clonidine has been researched along with Aging in 113 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the pressor and tachycardiac responses to ephedrine in elderly and young patients given either clonidine or midazolam during propofol anesthesia." | 9.10 | The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia. ( Ishiyama, T; Kashimoto, S; Kumazawa, T; Matsukawa, T; Oguchi, T, 2003) |
| "To assess the contribution of sympathetic outflow to blood pressure in patients with essential hypertension, we measured blood pressure and plasma norepinephrine responses to clonidine, an antihypertensive agent that decreases central sympathetic outflow, in 44 patients and in 41 normotensive control subjects of similar age." | 7.67 | Clonidine suppression testing in essential hypertension. ( Goldstein, DS; Keiser, HR; Levinson, PD; Pitterman, A; Stull, R; Zimlichman, R, 1985) |
| "In 139 patients anxiety, sedation and adverse effects were measured at 6 consecutive perioperative time points after administration of midazolam, clonidine or a placebo." | 5.14 | [Quality of premedication and patient satisfaction after premedication with midazolam, clonidine or placebo : Randomized double-blind study with age-adjusted dosage]. ( Ivleva-Sauerborn, A; Seifert, B; Spahn, DR; Zalunardo, MP, 2010) |
| "We studied the pressor and tachycardiac responses to ephedrine in elderly and young patients given either clonidine or midazolam during propofol anesthesia." | 5.10 | The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia. ( Ishiyama, T; Kashimoto, S; Kumazawa, T; Matsukawa, T; Oguchi, T, 2003) |
| "The effects of aging on sympathetic nervous system and adrenomedullary outflow were estimated by the measurement of plasma norepinephrine (NE) and epinephrine (EPI) responses to yohimbine and clonidine in healthy young and healthy older subjects." | 5.09 | Increased plasma norepinephrine response to yohimbine in elderly men. ( Dobie, DJ; Peskind, ER; Petrie, EC; Raskind, MA; Veith, RC, 2000) |
| "In a previous study, we showed that clonidine, an α₂-adrenoceptor agonist, administered prior to hypoxia improves post-hypoxic contractility (PC) and endothelium-dependent dilatation (PED) in isolated young rat aortas." | 3.78 | Ageing influences the effect of pre-hypoxic administration of clonidine, an alpha₂-adrenoceptor agonist, on post-hypoxic vasomotricity. ( De Kock, M; Gourdin, MJ; Jamart, J; Ponchau, O, 2012) |
| "To determine if centrally reducing sympathetic tone with clonidine will reverse the downregulation in the alpha-adrenergic (alphaAR) and beta-adrenergic (betaAR) responses seen with normal aging." | 3.73 | Normal aging impairs upregulation of the beta-adrenergic but not the alpha-adrenergic response: aging and adrenergic upregulation. ( Levy, WC; Madden, KM; Stratton, JR, 2006) |
| "Functional correlates of alpha1-adrenoceptors were studied in thoracic aorta and carotid arteries from Wistar rats, at maturation (3- and 8-week-old) and aging (17- and 29-week-old) phases, using phenylephrine (PHE) and KCl." | 3.70 | Maturation and aging-related differences in responsiveness of rat aorta and carotid arteries to alpha1-adrenoceptor stimulation. ( Campos-Mello, C; Correa, FM; de Oliveira, AM; Leitão, MC, 1998) |
| " In order to investigate further whether the increased sensitivity to inhibition by nifedipine of the responses to noradrenaline of aortae from spontaneously hypertensive stroke-prone (SHRSP) rats is related to the development of the hypertension, we have compared the sensitivity to noradrenaline, potassium chloride (KCl) and nifedipine of aortae from SHRSP and control (Wistar-Kyoto) WKY rats of different age groups (young: 3-5 weeks, and adult: 13-16 weeks)." | 3.69 | The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age. ( Iwanov, V; Jiang, GC; Moulds, RF, 1995) |
| "In the postmortem human brain, the specific binding of the agonists [3H]clonidine and [3H]bromoxidine ([3H]UK14034) and of the antagonist [3H]2-methoxyidazoxan (RX821002) and inhibition by l-epinephrine of [3H]RX821002 binding were determined in parallel to quantify the fractions of high (RH)- and low-affinity (RL) agonist sites of alpha-2A adrenoceptors and to investigate the association of these inhibitory receptors with various regulatory Gi proteins and the effect of aging." | 3.69 | Density of alpha-2A adrenoceptors and Gi proteins in the human brain: ratio of high-affinity agonist sites to antagonist sites and effect of age. ( García-Sevilla, JA; Sastre, M, 1994) |
| "We studied basal serum GH and GH responses to iv clonidine and insulin-induced hypoglycemia in a group of four young (5-7 yr old) and four older (10-14 yr old) adult male rhesus monkeys under two restraint conditions, chair adaptation and a tether and vest system, to determine what changes in GH secretion occur with aging." | 3.68 | Changes in basal and stimulated growth hormone secretion in the aging rhesus monkey: a comparison of chair restraint and tether and vest sampling. ( Barry, S; Schutzengel, RE; Styne, DM; Wheeler, MD, 1990) |
