clonidine has been researched along with Agitation, Psychomotor in 42 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The study goal was to determine whether clonidine treatment of neonatal abstinence syndrome (NAS) would result in a better neurobehavioral performance compared with morphine." | 9.20 | Morphine versus clonidine for neonatal abstinence syndrome. ( Bada, HS; Breheny, P; Caldwell, R; Capilouto, G; Garlitz, K; Gibson, J; Leggas, M; Li, Y; Sithisarn, T, 2015) |
| "One patient's akathisia also appeared to respond to clonidine." | 5.27 | Clonidine in the treatment of mania and mixed bipolar disorder. ( Cohen, BM; Jonas, JM; Lipinski, JF; Zubenko, GS, 1984) |
| "The study goal was to determine whether clonidine treatment of neonatal abstinence syndrome (NAS) would result in a better neurobehavioral performance compared with morphine." | 5.20 | Morphine versus clonidine for neonatal abstinence syndrome. ( Bada, HS; Breheny, P; Caldwell, R; Capilouto, G; Garlitz, K; Gibson, J; Leggas, M; Li, Y; Sithisarn, T, 2015) |
| "In this study, we evaluated the effect of intrathecal and oral clonidine as supplements to spinal anesthesia with lidocaine in patients at risk of postoperative alcohol withdrawal syndrome (AWS)." | 5.11 | Intrathecal and oral clonidine as prophylaxis for postoperative alcohol withdrawal syndrome: a randomized double-blinded study. ( Axelsson, K; Berggren, L; Dobrydnjov, I; Holmström, B; Samarütel, J, 2004) |
| " The hypothesis of this study was that central NE responsivity would predict aggression response to treatment with a NE medication, pindolol." | 5.11 | Noradrenergic activity is associated with response to pindolol in aggressive Alzheimer's disease patients. ( Eryavec, G; Herrmann, N; Khan, LR; Lanctôt, KL, 2004) |
| "Clonidine is an effective adjunctive agent for the prevention of emergence agitation in children, but evidence in the smallest age groups is sparse We aim to investigate the efficacy and safety of an intraoperative bolus of intravenous clonidine for preventing emergence agitation in children 3-12 months of age." | 3.30 | Clonidine for preventing emergence agitation in infants (PREVENT AGITATION II): Protocol and statistical analysis plan. ( Afshari, A; Falcon, L; Garioud, ALB; Mondrup, F; Nielsen, BN, 2023) |
| "Clonidine has proven to be effective in reducing the incidence of post-operative agitation at a higher dose (3 and 2 μg kg⁻¹)." | 2.76 | Efficacy of low-dose caudal clonidine in reduction of sevoflurane-induced agitation in children undergoing urogenital and lower limb surgery: a prospective randomised double-blind study. ( Agarwala, RB; Ghosh, SM; Pandey, M; Vajifdar, H, 2011) |
| "Sevoflurane anaesthesia was administered via a facemask (O2/N2O: 40/60)." | 2.73 | Oral clonidine vs midazolam in the prevention of sevoflurane-induced agitation in children. a prospective, randomized, controlled trial. ( De Groote, F; De Hert, S; De Villé, A; Dierick, A; Tazeroualti, N; Van der Linden, P, 2007) |
| "Akathisia is also a rare cause of psychomotor agitation in patients with traumatic brain injury (TBI)." | 2.48 | Akathisia--rare cause of psychomotor agitation in patients with traumatic brain injury: case report and review of literature. ( Ribbers, GM; Wielenga-Boiten, JE, 2012) |
| "Whether the additional PTSD and functional neurologic deficits were due to a direct effect of the lightning strike on the central nervous system or a secondary response is open to speculation." | 1.39 | Central hyperadrenergic state after lightning strike. ( Ahlskog, JE; Craft, JM; Gelfman, R; Kantor, B; Low, PA; Parsaik, AK; Seime, RJ; Sheldon, SH; Singer, W; Staab, JP, 2013) |
