clonidine and Alcohol Withdrawal Associated Autonomic Hyperactivity studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

Excerpt	Relevance	Reference
"We describe two cases of severe colonic pseudo-obstruction (Ogilvie's Syndrome) after high dose clonidine i."	7.69	Acute colonic pseudoobstruction (Ogilvie's syndrome) in two patients receiving high dose clonidine for delirium tremens. ( Cantieni, R; Frutiger, A; Stieger, DS, 1997)
"We describe two cases of severe colonic pseudo-obstruction (Ogilvie's Syndrome) after high dose clonidine i."	3.69	Acute colonic pseudoobstruction (Ogilvie's syndrome) in two patients receiving high dose clonidine for delirium tremens. ( Cantieni, R; Frutiger, A; Stieger, DS, 1997)
"Alprazolam was significantly more efficacious than both clonidine and placebo in decreasing withdrawal symptoms."	2.67	Double-blind study of alprazolam, diazepam, clonidine, and placebo in the alcohol withdrawal syndrome: preliminary findings. ( Adinoff, B, 1994)
" Risk of bradycardia of high potential danger did not occur with a median daily dosage of 1."	2.67	[Clonidine supplemented analgesia and sedation in prevention of postoperative delirium]. ( Hartmann, M; Seitz, W; Verner, L, 1990)
" Dosage should be individualized, based on withdrawal severity measured by withdrawal scales, comorbid illness, and history of withdrawal seizures."	2.40	Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal. ( Mayo-Smith, MF, 1997)
"Delirium tremens is linked with a chronic depression of the central nervous system by alcohol and a compensatory hyperactivity of neurotransmitters."	2.38	[Delirium tremens. Recent neurophysiologic concepts and therapeutic outlook]. ( Meignan, ML, 1992)
"Methadone was tapered and discontinued prior to ROD and Naltrexone was administered in increasing daily doses."	1.32	Unexpected delirium during Rapid Opioid Detoxification (ROD). ( Golden, SA; Sakhrani, DL, 2004)

Research

Studies (33)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Ratio of Glutamate to Creatine in the Anterior Cingulate of the Brain, Measured on Day 25

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (30.30)	18.7374
1990's	16 (48.48)	18.2507
2000's	7 (21.21)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Hensel, M	1
Kox, WJ	2
Spies, CD	1
Otter, HE	1
Hüske, B	1
Sinha, P	1
Neumann, T	1
Rettig, J	1
Lenzenhuber, E	1
Sellers, EM	1
Golden, SA	1
Sakhrani, DL	1
Sharma, V	1
Stanley, KM	1
Worrall, CL	1
Lunsford, SL	1
Simpson, KN	1
Miller, JG	1
Spencer, AP	1
Hemmingsen, R	1
Clemmesen, L	1
Barry, DI	1
Adams, MA	1
Hirst, M	1
Metz, G	1
Nebel, B	1
Nardoni, A	2
Copetti, R	2
Baldissera, S	2
Busetti, G	1
Cella, R	2
Venturini, G	1
Iacono, M	1
Adinoff, B	1
De Marinis, L	1
Mancini, A	1
Fiumara, C	1
Conte, G	1
Iacona, T	1
Ianiri, L	1
Zeppetelli, E	1
Gobbi, G	1
Tempesta, E	1
Mayo-Smith, MF	1
Stieger, DS	1
Cantieni, R	1
Frutiger, A	1
Mrazek, M	1
Menges, C	1
Steffes, J	1
Thelen, B	1
Erkwoh, R	1
Soyka, M	1
Horak, M	1
Zilker, T	1
Balldin, J	3
Berggren, U	1
Engel, J	1
Lindstedt, G	1
Sundkler, A	1
Wålinder, J	1
Meignan, ML	1
Bokström, K	2
Verner, L	3
Hartmann, M	3
Schmelzeisen, R	1
Rommelspacher, H	1
Schmidt, LG	1
Helmchen, H	1
Lorenz, M	1
Gaab, MR	1
Rominger, KL	1
Schäfer, E	1
Vrecko, HG	1
Palme, M	1
Huber, FT	1
Bartels, H	1
Siewert, JR	1
Naber, M	1
Franz, W	1
Overbeck, W	1
Seitz, W	1
Robinson, BJ	1
Robinson, GM	1
Maling, TJ	1
Johnson, RH	1
Nutt, D	1
Glue, P	1
Molyneux, S	1
Clark, E	1
Heuzeroth, L	1
Grüneklee, D	1
Cushman, P	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Acamprosate for Central Nervous System Hyperexcitability and Neuroadaptation in Alcohol Withdrawal[NCT00106106]	Phase 2	56 participants (Actual)	Interventional	2005-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The ratio of glutamate to creatine was determined using magnetic resonance spectroscopy (MRS), a technique that complements magnetic resonance imaging (MRI). MRS is used to determine the concentration of brain metabolites, such as glutamate, in brain tissue. MRS utilizes a magnetic field to look at magnetic nuclei, which absorb and re-emit electromagnetic energy in the presence of the magnetic field. By looking at the peaks in the resultant spectra the structure and concentration of metabolites can be determined. (NCT00106106)
Timeframe: Day 25