| "To assess the contribution of sympathetic outflow to blood pressure in patients with essential hypertension, we measured blood pressure and plasma norepinephrine responses to clonidine, an antihypertensive agent that decreases central sympathetic outflow, in 44 patients and in 41 normotensive control subjects of similar age." | 3.67 | Clonidine suppression testing in essential hypertension. ( Goldstein, DS; Keiser, HR; Levinson, PD; Pitterman, A; Stull, R; Zimlichman, R, 1985) |
| " The effects of oestrogen treatment and maturation were studied in female rabbits and of aging and amitriptyline treatment in male rabbits." | 3.67 | A comparison of alpha 2-adrenoceptor regulation in brain and platelets. ( Barr, S; Hamilton, CA; Jones, CR; Mishra, N; Reid, JL, 1985) |
| "The effects of Alzheimer's disease (AD) and normal aging on resting CNS adrenergic activity were estimated by measuring cerebrospinal fluid (CSF) epinephrine (EPI) concentrations in 74 persons with AD, 42 cognitively normal healthy older persons, and 54 healthy young persons." | 2.69 | Cerebrospinal fluid epinephrine in Alzheimer's disease and normal aging. ( Brodkin, K; Dobie, DJ; Elrod, R; Jensen, C; Murray, S; Pascualy, M; Peskind, ER; Petrie, E; Raskind, MA; Veith, RC, 1998) |
| "Patients with Korsakoff's disease, attention deficit disorder or schizophrenia may benefit from treatment with alpha 2-agents." | 2.39 | Pharmacological manipulations of the alpha 2-noradrenergic system. Effects on cognition. ( Coull, JT, 1994) |
| " The pharmacokinetic analysis was conducted by nonlinear mixed effect modelling, which enables to establish the separate influences of determinants on drug blood level and to provide individualized dosing." | 1.46 | Population pharmacokinetics of intravenous clonidine for sedation during paediatric extracorporeal membrane oxygenation and continuous venovenous hemofiltration. ( Ahsman, MJ; de Wildt, SN; Kleiber, N; Mathôt, RAA; Tibboel, D; Wildschut, ED, 2017) |
| "Age and hypertension are two major determinants of arterial stiffness, as well as endothelial dysfunction." | 1.38 | Chronic reduction of nitric oxide level in adult spontaneously hypertensive rats induces aortic stiffness similar to old spontaneously hypertensive rats. ( Clavreul, N; Isabelle, M; Ragonnet, C; Sansilvestri-Morel, P; Simonet, S; Vayssettes-Courchay, C; Verbeuren, TJ, 2012) |
| "Clonidine treatment had no evident effects on caspase-3 mRNA level and DNA fragmentation in the cortex of an 8-day-old rat." | 1.32 | Clonidine increases caspase-3 mRNA level and DNA fragmentation in the developing rat brainstem. ( Bannova, AV; Dygalo, NN; Kalinina, TS; Shishkina, GT, 2004) |
| "Clonidine (5 mg/kg) was ineffective at all ages." | 1.30 | Reproductive behavioral responsiveness to noradrenergic stimulation in developing guinea pigs. ( Olster, DH, 1998) |
| "clonidine at lower doses (2 and 5 micrograms) but not higher doses (10 and 20 micrograms) was observed." | 1.30 | Age-related decrease in centrally-mediated pressor response to clonidine in conscious rats. ( Araki, H; Futagami, K; Gomita, Y; Kawasaki, H, 1998) |
| "Memory deficits were induced by the muscarinic cholinoceptor antagonist scopolamine (in young and old rats and mice), by the alpha 2-adrenoceptor agonist clonidine, by electroconvulsive shock, and by hypoxy." | 1.29 | Effects of cytidine diphosphate choline on rats with memory deficits. ( Getova, D; Kehayov, RA; Lazarova, MB; Mosharrof, AH; Petkov, VD; Petkov, VV; Vaglenova, J, 1993) |
| "Pretreatment with clonidine (100 micrograms/kg, i." | 1.29 | 6-Hydroxydopamine treatment of neonatal rats. II. Effects on the development of the hindlimb flexor reflex. ( Jones, DJ; Simmons, KE, 1993) |
| "Clonidine is a clinically used antihypertensive which has been suggested to produce physiological changes in children after exposure in utero." | 1.28 | Early postnatal clonidine treatment results in altered regional catecholamine utilisation in adult rat brain. ( Boer, GJ; Feenstra, MG; van Galen, H, 1992) |
| "The clonidine response was blocked by alpha-2, but not alpha-1 antagonists, and appeared to result from actions at postsynaptic alpha-2 receptors in that area of cortex most critical for spatial working memory, the principal sulcal cortex." | 1.27 | Noradrenergic mechanisms in age-related cognitive decline. ( Arnsten, AF; Goldman-Rakic, PS, 1987) |
| " Independent groups of pups from dams given either 6% or 25% casein diets received one of five doses of clonidine at 5, 10, 15, 20 or 25 days of age and dose-response relationships for motor activity were determined." | 1.27 | Altered development of responsiveness to clonidine in severely malnourished rats. ( Goodlett, CR; Morgane, PJ; Resnick, O; Valentino, ML, 1985) |
| "The 5-hydroxytryptophan-induced rise was prevented by the serotonergic antagonist cyproheptadine but not by the dopaminergic antagonist haloperidol." | 1.26 | Maturation of central nervous system control of growth hormone secretion in rats. ( Kuhn, CM; Schanberg, SM, 1981) |
| " Observed on four drug-induced behavior categories, it was found that both clonidine and propranolol attenuated the toxic effects of relatively low dose levels of digitoxin, while at higher digitoxin dose levels only propranolol was able to reduce significantly the ED50 and the LD50." | 1.26 | Effect of age, clonidine or propranolol on behavioral toxicity induced with digitoxin in mice. ( Felleman, VH; Palfai, T, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (38.05) | 18.7374 |