| "Two cases of tardive akathisia, which were misdiagnosed as anxiety originating from a schizophrenic disorder, had been treated with anxiolytics in addition to neuroleptics and anticholinergics." | 1.28 | Treatment of tardive akathisia with clonidine. ( Koga, I; Nishikawa, T; Tanaka, M; Uchida, Y, 1990) |
| "Six patients with akathisia were treated with clonidine in an open, on-drug/off-drug trial." | 1.27 | Use of clonidine in treating neuroleptic-induced akathisia. ( Cohen, BM; Jonas, JM; Lipinski, JF; Zubenko, GS, 1984) |
| "One patient's akathisia also appeared to respond to clonidine." | 1.27 | Clonidine in the treatment of mania and mixed bipolar disorder. ( Cohen, BM; Jonas, JM; Lipinski, JF; Zubenko, GS, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (19.05) | 18.7374 |
| 1990's | 2 (4.76) | 18.2507 |
| 2000's | 16 (38.10) | 29.6817 |
| 2010's | 15 (35.71) | 24.3611 |
| 2020's | 1 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Garioud, ALB | 1 |
| Nielsen, BN | 2 |
| Falcon, L | 1 |
| Mondrup, F | 1 |
| Afshari, A | 2 |
| Ydemann, M | 1 |
| Henneberg, S | 1 |
| Jakobsen, JC | 1 |
| Wetterslev, J | 1 |
| Lauritsen, T | 1 |
| Steen, N | 1 |
| Edstrøm, B | 1 |
| Engelhardt, T | 2 |
| Lauder, GR | 1 |
| Tan, D | 1 |
| Xia, H | 1 |
| Sun, S | 1 |
| Wang, F | 1 |
| Wielenga-Boiten, JE | 1 |
| Ribbers, GM | 1 |
| Parsaik, AK | 1 |
| Ahlskog, JE | 1 |
| Singer, W | 1 |
| Gelfman, R | 1 |
| Sheldon, SH | 1 |
| Seime, RJ | 1 |
| Craft, JM | 1 |
| Staab, JP | 1 |
| Kantor, B | 1 |
| Low, PA | 1 |
| Bortone, L | 2 |
| Bertolizio, G | 1 |
| Frawley, G | 2 |
| Somaini, M | 1 |
| Ingelmo, PM | 2 |
| Stucke, AG | 1 |
| Weisman, SJ | 1 |
| Bada, HS | 1 |
| Sithisarn, T | 1 |
| Gibson, J | 1 |
| Garlitz, K | 1 |
| Caldwell, R | 1 |
| Capilouto, G | 1 |
| Li, Y | 1 |
| Leggas, M | 1 |
| Breheny, P | 1 |
| Naguy, A | 1 |
| Dahmani, S | 1 |
| Brasher, C | 1 |
| Stany, I | 1 |
| Golmard, J | 1 |
| Skhiri, A | 1 |
| Bruneau, B | 1 |
| Nivoche, Y | 1 |
| Constant, I | 2 |
| Murat, I | 2 |
| Ghai, B | 1 |
| Ram, J | 1 |
| Chauhan, S | 1 |
| Wig, J | 1 |
| Ghosh, SM | 1 |
| Agarwala, RB | 1 |
| Pandey, M | 1 |
| Vajifdar, H | 1 |
| Jöhr, M | 1 |
| Calligaris, L | 1 |
| Vidoni, A | 1 |
| Bruno, I | 1 |
| Vidoni, M | 1 |
| Barbi, E | 1 |
| Vanderschuren, LJ | 1 |
| Beemster, P | 1 |
| Schoffelmeer, AN | 1 |
| Yaksh, TL | 1 |
| Horais, KA | 1 |
| Tozier, NA | 1 |
| Allen, JW | 1 |
| Rathbun, M | 1 |
| Rossi, SS | 1 |
| Sommer, C | 1 |
| Meschter, C | 1 |
| Richter, PJ | 1 |
| Hildebrand, KR | 1 |
| Leport, Y | 1 |
| Richard, P | 1 |
| Moutard, ML | 1 |
| Dobrydnjov, I | 1 |
| Axelsson, K | 1 |
| Berggren, L | 1 |
| Samarütel, J | 1 |
| Holmström, B | 1 |
| Herrmann, N | 1 |
| Lanctôt, KL | 1 |
| Eryavec, G | 1 |
| Khan, LR | 1 |
| Cummings, MR | 1 |
| Miller, BD | 1 |
| Tesoro, S | 1 |
| Mezzetti, D | 1 |
| Marchesini, L | 1 |
| Peduto, VA | 1 |
| Bordes, M | 1 |
| Cros, AM | 1 |
| Lankinen, U | 1 |
| Avela, R | 1 |
| Tarkkila, P | 1 |
| Kratochvil, CJ | 1 |
| Varley, C | 1 |
| Cummins, TK | 1 |
| Martin, A | 1 |
| Malviya, S | 2 |
| Voepel-Lewis, T | 1 |
| Ramamurthi, RJ | 1 |
| Burke, C | 1 |
| Tait, AR | 1 |
| Tazeroualti, N | 1 |
| De Groote, F | 1 |
| De Hert, S | 1 |
| De Villé, A | 1 |
| Dierick, A | 1 |
| Van der Linden, P | 1 |
| Sathishkumar, S | 1 |
| Dorje, P | 1 |
| Wrench, I | 1 |