Ratio of Glutamate to Creatine in the Anterior Cingulate of the Brain, Measured on Day 4

Intervention	Ratio of glutamate to creatine (Mean)
Placebo	1.350375
Acamprosate	1.166667

Reviews

4 reviews available for clonidine and Alcohol Withdrawal Associated Autonomic Hyperactivity

Trials

10 trials available for clonidine and Alcohol Withdrawal Associated Autonomic Hyperactivity

Other Studies

19 other studies available for clonidine and Alcohol Withdrawal Associated Autonomic Hyperactivity

Article	Year
Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal. JAMA, 1997, Jul-09, Volume: 278, Issue:2 Topics: Adrenergic beta-Antagonists; Alcohol Withdrawal Delirium; Antipsychotic Agents; Benzodiazepines; Car	1997
[Delirium tremens. Recent neurophysiologic concepts and therapeutic outlook]. Cahiers d'anesthesiologie, 1992, Volume: 40, Issue:3 Topics: Alcohol Withdrawal Delirium; Carbamazepine; Chlormethiazole; Clonidine; Ethanol; Haloperidol; Humans	1992
[Pathobiochemistry and pharmacotherapy of alcohol withdrawal delirium]. Der Nervenarzt, 1991, Volume: 62, Issue:11 Topics: Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Benzodiazepines; Brain; Carbamazepine; Chlormethia	1991
Clonidine and alcohol withdrawal. Advances in alcohol & substance abuse, 1987, Volume: 7, Issue:1 Topics: Alcohol Withdrawal Delirium; Alcoholism; Clonidine; Humans; Psychoses, Alcoholic	1987