| 1990's | 47 (41.59) | 18.2507 |
| 2000's | 17 (15.04) | 29.6817 |
| 2010's | 6 (5.31) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, CJ | 1 |
| Zhou, M | 1 |
| Li, HG | 1 |
| Lv, Q | 1 |
| Xu, XL | 1 |
| Guo, LJ | 1 |
| Kleiber, N | 1 |
| Mathôt, RAA | 1 |
| Ahsman, MJ | 1 |
| Wildschut, ED | 1 |
| Tibboel, D | 1 |
| de Wildt, SN | 1 |
| Hirono, M | 1 |
| Matsunaga, W | 1 |
| Chimura, T | 1 |
| Obata, K | 1 |
| Zalunardo, MP | 1 |
| Ivleva-Sauerborn, A | 1 |
| Seifert, B | 1 |
| Spahn, DR | 1 |
| Delorey, DS | 1 |
| Clifford, PS | 1 |
| Mittelstadt, S | 1 |
| Anton, MM | 1 |
| Kluess, HA | 1 |
| Tune, JD | 1 |
| Dincer, UD | 1 |
| Buckwalter, JB | 1 |
| Isabelle, M | 1 |
| Simonet, S | 1 |
| Ragonnet, C | 1 |
| Sansilvestri-Morel, P | 1 |
| Clavreul, N | 1 |
| Vayssettes-Courchay, C | 1 |
| Verbeuren, TJ | 1 |
| Gourdin, MJ | 1 |
| Ponchau, O | 1 |
| Jamart, J | 1 |
| De Kock, M | 1 |
| Ishiyama, T | 1 |
| Kashimoto, S | 1 |
| Oguchi, T | 1 |
| Matsukawa, T | 1 |
| Kumazawa, T | 1 |
| Eikelis, N | 1 |
| Schlaich, M | 1 |
| Aggarwal, A | 1 |
| Kaye, D | 1 |
| Esler, M | 1 |
| Shirokawa, T | 1 |
| Ishida, Y | 1 |
| Isobe, K | 1 |
| Coleman, K | 1 |
| Dahl, RE | 1 |
| Ryan, ND | 1 |
| Cameron, JL | 1 |
| Collier, TJ | 1 |
| Greene, JG | 1 |
| Felten, DL | 1 |
| Stevens, SY | 1 |
| Collier, KS | 1 |
| Dygalo, NN | 2 |
| Bannova, AV | 1 |
| Kalinina, TS | 1 |
| Shishkina, GT | 1 |
| Li, Y | 1 |
| van den Pol, AN | 1 |
| Moore, TL | 1 |
| Schettler, SP | 1 |
| Killiany, RJ | 1 |
| Herndon, JG | 1 |
| Luebke, JI | 1 |
| Moss, MB | 1 |
| Rosene, DL | 1 |
| Dinenno, FA | 1 |
| Masuki, S | 1 |
| Joyner, MJ | 1 |
| Akbas, M | 1 |
| Akbas, H | 1 |
| Yegin, A | 1 |
| Sahin, N | 1 |
| Titiz, TA | 1 |
| Madden, KM | 1 |
| Levy, WC | 1 |
| Stratton, JR | 1 |
| Kotecha, A | 1 |
| Elsheikh, A | 1 |
| Roberts, CR | 1 |
| Zhu, H | 1 |
| Garway-Heath, DF | 1 |
| Bruck, H | 1 |
| Schwerdtfeger, T | 1 |
| Toliat, M | 1 |
| Leineweber, K | 1 |
| Heusch, G | 1 |
| Philipp, T | 1 |
| Nürnberg, P | 1 |
| Brodde, OE | 2 |
| Hamilton, CA | 2 |
| Howe, CA | 1 |
| Reid, JL | 2 |
| Sonntag, WE | 1 |
| Forman, LJ | 1 |
| Miki, N | 1 |
| Steger, RW | 1 |
| Ramos, T | 1 |
| Arimura, A | 1 |
| Meites, J | 1 |
| Dausse, JP | 2 |
| Le Quan-Bui, KH | 1 |
| Meyer, P | 2 |
| Nomura, Y | 6 |
| Oki, K | 1 |
| Segawa, T | 4 |
| Morris, MJ | 1 |
| Devynck, MA | 1 |
| Cantor, EH | 1 |
| Abraham, S | 1 |
| Spector, S | 1 |
| Estes, KS | 1 |
| Simpkins, JW | 1 |
| Lai, R | 1 |
| Watanabe, Y | 1 |
| Yoshida, H | 1 |
| Kawai, M | 4 |
| Mita, K | 1 |
| Gil-Ad, I | 1 |
| Gurewitz, R | 1 |
| Marcovici, O | 1 |
| Rosenfeld, J | 1 |
| Laron, Z | 1 |
| Sakaue, T | 1 |
| Watanabe, C | 1 |
| Shapiro, AK | 1 |
| Shapiro, E | 1 |
| Kuhn, CM | 2 |
| Schanberg, SM | 1 |
| Chan, SH | 1 |
| Lai, YY | 1 |
| Palfai, T | 1 |
| Felleman, VH | 1 |
| Iushkova, AA | 1 |
| Moriyama, N | 1 |
| Kurimoto, S | 1 |
| Inagaki, O | 1 |
| Takanashi, M | 1 |
| Hamada, K | 1 |
| Kawabe, K | 1 |
| Peskind, ER | 5 |
| Wingerson, D | 1 |
| Murray, S | 2 |
| Pascualy, M | 2 |
| Dobie, DJ | 3 |
| Le Corre, P | 1 |
| Le Verge, R | 1 |
| Veith, RC | 5 |
| Raskind, MA | 5 |
| Tanaka, H | 1 |
| Manita, S | 1 |
| Matsuda, T | 1 |
| Adachi, M | 1 |
| Shigenobu, K | 1 |
| Jiang, GC | 1 |
| Iwanov, V | 1 |
| Moulds, RF | 1 |
| Gurdal, H | 1 |
| Cai, G | 1 |
| Johnson, MD | 1 |
| Gascón, S | 1 |
| Dierssen, M | 1 |
| Màrmol, F | 1 |
| Vivas, NM | 1 |
| Badia, A | 1 |
| Sastre, M | 1 |
| García-Sevilla, JA | 1 |
| De Gennaro Colonna, V | 1 |
| Cella, SG | 3 |
| Parenti, M | 1 |
| Locatelli, V | 2 |
| Cocchi, D | 1 |
| Müller, EE | 3 |
| Coull, JT | 1 |
| Petkov, VD | 1 |
| Kehayov, RA | 1 |
| Mosharrof, AH | 1 |
| Petkov, VV | 1 |
| Getova, D | 1 |
| Lazarova, MB | 1 |
| Vaglenova, J | 1 |
| de Avellar, MC | 1 |
| Markus, RP | 1 |
| Arce, VM | 1 |
| Pieretti, F | 1 |
| Settembrini, BP | 1 |
| Simmons, KE | 1 |
| Jones, DJ | 1 |
| Flügge, G | 1 |
| Brandt, S | 1 |
| Fuchs, E | 1 |
| Regunathan, S | 1 |
| Nassir, Y | 1 |
| Sundaram, K | 1 |
| Vaughan, ED | 1 |
| Reis, DJ | 1 |
| Felsen, D | 1 |
| Docherty, JR | 2 |
| Vahl, N | 1 |
| Jørgensen, JO | 1 |
| Jurik, AG | 1 |
| Christiansen, JS | 1 |
| Ibarra, M | 1 |
| Terrón, JA | 1 |
| López-Guerrero, JJ | 1 |
| Villalobos-Molina, R | 2 |
| Riekkinen, M | 1 |
| Kemppainen, S | 1 |
| Riekkinen, P | 1 |
| Juul, A | 1 |
| Holm, K | 1 |
| Kastrup, KW | 1 |
| Pedersen, SA | 1 |
| Michaelsen, KF | 1 |
| Scheike, T | 1 |
| Rasmussen, S | 1 |
| Müller, J | 1 |
| Skakkebaek, NE | 1 |
| Arnsten, AF | 4 |
| Steere, JC | 1 |
| Jentsch, DJ | 1 |
| Li, BM | 1 |
| Olster, DH | 1 |
| Kawasaki, H | 1 |
| Araki, H | 1 |
| Futagami, K | 1 |
| Gomita, Y | 1 |
| de Oliveira, AM | 1 |
| Campos-Mello, C | 1 |
| Leitão, MC | 1 |
| Correa, FM | 1 |
| Elrod, R | 1 |
| Petrie, E | 1 |
| Jensen, C | 1 |
| Brodkin, K | 1 |
| Holmes, C | 1 |
| Goldstein, DS | 3 |
| Yoshioka, S | 1 |
| Mitani, H | 1 |
| Maeda, K | 1 |
| Takeo, S | 1 |
| Matsuda, K | 1 |
| Katayama, S | 1 |
| Mizukawa, R | 1 |
| Kawahara, R | 1 |
| Thomas, AJ | 1 |
| Erokwu, BO | 1 |
| Yamamoto, BK | 1 |
| Ernsberger, P | 1 |
| Bishara, O | 1 |
| Strohl, KP | 1 |