| Zubenko, GS | 2 |
| Cohen, BM | 2 |
| Lipinski, JF | 2 |
| Jonas, JM | 2 |
| Kulka, PJ | 1 |
| Bressem, M | 1 |
| Tryba, M | 1 |
| Mikawa, K | 1 |
| Nishina, K | 1 |
| Shiga, M | 1 |
| Sachdev, P | 1 |
| Chee, KY | 1 |
| Nishikawa, T | 1 |
| Koga, I | 1 |
| Uchida, Y | 1 |
| Tanaka, M | 1 |
| Sandyk, R | 1 |
| Adler, LA | 1 |
| Angrist, B | 2 |
| Peselow, E | 2 |
| Reitano, J | 1 |
| Rotrosen, J | 2 |
| Adler, L | 1 |
| Corwin, J | 1 |
| Khot, V | 1 |
| Goodwin, J | 1 |
| Wandry, G | 1 |
| Cerri, C | 1 |
| Cocco, E | 1 |
| Rovati, L | 1 |
| Roehrich, H | 1 |
| Gold, MS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does Intraoperative Clonidine Reduce Post Operative Agitation in Children Anaesthetised With Sevoflurane? A RCT Including Pharmacokinetic Investigation.[NCT02361476] | Phase 4 | 379 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Clonidine for Tourniquet-related Pain in Children: A Pilot Study[NCT04564430] | Phase 4 | 20 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| Non-Opiate Treatment After Prenatal Opiate Exposure to Prevent Postnatal Injury to the Young Brain[NCT03396588] | Phase 3 | 120 participants (Actual) | Interventional | 2017-12-07 | Active, not recruiting | ||
| Pharmacological Treatment of Neonatal Abstinence Syndrome: Opiate Versus Non-Opiate[NCT01734551] | Phase 4 | 31 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| Use of Intraoperative Clonidine for Prevention of Postoperative Agitation in Pedriatic Anesthesia With Sevoflurane.[NCT02181543] | Phase 3 | 30 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| ROPIVACAINE WITH CLONIDINE FOR PEDIATRIC RECTUS SHEATH BLOCKS- THE MAGIC COMBINATION? - A Double Blinded Prospective Study[NCT02439281] | 50 participants (Actual) | Interventional | 2015-05-31 | Terminated (stopped due to The patients were discharged on the day of the surgery.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Amount used (NCT02361476)
Timeframe: Recorded during the stay in the postoperative recovery room
| Intervention | mg morphine equivalents (Mean) |
|---|---|
| Intervention | 0.46 |
| Placebo | 0.7 |
Time to administration (NCT02361476)
Timeframe: recovery room
| Intervention | MEDIAN time (min) to administration (Median) |
|---|---|
| Intervention | 105 |
| Placebo | 60 |
"Pain score used:~FLACC score = Face, Legs, Activity, Cry, Consolability Score ranges from 0 to 10 (severity increases with increasing score) Pain is FLACC score more than 3" (NCT02361476)
Timeframe: recovery room - hours
| Intervention | Pain Score (Mean) |
|---|---|
| Intervention | 1.57 |
| Placebo | 2.45 |
Measured by Watchae Scale (score 1-4), scores 1-2 = no agitation and scores 3-4 = agitated (NCT02361476)
Timeframe: 1 day
| Intervention | participants with agitation (Number) |
|---|---|
| Intervention | 46 |
| Placebo | 86 |
(NCT02361476)
Timeframe: from intervention to discharge from the recovery room
| Intervention | participants (Number) | ||
|---|---|---|---|
| adverse events | serious adverse events | Treated for low blood pressure | |
| Intervention | 0 | 2 | 0 |
| Placebo | 5 | 2 | 0 |
Total number days of treatment (NCT01734551)
Timeframe: 120 days
| Intervention | days (Median) |
|---|---|
| Morphine | 39 |
| Clonidine | 27 |