Article	Year
Alcohol withdrawal severity is decreased by symptom-orientated adjusted bolus therapy in the ICU. Intensive care medicine, 2003, Volume: 29, Issue:12 Topics: Adult; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Antipsychotic Agents; Clonidine; Decision T	2003
Double-blind study of alprazolam, diazepam, clonidine, and placebo in the alcohol withdrawal syndrome: preliminary findings. Alcoholism, clinical and experimental research, 1994, Volume: 18, Issue:4 Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Alprazolam; Blood Pressure; Clonidine; Diazepam; Dou	1994
Growth hormone response to growth hormone-releasing hormone in early abstinent alcoholic patients. Psychoneuroendocrinology, 1993, Volume: 18, Issue:7 Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Clonidine; Female; Growth Hormone; Growth Hormone-Re	1993
Alpha-2-adrenoceptor sensitivity in early alcohol withdrawal. Biological psychiatry, 1992, Apr-01, Volume: 31, Issue:7 Topics: Adult; Alcohol Withdrawal Delirium; Blood Pressure; Chlormethiazole; Chlorprothixene; Clonidine; Dos	1992
[Does the use of sympathicolytics to prevent withdrawal syndromes compromise microvascular anastomoses?]. Deutsche zahnarztliche Zeitschrift, 1992, Volume: 47, Issue:1 Topics: Adult; Aged; Alcohol Withdrawal Delirium; Clonidine; Female; Humans; Male; Microcirculation; Middle	1992
[Treatment of postoperative alcohol withdrawal syndrome after esophageal resection]. Langenbecks Archiv fur Chirurgie. Supplement II, Verhandlungen der Deutschen Gesellschaft fur Chirurgie. Deutsche Gesellschaft fur Chirurgie. Kongress, 1990 Topics: Alcohol Withdrawal Delirium; Clonidine; Esophageal Neoplasms; Esophagectomy; Ethanol; Humans; Midazo	1990
[Clonidine supplemented analgesia and sedation in prevention of postoperative delirium]. Anasthesie, Intensivtherapie, Notfallmedizin, 1990, Volume: 25, Issue:4 Topics: Adult; Aged; Alcohol Withdrawal Delirium; Anesthesia, General; Arousal; Clonidine; Critical Care; Di	1990
Is clonidine useful in the treatment of alcohol withdrawal? Alcoholism, clinical and experimental research, 1989, Volume: 13, Issue:1 Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlormethiazole; Clinical Trials as Topic; Clonidine	1989
[Clonidine--an alternative in the treatment of delirium tremens]. Medizinische Klinik (Munich, Germany : 1983), 1988, Nov-25, Volume: 83, Issue:23 Topics: Adult; Alcohol Withdrawal Delirium; Clinical Trials as Topic; Clonidine; Female; Humans; Infusions,	1988
Treatment of alcohol abstinence symptoms with the alpha 2-agonist clonidine. Acta psychiatrica Scandinavica. Supplementum, 1986, Volume: 327 Topics: Adult; Alcohol Withdrawal Delirium; Carbamazepine; Chlorprothixene; Clinical Trials as Topic; Clonid	1986