| Petrie, EC | 1 |
| Alpern, HP | 1 |
| Greer, CA | 1 |
| Nisticò, G | 4 |
| De Sarro, GB | 3 |
| Bagetta, G | 2 |
| Mollace, V | 3 |
| Feenstra, MG | 1 |
| van Galen, H | 1 |
| Boer, GJ | 1 |
| Miyamoto, A | 1 |
| Kowatch, MA | 1 |
| Roth, GS | 1 |
| Contant, TA | 1 |
| Bernasconi, S | 1 |
| Volta, C | 1 |
| Cozzini, A | 1 |
| Ziveri, M | 1 |
| Ghizzoni, L | 1 |
| Panza, C | 1 |
| Ghigo, E | 2 |
| Rossolini, G | 1 |
| Viticchi, C | 1 |
| Basso, A | 1 |
| Zaia, A | 1 |
| Piantanelli, L | 1 |
| Takayanagi, I | 2 |
| Kawano, K | 1 |
| Koike, K | 2 |
| Yoshida, M | 1 |
| Latifpour, J | 1 |
| Nishimoto, T | 1 |
| Weiss, RM | 1 |
| Khoreva, SA | 1 |
| Vasil'ev, NV | 1 |
| Pascual, J | 1 |
| del Arco, C | 1 |
| González, AM | 1 |
| Díaz, A | 1 |
| del Olmo, E | 1 |
| Pazos, A | 1 |
| Jackson, WJ | 1 |
| Buccafusco, JJ | 1 |
| Sartin, JL | 1 |
| Kemppainen, RJ | 1 |
| Cummins, KA | 1 |
| Marple, DN | 1 |
| Williams, JC | 1 |
| Arce, V | 1 |
| Loche, S | 1 |
| Devesa, J | 1 |
| Tanaka, E | 2 |
| Nistico', G | 1 |
| Habu, T | 1 |
| Letić-Gavrilović, A | 1 |
| Abe, K | 1 |
| Wheeler, MD | 1 |
| Schutzengel, RE | 1 |
| Barry, S | 1 |
| Styne, DM | 1 |
| Dunnett, SB | 1 |
| Martel, FL | 1 |
| Flood, JF | 1 |
| Morley, JE | 1 |
| Masuda, Y | 1 |
| Pelaggi, T | 1 |
| Brunello, N | 1 |
| Riva, M | 1 |
| Rovescalli, AC | 1 |
| Galimberti, R | 1 |
| Racagni, G | 1 |
| Florini, JR | 1 |
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| McNamara, JP | 1 |
| Goldman-Rakic, PS | 2 |
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| Ascioti, C | 1 |
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| Hård, E | 1 |
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| Lindh, AS | 1 |
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| Featherstone, JA | 1 |
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| Ignar, DM | 1 |
| Linville, DG | 1 |
| Spear, LP | 1 |
| Beard, JC | 1 |
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| Tesolin, B | 1 |
| Shvaloff, A | 1 |
| Le Roch, K | 1 |
| Berthaux, P | 1 |
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| Cruse, RP | 1 |
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| Zimlichman, R | 2 |
| Stull, R | 2 |
| Folio, CJ | 1 |
| Keiser, HR | 2 |
| Smythe, JW | 1 |
| Pappas, BA | 1 |
| Levinson, PD | 1 |
| Pitterman, A | 1 |
| Hyland, L | 1 |
| Jones, CR | 1 |
| Mishra, N | 1 |
| Barr, S | 1 |
| Goodlett, CR | 1 |
| Valentino, ML | 1 |
| Resnick, O | 1 |
| Morgane, PJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Premedication by Midazolam on Preoperative Anxiety for Emergency Surgery[NCT02213302] | Phase 4 | 59 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Central Corneal Thickness and 24-hour Fluctuation of Intraocular Pressure[NCT00941525] | Phase 4 | 174 participants (Actual) | Interventional | 2009-09-30 | Completed | ||
| Prazosin for Disruptive Agitation in Alzheimer's Disease (AD) (PEACE-AD)[NCT03710642] | Phase 2 | 35 participants (Actual) | Interventional | 2018-10-23 | Completed | ||
| Effects of Growth Hormone and IGF-1 on Anabolic Signals and Stem Cell Recruitment in Human Skeletal Muscle[NCT03878992] | 12 participants (Anticipated) | Interventional | 2019-04-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The ADCS-ADL-Severe questionnaire is a secondary outcome measure aimed at detecting functional decline in people with severe AD. This scale is best suited for evaluating people with MMSE scores below 15/30, or equivalent. Questions are administered to a qualified caregiver informant about a set of 19 basic and instrumental ADL. Instrumental ADL are selected to be relevant to this level of severity of dementia, e.g., obtaining a beverage, turning lights on and off, turning a faucet on and off. Performance of each of these activities during the past 4 weeks, as well as the level of performance, are rated. A total score is derived by summing scores across items, and ranges from 0 (maximal impairment) to 54 (maximally independent function).~This outcome is the change from baseline to week 12." (NCT03710642)
Timeframe: 12 weeks
| Intervention | score on a scale (Least Squares Mean) |
|---|---|
| Treatment (Prazosin) | -1.47055 |
| Placebo Oral Capsule | -4.53993 |
"The ADCS-CGIC-A is the primary outcome measure. It will be anchored to disruptive agitation, the target behaviors in this study. It measures whether the effects of active treatment are substantial enough to be detected by a skilled and experienced clinician on the basis of a direct examination of the participant and an interview of the participant's primary caregiver and other LTC facility staff. The baseline assessment is qualitative therefore there is no score at baseline; post-baseline scores represent a change score compared to baseline.~The ADCS-CGIC-A is a 7-point scale that is structured as the clinician's assessment of change from baseline compared to the ADCS-CGIC-A Baseline Worksheet. There is no baseline score; post-baseline scores range from 1 (improvement) to 7 (worsening). A score of 1-2 indicates clinically meaningful improvement; a score of 3-5 indicates no clinically meaningful change; a score of 6-7 indicates clinically meaningful worsening." (NCT03710642)
Timeframe: From Baseline through Week 12.
