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clonidine and Age-Related Memory Disorders

clonidine has been researched along with Age-Related Memory Disorders in 18 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

ExcerptRelevanceReference
"Current pharmacotherapies for PTSD manage only a subset of these symptoms and typically have adverse side effects which limit their overall effectiveness."5.39Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. ( Diamond, DM; Fleshner, M; Zoladz, PR, 2013)
"Sub-acute brain ischemia is a risk factor for the development of vascular dementia (VaD)."1.40Pharmacological modulation of I(1)-imidazoline and α2-adrenoceptors in sub acute brain ischemia induced vascular dementia. ( Gupta, S; Sharma, B, 2014)
"Current pharmacotherapies for PTSD manage only a subset of these symptoms and typically have adverse side effects which limit their overall effectiveness."1.39Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. ( Diamond, DM; Fleshner, M; Zoladz, PR, 2013)
"Additionally, only reboxetine reduced memory deficits in the MWM."1.38Morris water maze performance deficit produced by intermittent swim stress is partially mediated by norepinephrine. ( Drugan, RC; Warner, TA, 2012)
"Clonidine pretreatment significantly alleviated these drug-induced deficits."1.35The effects of clonidine on discrete-trial delayed spatial alternation in two rat models of memory loss. ( Bardgett, ME; Griffith, MS; Lamontagne, T; McDaniel, T; Points, M; Ramsey-Faulkner, C; Roflow, J; Topmiller, J, 2008)
"Clonidine pretreatment (0."1.31Noradrenergic alpha-2 receptor agonists reverse working memory deficits induced by the anxiogenic drug, FG7142, in rats. ( Arnsten, AF; Birnbaum, SG; Podell, DM, 2000)
"Memory deficits were induced by the muscarinic cholinoceptor antagonist scopolamine (in young and old rats and mice), by the alpha 2-adrenoceptor agonist clonidine, by electroconvulsive shock, and by hypoxy."1.29Effects of cytidine diphosphate choline on rats with memory deficits. ( Getova, D; Kehayov, RA; Lazarova, MB; Mosharrof, AH; Petkov, VD; Petkov, VV; Vaglenova, J, 1993)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.56)18.7374
1990's3 (16.67)18.2507
2000's5 (27.78)29.6817
2010's8 (44.44)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Sang, Z2
Pan, W1
Wang, K2
Ma, Q1
Yu, L1
Yang, Y1
Bai, P2
Leng, C1
Xu, Q1
Li, X1
Tan, Z1
Liu, W1
Zhang, P1
Shi, J1
Cheng, X1
Zhang, Q1
Zheng, C1
Cheng, Y1
Yang, J1
Lu, X1
Marin, FN1
Franzen, JM1
Troyner, F1
Molina, VA1
Giachero, M1
Bertoglio, LJ1
Jafari-Sabet, M1
Banafshe, HR1
Khodadadnejad, MA1
Gupta, S1
Sharma, B1
Norozpour, Y1
Nasehi, M2
Sabouri-Khanghah, V1
Torabi-Nami, M1
Zarrindast, MR2
Beiranvand, A1
Moghaddasi, M1
Warner, TA1
Drugan, RC1
Zoladz, PR1
Fleshner, M1
Diamond, DM1
Collier, TJ1
Greene, JG1
Felten, DL1
Stevens, SY1
Collier, KS1
Jentsch, JD2
Anzivino, LA1
Marrs, W1
Kuperman, J1
Avedian, T1
Roth, RH1
Bardgett, ME1
Points, M1
Ramsey-Faulkner, C1
Topmiller, J1
Roflow, J1
McDaniel, T1
Lamontagne, T1
Griffith, MS1
Petkov, VD3
Kehayov, RA1
Mosharrof, AH1
Petkov, VV1
Getova, D1
Lazarova, MB2
Vaglenova, J1
Birnbaum, SG1
Podell, DM1
Arnsten, AF1
Lazarova-Bakarova, MB1
Petkova, BP1
Todorov, IK1
Voronina, TA1
Garibova, TL1
Trofimov, SS1
Sopyev, ZhA1
Fein, G1
Merrin, EL1
Davenport, L1
Buffum, JC1