Scores obtained Bayley Scales of Infant and Toddler Development Third Edition in the developmental domains of motor, cognitive, and language. This tool for measures of motor, cognitive and language development is a series of standardized measurements and for each domain, the standardized scores have a mean of 100 and standard deviation of 15. Scores below 1 standard deviation (= or less than 84) is considered below normal. Scores above 1 standard deviation (over 115) represent higher than normal functioning in each domain The score for each domain (motor, cognitive, and language functioning) represents the full-scale score (NCT01734551)
Timeframe: 1 year of life
| Intervention | scores on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Bayley III motor | Cognitive | Language total | Language Receptive | Language Expressive | |
| Clonidine | 95.8 | 93.3 | 95.8 | 95.0 | 99.2 |
| Morphine | 97.6 | 92.9 | 98.0 | 101.1 | 100.0 |
Mean of total Finnegan Scores obtained every 3 hours on days 2, 7, and 14 following start of treatment; A score is a number representing the total score or sum from 21 items or symptoms or manifestations of opiate withdrawal in newborn infants. The total score ranges from 0 to 43. Reference: 1. Finnegan LP, Connaughton JF, Jr., Kron RE, et al. Neonatal abstinence syndrome: assessment and management. Addict Dis 1975;2(1-2):141-58. Although normal newborn may manifest mild symptoms that will give scores in the range of 0 to 7. A score of 8 consecutively obtained times 3 indicate that infant will benefit from treatment, in this study morphine or clonidine. A decrease in scores especially to less than 8 is suggestive of a good response to treatment. (NCT01734551)
Timeframe: 14 days
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Finnegan scores day 2 of treatment | Finnegan scores day 7 of treatment | Finnegan scores day 14 of treatment | |
| Clonidine | 8.5 | 5.7 | 6.7 |
| Morphine | 7.5 | 6.6 | 7.1 |
The summary scores from the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) give a measure of infant neurobehavior in the following areas (score range): habituation (1-9), regulation (2.20-7.50), attention (1.29 -8.4), Handling (0 - 1), quality of movement (1.20 - 6.20), Non-optimal reflexes (0-12), Asymmetric reflexes (0-7), arousal (2.43 - 6.67), hypertonicity (0- 8), hypotonicity (0 - 5.0), excitability (0-11), lethargy (0 - 11.0). and stress/abstinence (0. - 0.57). A higher score for each item means a higher level of the construct. For example, a higher score for hypertonicity means the infant is more hypertonic and higher score on hypotonicity means the infant is more hypotonic. No cut-off score published for normal or abnormal behavioral performance. Reference: Lester BM et al. Summary Statistics of Neonatal Intensive Care Unit Network Neurobehavioral Scale Scores From the Maternal Lifestyle Study: A Quasinormative Sample, in Pediatrics 2004; 113,668. (NCT01734551)
Timeframe: 5-10 days after treatment starts
| Intervention | scores on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Attention | Handling | Quality of movement | Regulation | Non-optimal reflexes | Asymmetric reflexes | Stress/abstinence | Arousal | Hypertonicity | Hypotonicity | Excitability | Lethargy | |
| Clonidine | 4.51 | 0.42 | 4.92 | 5.26 | 4.13 | 0.00 | 0.08 | 3.95 | 0.25 | 0.19 | 2.38 | 5.13 |
| Morphine | 5.06 | 0.36 | 4.77 | 5.2 | 3.73 | 0.20 | 0.07 | 3.91 | 0.40 | 0.13 | 2.6 | 3.6 |
Numeric Rating Pain Scores ( 0-10), will be obtained every 2 hours after PACU discharge up to 18 hours or until hospital discharge, whichever occurs first. The pain score of 0, means no pain, is a good outcome , and a pain score of 10 is excruciating pain, a very bad outcome. The average of these scores will be evaluated.The pain scores will not longer be documented after the numbness went away. (NCT02439281)