| Intervention | score on a scale (Least Squares Mean) |
|---|---|
| Treatment (Prazosin) | 3.434 |
| Placebo Oral Capsule | 3.442 |
"Comparison of effects on caregiver distress/occupational disruptiveness scores on the NPI/NPI-NH. Minimum score is 0 and maximum score is 60. A higher score is a worse outcome.~This outcome is the change from baseline to week 12." (NCT03710642)
Timeframe: 12 weeks
| Intervention | score on a scale (Least Squares Mean) |
|---|---|
| Treatment (Prazosin) | -2.4438 |
| Placebo Oral Capsule | 0.9446 |
"The NPI was designed to characterize the neuropsychiatric symptoms and psychopathology of patients with AD and other dementias residing in the community about which information was obtained from family caregivers. The content of the questions and their scoring in the NPI-NH are identical to those of the NPI except for some slight rephrasing to be consistent with the LTC environment where information is gathered from professional caregivers. Assessment of the impact of behavioral disturbances on family and professional caregivers, is assessed by a caregiver distress scale in the NPI and an occupational disruptiveness scale in the NPI-NH; scoring of this component remains identical. Minimum score is 0 and highest score is 144. A higher score means a worse outcome.~This outcome is the change from baseline to week 12." (NCT03710642)
Timeframe: 12 weeks
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Treatment (Prazosin) | -6.033 |
| Placebo Oral Capsule | 5.506 |
Cumulative total dose of Lorazepam rescue medication administered during the trial. Information on the total mg rescue lorazepam administered will be collected as additional secondary outcome measures. If prazosin is more effective than placebo, it is predicted that participants randomized to prazosin will be prescribed lower cumulative mg of rescue lorazepam for management of persistent or worsening disruptive agitation. (NCT03710642)
Timeframe: 12 weeks
| Intervention | mg (Mean) |
|---|---|
| Treatment (Prazosin) | 0.25 |
| Placebo Oral Capsule | 0.14 |
Comparison of proportions of responders versus non responders on the ADCS-CGIC-A. Responders are defined as those with moderate or marked improvement in agitation symptoms compared to baseline assessment. (NCT03710642)
Timeframe: 12 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment (Prazosin) | 7 |
| Placebo Oral Capsule | 1 |
Cox proportional hazard modelling comparing the median time to drop out between treatment groups. (NCT03710642)
Timeframe: 12 weeks
| Intervention | days (Median) |
|---|---|
| Treatment (Prazosin) | 65.63 |
| Placebo Oral Capsule | 54.62 |
1 review available for clonidine and Aging
| Article | Year |
|---|---|
Pharmacological manipulations of the alpha 2-noradrenergic system. Effects on cognition.
Topics: Aging; Alcohol Amnestic Disorder; Animals; Attention Deficit Disorder with Hyperactivity; Brain; Clo | 1994 |
8 trials available for clonidine and Aging
| Article | Year |
|---|---|
[Quality of premedication and patient satisfaction after premedication with midazolam, clonidine or placebo : Randomized double-blind study with age-adjusted dosage].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aging; Anesthesia; Anxiety; Blood Gas Analysis; | 2010 |
The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adult; Aged; Aging; Anesthesia, Intravenous; Anest | 2003 |
Interactions between leptin and the human sympathetic nervous system.
Topics: Adult; Aging; Antihypertensive Agents; Autonomic Nervous System Diseases; Clonidine; Epinephrine; Fe | 2003 |
Impaired modulation of sympathetic alpha-adrenergic vasoconstriction in contracting forearm muscle of ageing men.
Topics: Adenosine; Adrenergic alpha-Agonists; Adult; Aged; Aging; Clonidine; Forearm; Hand Strength; Humans; | 2005 |
Comparison of the effects of clonidine and ketamine added to ropivacaine on stress hormone levels and the duration of caudal analgesia.
Topics: Adjuvants, Anesthesia; Aging; Amides; Anesthesia, Caudal; Anesthetics, Dissociative; Anesthetics, Lo | 2005 |
Effects of Alzheimer's disease and normal aging on cerebrospinal fluid norepinephrine responses to yohimbine and clonidine.
Topics: Adult; Aged; Aging; Alzheimer Disease; Ambulatory Care; Analysis of Variance; Blood Pressure; Clonid | 1995 |
Cerebrospinal fluid epinephrine in Alzheimer's disease and normal aging.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Aging; Alzheimer Disease; Bloo | 1998 |
Increased plasma norepinephrine response to yohimbine in elderly men.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Aging; Blood Pressure; Clonidi | 2000 |
104 other studies available for clonidine and Aging
| Article | Year |
|---|---|
Clonidine suppresses the induction of long-term potentiation by inhibiting HCN channels at the Schaffer collateral-CA1 synapse in anesthetized adult rats.
Topics: Aging; Anesthesia; Animals; Blood Pressure; CA1 Region, Hippocampal; Cells, Cultured; Clonidine; Glu | 2013 |
Population pharmacokinetics of intravenous clonidine for sedation during paediatric extracorporeal membrane oxygenation and continuous venovenous hemofiltration.
Topics: Adolescent; Aging; Child; Child, Preschool; Clonidine; Computer Simulation; Disease Progression; Ext | 2017 |
Developmental enhancement of alpha2-adrenoceptor-mediated suppression of inhibitory synaptic transmission onto mouse cerebellar Purkinje cells.
Topics: Action Potentials; Adrenergic alpha-Agonists; Aging; Animals; Animals, Newborn; Cell Differentiation | 2008 |
The effect of aging on adrenergic and nonadrenergic receptor expression and responsiveness in canine skeletal muscle.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Aging; Animals; Arteries | 2012 |
Chronic reduction of nitric oxide level in adult spontaneously hypertensive rats induces aortic stiffness similar to old spontaneously hypertensive rats.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Blood Pressure; Clonidine; Hyperten | 2012 |
Ageing influences the effect of pre-hypoxic administration of clonidine, an alpha₂-adrenoceptor agonist, on post-hypoxic vasomotricity.
Topics: Adrenergic alpha-2 Receptor Agonists; Aging; Animals; Aorta, Thoracic; Clonidine; Endothelium, Vascu | 2012 |
Age-related changes in the release and uptake activity of presynaptic axon terminals of rat locus coeruleus neurons.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Aging; Animals; Clonidine; Fluoxetine; Fron | 2003 |
Growth hormone response to growth hormone-releasing hormone and clonidine in young monkeys: correlation with behavioral characteristics.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Anxiety; Area Under Curve; Behavior, Animal; Clonidine; F | 2003 |
Reduced cortical noradrenergic neurotransmission is associated with increased neophobia and impaired spatial memory in aged rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals | 2004 |
Clonidine increases caspase-3 mRNA level and DNA fragmentation in the developing rat brainstem.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Binding, | 2004 |
Direct and indirect inhibition by catecholamines of hypocretin/orexin neurons.
