 1 |
| Eschalier, A | 1 |
| Hirose, H | 1 |
| Maruyama, H | 1 |
| Ito, K | 1 |
| Kido, K | 1 |
| Koyama, K | 1 |
| Saruta, T | 1 |
| Beenen, OH | 3 |
| Pfaffendorf, M | 3 |
| van Zwieten, PA | 3 |
| Mathy, MJ | 2 |
| O'Donnell, JM | 1 |
| Banyasz, T | 1 |
| Kovacs, T | 1 |
| Dunbar, JC | 2 |
| Clough-Helfman, C | 1 |
| Barraco, RA | 1 |
| Anderson, GF | 1 |
| Bitar, MS | 2 |
| Pilcher, CW | 2 |
| Satia, MC | 1 |
| Damani, RR | 1 |
| Goyal, RK | 1 |
| Padayatti, PS | 1 |
| Paulose, CS | 1 |
| Mozaffari, MS | 1 |
| Patel, C | 1 |
| Warren, BK | 1 |
| Schaffer, SW | 1 |
| Nakasone, J | 1 |
| Higuchi, M | 1 |
| Miyagi, K | 1 |
| Matsuzaki, T | 1 |
| Noguchi, K | 1 |
| Sakanashi, M | 2 |
| Yamashiro, S | 1 |
| Itomine, T | 1 |
| Kanie, N | 1 |
| Inose, A | 1 |
| Kita, T | 1 |
| Kagawa, K | 1 |
| Mammoto, T | 1 |
| Takada, K | 1 |
| Hayashi, Y | 1 |
| Mashimo, T | 1 |
| Kishi, Y | 1 |
| Abebe, W | 1 |
| Harris, KH | 2 |
| MacLeod, KM | 2 |
| Colemen, ER | 1 |
| Shaffer, LR | 1 |
| Marzouq, L | 1 |
| Allard, WJ | 1 |
| Vicario, PP | 1 |
| Saperstein, R | 1 |
| Slater, EE | 1 |
| Strout, HV | 1 |
| Zhang, PL | 1 |
| Patel, KP | 1 |
| Sakai, Y | 1 |
| Honda, H | 1 |
| Chang, EB | 1 |
| Fedorak, RN | 1 |
| Field, M | 1 |
| White, RE | 1 |
| Locatelli, V | 1 |
| Miyoshi, H | 1 |
| Bestetti, G | 1 |
| Rossi, GL | 1 |
| Müller, EE | 1 |
| Regan, TJ | 1 |
| Altszuler, N | 1 |
| Eaddy, C | 1 |
| Bakth, S | 1 |
| Wakabayashi, I | 1 |
| Hatake, K | 1 |
| Kimura, N | 1 |
| Kakishita, E | 1 |
| Nagai, K | 1 |
46 other studies available for clonidine and Alloxan Diabetes
| Article | Year |
|---|---|
Co-treatment with clonidine and a GRK2 inhibitor prevented rebound hypertension and endothelial dysfunction after withdrawal in diabetes.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Clonidine; Diabetes Mellitus, Exp | 2018 |
Leptin and HPA axis activity in diabetic rats: Effects of adrenergic agonists.
Topics: Adrenergic Agonists; Adrenergic alpha-Agonists; Animals; Clonidine; Corticosterone; Diabetes Mellitu | 2019 |
Resveratrol Ameliorates Clonidine-Induced Endothelium-Dependent Relaxation Involving Akt and Endothelial Nitric Oxide Synthase Regulation in Type 2 Diabetic Mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antioxidants; Clonidine; Diabetes Mellitus, Experimen | 2015 |
Clonidine and a novel clonidine analog AL-12 cause sympathoinhibition in spontaneously hypertensive and diabetic spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Diabetes Mel | 2008 |
Gender differences in vascular reactivity of aortas from streptozotocin-induced diabetic mice.