Other Studies

18 other studies available for clonidine and Age-Related Memory Disorders

ArticleYear
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2017, Apr-21, Volume: 130

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholine

2017
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.
    European journal of medicinal chemistry, 2019, Dec-01, Volume: 183

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biological Tr

2019
Taking advantage of fear generalization-associated destabilization to attenuate the underlying memory via reconsolidation intervention.
    Neuropharmacology, 2020, 12-15, Volume: 181

    Topics: Adrenergic alpha-Agonists; Animals; CA1 Region, Hippocampal; Clonidine; Early Growth Response Protei

2020
Modulation of muscimol state-dependent memory by α2-adrenoceptors of the dorsal hippocampal area.
    European journal of pharmacology, 2013, Jun-15, Volume: 710, Issue:1-3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Avoidance Le

2013
Pharmacological modulation of I(1)-imidazoline and α2-adrenoceptors in sub acute brain ischemia induced vascular dementia.
    European journal of pharmacology, 2014, Jan-15, Volume: 723

    Topics: Acetylcholinesterase; Adrenergic alpha-2 Receptor Agonists; Animals; Brain; Brain Ischemia; Catalase

2014
The effect of CA1 α2 adrenergic receptors on memory retention deficit induced by total sleep deprivation and the reversal of circadian rhythm in a rat model.
    Neurobiology of learning and memory, 2016, Volume: 133

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Behavior, An

2016
Involvement of medial prefrontal cortex alpha-2 adrenoceptors on memory acquisition deficit induced by arachidonylcyclopropylamide, a cannabinoid CB1 receptor agonist, in rats; possible involvement of Ca2+ channels.
    Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:9

    Topics: Amnesia; Animals; Arachidonic Acids; Calcium Channels; Clonidine; Dose-Response Relationship, Drug;

2016
Morris water maze performance deficit produced by intermittent swim stress is partially mediated by norepinephrine.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Analy

2012
Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD.
    Progress in neuro-psychopharmacology & biological psychiatry, 2013, Jul-01, Volume: 44

    Topics: Adrenocorticotropic Hormone; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antihypertens

2013
Reduced cortical noradrenergic neurotransmission is associated with increased neophobia and impaired spatial memory in aged rats.
    Neurobiology of aging, 2004, Volume: 25, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals

2004
A low dose of the alpha2 agonist clonidine ameliorates the visual attention and spatial working memory deficits produced by phencyclidine administration to rats.
    Psychopharmacology, 2004, Volume: 175, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Attention; Clonidine; Dose-Response Relationship, Dru

2004
Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analy

2005
The effects of clonidine on discrete-trial delayed spatial alternation in two rat models of memory loss.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:8

    Topics: Adrenergic alpha-Agonists; Animals; Attention; Clonidine; Dizocilpine Maleate; Excitatory Amino Acid

2008
Effects of cytidine diphosphate choline on rats with memory deficits.
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:8

    Topics: Aging; Animals; Avoidance Learning; Clonidine; Cytidine Diphosphate Choline; Electroshock; Fetal Alc

1993
Noradrenergic alpha-2 receptor agonists reverse working memory deficits induced by the anxiogenic drug, FG7142, in rats.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Carbolines; Clonidine; GAB

2000
Memory impairment induced by combined disturbance of noradrenergic and dopaminergic neurotransmissions: effects of nootropic drugs.
    Acta physiologica et pharmacologica Bulgarica, 1991, Volume: 17, Issue:1

    Topics: Animals; Avoidance Learning; Benzoates; Central Nervous System Agents; Clonidine; Dopamine; Haloperi

1991
Comparative studies on the influence of ONK (N(5-hydroxynicotinoil) glutamic acid), piracetam and meclofenoxate on the learning- and memory-impairing effect of scopolamine, clonidine, and methergoline.
    Acta physiologica et pharmacologica Bulgarica, 1991, Volume: 17, Issue:4

    Topics: Animals; Avoidance Learning; Clonidine; Glutamates; Learning Disabilities; Male; Meclofenoxate; Memo

1991
Memory deficits associated with clonidine.
    General hospital psychiatry, 1987, Volume: 9, Issue:2

    Topics: Aged; Clonidine; Humans; Male; Memory Disorders; Neuropsychological Tests

1987