Topics: Action Potentials; Adrenergic alpha-Agonists; Aging; Animals; Calcium Channels; Catecholamines; Clon | 2005 |
Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Age Factors; Aging; Analysis of Variance; A | 2005 |
Normal aging impairs upregulation of the beta-adrenergic but not the alpha-adrenergic response: aging and adrenergic upregulation.
Topics: Adult; Aged; Aged, 80 and over; Aging; Blood Pressure; Clonidine; Female; Humans; Isoproterenol; Mal | 2006 |
Corneal thickness- and age-related biomechanical properties of the cornea measured with the ocular response analyzer.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Aging; Biomechanical Phenomena; Clonidine | 2006 |
Presynaptic alpha-2C adrenoceptor-mediated control of noradrenaline release in humans: genotype- or age-dependent?
Topics: Adrenergic alpha-Agonists; Adult; Aging; Blood Pressure; Clonidine; Female; Genotype; Heart Rate; Hu | 2007 |
Changes in brain alpha-adrenoceptors with increasing age in rabbits.
Topics: Aging; Animals; Blood Pressure; Brain; Clonidine; Male; Prazosin; Rabbits; Receptors, Adrenergic, al | 1984 |
Effects of CNS active drugs and somatostatin antiserum on growth hormone release in young and old male rats.
Topics: Aging; alpha-Methyltyrosine; Animals; Benzilates; Clonidine; Immune Sera; Kinetics; Male; Methyltyro | 1981 |
Effect of neonatal 6-hydroxydopamine treatment on alpha 1- and alpha 2-adrenoceptors in rat cerebral cortex.
Topics: Aging; Animals; Animals, Newborn; Brain; Clonidine; Female; Hydroxydopamines; Kinetics; Prazosin; Pr | 1982 |
Pharmacological characterization of central alpha-adrenoceptors which mediate clonidine-induced locomotor hypoactivity in the developing rat.
Topics: Aging; Animals; Central Nervous System; Clonidine; Female; Male; Motor Activity; Phentolamine; Piper | 1980 |
Ontogeny of alpha 1 and alpha 2-adrenoceptors in rat brain.
Topics: Aging; Animals; Brain; Clonidine; Female; Male; Norepinephrine; Prazosin; Rats; Receptors, Adrenergi | 1980 |
Central neurotransmitter receptors in hypertensive rats.
Topics: Aging; Animals; Blood Pressure; Brain; Clonidine; Hypertension; Hypothalamus; Male; Radioligand Assa | 1981 |
Resumption of pulsatile luteinizing hormone release after alpha-adrenergic stimulation in aging constant estrous rat.
Topics: Aging; Animals; Body Weight; Castration; Clonidine; Estrus; Female; Luteinizing Hormone; Organ Size; | 1982 |
Endogenous and exogenous regulation of human alpha- and beta-adrenergic receptors.
Topics: Adolescent; Adult; Aged; Aging; Blood Platelets; Clonidine; Estrogens; Female; Guanosine Triphosphat | 1983 |
The influence of aging on alpha-adrenoceptors in rat heart and vas deferens.
Topics: Aging; Animals; Clonidine; Heart; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rat | 1983 |
Involvement of sulfhydryl groups in cerebral cortical [3H]clonidine binding in developing rats.
Topics: 4-Chloromercuribenzenesulfonate; Aging; Animals; Cerebral Cortex; Clonidine; Dithiothreitol; Ethylma | 1983 |
Developmental changes of cerebral cortical [3H]clonidine binding in rats: influences of guanine nucleotide and cations.
Topics: Aging; Animals; Cerebral Cortex; Clonidine; Female; Guanosine Triphosphate; Imidazoline Receptors; K | 1984 |
Effect of aging on human plasma growth hormone response to clonidine.
Topics: Adult; Aged; Aging; Clonidine; Female; Growth Hormone; Humans; Hypertension; Male; Middle Aged; Refe | 1984 |
Specific binding of [3H]WB 4101, [3H]clonidine and [3H]dihydroalprenolol in cerebral cortical membranes in developing, adult and old rats.
Topics: Aging; Alprenolol; Animals; Cerebral Cortex; Clonidine; Dihydroalprenolol; Dioxanes; Dioxins; Female | 1984 |
Tourette syndrome: history and present status.
Topics: Aging; Clonidine; Demography; Ethnicity; Forecasting; Haloperidol; History, 15th Century; History, 1 | 1982 |
Maturation of central nervous system control of growth hormone secretion in rats.
Topics: 5-Hydroxytryptophan; Aging; Animals; Central Nervous System; Clonidine; Female; Growth Hormone; Male | 1981 |
Effects of aging on pain responses and analgesic efficacy of morphine and clonidine in rats.
Topics: Aging; Animals; Clonidine; Male; Morphine; Muridae; Nociceptors; Sensory Thresholds | 1982 |
Effect of age, clonidine or propranolol on behavioral toxicity induced with digitoxin in mice.
Topics: Aging; Animals; Behavior, Animal; Clonidine; Digitoxin; Drug Interactions; Gait; Male; Mice; Postura | 1982 |
[Changes in the number of alpha 2- and beta-adrenoreceptors in the brain stem and cerebral cortex of rats in ontogeny].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Brain Chemistry; Brain Stem; | 1995 |
Renal aging change of alpha 1-adrenoceptor in Wistar rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Autoradiography; Binding Sites; Clonidine; Kidney; Kin | 1995 |
Sustained negative inotropism mediated by alpha-adrenoceptors in adult mouse myocardia: developmental conversion from positive response in the neonate.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Atropine; | 1995 |
The difference in nifedipine sensitivity between hypertensive and normotensive rat aortae is dependent on age.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Aorta, Thoracic; Clonidine; Dioxanes; Hypertension; In | 1995 |
Alpha 1-adrenoceptor responsiveness in the aging aorta.
Topics: Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Aorta; Binding, Competitive; Clo | 1995 |
Effects of age on alpha 1-adrenoceptor subtypes in the heart ventricular muscle of the rat.
Topics: Adrenergic alpha-Antagonists; Aging; Alkylating Agents; Animals; Binding, Competitive; Clonidine; Di | 1993 |
Density of alpha-2A adrenoceptors and Gi proteins in the human brain: ratio of high-affinity agonist sites to antagonist sites and effect of age.
Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; | 1994 |
Neuroendocrine aging: its impact on somatotrophic function.
Topics: Aging; Animals; Clonidine; Cluster Analysis; Dogs; Female; Growth Hormone; Hypothalamus; Insulin-Lik | 1994 |
Effects of cytidine diphosphate choline on rats with memory deficits.
Topics: Aging; Animals; Avoidance Learning; Clonidine; Cytidine Diphosphate Choline; Electroshock; Fetal Alc | 1993 |
Age-related changes in norepinephrine release and its modulation by presynaptic alpha-2 adrenoceptors in the rat vas deferens.