Timeframe: Logistic regression of the 4 th pain score assessment
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine Group | 2 |
| Ropivacaine/ Clonidine Group | 1.5 |
The investigators hypothesize that patient postoperative anxiety scores are lower in the Ropivacaine/Clonidine group and postoperative anxiety scores decrease more in Ropivacaine /Clonidine Group, than in Ropivacaine Group. (NCT02439281)
Timeframe: 6 hours after block placement
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine Group | 30 |
| Ropivacaine/ Clonidine Group | 29 |
The investigators expect no difference in incidence of complications (e.g. oversedation, hypotension, bradycardia episodes, etc.). (NCT02439281)
Timeframe: until study completion
| Intervention | Participants (Count of Participants) |
|---|---|
| Ropivacaine/ Clonidine Group | 1 |
| Ropivacaine Group | 1 |
The investigators hypothesize that rectus sheath injections with ropivacaine/ clonidine would result in longer duration of analgesia and decreased pain scores compared to ropivacaine alone. (NCT02439281)
Timeframe: indicated by the first request for pain medication at umbilicus site
| Intervention | minutes (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 230 |
| Ropivacaine Group | 240 |
The investigators hypothesize that rectus sheath injections with ropivacaine and clonidine result in longer duration of sensory block (paresthesia) compared to ropivacaine alone. (NCT02439281)
Timeframe: Indicated by return of normal sensation (expected average of 12 hours after block placement).
| Intervention | minutes (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 823.5 |
| Ropivacaine Group | 540 |
Total intravenous morphine equivalents mg/kg (NCT02439281)
Timeframe: 18 hours after surgery
| Intervention | mg/kg (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 0.20 |
| Ropivacaine Group | 0.22 |
The investigators hypothesize that rectus sheath injections with ropivacaine/ clonidine would result in better satisfaction with pain control. (NCT02439281)
Timeframe: Prior to hospital discharge (up to 24 hours after surgery)
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 9 |
| Ropivacaine Group | 9 |
6 reviews available for clonidine and Agitation, Psychomotor
| Article | Year |
|---|---|
Effect of ancillary drugs on sevoflurane related emergence agitation in children undergoing ophthalmic surgery: a Bayesian network meta-analysis.
Topics: Akathisia, Drug-Induced; Analgesics; Anesthesia Recovery Period; Anesthetics, Inhalation; Bayes Theo | 2019 |
Akathisia--rare cause of psychomotor agitation in patients with traumatic brain injury: case report and review of literature.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Brain Injuries; Clonidine; Female; Humans; Psychomotor | 2012 |
Clonidine Use in Psychiatry: Panacea or Panache.
Topics: Animals; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Clonidine; Humans; Men | 2016 |
Premedication with clonidine is superior to benzodiazepines. A meta analysis of published studies.
Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Benzodiazepines; Child; Child, Preschool; Clo | 2010 |
Pharmacologic management of behavioral instability in medically ill pediatric patients.
Topics: Adolescent; Adrenergic alpha-Agonists; Aggression; Analgesics, Non-Narcotic; Behavior Therapy; Behav | 2004 |
[Inhalation induction with sevoflurane in paediatrics: what is new?].