Topics: Acetylcholine; Adiponectin; Animals; Aorta; Arginine; Clonidine; Diabetes Mellitus, Experimental; En | 2010 |
Inhibitor of G protein-coupled receptor kinase 2 normalizes vascular endothelial function in type 2 diabetic mice by improving β-arrestin 2 translocation and ameliorating Akt/eNOS signal dysfunction.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Blood Pre | 2012 |
Suppressed G-protein-coupled receptor kinase 2 activity protects female diabetic-mouse aorta against endothelial dysfunction.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Aorta; Clonidine; Diabetes Mellitus, Experimental; Di | 2013 |
The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats.
Topics: Animals; Blood Glucose; Clonidine; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Res | 2004 |
Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model.
Topics: Acetylcholine; Animals; Aorta; Clonidine; Cyclic GMP-Dependent Protein Kinases; Diabetes Mellitus, E | 2004 |
Intrathecal clonidine inhibits mechanical allodynia via activation of the spinal muscarinic M1 receptor in streptozotocin-induced diabetic mice.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Analgesics; Animals; Atropine; | 2004 |
Activation of imidazoline receptors in adrenal gland to lower plasma glucose in streptozotocin-induced diabetic rats.
Topics: Adrenal Glands; Adrenal Medulla; Adrenalectomy; Agmatine; Animals; beta-Endorphin; Blood Glucose; Bl | 2005 |
The HND mouse, a nonobese model of type 2 diabetes mellitus with impaired insulin secretion.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Animals, Wild; Blood Glucose; Clonidine; Crosses, | 2005 |
Alpha1A- and alpha1D-adrenoceptors are the major functional subtypes of renal alpha1-adrenoceptors in streptozotocin-induced diabetic and normal Sprague-Dawley rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Diabetes Mellitus, Expe | 2008 |
Possible involvement of Akt activity in endothelial dysfunction in type 2 diabetic mice.
Topics: Adrenomedullin; Animals; Aorta; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Clonidine; | 2008 |
Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Clonidine; D | 2008 |
Nifedipine and alpha adrenoceptors in rat aorta. II. Role of extracellular calcium in enhanced alpha-2 adrenoceptor-mediated contraction in diabetes.
Topics: Animals; Aorta; Calcium; Clonidine; Diabetes Mellitus, Experimental; Dose-Response Relationship, Dru | 1984 |
Protection against alloxan-induced diabetes in mice by stimulation of alpha 2-adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Alloxan; Animals; Clonidine; Diabetes Mellitus, Experimental; Epinephrine | 1983 |
Increased alpha 2-adrenoreceptor mediated vascular contraction in diabetic rats.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Calcium; Clonidine; Diabetes Mellitus, Experimental; In V | 1983 |
Mechanisms involved in the hyperglycemic response induced by clonidine and other alpha-2 adrenoceptor agonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Diabetes Mellitus, Expe | 1984 |
Influence of clonidine on alloxan-induced diabetes in rats.
Topics: Alloxan; Animals; Blood Glucose; Clonidine; Diabetes Mellitus, Experimental; Imidazoline Receptors; | 1995 |
Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics.
Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Aspirin; Clonidine; Diabetes Mellitus, Experi | 1994 |
Effects of alpha 2- and beta-adrenergic agonism on glucagon secretion from perfused pancreata of normal and streptozocin-induced diabetic rats.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Clonidine | 1993 |
Contractile responses to various inotropic agents in isolated hearts obtained from hypertensive diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Opposite influences of hypertension and diabetes mellitus on pressor responses induced by different alpha-adrenoceptor agonists and angiotensin II in pithed rats.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Azepines; Blood Glucose; Blood Pressure; Brimoni | 1996 |
Influence of nifedipine on pressor responses induced by different alpha-adrenoceptor agonists and angiotensin II in pithed diabetic hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Blood Pressure; Brimonidine Tartrate; Calcium | 1996 |
Altered thermoregulatory responses to clonidine in streptozotocin-diabetic rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Body Temperature Regulation; Cloni | 1996 |
Effect of insulin and clonidine on the evoked release of norepinephrine and serotonin from the nucleus tractus solitarius of the diabetic rat.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Diabetes Mellitus, Experimental; Disease Models, Anim | 1995 |
Insulin-dependent attenuation in alpha 2-adrenoreceptor-mediated nociception in experimental diabetes.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 1997 |
Beneficial effects of clonidine in streptozotocin-induced diabetes and DOCA-hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cardiomegaly; Clonidine; Desoxycorticosterone; D | 1997 |
Alpha2 adrenergic and high affinity serotonergic receptor changes in the brain stem of streptozotocin-induced diabetic rats.