Topics: Aging; Animals; Clonidine; Electric Stimulation; Epididymis; Estradiol; In Vitro Techniques; Male; M | 1993 |
Combined administration of growth-hormone-releasing hormone and clonidine restores defective growth hormone secretion in old dogs.
Topics: Aging; Animals; Clonidine; Dogs; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Insulin-L | 1993 |
6-Hydroxydopamine treatment of neonatal rats. II. Effects on the development of the hindlimb flexor reflex.
Topics: Aging; Animals; Animals, Newborn; Clonidine; Electric Stimulation; Hindlimb; Motor Activity; Movemen | 1993 |
Postnatal development of central nervous alpha 2-adrenergic binding sites: an in vitro autoradiography study in the tree shrew.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Clo | 1993 |
Expression of I2-imidazoline sites in rat prostate. Effect of castration and aging.
Topics: Adrenergic Agonists; Aging; Animals; Binding, Competitive; Cell Membrane; Clonidine; Dioxanes; Gene | 1996 |
Effects of aging on prejunctional control of neurotransmission in the rat.
Topics: Adrenergic Fibers; Aging; Animals; Catecholamines; Clonidine; Male; Neurotransmitter Agents; Presyna | 1996 |
Abdominal adiposity and physical fitness are major determinants of the age associated decline in stimulated GH secretion in healthy adults.
Topics: Abdomen; Adipose Tissue; Adult; Aging; Arginine; Body Constitution; Clonidine; Female; Growth Hormon | 1996 |
Evidence for an age-dependent functional expression of alpha 1D-adrenoceptors in the rat vasculature.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Blood Pressure; Blood Vessels; Clonidine; Male; Phenyl | 1997 |
Effects of stimulation of alpha 1-adrenergic and NMDA/glycine-B receptors on learning defects in aged rats.
Topics: Aging; Animals; Clonidine; Cycloserine; Male; Maze Learning; Rats; Rats, Wistar; Receptors, Adrenerg | 1997 |
Free insulin-like growth factor I serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of growth hormone deficiency.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aging; Biomarkers; Child; Child, Preschool; Clon | 1997 |
Noradrenergic influences on prefrontal cortical cognitive function: opposing actions at postjunctional alpha 1 versus alpha 2-adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Azepines; Brimonidine Tartr | 1998 |
Reproductive behavioral responsiveness to noradrenergic stimulation in developing guinea pigs.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Clonidine; Dose-Response Relationship, Drug; Estradiol; F | 1998 |
Age-related decrease in centrally-mediated pressor response to clonidine in conscious rats.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Antihypertensive Agents; Blood Pressure; Brain; Clonidine | 1998 |
Maturation and aging-related differences in responsiveness of rat aorta and carotid arteries to alpha1-adrenoceptor stimulation.
Topics: Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Aorta, Thoracic; Carotid Arterie | 1998 |
Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aged; Aging; Alzheimer Disease; Antimetabol | 1999 |
Age-specific effects of noradrenergic alpha-2 agonist clonidine on the development of amygdaloid kindling in developing rats.
Topics: Adrenergic alpha-Agonists; Aging; Amygdala; Animals; Anticonvulsants; Clonidine; Convulsants; Epilep | 2000 |
Alterations in respiratory behavior, brain neurochemistry and receptor density induced by pharmacologic suppression of sleep in the neonatal period.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Animals, Newborn; Animals, Suckling; Brain; Brain Chemist | 2000 |
A dopaminergic basis for the effects of amphetamine on a mouse "preadolescent hyperkinetic" model.
Topics: Adolescent; Aging; Amphetamine; Animals; Apomorphine; Clonidine; Disease Models, Animal; Humans; Hyp | 1977 |
Altered sensitivity of alpha 2-adrenoceptors in the brain during aging in rats.
Topics: Aging; Animals; Brain; Cardiovascular Physiological Phenomena; Cardiovascular System; Clonidine; Loc | 1992 |
Early postnatal clonidine treatment results in altered regional catecholamine utilisation in adult rat brain.
Topics: Aging; alpha-Methyltyrosine; Animals; Animals, Newborn; Brain Chemistry; Catecholamines; Chromatogra | 1992 |
Alpha 1-adrenoceptors in parotid cells: age does not alter the ratio of alpha 1A and alpha 1B subtypes.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Calcium; Clonidine; Dioxanes; Epinephrine; In Vitro Te | 1992 |
Alpha-2 adrenergic agonists decrease distractibility in aged monkeys performing the delayed response task.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Attention; Benzazepines; Cl | 1992 |
GH response to GHRH, insulin, clonidine and arginine after GHRH pretreatment in children.
Topics: Adolescent; Aging; Arginine; Child; Child, Preschool; Clonidine; Female; Growth Hormone; Growth Horm | 1992 |
Thymus-induced recovery of age-related decrease of brain cortex alpha- and beta-adrenoceptors.
Topics: Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Cerebral Cortex; Clonidine; Dihydroalprenolol; | 1991 |
Effects of aging on alpha 2-adrenoceptor mechanisms in isolated guinea-pig tracheal preparations.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Clonidine; Corticosterone; Dinoprost; Guinea Pigs; In Vit | 1991 |
Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Calcium; Clonidine; Female; | 1991 |
[The characteristics of the tension of neurohumoral regulation during the physical loading of dogs].
Topics: Aging; Animals; Clonidine; Dinoprostone; Dogs; Hormones; Male; Neurotransmitter Agents; Physical Exe | 1991 |
Regionally specific age-dependent decline in alpha 2-adrenoceptors: an autoradiographic study in human brain.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Aging; Autoradiography; Brain; Brimonidin | 1991 |
Clonidine enhances delayed matching-to-sample performance by young and aged monkeys.
Topics: Aging; Animals; Clonidine; Cognition; Macaca; Macaca fascicularis; Macaca mulatta; Psychomotor Perfo | 1991 |
Developmental changes in the regulation of plasma growth hormone concentrations in Holstein calves.
Topics: Aging; Animal Feed; Animals; Cattle; Clonidine; Digestion; Edible Grain; Growth Hormone; Growth Horm | 1991 |
Synergistic effect of growth hormone-releasing hormone (GHRH) and clonidine in stimulating GH release in young and old dogs.
Topics: Aging; Animals; Clonidine; Dogs; Drug Synergism; Female; Growth Hormone; Growth Hormone-Releasing Ho | 1990 |
[Changes of three types in the secretory systems present in the rat submandibular glands during aging].