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Drug Synergism; | 2006 |
16 trials available for clonidine and Agitation, Psychomotor
| Article | Year |
|---|---|
Clonidine for preventing emergence agitation in infants (PREVENT AGITATION II): Protocol and statistical analysis plan.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Child; Clonidine; Double-B | 2023 |
Intraoperative clonidine for prevention of postoperative agitation in children anaesthetised with sevoflurane (PREVENT AGITATION): a randomised, placebo-controlled, double-blind trial.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; D | 2018 |
Intraoperative clonidine for prevention of postoperative agitation in children anaesthetised with sevoflurane (PREVENT AGITATION): a randomised, placebo-controlled, double-blind trial.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; D | 2018 |
Intraoperative clonidine for prevention of postoperative agitation in children anaesthetised with sevoflurane (PREVENT AGITATION): a randomised, placebo-controlled, double-blind trial.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; D | 2018 |
Intraoperative clonidine for prevention of postoperative agitation in children anaesthetised with sevoflurane (PREVENT AGITATION): a randomised, placebo-controlled, double-blind trial.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; D | 2018 |
The effect of fentanyl and clonidine on early postoperative negative behavior in children: a double-blind placebo controlled trial.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Anxiety; Child; Child Behavior; Child, Preschool; Clo | 2014 |
Morphine versus clonidine for neonatal abstinence syndrome.
Topics: Analgesics; Arousal; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administ | 2015 |
Morphine versus clonidine for neonatal abstinence syndrome.
Topics: Analgesics; Arousal; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administ | 2015 |
Morphine versus clonidine for neonatal abstinence syndrome.
Topics: Analgesics; Arousal; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administ | 2015 |
Morphine versus clonidine for neonatal abstinence syndrome.
Topics: Analgesics; Arousal; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administ | 2015 |
Effects of clonidine on recovery after sevoflurane anaesthesia in children undergoing cataract surgery.
Topics: Anesthesia, Inhalation; Blood Pressure; Cataract Extraction; Child; Child, Preschool; Clonidine; Fem | 2010 |
Efficacy of low-dose caudal clonidine in reduction of sevoflurane-induced agitation in children undergoing urogenital and lower limb surgery: a prospective randomised double-blind study.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia, Caudal; Anesthetics, Combined; Anesthetics, Inhala | 2011 |
Agitation and changes of Bispectral Index and electroencephalographic-derived variables during sevoflurane induction in children: clonidine premedication reduces agitation compared with midazolam.
Topics: Adjuvants, Anesthesia; Analgesics; Anesthetics, Inhalation; Central Nervous System; Child; Child, Pr | 2004 |
Intrathecal and oral clonidine as prophylaxis for postoperative alcohol withdrawal syndrome: a randomized double-blinded study.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Aged; Alcoholism; Anesthesia; Central Nervous Syste | 2004 |
Noradrenergic activity is associated with response to pindolol in aggressive Alzheimer's disease patients.
Topics: Administration, Oral; Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Behavioral Symptoms; C | 2004 |
Clonidine treatment for agitation in children after sevoflurane anesthesia.
Topics: Adrenergic alpha-Agonists; Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Humans; Infa | 2005 |
The prevention of emergence agitation with tropisetron or clonidine after sevoflurane anesthesia in small children undergoing adenoidectomy.
Topics: Adenoidectomy; Akathisia, Drug-Induced; Anesthesia, Inhalation; Chi-Square Distribution; Child; Chil | 2006 |
Clonidine for the prevention of emergence agitation in young children: efficacy and recovery profile.
Topics: Adrenergic alpha-Agonists; Anesthesia, General; Anesthetics, Inhalation; Child; Child, Preschool; Cl | 2006 |
Oral clonidine vs midazolam in the prevention of sevoflurane-induced agitation in children. a prospective, randomized, controlled trial.
Topics: Administration, Oral; Analgesics; Anesthesia Recovery Period; Anesthetics, Inhalation; Child; Child, | 2007 |
Clonidine prevents sevoflurane-induced agitation in children.
Topics: Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Clonidine; Double-Blind Method; He | 2001 |
Clonidine prevents sevoflurane-induced agitation in children.
Topics: Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Clonidine; Double-Blind Method; He | 2001 |
Clonidine prevents sevoflurane-induced agitation in children.
Topics: Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Clonidine; Double-Blind Method; He | 2001 |
Clonidine prevents sevoflurane-induced agitation in children.