Topics: Affinity Labels; Animals; Binding, Competitive; Brain Stem; Chromatography, High Pressure Liquid; Cl | 1999 |
NaCl-induced hypertensive rat model of non-insulin-dependent diabetes: role of sympathetic modulation.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agon | 2000 |
Diabetes attenuates the response of the lumbospinal noradrenergic system to idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Body Weight; Clonidine; Diabetes Mellit | 2000 |
Comparison of contractile responses relative to protein between isolated diabetic and non-diabetic rat aortae to KCl and alpha-adrenoceptor agonists in different extracellular calcium concentrations.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Calcium; Clonidine; Diabetes Mellitus, Experime | 2000 |
Mechanisms underlying attenuated contractile response of aortic rings to noradrenaline in fructose-fed mice.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, | 2001 |
Diabetes attenuates the minimum anaesthetic concentration (MAC) and MAC-blocking adrenergic response reducing actions of clonidine in rats.
Topics: Adrenergic alpha-Agonists; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Clonidine; Diab | 2001 |
Enhanced contractile responses of arteries from diabetic rats to alpha 1-adrenoceptor stimulation in the absence and presence of extracellular calcium.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Arteries; Calcium; Clonidine; Diabetes Mellitus | 1990 |
Central adrenergic suppression augments the insulin and glucagon secretory, and the glycogenolytic responses in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Clonidine; Diabetes Mellitus, Experimental; Glucagon; Glycogen; | 1991 |
The function but not the expression of rat liver inhibitory guanine nucleotide binding protein is altered in streptozotocin-induced diabetes.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Antibody Specificity; Cell Membrane; Clonidine; Col | 1991 |
Blunted diuretic and natriuretic responses to central administration of clonidine in streptozocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Blood Pressure; Cerebral Ventricles; Clonidine; Denervation; Diabetes Mellit | 1991 |
Hyperactivity of Ca channels in vasa deferentia smooth muscle of diabetic rats.
Topics: Animals; Clonidine; Diabetes Mellitus, Experimental; Ion Channels; Male; Muscle Contraction; Muscle, | 1987 |
Influence of the endothelium on contractile responses of arteries from diabetic rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arteries; Clonidine; Cyclic GMP; Diabetes Mellitus, Experim | 1988 |
Experimental diabetic diarrhea in rats. Intestinal mucosal denervation hypersensitivity and treatment with clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Antidiarrheals; Clonidine; Denervation; Diabetes Mellitus, Exper | 1986 |
Enhanced vascular alpha-adrenergic neuroeffector system in diabetes: importance of calcium.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Clonidine; Diabetes Melli | 1988 |
Effect of growth hormone-releasing stimuli in streptozotocin diabetic rats.
Topics: Animals; Clonidine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Diabetes Mellitus, Experimental; Growth | 1985 |
Relation of growth hormone and myocardial collagen accumulation in experimental diabetes.
Topics: Animals; Blood Glucose; Clonidine; Collagen; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Non | 1987 |
Modulation of vascular tonus by the endothelium in experimental diabetes.
Topics: Acetylcholine; Animals; Clonidine; Diabetes Mellitus, Experimental; Endothelium; Muscle Contraction; | 1987 |