Topics: Aging; Animals; Clonidine; Isoproterenol; Male; Norepinephrine; Rats; Receptors, Adrenergic; Saliva; | 1990 |
Altered responsiveness of central alpha 2-adrenoceptors in aging.
Topics: Aging; Animals; Behavior, Animal; Clonidine; Electroencephalography; Locus Coeruleus; Male; Rats; Ra | 1990 |
Protein secretion by rat submandibular glands in response to isoproterenol, alpha-methylnoradrenaline and clonidine during aging.
Topics: Aging; Animals; Clonidine; Isoelectric Focusing; Isoproterenol; Male; Nordefrin; Organ Size; Rats; R | 1990 |
Changes in basal and stimulated growth hormone secretion in the aging rhesus monkey: a comparison of chair restraint and tether and vest sampling.
Topics: Aging; Animals; Clonidine; Growth Hormone; Growth Hormone-Releasing Hormone; Hydrocortisone; Hypogly | 1990 |
Proactive interference effects on short-term memory in rats: I. Basic parameters and drug effects.
Topics: Aging; Animals; Appetitive Behavior; Association Learning; Clonidine; Discrimination Learning; Dose- | 1990 |
Pharmacological enhancement of long-term memory retention in old mice.
Topics: Aging; Animals; Clonidine; Male; Memory; Mice; Mice, Inbred C57BL; Neuropeptide Y | 1990 |
The effects of phosphatidylserine on the decreased cardiovascular response to clonidine microinfused into the nucleus tractus solitarii of old rats.
Topics: Aging; Animals; Blood Pressure; Clonidine; Heart Rate; Hemodynamics; Infusions, Intravenous; Male; M | 1990 |
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imiprami | 1988 |
Skeletal muscle fiber types and myosin ATPase activity do not change with age or growth hormone administration.
Topics: Aging; Animals; Clonidine; Growth Hormone; Muscles; Myocardium; Myosins; Rats; Rats, Inbred F344 | 1989 |
A functional study of the development of the cardiac sympathetic neuroeffector junction in the SHR.
Topics: Aging; Animals; Blood Pressure; Clonidine; Desipramine; Dose-Response Relationship, Drug; Electric S | 1989 |
Ontogeny of noradrenergic effects on ultrasonic vocalizations in rat pups.
Topics: Aging; Animals; Animals, Newborn; Arousal; Brain; Clonidine; Emotions; Naltrexone; Rats; Rats, Inbre | 1989 |
Effect of aging on presynaptic alpha 2-adrenoceptor mechanisms in guinea pig ileum.
Topics: Aging; Animals; Clonidine; Cystamine; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; | 1989 |
Lipolytic response of bovine adipose tissue to alpha and beta adrenergic agents 30 days pre- and 120 days postpartum.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; A | 1989 |
Noradrenergic mechanisms in age-related cognitive decline.
Topics: Aging; Animals; Cerebral Cortex; Clonidine; Cognition; Female; Macaca mulatta; Norepinephrine; Recep | 1987 |
Age related changes in the inhibitory effect of clonidine on high K+-evoked noradrenaline release from brain slices of rats.
Topics: Aging; Animals; Cerebral Cortex; Clonidine; In Vitro Techniques; Male; Norepinephrine; Potassium; Ra | 1988 |
Microinfusion of clonidine and yohimbine into locus coeruleus alters EEG power spectrum: effects of aging and reversal by phosphatidylserine.
Topics: Aging; Animals; Clonidine; Cortical Synchronization; Electroencephalography; Locus Coeruleus; Male; | 1988 |
Effect of clonidine on ultrasonic vocalization in preweaning rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Body Temperature; Clonidine; Dioxanes; Dose-Response R | 1988 |
Age-related alterations in cardiovascular responsiveness to clonidine infused into the nucleus tractus solitarii in rats.
Topics: Aging; Animals; Blood Pressure; Brain; Clonidine; Heart Rate; Infusions, Parenteral; Male; Rats; Rat | 1989 |
Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates.
Topics: Aging; Animals; Cerebral Cortex; Clonidine; Cognition; Female; Hydroxydopamines; Macaca mulatta; Mem | 1985 |
Alpha 2-adrenoceptor-GTP binding regulatory protein-adenylate cyclase system in cerebral cortical membranes of adult and senescent rats.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Aging; Animals; Cerebral Cortex; Clonidine; Colforsin; E | 1986 |
Age and alpha-2 adrenergic regulation of plasma norepinephrine kinetics in humans.
Topics: Adult; Aged; Aging; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Humans; Kinetics; M | 1987 |
Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat.
Topics: Aging; Animals; Animals, Newborn; Apomorphine; Body Temperature; Catecholamines; Clonidine; Cold Tem | 1988 |
Cholinergic influences on wall climbing and its ontogenetic decline.
Topics: Aging; Animals; Clonidine; Electroshock; Female; Male; Motor Activity; Parasympathetic Nervous Syste | 1988 |
Increased plasma and cerebrospinal fluid norepinephrine in older men: differential suppression by clonidine.
Topics: Adult; Aging; Clonidine; Humans; Male; Middle Aged; Norepinephrine; Reference Values | 1988 |
Age-related variation of EEG responses to clonidine, prazosin and yohimbine in rats.
Topics: Aging; Animals; Brain; Clonidine; Electroencephalography; Electrophysiology; Prazosin; Rats; Yohimbi | 1987 |
The natural history of Tourette syndrome: a follow-up study.
Topics: Adaptation, Psychological; Adolescent; Adolescent Behavior; Adult; Aging; Clonidine; Fluphenazine; F | 1987 |
Dietary salt intake and the clonidine suppression test.
Topics: Adult; Aging; Body Weight; Cardiography, Impedance; Catecholamines; Clonidine; Humans; Hypertension; | 1987 |
Neonatal 6-hydroxydopamine potentiates clonidine's locomotor effects throughout maturation in the rat.
Topics: Aging; Animals; Animals, Newborn; Catecholamines; Clonidine; Female; Hydroxydopamines; Motor Activit | 1985 |
Clonidine suppression testing in essential hypertension.
Topics: Adult; Aging; Blood Pressure; Clonidine; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged | 1985 |
Further examination of the effects of ageing on the adrenoceptor responsiveness of the rat vas deferens.
Topics: Aging; Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Male; M | 1985 |
A comparison of alpha 2-adrenoceptor regulation in brain and platelets.
Topics: Aging; Amitriptyline; Animals; Blood Platelets; Brain; Clonidine; Estradiol; Female; Injections, Int | 1985 |
Altered development of responsiveness to clonidine in severely malnourished rats.
Topics: Aging; Animals; Body Weight; Clonidine; Female; Motor Activity; Nutrition Disorders; Rats; Rats, Inb | 1985 |