Topics: Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Clonidine; Double-Blind Method; He | 2001 |
Pharmacological characterization of tardive akathisia.
Topics: Administration, Oral; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Arousal; Atenolol; Benztr | 1990 |
Noradrenergic mechanisms in akathisia: treatment with propranolol and clonidine.
Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Clonidine; Female; Humans; Male; Middle Aged; | 1987 |
20 other studies available for clonidine and Agitation, Psychomotor
| Article | Year |
|---|---|
α-2-receptor agonist use in children: some answers, more questions.
Topics: Adrenergic alpha-Agonists; Child; Clonidine; Double-Blind Method; Evidence-Based Medicine; Humans; M | 2018 |
Central hyperadrenergic state after lightning strike.
Topics: Activities of Daily Living; Adrenergic alpha-Agonists; Anxiety; Arrhythmias, Cardiac; Autonomic Nerv | 2013 |
Can we tell emergence agitation from pain? Comment on Bortone et al.: the effect of fentanyl and clonidine on early postoperative negative behavior in children.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Clonidine; Female; Fentanyl; Humans; Male; Postoperat | 2014 |
We can't tell emergence agitation from pain, yet. Reply to: Stucke and Weisman 'Can we tell emergence agitation from pain?'.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Clonidine; Female; Fentanyl; Humans; Male; Postoperat | 2015 |
Clonidine in paediatric anaesthesia.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia; Anesthetics, Local; Child; Clonidine; Humans; Nerv | 2011 |
Efficacy of clonidine in hyperammonemia induced hyperexcitability syndrome.
Topics: Adrenergic alpha-Agonists; Ammonia; Brain Chemistry; Clonidine; Glucose; Glutamic Acid; Humans; Hype | 2013 |
On the role of noradrenaline in psychostimulant-induced psychomotor activity and sensitization.
Topics: Amphetamine-Related Disorders; Animals; Central Nervous System Stimulants; Clonidine; Cocaine; Cocai | 2003 |
Chronically infused intrathecal morphine in dogs.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Arousal; Behavior, Animal; Blood Pressure; C | 2003 |
Less is more: inpatient management of a child with complex pharmacotherapy.
Topics: Aggression; Amphetamines; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Depressio | 2006 |
Management of emergence agitation.
Topics: Analgesics; Anesthesia Recovery Period; Clonidine; Humans; Postoperative Complications; Psychomotor | 2007 |
Oral clonidine vs midazolam in the prevention of sevoflurane-induced agitation in children.
Topics: Analgesics; Anesthetics, Inhalation; Clonidine; Humans; Methyl Ethers; Postoperative Complications; | 2007 |
Use of clonidine in treating neuroleptic-induced akathisia.
Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Anxiety Disorders; Bipolar D | 1984 |
Clonidine in the treatment of mania and mixed bipolar disorder.
Topics: Adolescent; Adult; Bipolar Disorder; Clonidine; Female; Humans; Male; Psychomotor Agitation | 1984 |
Prevention of sevoflurane-induced agitation with oral clonidine premedication.
Topics: Adrenergic alpha-Agonists; Anesthetics, Inhalation; Child; Child, Preschool; Clonidine; Humans; Meth | 2002 |
Treatment of tardive akathisia with clonidine.
Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Anxiety; Clonidine; Diagnosis, Differential; H | 1990 |
Antimanic effects of clonidine and the endogenous opioid system.
Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Bipolar Disorder; Brain; Clonidine; Endorphins; Human | 1985 |
Clonidine in neuroleptic-induced akathisia.
Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Anxiety; Clonidine; Hospitalization; Humans; M | 1987 |
Time course of effects of clonidine.
Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Clonidine; Dyskinesia, Drug-Induced; Humans; Psychomo | 1987 |
Propranolol and clonidine in detoxification.
Topics: Clonidine; Humans; Lorazepam; Methadone; Opioid-Related Disorders; Propranolol; Psychomotor Agitatio | 1988 |
Propranolol as adjunct to clonidine in opiate detoxification.
Topics: Adult; Clonidine; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Opioid-Related Disor | 1987 |