Article	Year
[Can alcoholic withdrawal delirium be prevented?]. Anaesthesiologie und Reanimation, 2003, Volume: 28, Issue:1 Topics: Alcohol Withdrawal Delirium; Alcoholism; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines;	2003
Unexpected delirium during Rapid Opioid Detoxification (ROD). Journal of addictive diseases, 2004, Volume: 23, Issue:1 Topics: Adult; Alcohol Withdrawal Delirium; Clonidine; Diagnostic and Statistical Manual of Mental Disorders	2004
Delirium tremens--a case study. The Nursing journal of India, 2003, Volume: 94, Issue:3 Topics: Adult; Alcohol Withdrawal Delirium; Antihypertensive Agents; Chlordiazepoxide; Clonidine; Humans; Hy	2003
Experience with an adult alcohol withdrawal syndrome practice guideline in internal medicine patients. Pharmacotherapy, 2005, Volume: 25, Issue:8 Topics: Adrenergic alpha-Agonists; Adult; Aged; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Antipsycho	2005
Alcohol withdrawal syndrome: how to predict, prevent, diagnose and treat it. Prescrire international, 2007, Volume: 16, Issue:87 Topics: Adrenergic beta-Antagonists; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Ambulatory Ca	2007
Blind study of the effect of the alpha-adrenergic agonists clonidine and lofexidine on alcohol withdrawal in the rat. Journal of studies on alcohol, 1984, Volume: 45, Issue:4 Topics: Alcohol Drinking; Alcohol Withdrawal Delirium; Animals; Behavior, Animal; Clonidine; Humans; Male; P	1984
The ethanol withdrawal syndrome in the rat: effects of drug treatment on adrenal gland and urinary catecholamines. Substance and alcohol actions/misuse, 1982, Volume: 3, Issue:5 Topics: Adrenal Glands; Alcohol Withdrawal Delirium; Animals; Catecholamines; Clonidine; Dexamethasone; Diaz	1982
[Clonidine in severe alcohol withdrawal delirium]. Fortschritte der Medizin, 1983, Jul-14, Volume: 101, Issue:26 Topics: Alcohol Withdrawal Delirium; Chlormethiazole; Clonidine; Diazepam; Haloperidol; Humans; Monitoring,	1983
[Clonidine in the treatment of alcoholic abstinence syndrome: present therapeutic prospectives and their possible combinations]. La Clinica terapeutica, 1982, Volume: 102, Issue:5 Topics: Adult; Aged; Alcohol Withdrawal Delirium; Clonidine; Droperidol; Drug Therapy, Combination; Female;	1982
[Clonidine in the treatment of the alcohol withdrawal syndrome. Preliminary report]. La Clinica terapeutica, 1981, Jun-30, Volume: 97, Issue:6 Topics: Adult; Aged; Alcohol Withdrawal Delirium; Clonidine; Female; Humans; Male; Middle Aged; Psychoses, A	1981
Acute colonic pseudoobstruction (Ogilvie's syndrome) in two patients receiving high dose clonidine for delirium tremens. Intensive care medicine, 1997, Volume: 23, Issue:7 Topics: Acute Disease; Adrenergic alpha-Agonists; Aged; Alcohol Withdrawal Delirium; Clonidine; Colonic Pseu	1997
[Therapeutic experiences with alcohol-related Korsakoff syndrome]. Der Nervenarzt, 1999, Volume: 70, Issue:9 Topics: Adrenergic alpha-Agonists; Adult; Alcohol Withdrawal Delirium; Alcoholism; Anti-Anxiety Agents; Brai	1999
[Ambulatory detoxification of alcoholic patients--evaluation of a model project]. Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)), 2000, Volume: 62, Issue:1 Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Ambulatory Care; Clonidine; Doxepin; Female; Follow-	2000
[Alcohol withdrawal syndrome and delirium tremens. Diagnosis and therapy]. MMW Fortschritte der Medizin, 1999, Aug-19, Volume: 141, Issue:33 Topics: Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Chlormethiazole;	1999
A rating scale for assessment of alcohol withdrawal psychopathology (AWIP). Alcoholism, clinical and experimental research, 1992, Volume: 16, Issue:2 Topics: Alcohol Withdrawal Delirium; Alcoholism; Carbamazepine; Chlormethiazole; Chlorprothixene; Clonidine;	1992
[SEP monitoring during clonidine therapy of alcohol delirium]. EEG-EMG Zeitschrift fur Elektroenzephalographie, Elektromyographie und verwandte Gebiete, 1991, Volume: 22, Issue:3 Topics: Alcohol Withdrawal Delirium; Clonidine; Evoked Potentials, Somatosensory; Female; Humans; Male; Midd	1991
[Pharmacokinetics of clonidine following intravenous administration of high doses for the treatment of delirium tremens]. Arzneimittel-Forschung, 1991, Volume: 41, Issue:4 Topics: Adult; Alcohol Withdrawal Delirium; Clonidine; Female; Humans; Injections, Intravenous; Male; Middle	1991
[Characteristics of alcohol withdrawal delirium in surgical patients and recommendations for treatment]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1991, Volume: 62, Issue:2 Topics: Adult; Aged; Alcohol Withdrawal Delirium; Blood Pressure; Clonidine; Combined Modality Therapy; Emer	1991
Alpha-2-adrenoceptor function in alcohol withdrawal: a pilot study of the effects of iv. clonidine in alcoholics and normals. Alcoholism, clinical and experimental research, 1988, Volume: 12, Issue:1 Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Blood Pressure; Clonidine; Growth Hormone; Humans; I	1988